1.
2.Which of the following is not true about hypoxanthine-guanine phosphoribosyl
transferase(HGPRT)?
a.Predominantly present in liver
b.Involved in purine metabolism
c.PRPP is the substrate required
d.Its deficiency leads to Lysch Nyhan disease
3.Sorghum causes pellagra due to the presence of
a.lysine b.Leucine c.Tryptophan d.Alanine
4.Second messenger for smooth muscle relaxation mediated by no is
a.cGMP b.cAMP c.Ca2+ d.Magnesium
5.Which of the following substance accumulates in brain in cerebrohepatorenal syndrome?
a.Pyruvate b.Short chain FA c.Very long chain FA d.Glycogen
6.Alcohol/ethanol induced fatty liver is caused by increased in ratio of
a.NAD+ toNADH b.NADH+NAD+ c.NADPH toNADH d.NADP+toNADPH
7.A 10yrs old boy rapidly develops hypoglycaemia after moderate activity.Blood examination
reveals raised levels of ketone bodies,Lactic acid and Triglycerides on examination,liver and
kidney were enlarged.Histopathology of liver shows deposits of glycogen in excess amount
what’s the diagnosis?
a.Von Gierke’s b.Cori’sdisease c.Mc Ardle’s d.Pompe’disease
8.Enzyme common to glycolysis and gluconeogenesis is/are which of the following
a.Phospho glycerate kinase b.PEPCK
c.Pyruvate Kinase d.Phosphofructokinase
9.Neonatal seizure associated with which vitamin deficiency
a.B5
b.Thiamine
c.Riboflavin
d.Pyridoxine(B6)
10.what shall be the enzyme deficient in a patient with hypopigmented skin,blue eyes and
inability to adjust to bright light?
11.All of the following are disorders of purine metabolism except
a.Lesch-Nyhan syndrome b.Hereditary orotic aciduria
c.Severe Combined Immunodeficiency d.Gout
12.Componets of 60S subunit of ribosome is which of the following
a.5.8S b.23S c.16S d.18S
13.Select one of the following statements that is NOT CORRECT:
a.Bilirubin is a cyclic tetrapyrrole
b.Albumin bound bilirubin is transported to the liver
c.High levels of bilirubin can cause damage to the brains of newborn infants
d.Bilirubin contains methyl and vinyl groups
14.Which of the following statements about purine nucleotide metabolism is correct?
a.An early step in purine biosynthesis is the formation of PRPP(phosphoribosyl1-
pyrophosphate)
b.orotic acid is an intermediate in pyrimidine nucleotide biosynthesis
c.Humans catabolize uridine and pseudo-uridine by analogous reactions
d.Ribonucleotide reductase converts nucleoside diphosphates to the corresponding deoxyribo
nucleoside diphosphates
15.
a.3’52 phosphodiester bond b.2’-5’phosphodiester bond
c.Hydrogen bond d.Covalent bond
16.In Beri-Beri,the blood levels of which of the following is higher than the normal?
a.Glutamate b.AcetylCoA
c.Succinyl COA and succinate d.Pyruvate and Alpha Ketoglutarate
17.Nitric oxide is synthesized from
a.L-Arginine b.L-Citrulline c.Lysine d.Tryptophan
18.which of the following is anaplerotic reaction
a.conversion of pyruvate to acetyl COA
b.Conversation of pyruvate to acetaldehyde
c.Converstaion of Pyruvate to lactic acid
d.Conversation of pyruvate to oxaloacetate
19.A diabetic patient presented with polyuria ,his blood glucose was 240mg/dl which of these
is likely to occur in this patient of type 1 DM?
a.Increased protein synthesis
b.Increased glycogenesis in muscle
c.Increased conversion of fatty acid to acetylcoA
d.Denovo cholesterol synthesis
20.
21.
22. Which one of the following statement about the fed and fasting metabolic states is
correct?
a.In the fasting state adipose tissue synthesizes glucose from the glycerol released by the
breakdown of triacylglycerol
b.In the fasting state adipose tissue synthesizes ketone bodies
c.In the fasting state the main fuel for red blood cells is fatty acids released from adipose tissue.
d.Plasma glucose is maintained in starvation and prolonged fasting by gluconeogene is in the
liver from the amino acids released by the breakdown of muscle protein.
23.which one of the following statements about the pyruvate dehydrogenase multienzyme
complex is correct?
a.In thamin(vitamin B1) deficiency,pyruvate formed in muscle cannot be transamunated to
alanine
b.In thamin(vitaminB1)deficiency ,pyruvate formed in muscle cannot be carboxylated to
oxaloacetate
c.The reaction of pyruvate dehydrogenase unvolves decarboxylation and oxidation of pyruvate
then formation of acetylCoA.
d.The reaction of pyruvate dehydrogenase is readily reversible so the acetylCoA can be used for
the synthesis of pyruvate and hence glucose.
24.Regarding synthesis of triacyl glycerol in adipose tissue all of the following are true
except?
a. synthesis from Dihydroxyacetone phosphate
b.Enzyme glycerol kinase plays an important role
c.Enzyme glycerol 3 phosphate dehydrogenase plays an important role
d.Phosphatidate is hydrolyzed
25.Common substrate for purine and pyrimidine synthesis are all except
a.Glutanine
b.Glycine
c.Aspartate
d.carbon dioxide
C.Fomration of propionic acid
d,Oxidation of branched chain fatty acid
27.Which one of the following sequences places the lipoproteins in the order of most dense
to least dense
a.HDL/VLDL/chylomicrons/LDL b.HDL/LDL/VLDL/chylomicrons
c.LDL/chylomicrons/HDL/VLDL d.VLDL/chylomicrons/LDL/HDL
28.True statement regarding chaperone proteins is the following
a.bind to hydrophobic regions of folded proteins
b.show ATPase activity
c.Show GTPase activity
d.Found exclusively in endoplasmic reticulum
29.A 2yr old child is hospitalized for evaluation of poor growth and low muscle tone. The
most striking physical findings is unruly “Kinky” hair but the child also has increased joint
laxity and thin skin.Which of following lab findings is most likely?
a.High ceruloplasmin b.High tissue copper
c.Low serum iron d.Low saturation of transferring.
30.The predominant isoenzyme of LDH in the cardiac muscle is?
a.LDH-1 b.LDH-2 c.LDH-3 d.LDH-5
31.Which of the following statement is true regarding Cyanide
a.Only minimally inhibits the ETC because cytochrome oxidate is the terminal component of the
chain
b.Inhibits mitochondrial respiration but energy production is unaffected
c.Also binds the copper of cytochrome oxidase
d.Bind toFe+++ of cytochromea3
32.The APO=B-48& APO-B-100 are,main proteins of different lipoproteins difference in them
due to
a.RNA splicing b.RNA editing c.Misreading ofmRNA d.DNA Duplication.
33.Select the correct statement which state corresponding vitamin deficiency in this
presentation and its assessment
a.Pyridoxine deficiency and RBC transaminase assessment
b.Riboflavin deficiency and RBC transketolase assessment
c.Thiamine deficiency and RBC transketolase assessment
d.Riboflavin deficiency and RBC transaldolase assessment
34.
35.
36. Allarecorrectabout telomerase except
a.It is an example of reversetranscriptase
b.It is found only in eukaryotes
c.It maintains high fidelity during DNA replication
d.It maintains the length of DNA
37.Enzymes affected in vitamin B12 deficiency
a. Methyl malonyl CoA mutase/isomerase
b.Methionine synthase
c.Folate reductase
d.Homocysteine synthase
38.A person ingests 100gms of proteins day and excretes 25 gms of nitrogen what is he/she?
a.Normal healthy individual b.Pregnant lady
c.Clinically ill d.Nephrotic syndrome
39.True statement regarding chaperone proteins is the following
a. Bind to hydrophobic regions of folded proteins
b.Show ATPase activity
c.show GTpase activity
d.Found exclusively in endoplasmic reticulum
40.Which among following is not an inhibitor of complex I of electron transport chain
a.Barbiturates b.Piercidin A c.Roteone d.Antimycin
41.Shine Dalgarno sequence in mRNA is near
a.UAG b.UAA c.UGA d.AUG
42.The predominant isoenzyme of LDH in the cardiac muscle is
a.LDH-1
b.LDH-2
c.LDH-3
d.LDH-5
43.All are true about HDL except
a.Carries cholesterol from peripheral tissues to liver
b.Pre beta HDL is the inactive precursor which later forms the active HDL
c.It has approtein ApoA Apo CII ApoE
d.HDL is the lipoprotein which moves farthest from starting point on electrophoresis
44.Phenylbutrate is used in urea cycle disorders because it
a.Seavenges nitrogen b.Activate enzymes
c.Maintains renal output d.Maintains energy production
45.Peptidyl transferase is an example of
a.Enzyme b.Catalyst c.Elongation factor d.Ribozyme
46.In starvation activities of all of the following enzyme is increased except
a.Pyruvate carboxylase b.Pyruvate kinase
c.PEP carboxykinase d.Glucose 6 phosphatase
47. The reaction:succinyl CoA+acetoacetate and acetoaccetyl CoA+ succinate occurs in all of
th following except
a.brain b.Striated muscle c.Liver d.cardiac muscle
48.Inner mitochondrial membrane contains a transporter of
a.NADH b.AcetylcoA c.ATP d.NADPH
49.Linolenic acid is considered to be nutritionally essential in humans because
a.It is co3 fatty acid
b.It contains three double bonds
c.In humans double bonds cannot be introduced into fatty acids beyond the 9 postion
d.In humans double bonds cannot be introduced into fatty acids beyond the 12 position
50.
51.which among the following is a feature of non competitive inhibition?
a.Increased Vmax b.Decreased Vmax c.Increased km d.Decreased Km
52.Which among the following amino acids absorbs UV light?
a.Leucine b.Lysine c.Tyrosine d.Valine
53.Which of the following is an omega 6 fatty acid?
a.Alpha linotenic acid b.Linoleic acid c.EPA d.DHA
54.
55.
56.
57.
58.Cholesterol present in LDL is
a.Binds to a cell receptor and diffuses across the cell membrane
b.When it enters the cell it suppress the activity of ACAT
c.Once in the cell is converted to cholesteryl ester by LCAT
d.Once it has accumulated in the cell,inhibits replenishment of LDL receptors
59.Ketrone body which is maximum in diabetic ketoacidosis?
a.Acetone b.Pyruvate c.Acetoacetic acid d.B-(OH) butyrate
60.Enzyme which is active in well fed state is
a.Camitine palmitoyl transferase 1 b.Pynivate carboxylase
c.Acety 1 CoA carboxylase d.HMG lyase
61.The protein avidin inactivates which of the following in egg
a.Pyridoxine b.Riboflavin c.Biotin d.Thiamine
62. A Patient who suffers from Mc Ardle’s disease is most likely to exhibit which one of the
following symptoms
a.hyperglycemia b.Enlarged liver
c.Abnormal glycogen structure d.Muscle cramps
63.Which of the following is true regarding carbohydrates
a.Lactose and maltose are disaccharides
b.Benedict test gives red colour with sucrose
c.Sucrose is a reducing sugar
d.Complex polysacchardies are converted to glucose and absorbed with the help ofhexokinase
64.Bitot’s spots on conjunctiva are seen in deficiency of
a.Vit B1 B.Vit A C.Vit C d.Vit D
65.A 63 yrs old female patient is suffering from gout.She gives history of increased uric acid
and taking allopurinol for this which acts on enzyme i.e xanthine oxidase and reduces uric
acid levels This action of allopurinol is which type of enzyme interaction
a.Uncompetitive inhibition b.Non-Competitive inhibition
c.Allosteric inhibition d.Suicidal inhibition
66.
67.
68.All of the following are true about sickle cell disease except
a.Single nucleotide change results in change of glutamine to valine
b.RFLP results from a single base change
c.Sticky patch is generated as a result of replacement of a non polar residue with a polar
residue
d.HbS confers resistance against malaria in heterozygotes
69.Which is the most correct sequence of events in gene repair mechanisms in patients
without a mutated repair process?
a.Nicking,excision,replacement ,sealing recongnition
b.Sealing ,recognition,nicking,excision,replacement
c.Recongnition,nicking,excision,replacement,sealing
d.Nicking sealing,recognition,excision,replacement
70.The normal function of ribonucleoride reductase is to catalyze which one of the following
reaction?
a.Form PRPP from adenosine diphosphate(ADP) and ribose
b.Convert xanthine to uric acid
c.Form carbamoyl phosphate from glutamine,Co2,and two ATP molecules
d.Convert ADP to dADP
