fi i i \. ig : ¥ i 2 -@/-_@; i--@? -@i—e) o|-@|—_e; of +©1|~8ii/-0f]-0/ {-@| -2-0)-2/[-9] @|-|-@|—@, it{-@|—e -si-e|-0!-9/-8/-@ @j-e|-®|-@!-@: of o}--2|{|-«||~-e)j-e||-0| —e: - ane mobile uou'ks. - reamed porkealt ta Bowe marrow oud parkvally im (1) Qfrargid oor te (yom ph kiss ue. ww Momoer ly to ly mphe i os leonfisepbs, GME (2) Planma Celi- Gamer Chemacherskiers-Tee w Peerner tines Neulbeplil - @) Pp: eo simo pl'l. { Grenoter te (3) Pe bane pha'ls cy) Momo cy bes Lyomphoey kes (6) Planma cell (© ceastonaty) Conecen len 154, s- a About mifooon/ 7 ww? . - Abbrox % . ey Qi Neubo phil = 62%¢ pea Eosimo plus = 234° Fy a Basoplvl = 0-4 % gi soars Momoey ly = 53% ae. Ka mphe egke = 30% OP monn on Oe: mm ATL a a eon 1, Neutrophils 50 1070 3,000 to 6,000 10 to 12 205 (ea we pee Tee3, Basophils 0to1 Oto 100 8 to 10 12 to 15 ee ee 5. Lymphocytes 20 1030 4,500 to 3,000 To 12 hot = a- 7 Leet ele Genesis of lymphocytes “or aa ve Neabop he’ nye phil Bos { { im) ee ! & to ‘@ ee SO Or pel oy, woe oe a ~® 12 Heke 16 @ i. Tel Mego P- —muder —iucleer — besophil Neakeopkil Eosinophil peenaet » Abouk 3 teins of trany WIBC an shored im the marvow o4 uvculake im the enki blood: ( Reposentenng a 6 day supply) ieee URC maT ac rdCell Type MYELOID Neutrophils Eosinophils Basophils LYMPHOID T lymphocytes B lymphocytes MONOCYTIC Monocytes ie of Total 50-70 14 <0.5 20-40 28 Functions Endothelial adhesion, chemotaxis, phagocytosis, antibacterial compounds in granules Interaction with T lymphocytes i Inflammation, initiation of tissue repair after injury Cellular immunity (helper, memory and cytotoxic T cells) Humoral immunity (plasma cells secreting immunoglobulins) Immunoregulatory—antigen- presenting cells, phagocytic, chemotaxis fw granulogbeas ~ Now reall 7 4-9 hero tm bleed » 4-5 dag iF cm vesue- Momoey bes lo-20 hare im bleod Omee tm +’ssue > car (then cotled te'ssue macoo phy e) Lympheesle ymph —~ Lymph a . im Pr monHs. modes- Life span 5 taleeks om Momtlys - heal un Aye 3 Infant > 20,000 /mm 3 Cluldacn % 10,000 - 15,000 Jum Adwk 4 4000 - 11,000) m4 @ Sexe Males > Fanaa [SUighth) (3) Diurnat K Meax in af bernoon Mim in early morning CG) Exercr'se + SQ) ime. (5) Sleep > Dee (6) Emokim cond (anmuetr) + Tne. wm eran : Ine. (8) Mens bowhion : Ime WW) Porlurrk'n + Tne. Pa bholoyseat o Ww Leu kopemu’a + Dee below 4o00 fry?WM Anaphy lactic Shock (2) Civrhosi's (3) Disorders I shleen e 4) Perms uto wy amem'a: C5) Ty phecd 4 Faraky pherd- ) Viral iheckeion (2) lea ko crtosi'e 3 Ime abo. 11,000 f eam? qv Sm Feckiong (2) Allergy (3) Coumon eat ta) Tuberculosis (5) Qlondutar Tn (3) Qramul oey bests t- Abnormal the ih mo. J qoramet ocy kes: US) Gramuloepbopernua s- Abmonme dec um gramubo cyber (5) Ajramlocy bests [Agramulesis | Grravtopenca 3- Ackue pathele ea} Comd. Chaneckem'zed L q cramulo cy bes for lentory Neath (6) Leuk emu'a t-rized by Leukemia is a type of blood cancer chi ‘production of large number of leukocytes including immature and abnormal leukocytes ‘Acute lymphocyte or lymphoblastic leukemia: Characterized by rapid increase in number of lymphocytes | 2. Chronic lymphocytic or ymphobiastcteukemia: | Characterized by gradual increase in number of lymphocytes 3. Acute myeloid or myelogenous leukemia ‘Characterized by rapid increase in number of myeloid ‘alls (granulocytes and monocytes) 4. Chronic myeloid or myelogenous leukemia Gharacterzed by gradual increase in number of myeloid cells Risk factors 1. Previous chemotherapy oF radiation therapy 2. Exposure to high levels of radiation like radiation from nuclear reactor accident 3. Long-term exposure to chemicals such as formaldehyde, benzene and other industrial chemicals. | Smoking | Genetic disorders such as Down syndrome 1. Persistent tredness or weakness 2 Weight oss: 3. Pain in bones or joints 4. Lymph nodes swelling 5. Frequent infections 6 z 8 ne ol a laces ee sieeSrarernmac nthe etna So cae ee ante ea etre Reopening WBe + - (a) brapedare cb» Ameba'd Movement ( Neubrophi Li y Ao bes ous of \gompho Ske ) (CO) Chemokanrs ay Phapoertesrs ( nleu bop hil, a Money kes) sPanelvovss 3-cy Neuboplil s- | Proteases Myeloperoxidases Destruction of Elastases microorganfeme Metalloproteinases: Cathelicidins Antimicrobial action I Platelet-activating factor __ Aggregation of platelets (@) Eo stmo pel ee Ciescu al Rar) 1. Eosinophil Destruction of parasitic worms, peroxidase bacteria and tumor cells 3. Eosinophil cationic Destruction of parasitic worms Neurotoxic action | * soca Acceleration of inflammatory 5. Cytokines: response Interleukin-4 and § Destruction of invading organisms (3) Banopli i Prise tice er) Net Prevention of intravascular saa blood clotting Destruction of microorganismsMeter) Acceleration of inflammatory response SL Destruction of invading organisms [RABE ere 3. Platelet-activating factor Aggregation of plateletes ee oo ccaleraton of fanmatny Sense 1 tareukins 24.8; pesston of invading efeniars ‘atioton ecole an 8 ens _ stron of ogee | 2. Gamma interferon actions of __ macrophak = Destruction of invading organisms: ToT Destruction of invading 4. Immunoglobulins carol