SAFETY DATA SHEET Version 6.

11
Revision Date 03.01.2024
according to Regulation (EC) No. 1907/2006 Print Date 25.02.2025
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Heptane
Product Number : 494526
Brand : Sigma-Aldrich
Index-No. : 601-008-00-2
REACH No. : 01-2119457603-38-XXXX
CAS-No. : 142-82-5

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Merck Life Science N.V.
Haarlerbergweg 21 A
1101 CH AMSTERDAM
NETHERLANDS
Telephone : +31 078 620-5411
Fax : +31 078 620-5421
E-mail address : technischeservicebenelux@merckgroup.com
1.4 Emergency telephone

Emergency Phone # : +(31)-858880596 (CHEMTREC)

112 (Alarmnummer)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Flammable liquids, (Category 2) H225: Highly flammable liquid and vapor.

Skin irritation, (Category 2) H315: Causes skin irritation.

Specific target organ toxicity - H336: May cause drowsiness or dizziness.

single exposure, (Category 3),
Central nervous system

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 Aspiration hazard, (Category 1) H304: May be fatal if swallowed and enters
airways.

Short-term (acute) aquatic H400: Very toxic to aquatic life.

hazard, (Category 1)

Long-term (chronic) aquatic H410: Very toxic to aquatic life with long
hazard, (Category 1) lasting effects.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal Word Danger

Hazard Statements
H225 Highly flammable liquid and vapor.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
P233 Keep container tightly closed.
P273 Avoid release to the environment.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P331 Do NOT induce vomiting.
Supplemental Hazard none
Statements

Reduced Labeling (<= 125 ml)

Pictogram

Signal Word Danger

Hazard Statements
H304 May be fatal if swallowed and enters airways.
Precautionary Statements
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
P331 Do NOT induce vomiting.
Supplemental Hazard none
Statements

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2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

Ecological information:
The substance/mixture does not contain components considered to have endocrine
disrupting properties according to REACH Article 57(f) or Commission Delegated regulation
(EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Toxicological information:
The substance/mixture does not contain components considered to have endocrine
disrupting properties according to REACH Article 57(f) or Commission Delegated regulation
(EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Formula : C7H16
Molecular weight : 100,20 g/mol
CAS-No. : 142-82-5
EC-No. : 205-563-8
Index-No. : 601-008-00-2
Component Classification Concentration
n-heptane
CAS-No. 142-82-5 Flam. Liq. 2; Skin Irrit. 2; <= 100 %
EC-No. 205-563-8 STOT SE 3; Asp. Tox. 1;
Index-No. 601-008-00-2 Aquatic Acute 1; Aquatic
Chronic 1; H225, H315,
H336, H304, H400, H410
Concentration limits:
20 %: STOT SE 3, H336;
M-Factor - Aquatic Acute:
1 - Aquatic Chronic: 1

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower.

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 In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Pulmonary
failure possible after aspiration of vomit. Call a physician immediately.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Flash back possible over considerable distance.
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.Remove
container from danger zone and cool with water. Prevent fire extinguishing water from
contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance
contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.

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6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary
measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands
and face after working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Store under inert gas.
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and
sources of ignition.

Storage class
Storage class (TRGS 510): 3: Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
Ingredients with workplace control parameters
Derived No Effect Level (DNEL)
Application Area Routes of Health effect Value
exposure
Worker DNEL, inhalation Systemic effects 2085 mg/m3
longterm
Worker DNEL, dermal Systemic effects
longterm
Consumer DNEL, inhalation Systemic effects 447 mg/m3
longterm
Consumer DNEL, dermal Systemic effects
longterm

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 Consumer DNEL, oral Systemic effects
longterm
Predicted No Effect Concentration (PNEC)
Compartment Value
No data available
8.2 Exposure controls
Personal protective equipment

Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN 16523-1 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN 16523-1 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,2 mm
Break through time: 60 min
Material tested:Dermatril® P (KCL 743 / Aldrich Z677388, Size M)
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic
compounds
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following
standards: DIN EN 143, DIN 14387 and other accompanying standards relating to
the used respiratory protection system.
Recommended Filter type: Filter type ABEK

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 The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Physical state liquid
b) Color No data available
c) Odor No data available
d) Melting Melting point/range: -91 °C
point/freezing point
e) Initial boiling point 98 °C
and boiling range
f) Flammability (solid, No data available
gas)
g) Upper/lower Upper explosion limit: 7 %(V)
flammability or Lower explosion limit: 1,1 %(V)
explosive limits
h) Flash point -4 °C - c.c.
i) Autoignition 223,0 °C
temperature
j) Decomposition No data available
temperature
k) pH No data available
l) Viscosity Viscosity, kinematic: 0,64 mm2/s at 20 °C

Viscosity, dynamic: No data available

m) Water solubility insoluble
n) Partition coefficient: log Pow: > 3 - Bioaccumulation is not expected.
n-octanol/water
o) Vapor pressure 48 hPa at 20,0 °C
p) Density 0,684 g/mL at 25 °C
Relative density No data available
q) Relative vapor No data available
density
r) Particle No data available
characteristics

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 s) Explosive properties No data available
t) Oxidizing properties none
9.2 Other safety information
No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
Vapors may form explosive mixture with air.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Risk of ignition or formation of inflammable gases or vapours with:
Strong oxidizing agents
phosphorus
in the presence of:
Chlorine

10.4 Conditions to avoid

Warming.
10.5 Incompatible materials
rubber, various plastics
10.6 Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - > 5.000 mg/kg
(OECD Test Guideline 401)
Remarks: The value is given in analogy to the following substances: isooctane
LC50 Inhalation - Rat - male and female - 4 h - > 29,29 mg/l - vapor

(OECD Test Guideline 403)

LD50 Dermal - Rabbit - male and female - > 2.000 mg/kg
(OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: isooctane
Skin corrosion/irritation
Skin - Rabbit
Result: Irritating to skin. - 24 h
(OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: isooctane
Remarks: Repeated or prolonged exposure may cause skin irritation and dermatitis, due to
degreasing properties of the product.

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 Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
(OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: isooctane
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative
(OECD Test Guideline 406)
Remarks: Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: Chromosome aberration test in vitro
Test system: rat hepatocytes
Method: OECD Test Guideline 473
Result: negative
Carcinogenicity
This product is or contains a component that is not classifiable as to its carcinogenicity
based on its IARC, ACGIH, NTP, or EPA classification.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
May cause drowsiness or dizziness.
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
May be fatal if swallowed and enters airways.
Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
RTECS: MI7700000
Prolonged or repeated exposure to skin causes defatting and dermatitis., Central nervous
system depression, narcosis, Damage to the lungs.
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.

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SECTION 12: Ecological information
12.1 Toxicity
No data available
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 10 d
Result: 70 % - Readily biodegradable.
Remarks: (ECHA)

Biochemical Oxygen 1.920 mg/g

Demand (BOD) Remarks: (IUCLID)
Theoretical oxygen 3.500 mg/g
demand Remarks: (Lit.)
Ratio BOD/ThBOD 55 %
Remarks: (Lit.)
12.3 Bioaccumulative potential
Indication of bioaccumulation.
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

Additional ecological Do not empty into drains. Avoid release to the environment.
information

SECTION 13: Disposal considerations

13.1 Waste treatment methods
No data available

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SECTION 14: Transport information
14.1 UN number
ADR/RID: 1206 IMDG: 1206 IATA: 1206
14.2 UN proper shipping name
ADR/RID: HEPTANES
IMDG: HEPTANES
IATA: Heptanes
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
14.6 Special precautions for user
Tunnel restriction code : (D/E)
Further information : No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
Authorisations and/or restrictions on use
National legislation
Seveso III: Directive 2012/18/EU of the E1 ENVIRONMENTAL HAZARDS
European Parliament and of the Council
on the control of major-accident hazards
involving dangerous substances.
P5c FLAMMABLE LIQUIDS

Other regulations
Take note of Dir 94/33/EC on the protection of young people at work.
15.2 Chemical Safety Assessment
A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements
H225 Highly flammable liquid and vapor.
H304 May be fatal if swallowed and enters airways.
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 H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods
by Inland Waterways; ADR - Agreement concerning the International Carriage of
Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM -
American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen,
Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for
Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration
associated with x% response; ELx - Loading rate associated with x% response; EmS -
Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; GHS - Globally Harmonized
System; GLP - Good Laboratory Practice; IARC - International Agency for Research on
Cancer; IATA - International Air Transport Association; IBC - International Code for the
Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half
maximal inhibitory concentration; ICAO - International Civil Aviation Organization;
IECSC - Inventory of Existing Chemical Substances in China; IMDG - International
Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial
Safety and Health Law (Japan); ISO - International Organisation for Standardization;
KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a
test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose);
MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. -
Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration;
NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading
Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for Economic
Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution
Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines
Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure
Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European
Parliament and of the Council concerning the Registration, Evaluation, Authorisation and
Restriction of Chemicals; RID - Regulations concerning the International Carriage of
Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS -
Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand
Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN
- United Nations; UNRTDG - United Nations Recommendations on the Transport of
Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

Further information
The information is believed to be correct but is not exhaustive and will be used solely as
a guideline, which is based on current knowledge of the chemical substance or mixture
and is applicable to appropriate safety precautions for the product. It does not represent
any guarantee of the properties of the product. Sigma-Aldrich Corporation and its
Affiliates shall not be held liable for any damage resulting from handling or from contact
with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.

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