SAFETY DATA SHEET Version 6.
3
Revision Date 03/18/2023
Print Date 01/06/2024
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers
Product name : Acetic acid
Product Number : 45726
Brand : Sigma
Index-No. : 607-002-00-6
CAS-No. : 64-19-7
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Synthesis of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Inc.
3050 SPRUCE ST
ST. LOUIS MO 63103
UNITED STATES
Telephone : +1 314 771-5765
Fax : +1 800 325-5052
1.4 Emergency telephone
Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-
527-3887 CHEMTREC (International) 24
Hours/day; 7 Days/week
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 3), H226
Skin corrosion (Category 1A), H314
Serious eye damage (Category 1), H318
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 GHS Label elements, including precautionary statements
Pictogram
Signal Word Danger
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Hazard statement(s)
H226 Flammable liquid and vapor.
H314 Causes severe skin burns and eye damage.
Precautionary statement(s)
P210 Keep away from heat/ sparks/ open flames/ hot surfaces. No
smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P264 Wash skin thoroughly after handling.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/ shower.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Immediately call a POISON CENTER/ doctor.
P305 + P351 + P338 + IF IN EYES: Rinse cautiously with water for several minutes.
P310 Remove contact lenses, if present and easy to do. Continue
rinsing. Immediately call a POISON CENTER/ doctor.
P363 Wash contaminated clothing before reuse.
P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant
foam to extinguish.
P403 + P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal
plant.
2.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none
SECTION 3: Composition/information on ingredients
3.1 Substances
Synonyms : Glacial acetic acid
Formula : C2H4O2
Molecular weight : 60.05 g/mol
CAS-No. : 64-19-7
EC-No. : 200-580-7
Index-No. : 607-002-00-6
Component Classification Concentration
acetic acid
Flam. Liq. 3; Skin Corr. <= 100 %
1A; Eye Dam. 1; H226,
H314, H318
Concentration limits:
10 - < 25 %: Eye Irrit. 2,
H319; 10 - < 25 %: Skin
Irrit. 2, H315; 25 - < 90
%: Skin Corr. 1B, H314;
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>= 90 %: Skin Corr. 1A,
H314; >= 90 %: 3,
H226;
For the full text of the H-Statements mentioned in this Section, see Section 16.
SECTION 4: First aid measures
4.1 Description of first-aid measures
General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.Move
out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of
water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a
physician.Continue rinsing eyes during transport to hospital.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse
mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Dry powder Dry sand
Unsuitable extinguishing media
Do NOT use water jet.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.
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SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of
vapors accumulating to form explosive concentrations. Vapors can accumulate in low
areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand,
earth, diatomaceous earth, vermiculite) and place in container for disposal according to
local / national regulations (see section 13).
6.4 Reference to other sections
For disposal see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Avoid inhalation of vapor or mist.
Advice on protection against fire and explosion
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of
electrostatic charge.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before
breaks and at the end of workday.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Moisture sensitive.
Storage class
Storage class (TRGS 510): 3: Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Ingredients with workplace control parameters
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Component CAS-No. Value Control Basis
parameters
acetic acid 64-19-7 TWA 10 ppm USA. ACGIH Threshold Limit
Values (TLV)
STEL 15 ppm USA. ACGIH Threshold Limit
Values (TLV)
TWA 10 ppm USA. NIOSH Recommended
25 mg/m3 Exposure Limits
ST 15 ppm USA. NIOSH Recommended
37 mg/m3 Exposure Limits
TWA 10 ppm USA. Occupational Exposure
25 mg/m3 Limits (OSHA) - Table Z-1
Limits for Air Contaminants
PEL 10 ppm California permissible exposure
25 mg/m3 limits for chemical
contaminants (Title 8, Article
107)
C 40 ppm California permissible exposure
limits for chemical
contaminants (Title 8, Article
107)
STEL 15 ppm California permissible exposure
37 mg/m3 limits for chemical
contaminants (Title 8, Article
107)
Derived No Effect Level (DNEL)
Application Area Routes of Health effect Value
exposure
Workers Inhalation Acute local effects 25 mg/m3
Workers Inhalation Long-term local effects 25 mg/m3
Workers Skin contact Long-term local effects 10mg/kg BW/d
Consumers Inhalation Acute local effects 25 mg/m3
Consumers Inhalation Long-term local effects 25 mg/m3
Predicted No Effect Concentration (PNEC)
Compartment Value
Soil 0.478 mg/kg
Sea water 0.3058 mg/l
Fresh water 3.058 mg/l
Sea sediment 1.136 mg/kg
Fresh water sediment 11.36 mg/kg
Sewage treatment plant 85 mg/l
Aquatic intermittent release 30.58 mg/l
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands
before breaks and at the end of workday.
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Personal protective equipment
Eye/face protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye
protection tested and approved under appropriate government standards such as
NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands.
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.3 mm
Break through time: 480 min
Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M)
Splash contact
Material: Nature latex/chloroprene
Minimum layer thickness: 0.6 mm
Break through time: 32 min
Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail
sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which
differ from EN 374, contact the supplier of the EC approved gloves. This
recommendation is advisory only and must be evaluated by an industrial hygienist
and safety officer familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use
scenario.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective
clothing., The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-
face respirator with multi-purpose combination (US) or type ABEK (EN 14387)
respirator cartridges as a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator. Use respirators and
components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Color: colorless
b) Odor stinging
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c) Odor Threshold No data available
d) pH 2.5 at 50 g/l at 20 °C (68 °F)
e) Melting Melting point/range: 16.2 °C (61.2 °F) - lit.
point/freezing point
f) Initial boiling point 117 - 118 °C 243 - 244 °F - lit.
and boiling range
g) Flash point 39 °C (102 °F) - closed cup
h) Evaporation rate No data available
i) Flammability (solid, Not applicable
gas)
j) Upper/lower Upper explosion limit: 19.9 %(V)
flammability or Lower explosion limit: 4 %(V)
explosive limits
k) Vapor pressure 20.79 hPa at 25 °C (77 °F)
l) Vapor density 2.07
m) Density 1.049 g/cm3 at 25 °C (77 °F) - lit.
Relative density No data available
n) Water solubility 602.9 g/l at 25 °C (77 °F) at 1,013 hPa - completely soluble
o) Partition coefficient: log Pow: -0.17 at 25 °C (77 °F) - Bioaccumulation is not
n-octanol/water expected., (ECHA)
p) Autoignition 463 °C (865 °F)
temperature
q) Decomposition Distillable in an undecomposed state at normal pressure.
temperature
r) Viscosity 1.17 mm2/s at 20 °C (68 °F) -
s) Explosive properties No data available
t) Oxidizing properties none
9.2 Other safety information
Surface tension 28.8 mN/m at 10.0 °C (50.0 °F)
Relative vapor 2.07
density
SECTION 10: Stability and reactivity
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
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10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
various metals
10.6 Hazardous decomposition products
In the event of fire: see section 5
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 3,310 mg/kg
Remarks: (RTECS)
LC50 Inhalation - Mouse - 4 h - 2,819 mg/l - vapor
Remarks: (RTECS)
Dermal: No data available
No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Causes burns. - 4 h
(OECD Test Guideline 404)
Remarks: (IUCLID)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes burns. - 4 h
(OECD Test Guideline 405)
Remarks: (IUCLID)
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Micronucleus test
Species: Rat
Cell type: Bone marrow
Application Route: inhalation (vapor)
Method: Mutagenicity (micronucleus test)
Result: negative
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Carcinogenicity
No data available
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
NTP: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is
on OSHA’s list of regulated carcinogens.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
RTECS: AF1225000
Material is extremely destructive to tissue of the mucous membranes and upper respiratory
tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation
and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough,
wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Ingestion or
inhalation of concentrated acetic acid causes damage to tissues of the respiratory and
digestive tracts. Symptoms include: hematemesis, bloody diarrhea, edema and/or
perforation of the esophagus and pylorus, pancreatitis, hematuria, anuria, uremia,
albuminuria, hemolysis, convulsions, bronchitis, pulmonary edema, pneumonia,
cardiovascular collapse, shock, and death. Direct contact or exposure to high
concentrations of vapor with skin or eyes can cause: erythema, blisters, tissue destruction
with slow healing, skin blackening, hyperkeratosis, fissures, corneal erosion, opacification,
iritis, conjunctivitis, and possible blindness.
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Stomach - Irregularities - Based on Human Evidence
Stomach - Irregularities - Based on Human Evidence
SECTION 12: Ecological information
12.1 Toxicity
Toxicity to fish semi-static test LC50 - Oncorhynchus mykiss (rainbow trout) - >
1,000 mg/l - 96 h
(OECD Test Guideline 203)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 1,000 mg/l - 48 h
and other aquatic (OECD Test Guideline 202)
invertebrates
Toxicity to algae static test EC50 - Skeletonema costatum - > 1,000 mg/l - 72 h
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(ISO 10253)
Toxicity to bacteria EC5 - Pseudomonas putida - 2,850 mg/l - 16 h
Remarks: neutral
(maximum permissible toxic concentration)
(Lit.)
microtox test EC50 - Photobacterium phosphoreum - 11 mg/l - 15
min
Remarks: (IUCLID)
12.2 Persistence and degradability
Biodegradability Result: 99 % - Readily biodegradable.
(OECD Test Guideline 301D)
Remarks: (HSDB)
Result: 95 % - Readily eliminated from water
(OECD Test Guideline 302B)
Biochemical Oxygen 880 mg/g
Demand (BOD) Remarks: (Lit.)
Ratio BOD/ThBOD 76 %
Remarks: (IUCLID)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not
conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product
Contact a licensed professional waste disposal service to dispose of this material. Offer
surplus and non-recyclable solutions to a licensed disposal company. Burn in a chemical
incinerator equipped with an afterburner and scrubber but exert extra care in igniting as
this material is highly flammable.
Contaminated packaging
Dispose of as unused product.
SECTION 14: Transport information
DOT (US)
Sigma - 45726
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UN number: 2789 Class: 8 (3) Packing group: II
Proper shipping name: Acetic acid, glacial
Reportable Quantity (RQ): 5000 lbs
Poison Inhalation Hazard: No
IMDG
UN number: 2789 Class: 8 (3) Packing group: II EMS-No: F-E, S-C
Proper shipping name: ACETIC ACID, GLACIAL
IATA
UN number: 2789 Class: 8 (3) Packing group: II
Proper shipping name: Acetic acid, glacial
SECTION 15: Regulatory information
SARA 302 Components
This material does not contain any components with a section 302 EHS TPQ.
SARA 313 Components
This material does not contain any chemical components with known CAS numbers that
exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section
313.
SARA 311/312 Hazards
Fire Hazard, Acute Health Hazard, Chronic Health Hazard
Massachusetts Right To Know Components
CAS-No. Revision Date
acetic acid 64-19-7 1993-04-24
Pennsylvania Right To Know Components
acetic acid CAS-No. Revision Date
64-19-7 1993-04-24
SECTION 16: Other information
Further information
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.
The branding on the header and/or footer of this document may temporarily not visually
match the product purchased as we transition our branding. However, all of the
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information in the document regarding the product remains unchanged and matches the
product ordered. For further information please contact mlsbranding@sial.com.
Version: 6.3 Revision Date: 03/18/2023 Print Date: 01/06/2024
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