Reg. No.
B.Tech. DEGREE EXAMINATION, JULY 2023
First / Second Semester
21BTB102T – INTRODUCTION TO COMPUTATIONAL BIOLOGY
(For the candidates admitted from the academic year 2022-2023)
Note:
(i) Part - A should be answered in OMR sheet within first 40 minutes and OMR sheet should be handed
over to hall invigilator at the end of 40th minute.
(ii) Part – B and Part – C should be answered in answer booklet.
Time: 3 Hours Max. Marks: 75
PART – A (20 × 1 = 20Marks) Marks BL CO PO
Answer ALL Questions
1. Which one is involved in photosynthesis? 1 1 1 4
(A) Chloroplasts (B) Endoplasmic reticulum
(C) Cell wall (D) Ribosomes
2. Name the process where paternal and maternal genetic material is 1 1 1 4
exchanged
(A) Bivalency (B) Crossing over
(C) Synapsis (D) Dyad formation
3. An example of single celled eukaryotic organism. 1 1 1 4
(A) Yeart (B) Ferns
(C) Bacteria (D) Protozoa
4. The organelle that has fluid filled sacs for storage 1 1 1 4
(A) ER (B) Golgi
(C) Vacuole (D) Centriole
5. What is the lipid related disease? 1 1 2 1
(A) Scurvy (B) Rickets
(C) Sickle cell anemia (D) Atherosclerosis
6. Carbohydrates are poly hydroxyl complex of 1 1 2 1
(A) Glycosidic bonds (B) Glucose and glucose
(C) Glucose and alcohol (D) Aldehydes and ketones
7. DNA contains 1 1 2 1
(A) Glycosydic bond (B) Phosphodiester bond
(C) Iconic bond (D) Peptide bond
8. Where is lipopolysaccharide present? 1 1 2 1
(A) Cell cytoplasm (B) Cell membrane
(C) Cell junction (D) Cell
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9. Which is not a stop codon? 1 1 3 2
(A) UAA (B) UAG
(C) UGA (D) CGA
10. Fibrous proteins have 1 1 3 2
(A) Structural functions (B) Metabolic functions
(C) Transport functions (D) Enzymatic functions
11. Amyloidosis is caused by 1 1 3 2
(A) Changes in secondary structure (B) Changes in tertiary structure
(C) Changes in quaternary structure (D) Changes in primary structure
12. PDB database is a 1 1 3 2
(A) Primary database (B) Secondary database
(C) Tertiary database (D) Composite database
13. The multiple projections from the cell body of neurons are 1 1 4 1
(A) Axons (B) Dendrites
(C) Spindle fiber (D) Flagella
14. Which of the following cells in the brain produced from monocytes? 1 1 4 3
(A) Microglia (B) Astrocytes
(C) Schwann (D) Oligodendrocytes
15. Multiple sclerosis is a disease caused by 1 1 4 1
(A) Schwann cells (B) Astrocytes
(C) Skin cells (D) Neuronal cell body
16. Type of machine learning are 1 1 4 1
(A) Deep learning (B) Supervised
(C) Unsupervised (D) Dynamic
17. Immune cells that allows for subsequent recognition of antigen 1 1 5 1
(A) Memory cell (B) Plasma cell
(C) Basophil (D) APC
18. Name the process a cell such as a neutrophil or a macrophage use to eat 1 1 5 1
prey
(A) Chemotoxis (B) Phagocytosis
(C) Endocytosis (D) Exocytosis
19. Which is not an auto immune diseases? 1 1 5 1
(A) Influenza (B) Rheumatoid arthritis
(C) Multiple sclerosis (D) Lupers
20. ______ secrete histamines to attract other immune cells. 1 1 5 1
(A) Macrophages (B) Mast cells
(C) Platelets (D) Neutrophils
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PART – B (4 × 10 = 40 Marks) Marks BL CO PO
Answer ANY FOUR Questions
21. State the properties and applications of stem cells. 10 2 1 4
22. Write a note on BLAST and its uses. 10 2 2 1
23. Describe transcription and the processing of its end product. 10 2 3 2
24. Write the basis of artificial neural network – also describe the parts of 10 2 4 1
neural network.
25. Illustrate with neat diagrams of humoral immunity. 10 2 5 1
26. Explain the types and uses of sequence databases. 10 2 2 1
PART – C (1 × 15 = 15 Marks) Marks BL CO PO
Answer ANY ONE Questions
27. How a skin cell is different from a nerve cells? 15 4 1 4
28. If two protein sequences are similar - Explain (Justify) 15 4 2 1
(i) How their function will be similar?
(ii) The organisms that contain these proteins are evolutionarily
related
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