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ACE Inhibitors

ACE inhibitors are medications used to treat high blood pressure and heart failure by blocking the angiotensin-converting enzyme, which reduces blood vessel constriction. They are indicated for conditions such as hypertension, heart failure, and diabetic nephropathy, and have therapeutic actions including lowering blood pressure and providing renal protection. Common adverse effects include hyperkalemia and serious allergic reactions, while serious adverse effects may involve renal impairment and fetal harm.

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Eugene Reishi
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47 views10 pages

ACE Inhibitors

ACE inhibitors are medications used to treat high blood pressure and heart failure by blocking the angiotensin-converting enzyme, which reduces blood vessel constriction. They are indicated for conditions such as hypertension, heart failure, and diabetic nephropathy, and have therapeutic actions including lowering blood pressure and providing renal protection. Common adverse effects include hyperkalemia and serious allergic reactions, while serious adverse effects may involve renal impairment and fetal harm.

Uploaded by

Eugene Reishi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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ACE Inhibitors

GROUP 1:
PELAEZ, FIONA MARIE V.
LAMION, ANGELYN
NARABE, EUGENE REISHI
DE ERIO, JASMINE
BARRO, SEAN KENLEY
QUIAPO, CINDY DIANNE
SABANTO, ELYN GRACE M.
Kambal Mohaemen G.
WHAT IS AN ACE INHIBITORS?

ACE inhibitors (Angiotensin-Converting Enzyme inhibitors) are a


class of medications primarily used to treat high blood pressure
(hypertension) and heart failure. They work by inhibiting the
action of the angiotensin-converting enzyme, which plays a
crucial role in the renin-angiotensin-aldosterone system (RAAS).
Capto(pril)
Benaze(pril)
DRUGS: “PRIL” work by blocking the
Enala(pril)
enzyme responsible for
Fosino(pril)
converting angiotensin I to
Lisino(pril)
angiotensin II.
Enalaprilat
01. LOWERING BLOOD
PRESSURE

HEART FAILURE
02. MANAGEMENT

03. RENAL PROTECTION


THERAPEUTIC
ACTIONS
04. POST MYOCARDIAL
INFARCTION

05. REDUCTION OF STROKE


RISK

06. DIABETES MANAGEMENT


THERAPEUTIC
ACTIONS
INDICATIONS
- TREATMENT FOR:

• LEFT
VENTRICLE
• HYPERTENSION DYSFUNCTION

• DIABETIC
• HEART FAILURE NEPHROPATHY
PHARMAKOKINETICS:

Absorption: After taking an Distribution: Once in the


ACE inhibitor by mouth, it is bloodstream, ACE inhibitors are
absorbed into the bloodstream distributed throughout the body.
through the intestines. The They mainly act in the blood
amount absorbed can vary vessels and kidneys, blocking the
between different ACE enzyme (ACE) that narrows blood
inhibitors and can be affected vessels. This causes the blood
by food intake. vessels to relax and lowers blood
pressure.
PHARMACOKINETICS:

Metabolism: Excretion:
Most ACE inhibitors are prodrugs, meaning they ACE inhibitors are primarily excreted
need to be metabolized in the liver to become active. through the kidneys.
Enalapril, for instance, is converted to enalaprilat (its Drugs like lisinopril and enalapril have
active form) in the liver. a significant renal route of excretion.
Lisinopril is an exception, as it is administered in its Dosage adjustments are required in
active form. patients with renal impairment.
Hepatic impairment can affect the metabolism of
prodrugs.
01. RELEASE TO THE EFFECTS OF
VASODILATION AND
ALTERATIONS IN BLOOD FLOW

02. GENERALLY WELL


TOLERATED

SERIOUS ALLERGIC
03. REACTIONS INCLUDING
ANGIOEDEMA

04. HYPERKALEMIA
ADVERSE
EFFECT
01. RENAL IMPAIRMENT

02. FETAL HARM

03. LIVER DYSFUNCTION

SERIOUS ADVERSE
04. NEUTROPENIA
EFFECTS

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