SAFETY DATA SHEET Version 6.

3
Revision Date 18.03.2023
according to Regulation (EC) No. 1907/2006 Print Date 03.05.2023
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Acetic acid
Product Number : 537020
Brand : Sigma-Aldrich
Index-No. : 607-002-00-6
REACH No. : 01-2119475328-30-XXXX
CAS-No. : 64-19-7

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : SIGMA-ALDRICH CANADA LTD.
2149 WINSTON PARK DRIVE
OAKVILLE ON L6H 6J8
CANADA
Telephone : +1 905 829-9500
Fax : +1 905 829-9292
1.4 Emergency telephone
Emergency Phone # : 800-424-9300 CHEMTREC (USA)
+1-703-527-3887 CHEMTREC
(International)
24 Hours/day; 7 Days/week

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 3), H226
Skin corrosion (Sub-category 1A), H314
Serious eye damage (Category 1), H318
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

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 Signal Word Danger
Hazard statement(s)
H226 Flammable liquid and vapor.
H314 Causes severe skin burns and eye damage.
Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P305 + P351 + P338 + IF IN EYES: Rinse cautiously with water for several minutes.
P310 Remove contact lenses, if present and easy to do. Continue
rinsing. Immediately call a POISON CENTER/ doctor.
Supplemental Hazard none
Statements

Reduced Labeling (<= 125 ml)

Pictogram

Signal Word Danger

Hazard statement(s)
H314 Causes severe skin burns and eye damage.
Precautionary statement(s)
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P305 + P351 + P338 + IF IN EYES: Rinse cautiously with water for several minutes.
P310 Remove contact lenses, if present and easy to do. Continue
rinsing. Immediately call a POISON CENTER/ doctor.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Synonyms : Glacial acetic acid

Formula : C2H4O2
Molecular weight : 60,05 g/mol
CAS-No. : 64-19-7
EC-No. : 200-580-7
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 Index-No. : 607-002-00-6
Component Classification Concentration
acetic acid
CAS-No. 64-19-7 Flam. Liq. 3; Skin Corr. <= 100 %
EC-No. 200-580-7 1A; Eye Dam. 1; H226,
Index-No. 607-002-00-6 H314, H318
Concentration limits:
>= 90 %: Skin Corr. 1A,
H314; 25 - < 90 %: Skin
Corr. 1B, H314; 10 - < 25
%: Skin Irrit. 2, H315; 10
- < 25 %: Eye Irrit. 2,
H319; 10 - < 25 %: Eye
Irrit. 2, H319; 10 - < 25
%: Skin Irrit. 2, H315; 25
- < 90 %: Skin Corr. 1B,
H314; >= 90 %: Skin
Corr. 1A, H314; >= 90 %:
3, H226;

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of
water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse
mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

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SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Dry powder Dry sand
Unsuitable extinguishing media
Do NOT use water jet.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of
vapors accumulating to form explosive concentrations. Vapors can accumulate in low
areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand,
earth, diatomaceous earth, vermiculite) and place in container for disposal according to
local / national regulations (see section 13).
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Advice on safe handling
Avoid inhalation of vapor or mist.
Advice on protection against fire and explosion
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of
electrostatic charge.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before
breaks and at the end of workday.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions

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 Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage. Store in cool place.
Moisture sensitive.
Storage class
Storage class (TRGS 510): 3: Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
Ingredients with workplace control parameters
Derived No Effect Level (DNEL)
Application Area Routes of Health effect Value
exposure
Workers Inhalation Acute local effects 25 mg/m3
Workers Inhalation Long-term local effects 25 mg/m3
Workers Skin contact Long-term local effects 10mg/kg BW/d
Consumers Inhalation Acute local effects 25 mg/m3
Consumers Inhalation Long-term local effects 25 mg/m3
Predicted No Effect Concentration (PNEC)
Compartment Value
Soil 0,478 mg/kg
Sea water 0,3058 mg/l
Fresh water 3,058 mg/l
Sea sediment 1,136 mg/kg
Fresh water sediment 11,36 mg/kg
Sewage treatment plant 85 mg/l
Aquatic intermittent release 30,58 mg/l
8.2 Exposure controls
Personal protective equipment

Eye/face protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye
protection tested and approved under appropriate government standards such as
NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU)
2016/425 and the standard EN 374 derived from it.
Full contact
Material: butyl-rubber
Minimum layer thickness: 0,3 mm

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 Break through time: 480 min
Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M)
Splash contact
Material: Nature latex/chloroprene
Minimum layer thickness: 0,6 mm
Break through time: 32 min
Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail
sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which
differ from EN 374, contact the supplier of the EC approved gloves. This
recommendation is advisory only and must be evaluated by an industrial hygienist
and safety officer familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use
scenario.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective
clothing., The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-
face respirator with multi-purpose combination (US) or type ABEK (EN 14387)
respirator cartridges as a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator. Use respirators and
components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Physical state liquid
b) Color colorless
c) Odor stinging
d) Melting Melting point/range: 16,2 °C - lit.
point/freezing point
e) Initial boiling point 117 - 118 °C - lit.
and boiling range
f) Flammability (solid, Not applicable
gas)
g) Upper/lower Upper explosion limit: 19,9 %(V)
flammability or Lower explosion limit: 4 %(V)
explosive limits
h) Flash point 39 °C - closed cup
i) Autoignition 463 °C

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 temperature
j) Decomposition Distillable in an undecomposed state at normal pressure.
temperature
k) pH 2,5 at 50 g/l at 20 °C

l) Viscosity Viscosity, kinematic: 1,17 mm2/s at 20 °C

Viscosity, dynamic: No data available

m) Water solubility 602,9 g/l at 25 °C at 1.013 hPa - completely soluble
n) Partition coefficient: log Pow: -0,17 at 25 °C - Bioaccumulation is not expected.,
n-octanol/water (ECHA)
o) Vapor pressure 20,79 hPa at 25 °C
p) Density 1,049 g/cm3 at 25 °C - lit.
Relative density No data available
q) Relative vapor No data available
density
r) Particle No data available
characteristics

s) Explosive properties No data available

t) Oxidizing properties none
9.2 Other safety information
Surface tension 28,8 mN/m at 10,0 °C

Relative vapor 2,07

density

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
Oxidizing agents, Soluble carbonates and phosphates, Hydroxides, Metals, Peroxides,
permanganates, for example potassium permanganate, Amines, Alcohols, Nitric acid
10.6 Hazardous decomposition products
In the event of fire: see section 5

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SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 3.310 mg/kg
Remarks: (RTECS)
LC50 Inhalation - Mouse - 4 h - 2.819 mg/l - vapor

Remarks: (RTECS)
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Causes burns. - 4 h
(OECD Test Guideline 404)
Remarks: (IUCLID)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes burns. - 4 h
(OECD Test Guideline 405)
Remarks: (IUCLID)
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative

Test Type: Micronucleus test

Species: Rat
Cell type: Bone marrow
Application Route: inhalation (vapor)
Method: Mutagenicity (micronucleus test)
Result: negative
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available

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 Aspiration hazard
No data available
11.2 Additional Information
RTECS: AF1225000
Material is extremely destructive to tissue of the mucous membranes and upper respiratory
tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation
and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough,
wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Ingestion or
inhalation of concentrated acetic acid causes damage to tissues of the respiratory and
digestive tracts. Symptoms include: hematemesis, bloody diarrhea, edema and/or
perforation of the esophagus and pylorus, pancreatitis, hematuria, anuria, uremia,
albuminuria, hemolysis, convulsions, bronchitis, pulmonary edema, pneumonia,
cardiovascular collapse, shock, and death. Direct contact or exposure to high
concentrations of vapor with skin or eyes can cause: erythema, blisters, tissue destruction
with slow healing, skin blackening, hyperkeratosis, fissures, corneal erosion, opacification,
iritis, conjunctivitis, and possible blindness.
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to fish semi-static test LC50 - Oncorhynchus mykiss (rainbow trout) - >
1.000 mg/l - 96 h
(OECD Test Guideline 203)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 1.000 mg/l - 48 h
and other aquatic (OECD Test Guideline 202)
invertebrates
Toxicity to algae static test EC50 - Skeletonema costatum - > 1.000 mg/l - 72 h
(ISO 10253)
Toxicity to bacteria EC5 - Pseudomonas putida - 2.850 mg/l - 16 h
Remarks: neutral
(maximum permissible toxic concentration)
(Lit.)

microtox test EC50 - Photobacterium phosphoreum - 11 mg/l - 15

min
Remarks: (IUCLID)

12.2 Persistence and degradability

Biodegradability Result: 99 % - Readily biodegradable.
(OECD Test Guideline 301D)
Remarks: (HSDB)

Result: 95 % - Readily eliminated from water

(OECD Test Guideline 302B)
Biochemical Oxygen 880 mg/g
Demand (BOD) Remarks: (Lit.)

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 Ratio BOD/ThBOD 76 %
Remarks: (IUCLID)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material
must be disposed of in accordance with the Directive on waste 2008/98/EC as well as
other national and local regulations. Leave chemicals in original containers. No mixing
with other waste. Handle uncleaned containers like the product itself.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 2789 IMDG: 2789 IATA: 2789
14.2 UN proper shipping name
ADR/RID: ACETIC ACID, GLACIAL
IMDG: ACETIC ACID, GLACIAL
IATA: Acetic acid, glacial
14.3 Transport hazard class(es)
ADR/RID: 8 (3) IMDG: 8 (3) IATA: 8 (3)
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
Tunnel restriction code : (D/E)
Further information : No data available

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SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
National legislation
Seveso III: Directive 2012/18/EU of the European : FLAMMABLE LIQUIDS
Parliament and of the Council on the control of
major-accident hazards involving dangerous
substances.

15.2 Chemical Safety Assessment

A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H226 Flammable liquid and vapor.
H314 Causes severe skin burns and eye damage.
H315 Causes skin irritation.
H318 Flammable liquid and vapor.
H319 Causes severe skin burns and eye damage.

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 Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods
by Inland Waterways; ADR - Agreement concerning the International Carriage of
Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM -
American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen,
Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for
Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration
associated with x% response; ELx - Loading rate associated with x% response; EmS -
Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; GHS - Globally Harmonized
System; GLP - Good Laboratory Practice; IARC - International Agency for Research on
Cancer; IATA - International Air Transport Association; IBC - International Code for the
Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half
maximal inhibitory concentration; ICAO - International Civil Aviation Organization;
IECSC - Inventory of Existing Chemical Substances in China; IMDG - International
Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial
Safety and Health Law (Japan); ISO - International Organisation for Standardization;
KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a
test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose);
MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. -
Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration;
NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading
Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for Economic
Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution
Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines
Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure
Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European
Parliament and of the Council concerning the Registration, Evaluation, Authorisation and
Restriction of Chemicals; RID - Regulations concerning the International Carriage of
Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS -
Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand
Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN
- United Nations; UNRTDG - United Nations Recommendations on the Transport of
Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

Further information
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for internal use only.
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

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