Ferid Murad, M.D., Ph.D.

9/05

OFFICE ADDRESS: HOME ADDRESS:

Department of Integrative Biology 3324 Nottingham
and Pharmacology West University Place
University of Texas Medical School-Houston Houston, TX 77005
P.O. Box 20708 Phone: (713) 664-3509
Houston, TX 77225
(713) 500-7509
FAX: (713) 500-0790, E-mail: Ferid.Murad@uth.tmc.edu

Date of Birth: September 14, 1936

Place of Birth: Whiting, Indiana
Citizenship: United States
Marital Status: Married, 1958, Carol A. Leopold
Children: Christine, Marianne, Carrie, Julie, Joseph

Education:
1954 - 1958 B.A., DePauw University, Greencastle, Indiana
Major - Premedical Science

1958 - 1965 M.D., Western Reserve University, School of Medicine

Cleveland, Ohio

1958 - 1965 Ph.D., Department of Pharmacology, Western Reserve University,

School of Medicine, Cleveland, Ohio

Honorary Degrees:
Honoris Causa, Tirana University, Albania, October, 1999
Doctor of Science, Honoris Causa, Case Western Reserve University, Cleveland, Ohio, May, 2000
Doctor of Science, Honoris Causa, Thomas Jefferson University, Philadelphia, PA, June, 2000
Doctor of Science, Honoris Causa, State University of Ceara, Fortaleza, Brazil, November, 2000
Doctor of Science, Honoris Causa, Luviv State Medical University, Luviv, Ukraine, November, 2001
Doctor of Science, Honoris Causa, Chinese University of Hong Kong, Hong Kong, December, 2002
Doctor of Science, Honoris Causa, DePauw University, Greencastle, Indiana, May 2004
Doctor of Science, Honoris Causa, Charles University, Prague, Czech Republic, June, 2005

Posititions Held:
1958 - 1965 Research Fellow, Department of Pharmacology, Western Reserve University,
School of Medicine, Cleveland, Ohio; worked with Drs. T.W. Rall and E.W.
Sutherland.

1965 - 1966 Intern in Internal Medicine, Massachusetts General Hospital, Boston,

Massachusetts, Dr. A. Leaf, Chairman of Internal Medicine.

1966 - 1967 Resident in Internal Medicine, Massachusetts General Hospital, Boston,

Massachusetts, Dr. A. Leaf, Chairman of Internal Medicine.

1967 - 1969 Clinical Associate and Senior Assistant Surgeon, Public Health Service,
National Heart and Lung Institute, Molecular Disease Branch, Section on
Metabolism, Bethesda, Maryland; worked with Dr. M. Vaughan.
Ferid Murad, M.D., Ph.D.
Curriculum Vitae
Page 2

1969 - 1970 Senior Staff Fellow, National Heart and Lung Institute, Molecular Disease
Branch, Section on Metabolism, Bethesda, Maryland; worked with Dr. M.
Vaughan.

1970 - 1975 Associate Professor, Departments of Internal Medicine and Pharmacology,

University of Virginia, School of Medicine, Charlottesville, Virginia.

1975 - 1981 Professor, Departments of Internal Medicine and Pharmacology, University of

Virginia, School of Medicine, Charlottesville, Virginia

1971 - 1981 Director, Clinical Research Center, University of Virginia, School of Medicine,
Charlottesville, Virginia.

1973 - 1981 Director, Division of Clinical Pharmacology, Department of Internal Medicine,

University of Virginia, School of Medicine, Charlottesville, Virginia

1981 - 1989 Professor, Departments of Internal Medicine and Pharmacology, Stanford

University, Stanford, California

1981 - 1986 Chief of Medicine, Palo Alto Veterans Administration Medical Center, Palo
Alto, California

1984 - 1986 Associate Chairman, Department of Medicine, Stanford University, Stanford,

California

1986 - 1988 Acting Chairman, Department of Medicine, Stanford University, Stanford

California

1986 - 1988 Acting Division Chief, Division of Respiratory Medicine, Department of

Medicine, Stanford University, Stanford, California

1988 - 1990 Divisional Vice President, Pharmaceutical Discovery, Abbott Laboratories,

Abbott Park, Illinois

1988 - 1996 Professor (Adjunct), Department of Pharmacology, Northwestern University

Medical School, Chicago, Illinois

1990 - 1992 Vice President, Pharmaceutical Research & Development, and Corporate
Officer, Abbott Laboratories, Abbott Park, Illinois

1992 - 1996 Consultant

1993 - 1995 CEO/President, Molecular Geriatrics Corporation, Lake Bluff, Illinois

1996 - 1997 Professor (Adjunct) Department of Cell and Molecular Biology, Northwestern
University, School of Medicine, Chicago, Illinois

1997 - 1999 Professor and Director, Division of Clinical Pharmacology, Departments of

Medicine and Integrative Biology and Pharmacology, University of Texas-
Houston, Medical School, Houston, Texas

1997 - 2005 Professor and Chairman, Department of Integrative Biology and

Pharmacology, University of Texas-Houston, Medical School, Houston, Texas
Ferid Murad, M.D., Ph.D.
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1997 - present Professor - University of Texas-Houston, Graduate School of Biomedical

Sciences, Houston, Texas

1998 - present Professor - Department of Medicine, University of Texas – Houston School of

Medicine, Houston, Texas.

1998 - present John S. Dunn Distinguished Chair in Physiology and Medicine

1998 – present Regental Professor, University of Texas - Houston

1999 - present Director, Institute of Molecular Medicine, University of Texas – Houston

School of Medicine, Houston, Texas.

1999 – present Professor (Adjunct) Dept. Medical Biochemistry, Ohio State University,
Columbus, Ohio

Medical Licensure:
Ohio
Massachusetts
Virginia
California
Texas

Societies:
Phi Beta Kappa (1959)
Alpha Omega Alpha (1963)
American Federation for Clinical Research (1969)
American Society for Pharmacology and Experimental Therapeutics (1970)
Albemarle Medical Society (1970)
American Association for the Advancement of Science (1970)
Endocrine Society (1971)
Southern Society for Clinical Investigation (1973)
American College of Clinical Pharmacology (1974)
American Society of Biological Chemists (1974)
American Society for Clinical Investigation (1975)
New York Academy of Sciences (1975)
Fellow, American College of Physicians (1976)
Association for Clinical Research Center Program Directors (1977 - 1981)
National Institutes of Health Alumni Association (1977)
Association of American Physicians (1981)
Association of Veterans Administration Chiefs of Medicine (1981)
Western Association of Physicians (1982)
American Heart Association - Council on Basic Science (1984)
Member, National Academy of Sciences (1997)
Member – American Physiological Society (1998)
Member, Institute of Medicine of the National Academy of Sciences (1998)
Member, American Academy of Arts and Sciences (2000)
Fellow, Cardiovascular Section of the American Physiological Society
Foreign Member – Macedonian Academy of Sciences and Arts (2000)
Foreign Member – Albanian Academy of Sciences (2000)
Honorary Member, Kosovo Academy of Arts and Sciences (2000)
Honorary Member, World Innovation Foundation (2005)
Ferid Murad, M.D., Ph.D.
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Honors and Awards:

Alfred S. Maschke Award for Clinical Excellence (Western Reserve University, 1965)
Mosby Book Award (Western Reserve University, 1965)
Diplomate of the National Board of Medical Examiners (1966)
Research Career Development Award (NIAMD, 1972 - 1977)
Diplomat of the American Board of Internal Medicine (1974)
American Heart Association - Ciba Award Recipient (1988)
Albert and Mary Lasker Award for Basic Research, (1996)
Nobel Prize in Physiology or Medicine (1998)
Award from Chairman Yassar Arafat, 1998
Resolution from the City of Houston, Texas (1998)
Resolution from the State of Texas (1998)
Resolution from the United States House of Representatives (1998)
Old Gold Award, DePauw University (1999)
Life of Quality Award for Sheltering Arms (1999)
Honor of the Nation Award from the President of Albania (1999)
Sagamore Wabash Award, The Highest honor from the Governor of Indiana (1999)
The Albanian American National Council Award (1999)
Distinguished Alumnus Award, Case Western Reserve University School of Medicine (1999)
Golden Plate Award from the American Academy of Achievement (1999)
Honorary Citizen, Gostivar, Macedonia (1999)
Resolution from Lake County, Indiana (1999)
Honorary Director, Epithelial Cell Biology Res. Ctr Chinese Univ. of Hong Kong (2000 to present)
Macedonian Medal of St. Apostle Paul (2000)
Consulting Editor, News in Physiological Sciences (2000)
Baxter Award for Distinguished Research in the Biomedical
Sciences Association of American Medical Colleges (AAMC) (2000)
Pictured on a postage stamp from Albania
Science and Technology Consultant, Shenzhen, China (2000)
Honorary Professor, Soochow University, Suzhou, China (2002)
Honorary Professor, Shanghai Second Medical University (2002)
Honorary Professor; Shanghai University of Traditional Medicine (2003)
Scientific Steering Committee China Nat. Center for Biotechnology (2002-05)
Scientific Steering Committee National Institute of Biological Science, Beijing (2002-05)
Honorary Board Member – World High Tech Society (2002-present)
Honorary Member, Islamic Academy of Sciences (2003)
Honorary Member, World Innovation Foundation (2004)
Fellow, European Academy of Sciences (2004)
Honorary Member, The National Society of High School Scholars (2004)
Member, International Advisory Board for Shanghai Xuhui District (2004)
Santiago Grisolia Award – Valencia, Spain (2005)
Editorial Board, Cell Biology International (2005- )
American Society Clinical Pharmacology Research Prize (2005)
Jury Member Premios Rey Jaime I Prize of Spain (2005)
Whiting High School Wall of Fame (2005)

Committees/Memberships/Named Lectureships:
Research Advisory Committee, Virginia Heart Association (1971 - 1975)
Editorial Board Member, Journal of Cyclic Nucleotide Research (1974 - 1988)
Various NIH site visits and special study sections (1971 - 1988)
Co-editor, Journal of Cyclic Nucleotide Research (1978 - 1982)
Member of Task Force in the NIH Evaluation of Research Needs in Endocrinology and Metabolic
Diseases (1978 - 1979)
Ad hoc reviewer and site visitor for American Cancer Society (1979)
Ferid Murad, M.D., Ph.D.
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Ad hoc member NIH Molecular Cytology Study Section (1979)

Ad hoc member NIH Pathology Study Section (1979)
Editorial Board Member, Journal of Biological Chemistry (1979 - 1984)
Vice Chairman - Cyclic Nucleotide Gordon Conference (June, 1980)
Ad hoc member NIH Endocrinology Training Grant Study Section (1980)
Ad hoc member NIH Pharmacology Study Section (1980)
Editorial Board Member, Analytical Biochemistry (1980 - 1983)
Pfizer Lecturer - St. Louis University (1980)
Pfizer Lecturer - Clinical Research Inst. of Montreal (1981), Stanford (1981), Rutgers (1981)
Chairman - Cyclic Nucleotide Gordon Conference (June, 1981)
Ad hoc member American Cancer Society Study Section (1982)
Ad hoc grant reviewer, Veterans Administration (1982)
Ad hoc grant reviewer, National Science Foundation (1982)
Pfizer Lecturer - University of Virginia (1983)
Ad hoc member, American Cancer Society Study Section (1984)
Co-editor - The Pharmacological Basis of Therapeutics, seventh edition (1985)
Member NIH - Pharmacology Study Section (1984 - 1987)
Associate Editor - Journal of Applied Cardiology (1986 - 1992)
Council Member - Western Association of Physicians (1986 - 1989)
Journal of Clinical Investigation - Editorial Committee (1986 - 1987)
Pfizer Lecturer - Washington University (1986)
Member - California University - Wide Task Force on AIDS (1987 - 1988)
Associate Editor - Journal of Clinical Investigation (1987 - 1988)
Co-editor - Advances in Pharmacology (1990 - present)
Editorial Advisory Board - The Journal of R&D Management (1990-1992)
National Inst. of Health, NIDDK Board of Scientific Counselors (1990-94) (Chairman, 1993-1994)
Member - American Federation Clinical Research Foundation - Board of Directors (1991-1993)
Annual Bashour Lecture - Southwestern University, Dallas (1992)
Editorial Board - Endothelium (1992-present)
Co-chairman First International Conf. Biochemistry and Molecular Biolgy of Nitric Oxide, UCLA,
(July, 1994)
Chairman Nitric Oxide and Cyclic GMP Signaling Workshop, 9th International Conf. on Second
Messengers and Phosphoproteins, Nashville, (October, 1995)
Co-chairman Second International Conf. Biochemistry and Molecular Biology of Nitric Oxide, UCLA,
(July, 1996)
Board of Directors, Tripos, Inc., (Biopharmaceutical Co.), (1996 - present)
Co-chairman International Conference on Nitric Oxide, Brazil, March, 1999
Scientific Advisor – Texas Biotechnology, Inc (1998 – present)
Annual Potter Lecture, Thomas Jefferson University (1998)
Annual Kauffman Lecture, University of Colorado (1998)
Editorial Board – General Pharmacology: The Vascular System (1998 – present)
Board Member – Cardiovascular Center, University of Virginia (1999 – present)
Board Member, Albanian International Scholarship Foundation (1998 – present)
Board of Directors – Neuronautics, Inc. (Biopharmaceutical Co.) (1999 – present)
Annual Crispell Lecture, University of Virginia (1999)
Annual William R. Martin Lecture, University of Kentucky (1999)
Commencement Addresses, Kincaid High Sch., St. John’s High Sch., Whiting High School (1999)
Annual Graduate Research Forum Lecture, University of Toronto (1999)
Annual Kukovitz Lecture, University of Graz (1999)
Annual Rehfuss Lecture, Thomas Jefferson University (1999)
Scientific Advisory Board, Medinox (1999 to present)
President’s Lecture, Chico State University (1999)
Founders Lecture, Assoc. Acad. Surgeons, Philadelphia (1999)
Annual Nathan Greenfield Lecture, Case Western Reserve University (1999)
Ferid Murad, M.D., Ph.D.
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Annual Priscilla White Lecture – Joslin Clinic and Dept. Medicine Harvard University Boston (2000)
Annual Sir Henry Dale Lecture – Johns Hopkins University (2000)
Evans Research Seminar, Boston University (2000)
Scientific Advisory Board Member, Arginox (2000 to present)
Hugh Davson Distinguished Lectureship, FASEB meeting (2000)
Benjamin Zweifach Memorial Lectureship, University of California, San Diego (2000)
Melvin Calvin Lecture, Michigan Technological University (2000)
Commencement Address, Case Western Reserve University, School of Medicine (2000)
Commencement Address, Thomas Jefferson University (2000)
Member, Scientific Advisory Board, Vasopharm (2000)
Member, Macedonian American Committee (2000)
Member of Executive Board of Assoc. of Sciences, Albanian Doctors in Macedonia (2000)
Member, Science and Technology Advisory Committee, DePauw University (2000)
Board Member Asian Pacific Holding Company of Hong Kong (2000 to present)
Honorary Board Member, National Albanian American Council (2001)
Roy E. Moon Distinguished Lectureship, Angelo State University (2001)
Board of Directors, Immuno-Rx, Inc. (2001-present)
Member, Scientific Advisory Board, Preventis, Inc. (2001-present)
Board of Directors, Kosova Foundation for Medical Development (2001-present)
Earl W. Sutherland Lectureship, Vanderbilt University (2001)
Sigma Xi Lecture, University of Northern Iowa (2001)
Member, Board of Patrons, Oxford International Biomedical Centre (2001)
Board of Directors, High Life, Inc. (2001-present)
Ehters lecture, Mayo Clinic (2001)
Honorary Board of Directors, National Albanian American Council (2001)
Member, Scientific Advisory Board, Biocapital II (2002-present)
Michaelides Lecture – International Meeting, Clinical Cardiology, Greece (2002)
Honorary Member, Hellenic Cardiological Society (2002)
International Research Advisory Bd of U. Health Network, Toronto, Canada (2002 – present)
Scientific Advisory Board, Nano Materia, Inc. (2002-present)
Klaus Hoffmann Lecture, University of Pittsburgh (2002)
Scientific Advisory Board, Juventis (2002-present)
Board of Directors, Sophia Laboratories (2002-2004)
Scientific Advisory Board, Oxon Medica (2002-present)
Board of Trustees, Case Western Reserve University (2002-present)
Scientific Advisory Board, Equity4Health Venture Fund (2003-present)
Member, American Federation for Medical Research (2003-present)
Scientific Advisory Board, Lumen Therapeutics, LLC (2003-present)
Member – International Raoul Wallenberg Foundation and the Angelo Roncalli International
Committee (2003 – present)
Scientific Advisory Board, PLx, Inc. (2003 – present)
Board of Directors, NIOXX (2003 - present)
Annual Michael Brady Lecture, University of Iowa, October, 2003
American Hall of Fame Committee member (2003 – present)
Lecturer International Peace Foundation
Member Albanian Scholarship Foundation Assembly
Member Board of Directors Foundation for Medical Development (2004-present)
Scientific Advisory Board, PTV Sciences, L.P. (2004-present)
Member Advisory Board of International Peace Foundation (2004 – present)
Board of Directors, Chun-Li Biotech. (2004-present)
Editorial Board of Cell Biology International (2005-present)
R.P. Zimmerman Lecture, Memorial Medical Center, Johnstown, PA (2005)
Editorial Board, “Open Access”, Advanced Studies on the Foundation of Knowledge (2005-present)
Ferid Murad, M.D., Ph.D.
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Medical Center and University Committees: (1970 - 1981, University of Virginia)

Clinical Research Center Advisory Committee (1971 - 1981)
Clinical Research Committee (1971 - 1976)
Drug and Pharmacy Committee (1971 - 1981)
Diabetes-Endocrinology Research Center Advisory Committee (1974 - 1981)
Medical Center Hour Committee (1975 - 1979)
Search Committee member for Department of Pathology Chairman (1976)
Search Committee member for Director of Cardiology (1975 - 1977)
Long Range Planning Committee for the Med. Ctr: co-chair of Research Section (1976-1981)
Member of University Committee for distribution of the Pratt bequest (1976 - 1981)
Search Committee member for Director of Clinical Pathology laboratories (1976 - 1977)
Member Planning Committee for a Combined Research Building (1976)
Faculty Promotions and Tenure Committee for the School of Medicine (1976 - 1981)
Member Medical School Instrumentation Center Committee (1977 - 1981)
Director – Postdoc. research training program in Diabetes and hormone action (1978 - 1981)
Member - Medical Scientist Training Program (M.D., Ph.D.) Committee (1978 - 1981)
Member - Faculty Forum for Scientific Research (1979 - 1981)
Member - Computer Technology Services Advisory Committee (1979 - 1981)
Member - Appointments Committee of the Center for Advanced Studies (1979 - 1981)
Chairman - Student Promotion Appeals Committee (1980)
Chairman - Hartford Fellowship Selection Committee (1981)

Medical Center and University Committees: (1981 to 1988, Stanford University)

Chairman - Research and Development Committee, Palo Alto Veterans Administration Medical
Center (1981 - 1982)
Member - Deans Committee, Veterans Administration Medical Center (1981 - 1987)
Member - Budget and Space Committee, Veterans Administration Medical Center (1981 - 1986)
Member - Medical Scientists Training Program Committee (1982 - 1986)
Member - Search Committee for Chief of Rehabilitation Medicine (1982 - 1983)
Chairman - Search Committee for Chief of Pulmonary Division (1982 - 1985)
Member - Housestaff Selection Committee, Department of Medicine (1982 - 1985)
Member - Research & Development Committee, Veterans Admin. Med.Center (1981-1986)
Member - Hospital Space Committee, Veterans Administration Medical Center (1982 - 1983)
Chairman - Kovitz Visiting Scientist Committee (1982 - 1988)
Faculty Advisor for Freshman & Sophomore undergraduate students (1982 - 1984)
Member - Senate of the Academic Council, Stanford University (1983 - 1985)
Member - Institute of Biological & Clinical Investigation Committee, Stanford Univ. (1983 - 1987)
Member - Hewlett Award Committee (1983 - 1988)
Member - Various Department & Medical School promotion committees
Chairman - Department of Medicine Committee on Clinical Excellence (1983 - 1985)
Member - various Department of Medicine Search Committees
Member - Search Committee for Director of Rehabilitation Medicine (1984 - 1985)
Member - Steering Committee for the Kaiser Family Foundation Study on the Future of the
Academic Medical Center (1985 - 1987)
Member - Stanford Hughes Institute Advisory and Selection Committee (1984 - 1988)
Member - Dean's Advisory Committee on Faculty Awards (1985 - 1988)
Professional Standards Board, Veterans Administration Medical Center (1986 - 1987)
Member - Dean's Faculty Budget Review Committee (1986 - 1988)
Member - Dean's Executive Committee (1986 - 1987)
Member - Faculty Practice Program Committee (1986 - 1987)
Member - Hospital Directors Council (1986 - 1987)
Member - Medical Service Steering Committee (1986 - 1987)
Member - Medical Staff Board (1986 - 1988)
Ferid Murad, M.D., Ph.D.
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Member - Search Committee for Chairman of the Department of Genetics (1987 - 1988)

Abbott Laboratories: (1988 to 1992)

Vice-President, Pharmaceutical Division, 1988-1990
Corporate Officer and V.P. Pharmaceutical R&D, 1990 - 1992
V.P. of Pharmaceutical Discovery programs (1988 to 1992); approximately 430 staff and $67
million budget
Directed pharmaceutical research and development programs (1990 to 1992) including Discovery,
Clinical Development, Regulatory, Drug Safety and Product Development; approximately 1500 staff
and $300 million budget
Brought forward more than 25 new chemical entities from Discovery as clinical candidates for
clinical development and/or out-licensing. Numerous IND's, NDA's, and SNDA's filed.
Anticipate many NDA's to be filed during the next 5-7 year period as a result of this effort.
Developed programs for NIH extramural funding and/or research collaborations with funding of
approximately $3 million per year
Developed a post-doctoral training program with 20-30 trainees in Discovery
Continued to direct my own research project in nitric oxide-cyclic GMP with 15-20 staff and about
$750,000 per year of extramural NIH grant support

Molecular Geriatrics Corporation: (1993 to 1995)

CEO and President, 1993 - 1995
A co-founder of the biopharmaceutical company focused on the therapeutics and diagnostics of
Alzheimer's Disease and other neurodegenerative diseases. Raised approximately $15 million
in private investments and grant support. Designed laboratory and office facilities and recruited
about 50 scientists and staff. Developed various university and NIH collaborations and
corporate partnership and world-wide licensing agreement with Upjohn Company for the
development and commercialization of an Alzheimer's Disease therapeutic agent.

Medical Center and University Committees: (1997-present, University of Texas)

Member - Dean’s Academic Council (1997 – present)
Member - Dean’s Strategic Advisory Group (1997)
Member - Dean’s Committee of Basic Science Chairs (1997 – present)
Member – Graduate Faculty, Graduate School of Biomedical Sciences (1997 – present)
Member – Search Committee, Director of Division of Pulmonary Medicine (1997 –1998)
Member - Search Committee, Chief of Clinical Cardiology (1998-2000)
Member – Intellectual Property Committee (1997 – 2001)
Chairman – Search Committee for Director of Institute of Molecular Medicine (1998 –1999)
Member - M.D./Ph.D. Board (1998-present).
Member – Advisory Board for Clinical Research Curriculum (2000 - present)
Member – External Advisory Board, U. of TX MD Anderson Cancer Ctr, Melanoma SPORE,
(2000-present)
Member – Search Committee for Director for University Clinical Research Center (2001-2002)
Member – IMM Project Building Committee – (2002 – present)
Member – Liaison Committee on Medical Education Subcommittee on Graduate Education
(2002- present)
Member – Search Committee for Executive Vice President for Research (2002 – present)
Member – Architectural Advisory Committee for the Institute of Molecular Medicine (2002 – present)
Member – Ground Rules Committee and Steering Committee for Biotech Park – (2002 – present)
Member – Search Committee Center for Membrane Biology (2002 – present)
Member – Various Search Committees for the Institute of Molecular Medicine (1998-present)
 Ferid Murad, M.D., Ph.D.
Curriculum Vitae
Page 9

Patents and Licenses:

1. Ferid Murad and John Lewicki. Two-site immunoassays using monoclonal antibodies of
different classes or subclasses and test kits for performing same. U.S. Patent Number
4,474,892; October 2, 1984; Foreign patent pending.

2. Ferid Murad, Dale Leitman and Cesar Molina. A sensitive assay for atrial natriuretic factor
and related peptides using cultured cells and a kit for same, 1985.

3. Ferid Murad, James F. Kerwin, Jr., and Lee Gorsky. Guanidino compounds as regulators of
nitric oxide synthase. U.S. Patent Number 5,380,945; January 10, 1995.

4. Iraida Sharina, Joshua Krumenacker, Emil Martin and Ferid Murad. Genomic organization
of the mouse and human soluble guanylyl cyclase genes. (Provisional patent, Sept., 2000).

5. Ka Bian, Norman Weisbrodt and Ferid Murad. Trichinella-derived specific down regulation of
inducible nitric oxide synthase. (Atty DKT: UTSH250USP1, Oct., 2000).

6. Emil Martin and Ferid Murad. Treatment or prevention of cGMP-dependent pathophysiology

with a mutant variant of soluble guanydyl cyclase (Provisional Patent, February, 2003)

7. Murad F, Nedospasov A., Natalya B, Pimonoin T, Martin E. Methods of detecting

nitrotyrosine and aminotyrosine residues of peptides and proteins.

PUBLICATIONS

Papers, Chapters and Books:

1. Murad, F., Chi, Y.M., Rall, T.W., Sutherland, E.W.: The effect of catecholamines and choline
esters on the formation of adenosine 3', 5'-phosphate by preparations from cardiac muscle and
liver. J. Biol. Chem. 237:1233-38, 1962.

2. Murad, F.: A study of agents which influence the formation and action of adenosine 3', 5'-
monophosphate. Dissertation, Western Reserve University, Graduate School, 1965.

3. Murad, F.: Immunohemolytic anemia during therapy with methyldopa. J. Amer. Med. Assoc.
203:149-50, 1968.

4. Murad, F., Vaughan, M.: Effect of glucagon on rat heart adenyl cyclase. Biochem. Pharmacol.
18: 1053-59, 1969.

5. Murad, F., Strauch, B.S., Vaughan, M.: The effect of gonadotropins on testicular adenyl cyclase.
Biochim. Biophys. Acta.: 177: 591-98, 1969.

6. Vaughan, M., Murad, F.: Adenyl cyclase activity in particles from fat cells. Biochemistry 8: 3092-
99, 1969.

7. Murad, F., Rall, T.W., Vaughan, M.: Conditions for the formation, partial purification and assay of
an inhibitor of adenosine 3', 5'-monophosphate. Biochim. Biophys. Acta. 192: 430-45, 1969.

8. Murad, F., Brewer, H.B., Vaughan, M.: Effect of thyrocalcitonin on adenosine 3', 5'-
monophosphate formation by rat kidney and bone. Proc. Nat. Acad. Sci. 65: 446-53, 1970.
Ferid Murad, M.D., Ph.D.
Curriculum Vitae
Page 10

9. Murad, F., Manganiello, V., Vaughan, M.: Effects of guanosine 3', 5'-monophosphate on glycerol
production and accumulation of adenosine 3', 5'-monophosphate during incubation of fat cells. J.
Biol. Chem. 245: 3352-60, 1970.

10. Stossel, T., Murad, F., Mason, R., Vaughan, M.: Regulation of glycogen metabolism in
polymorphonuclear leukocytes. J. Biol. Chem. 245: 6228-34, 1970.

11. Murad, F., Manganiello, V., Vaughan, M.: A simple sensitive protein binding assay for guanosine
3', 5'-monophosphate. Proc. Nat. Acad. Sci. 68; 736-39, 1971.

12. Manganiello, V., Murad, F., Vaughan, M.: Effects of lipolytic and antilipolytic agents on cyclic 3', 5'-
adenosine monophosphate in fat cells. J. Biol. Chem. 246: 2195-02, 1971.

13. Murad, F., Gilman, A.G.: Adenosine 3', 5'-monophosphate and guanosine 3', 5'-monophosphate:
A simultaneous protein binding assay. Biochim. Biophys. Acta. 252: 397-400, 1971.

14. Murad, F., Pak, C.: Urinary excretion of adenosine 3', 5'-monophosphate and guanosine 3', 5'-
monophosphate. New Eng. J. Med. 286: 1382-87, 1972.

15. Mendoza, S., Murad, F., Handler, J., Orloff, J.: Refractoriness of toad bladder to stimulation of
sodium transport. Amer. J. Physiol. 223: 104-09, 1972.

16. Murad, F.: Cyclic AMP: A mediator of hormone response and its clinical application. Virginia
Monthly 99: 1197-1201, 1972.

17. Murad, F., Weitzman, R.: Effects of parathyroid hormone and calcitonin on cyclic AMP
metabolism. Proceedings of the Fourth International Congress of Endocrinology 273: 468-
73, 1972.

18. Murad, F.: Clinical applications of cyclic nucleotide levels. In: Pharmacology and the Future of
Man, Proceedings of the Fifth International Congress of Pharmacology 5: 233-44, 1972, S.
Karger, Basel.

19. Murad, F.: Beta-blockade of epinephrine induced cyclic AMP accumulation in heart, liver, fat and
trachea. Biochim. Biophy. Acta. 304: 181-87, 1973.

20. Thomas, E.W., Murad, F., Looney, W.B., Morris, H.P.: Adenosine 3', 5'-monophosphate and
guanosine 3', 5'-monophosphate: Concentrations in Morris hepatomas of different growth rates.
Biochim. Biophys. Acta. 297: 564-67, 1973.

21. Middler, S., Pak, C.Y., Murad, F., Bartter, F.: Thiazide diuretics and calcium metabolism.
Metabolism 22: 139-46, 1973.

22. Murad, F., Weitzman, R.: Hormonal regulation of cyclic AMP. Seminars in Drug Treatment 3:
189-202, 1973.

23. Murad, F.: Principles of drug interactions. Consultant, Vol. 14, No. 9, pp. 56-59, September,
1974.

24. Murad, F.: Clinical studies and applications of cyclic nucleotides. Advances in Cyclic Nucleotide
Research, Vol. 3, pp. 335-383, 1973, G.A. Robison and P. Greengard, Eds., Raven Press, New
York.
Ferid Murad, M.D., Ph.D.
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Page 11

25. Murad, F.: Techniques for the formation, partial purification and assay of a cyclic AMP inhibitor.
Methods in Enzymology: Hormone Action Part C Cyclic Nucleotides, Vol. 38, pp. 273-283, 1974,
J. Hardman and B. O'Malley, Eds., Academic Press, New York.

26. Gilman, A.G., Murad, F.: Assay of cyclic nucleotides by receptor protein binding displacement.
Methods in Enzymology: Hormone Action Part C Cyclic Nucleotides, Vol. 38, pp. 49-61, 1974, J.
Hardman and B. O'Malley, Eds., Academic Press, New York.

27. Kimura, H., Thomas, E., Murad, F.: Effects of decapitation, ether and pentobarbital on guanosine
3', 5'-phosphate and adenosine 3', 5'-phosphate levels in rat tissues. Biochim. Biophys. Acta.
343: 519-28, 1974.

28. Kimura, H., Murad, F.: Nonenzymatic formation of cyclic GMP from GTP. J. Biol. Chem. 249:
329-31, 1974.

29. Murad, F., Kimura, H.: Cyclic nucleotide levels in incubations of guinea pig trachea. Biochim.
Biophys. Acta. 343: 275-86, 1974.

30. Kimura, H., Murad, F.: Evidence for two different forms of guanylate cyclase in rat heart. J. Biol.
Chem. 249: 6910-19, 1974.

31. Murad, F.: Mechanism of action of some bronchodilators: Cyclic nucleotide metabolism in
tracheal preparations. Amer. Review of Resp. Dis. 110: 111-18, 1974.

32. Gilman, A.G., Murad, F.: Hormones and hormone antagonists. In, The Pharmacological Basis of
Therapeutics, 5th Edition, pp. 1369-1371, 1975, Ed., L.S. Goodman and A. Gilman, the Macmillan
Co., New York.

33. Gilman, A.G., Murad, F.: Adenohypophyseal hormones and related substances. In, The
Pharmacological Basis of Therapeutics, 5th Edition, pp. 1372-1397, 1975, Ed., L.S. Goodman and
A. Gilman, The Macmillan Co., New York.

34. Gilman, A.G., Murad, F.: Thyroid and antithyroid drugs. In, The Pharmacological Basis of
Therapeutics, 5th Edition, pp. 1398-1422, 1975, Ed., L.S. Goodman and A. Gilman, The Macmillan
Co., New York.

35. Murad, F., Gilman, A.G.: Estrogens and progestins. In, The Pharmacological Basis of
Therapeutics 5th Edition, pp. 1423-1450, 1975, Ed., L.S. Goodman and A. Gilman, The Macmillan
Co., New York.

36. Murad, F., Gilman, A.G.: Androgens and anabolic steroids. In, The Pharmacological Basis of
Therapeutics, 5th Edition, pp. 1451-1471, 1975, Ed., L.S. Goodman and A. Gilman, The Macmillan
Co., New York.

37. Murad, F., Moss, W., Johanson, A., Selden, R.: Urinary excretion of cyclic AMP and cyclic GMP in
normal children and those with cystic fibrosis. J. Clin. Endocrin. Metab. 40: 552-59, 1975.

38. McLean, M.J., Lapsley, R.A., Shigenobu, K., Murad, F., Sperelakis, N.: High cyclic AMP levels in
young chick embryonic hearts. Developmental Biology 42: 196-201, 1975.

39. Kimura, H., Murad, F.: Two forms of guanylate cyclase in mammalian tissues and possible
mechanisms for their regulation. Metabolism 24: 439-45, 1975.
Ferid Murad, M.D., Ph.D.
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40. Murad, F.: What you should know before prescribing an oral contraceptive. Consultant 15 (3):
187-88, 1975.

41. Taylor, A., Murad, F., Owen, J.: Drug Interactions. Annual Review of Allergy, 1974, Ed., C.A.
Frazier, Medical Examination Publishing, Inc., Flushing, New York.

42. Murad, F.: Role of cyclic nucleotides and feedback systems to regulate cyclic AMP accumulation
and action. Proceedings of the First Portonovo Conference, (1974): 107-14, 1978, Cofese,
Palermo.

43. Kimura, H., Murad, F.: Localization of particulate guanylate cyclase in plasma membranes and
microsomes of rat liver. J. Biol. Chem. 250: 4810-17, 1975.

44. Kimura, H., Murad, F.: Increased particulate and decreased soluble guanylate cyclase activity in
regenerating liver, fetal liver, and hepatoma. Proc. Natl. Acad. Sci. 72: 1965-69, 1975.

45. Curnow, R.T., Carey, R.C., Taylor, A., Johanson, A., Murad, F.: Somatostatin inhibition of insulin
and gastrin hypersecretion in pancreatic islet cell carcinoma. N. Eng. J. Med. 292: 1385-86, 1975.

46. Kimura, H., Murad, F.: Subcellular localization of guanylate cyclase. Life Sciences 17: 837-44,
1975.

47. Murad, F., Kimura, H., Hopkins, H., Looney, W., Kovacs, C.: Increased urinary excretion of cyclic
GMP in rats bearing Morris hepatoma 3924A. Science 190: 58-60, 1975.

48. Murad, F., Weitzman, R., Taylor, A.: Use of Cyclic Nucleotides to Evaluate Calcium Disorders. In,
Clinical Aspects of Cyclic Nucleotides, Ed., L. Volicer, Spectrum Pub., Inc., New York, pp. 1-18,
1977.

49. Criss, W.E., Murad, F.: Cyclic Nucleotide Metabolism in Tumors. In, Clinical Aspects of Cyclic
Nucleotides, Ed., L. Volicer, Spectrum Publications, Inc., New York, 1977, pp. 429-48.

50. Kimura, H., Mittal, C.K., Murad, F.: Activation of guanylate cyclase from rat liver and other tissues
with sodium azide. J. Biol. Chem. 250: 8016-22, 1975.

51. Kimura, H., Mittal, C.K., Murad, F.: Increases in cyclic GMP levels in brain and liver with sodium
azide, an activator of guanylate cyclase. Nature 257: 700-02, 1975.

52. Mittal, C.K., Kimura, H., Murad, F.: Requirement for a macromolecular factor for sodium azide
activation of guanylate cyclase. J. Cyclic Nucl. Res. 1: 261-69, 1975.

53. Kimura, H., Murad, F.: Sodium azide-induced magnesium guanylate cyclase activity. Proc. of the
First Japanese Cyclic Nucleotide Conf., July 7-8, 1976, pp. 22-25.

54. Criss, W.E.., Murad, F., Kimura, H., Morris, H.P.: Properties of guanylate cyclase in adult rat liver
and several Morris hepatomas. Biochim. Biophys. Acta. 445: 500-08, 1976.

55. Criss, W.E., Murad, F.: Urinary excretion of guanosine 3', 5'-monophosphate and adenosine 3', 5'-
monophosphate in rats bearing transplantable liver and kidney tumors. Cancer Res. 36: 182-84,
1976.

56. Criss, W.E., Murad, F., Kimura, H.: Properties of guanylate cyclase from rat kidney cortex and
transplantable kidney tumors. J. Cyclic Nucl. Res. 2: 11-19, 1976.
Ferid Murad, M.D., Ph.D.
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57. Kimura, H., Mittal, C.K., Murad, F.: Appearance of magnesium guanylate cyclase activity in rat
liver with sodium-azide activation. J. Biol. Chem. 251: 7769-73, 1976.

58. Arnold, W.P., Murad, F.: Some properties of guanylate cyclase in mammalian broken cell
preparations. Proc. of the Brooklodge Pulmonary Conference, April, 1976, in Lung Cells in
Disease, Ed., A. Bouhuys, Elsevier/North Holland Press, 1976, 281-84.

59. Murad, F.: Cyclic GMP metabolism in transplantable tumors. Proceedings of the 25th Annual
Conference of the Rutgers Bureau of Biological Res. In, Cyclic Nucleotides and the Regulation of
Cell Growth, Ed., M. Abou-Sabe, Dowden Hutchinson and Ross, Inc., Stroudsburg, Pa., 1976,
191-206.

60. Murad, F., Kimura, H., Mittal, C.K., Arnold, W.P.: Guanylate Cyclase: Properties and regulation.
Proc. of the V Int. Congress of Endocrinology, Hamburg, July, 1976, Excerpta Medica.

61. Larner, J., Takeda, Y., Brewer, H.B., Huang, L.C., Hazen, R., Brooker, G., Murad, F., Roach, P.:
Studies on glycogen synthase and its control by hormones. In Metabolic Interconversion of
Enzymes, Ed., S. Shaltiel, Springer-Verlag, pp. 71-85, 1976.

62. Katsuki, S., Murad, F.: Regulation of cyclic 3', 5'-adenosine monophosphate and cyclic 3', 5'-
guanosine monophosphate levels and contractility in bovine tracheal smooth muscle. Molecular
Pharmacology 13: 330-41, 1977.

63. Mittal, C.K., Murad, F.: Formation of adenosine 3', 5'-monophosphate by preparations of
guanylate cyclase from rat liver and other tissues. J. Biol. Chem. 252: 3136-40, 1977.

64. Ichihara, K., Larner, J., Kimura, H., Murad, F.: Activation of liver guanylate cyclase by bile salts
and contaminants in crude secretin and pancreozymin preparations. Biochim. Biophys. Acta.
481: 734-40, 1977.

65. Murad, F.: Intrauterine devices containing progesterone. Drug Therapy: 5-7, May, 1977.

66. Katsuki, S., Arnold, W., Mittal, C.K., Murad, F.: Stimulation of guanylate cyclase by sodium
nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the
effects of sodium azide and hydroxylamine. J. Cyclic Nucl. Res. 3: 23-35, 1977.

67. Mittal, C.K., Kimura, H., Murad, F.: Purification and properties of a protein required for sodium
azide activation of guanylate cyclase. J. Biol. Chem. 252: 4348-90, 1977.

68. Arnold, W.P., Mittal, C.K., Katsuki, S., Murad, F.: Nitric oxide activates guanylate cyclase and
increases guanosine 3', 5'-monophosphate levels in various tissue preparations. Proc. Nat. Acad.
Sci. USA 74: 3203-07, 1977.

69. Katsuki, S., Arnold, W.P., Mittal, C.K., Murad, F.: Stimulation of formation and accumulation of
cyclic GMP by smooth muscle relaxing agents. Proc. of the 2nd Japanese Cyclic Nucleotide
Conference, July 7 - 9, 1977, pp. 44-50.

70. Mittal, C.K., Murad, F.: Activation of guanylate cyclase with superoxide dismutase and hydroxyl
radical, a physiological regulator of cyclic GMP formation. Proc. Nat. Acad. Sci. 74: 4360-64,
1977.
Ferid Murad, M.D., Ph.D.
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71. Katsuki, S., Arnold, W.P., Murad, F.: Effect of sodium nitroprusside, nitroglycerin and sodium
azide on levels of cyclic nucleotides and mechanical activity of various tissues. J. Cyclic Nucl.
Res. 3: 239-47, 1977.

72. Murad, F.: Utility and interpretation of urinary cyclic AMP in primary and pseudohypo-parathryroid
disorders. World Journal of Surgery 1: 532-34, 1977.

73. Arnold, W.P., Aldred, R., Murad, F.: Cigarette smoke activates guanylate cyclase and increases
cyclic GMP levels in tissues. Science 198: 934-36, 1977.

74. Curnow, R.T., Carey, R.M., Taylor, A.M., Johanson, A., Murad, F.: Inhibition of luteinizing
hormone release by somatostatin. Southern Med. J. 70: 871, 1977.

75. Mittal, C.K., Murad, F.: Properties and oxidative regulation of guanylate cyclase. J. Cyclic Nucl.
Res. 3: 381-91, 1977.

76. Murad, F., Aurbach, G.D.: Cyclic GMP in metabolism: Interrelationship of biogenic amines,
hormones and other agents. In, The Year in Metabolism 1976-1977, N. Freinkel, Ed., Plenum
Medical Book Co., New York, pp. 1-32, 1978.

77. Bergman, M.J., Guerrant, R.L., Murad, F., Richardson, S.N., Weaver, D., Mandell, G.L.: The
interaction of polymorphonuclear neutrophils with Escherichia Coli: Effect of enterotoxin on
phagocytosis, killing, chemotaxis and cyclic AMP. J. Clin. Invest. 61: 227-34, 1978.

78. Murad, F., Mittal, C.K., Arnold, W.P., Katsuki, S., Kimura, H.: Guanylate cyclase: Activation by
azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and
myoglobin. Adv. Cyclic Nucl. Res. 9: 145-58, 1978.

79. Mittal, C.K., Arnold, W.P., Murad, F.: Characterization of protein inhibitors of guanylate cyclase
activation from rat heart and bovine lung. J. Biol. Chem. 253: 1266-71, 1978.

80. Murad, F., Mittal, C.K., Arnold, W.P., Ichihara, K., Braughler, E., El-Zayat, M.: Properties and
regulation of guanylate cyclase: Activation by azide, nitro compounds and hydroxyl radical and
effects of heme containing proteins. Proc. of the NATO Adv. Study Inst. on Cyclic Nucleotides,
Italy, 1977, in Molecular Biology and Pharmacology of Cyclic Nucleotides, Eds., G. Folca and R.
Paoletti, Elsevier, Amsterdam, pp. 33-42, 1978.

81. Hughes, J., Murad, F., Chang, B., Guerrant, R.: The role of cyclic GMP in the mechanism of
action of the heat-stable enterotoxin of E. Coli. Nature 271: 755-56, 1978.

82. Murad, F., Mittal, C.K., Arnold, W.P., Braughler, J.M.: Effect of nitro-compound smooth muscle
relaxants and other materials on cyclic GMP metabolism. Proc. of the 7th International Congress
of Pharmacology, Paris, France, July, 1978, in Advances in Pharmacology and Therapeutics, Vol.
3 Ions, Cyclic Nucleotides, Cholinergy, Ed., J.C. Stocklet, Pergamon Press, New York, pp. 123-32,
1978.

83. Garbers, D., Murad, F.: Guanylate cyclase assay methods. Adv. Cyclic Nucl. Res. 10: 57-67,
1979.

84. Murad, F.: Over the Counter Drugs. Drug Therapy, 1979.

85. Mittal, C.K., Braughler, J.M., Ichihara, K., Murad, F.: Synthesis of adenosine 3', 5'-monophosphate
by guanylate cyclase a new pathway for its formation. Biochim. Biophys. Acta. 585: 333-42,
1979.
Ferid Murad, M.D., Ph.D.
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86. Braughler, J.M., Mittal, C.K., Murad, F.: Purification of soluble guanylate cyclase from rat liver.
Proc. Natl. Acad. Sci., USA 76: 219-22, 1979.

87. Ichihara, K., Murad, F.: Guanylate cyclase activity in rat liver and other tissues with starvation and
streptozotocin-induced diabetes mellitus. Arch. Biochem. Biophys. 194: 292-98, 1979.

88. Neer, E., Murad, F.: Separation of soluble adenylate and guanylate cyclases from the mature rat
testis. Biochim. Biophys. Acta. 583: 531-34, 1979.

89. Murad, F., Arnold, W.P., Mittal, C.K., Braughler, J.M.: Properties and regulation of guanylate
cyclase and some proposed functions for cyclic GMP. Adv. Cyclic Nucl. Res. 11: 175-204, 1979.

90. Ichihara, K., El-Zayat, M., Mittal, C.K., Murad, F.: Fatty acid activation of guanylate cyclase from
fibroblasts and liver. Arch. Biochem. Biophysics 197: 44-51, 1979.

91. Larner, J. Roach, P.J., Huang, L.C., Brooker, G., Murad, F., Hazen, R.: Hormonal control of
glycogen metabolism. In Hormones and Energy Metabolism, Eds., I.M. Klachko, R.R. Anderson
and M. Heimberg, Plenum, New York, pp. 103-23, 1979.

92. Braughler, J.M., Mittal, C.K., Murad, F.: Effects of thiols, sugars and proteins on nitric oxide
activation of guanylate cyclase. J. Biol. Chem. 254: 12450-54, 1979.

93. Murad, F., Haynes, R.C.: Hormones and Hormone Antagonists in The Pharmacological Basis of
Therapeutics, sixth edition, Eds., L.S. Goodman, A. Gilman and A.G. Gilman, Macmillan, New
York, pp. 1367-69, 1980.

94. Murad, F., Haynes, R.C.: Adenohypophyseal hormones and related substances, Chapter 59, in
The Pharmacological Basis of Therapeutics, sixth edition, Eds., L.S. Goodman, A. Gilman and
A.G. Gilman, Macmillan, New York, pp. 1369-96, 1980.

95. Haynes, R.C., Murad, F.: Thyroid and antithyroid drugs, Chapter 60, in The Pharmacological
Basis of Therapeutics, sixth edition, Eds., L.S. Goodman, A. Gilman and A.G. Gilman, Macmillan,
New York, pp. 1397-1419, 1980.

96. Murad, F., Haynes, R.C.: Estrogens and progestins, Chapter 61, in The Pharmacological Basis of
Therapeutics, sixth edition, Eds., L.S. Goodman, A. Gilman and A.G. Gilman, Macmillan, New
York, pp. 1420-47, 1980.

97. Murad, F., Haynes, R.C.: Androgens and anabolic steroids, Chapter 62, in The Pharmacological
Basis of Therapeutics, sixth edition, Eds., L.S. Goodman, A. Gilman and A.G. Gilman, Macmillan,
New York, pp. 1448-65, 1980.

98. Haynes, R.C., Murad, F.: Adrenocorticotropic hormones: Adrenocortical steroids and their
synthetic analogs. Inhibitors of adrenocortical steroid biosynthesis, Chapter 63, in The
Pharmacological Basis of Therapeutics, sixth edition, Eds., L.S. Goodman, A. Gilman and A.G.
Gilman, Macmillan, New York, pp. 1466-96, 1980.

99. Haynes, R.C., Murad, F.: Agents affecting calcification: Calcium parathyroid hormone, calcitonin
vitamin D, and other compounds, Chapter 65, in The Pharmacological Basis of Therapeutics, sixth
edition, Eds., L.S. Goodman, A. Gilman and A.G. Gilman, Macmillan, New York, pp. 1524-50,
1980.
Ferid Murad, M.D., Ph.D.
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100. Guerrant, R.L., Hughes, J.M., Chang, B., Robertson, D.C., Murad, F.: Activation of intestinal
guanylate cyclase by heat stable enterotoxin of Escherichia Coli: Studies of tissue specificity,
potential receptors and intermediates. J. Infec. Dis. 142: 220-28, 1980.

101. Thorner, M.O., Hackett, J.T., Murad, F., MacLeod, R.M.: Calcium rather than cyclic AMP as the
physiological intracellular regulator of prolactin release. Neuroendocrinology 31: 390-402, 1980.

102. Brooker, G., Murad, F.: Automated Gamma-Flo radioimmunoassay of urinary cyclic AMP. Clin.
Chem. 26: 1738-40, 1980.

103. Greenberg, R.N., Murad, F., Chang, B., Robertson, D.C., Guerrant, R.L.: Inhibition of Escherichia.
Coli. heat-stable enterotoxin by indomethacin and chlorpromazine. Infec. and Immun. 29: 908-
13, 1980.

104. Lewicki, J.A., Brandwein, H.J., Waldman, S.A., Murad, F.: Purified guanylate cyclase:
Characterization, iodination, and preparation of monoclonal antibodies. J. Cyclic Nucl. Res. 6:
283-96, 1980.

105. Brandwein, H.J., Lewicki, J.A., Murad, F.: Reversible inactivation of guanylate cyclase by mixed
disulfide formation. J. Biol. Chem. 256: 2958-62, 1981.

106. Dohi, T., Murad, F.: Effects of pyruvate and other metabolites on cyclic GMP levels in incubations
of rat hepatocytes and kidney cortex. Biochim. Biophy. Acta. 673: 14-25, 1981.

107. Murad, F., Lewicki, J.A., Brandwein, H.J., Mittal, C.K., Waldman, S.A.: Guanylate cyclase:
Purification, properties, free radical activation, radiolabelling, and preparation of hybridoma
antibodies. Adv. Cyclic Nucl. Res. 14: 229-39, 1981.

108. Brandwein, H.J., Lewicki, J.A., Murad, F.: Production and characterization of monoclonal
antibodies to soluble guanylate cyclase. Proc. Nat. Acad. Sci. 78: 4241-45, 1981.

109. Mittal, C.K., Murad, F.: Guanylate Cyclase: Regulation of Cyclic GMP Metabolism in Handbook of
Experimental Pharmacology. Ed., J.A. Nathanson and J.W. Kebabian, Springler-Verlag, Berlin,
Vol. 58-I, pp. 225-60, 1982.

110. Murad, F.: Regulation and Roles of Cyclic Nucleotides, in Pathophysiology of Anoxia, and
Ischemia. Eds., R.A. Crowley and B.F. Trump, Williams and Wilkins, Baltimore, MD, pp. 147-53,
1982.

111. Greenberg, R.N., Guerrant, R.L., Chang, B., Robertson, D.C., Murad, F.: Inhibition of E. Coli heat-
stable enterotoxin effects of intestinal guanylate cyclase and fluid secretion by quinacrine.
Biochem. Pharm. 31: 2005-09, 1982.

112. Lowance, D.T., Murad, F., Darrow, W.R., Bonus, L.: Bioequivalence of a slow-release potassium
tablet and a liquid potassium supplement. Intl. J. Clin. Pharm. Ther. and Toxic. 20: 204-08,
1982.

113. Ariano, M., Lewicki, J.A., Brandwein, H.J., Murad, F.: Immunohistochemical localization of
guanylate cyclase within neurons of rat brain. Proc. Nat. Acad. Sci. USA. 79: 1316-20, 1982.

114. Greenberg, R.N., Murad, F., Guerrant, R.L.: Lanthanum chloride inhibition of the secretory
response to E. Coli heat-stable enterotoxin. Infect. and Immun. 35: 483-88, 1982.
Ferid Murad, M.D., Ph.D.
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115. Brandwein, H.J., Lewicki, J.A., Waldman, S.A., Murad, F.: Effect of GTP analogues on purified
soluble guanylate cyclase. J. Biol. Chem. 257: 1309-11, 1982.

116. Lewicki, J.A., Brandwein, H.J., Mittal, C.K., Arnold, W.P., Murad, F.: Properties of purified soluble
guanylate cyclase activated by nitric oxide and sodium nitroprusside. J. Cyclic Nucl. Res. 8: 17-
25, 1982.

117. Rapoport, R.M., Draznin, M., Murad, F.: Sodium nitroprusside-induced protein phosphorylation in
intact rat aorta is mimicked by 8-bromo-cyclic GMP. Proc. Nat. Acad. Sci. USA 79: 6470-74,
1982.

118. Waldman, S.A., Lewicki, J.A., Brandwein, H.J., Murad, F.: Partial purification and characterization
of particulate guanylate cyclase from rat liver after solubization with trypsin. J. Cyclic Nucl. Res.
8: 359-70, 1982.

119. Rapoport, R.M., Murad, F.: Agonist-induced endothelial-dependent relaxation in rat thoracic aorta
may be mediated through cyclic GMP. Circ. Res. 52: 352-57, 1983.

120. Lewicki, J.A., Chang, B., Murad, F.: Quantification of guanylate cyclase concentrations by a direct
double determinant tandem immunoradiometric assay. J. Biol. Chem. 258: 3509-15, 1983.

121. Rapoport, R.M., Murad, F.: Effect of ouabain and alterations in potassium concentration on
relaxation induced by sodium nitroprusside. Blood Vessels 20: 255-64, 1983.

122. Waldman, S.A., Lewicki, J.A., Chang, L., Murad, F.: Highly purified particulate guanylate cyclase
from rat lung: Characterization and comparison with soluble guanylate cyclase. Molec. and Cell
Biochem. 57: 155-66, 1983.

123. Rapoport, R.M., Draznin, M.B., Murad, F.: Endothelium-dependent vasodilator-and

nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic
GMP-dependent protein phosphorylation. Trans. Assoc. Amer. Phys. 96: 19-30, 1983.

124. Rapoport, R.M., Draznin, M.B., Murad, F.: Endothelium dependent relaxation in rat aorta may be
mediated through cyclic GMP-dependent protein phosphorylation. Nature 306: 274-76, 1983.

125. Fiscus, R.R., Rapoport, R.M., Murad, F.: Endothelium-dependent and nitrovasodilator-induced
activation of cyclic GMP-dependent protein kinase in rat aorta. J. Cyclic Nucl. and Protein
Phosphor. Res. 9: 415-25, 1983.

126. Rapoport, R.M., Murad, F.: Endothelium-dependent and nitrovasodilator-induced relaxation of

vascular smooth muscle: Role for cyclic GMP. J. Cyclic Nucl. and Protein Phosphor. Res. 9:
281-96, 1983.

127. Waldman, S.A., O'Hanley, P.D., Falkow, S., Schoolnik, G.K., Murad, F.: A simple, sensitive and
specific assay for heat-stable enterotoxin from E. Coli. J. Infect. Dis. 149: 83-89, 1984.

128. Waldman, S.A., Sinacore, M.S., Lewicki, J.A., Chang, L.Y., Murad, F.: Selective activation of
particulate guanylate cyclase by a specific class of porphyrins. J. Biol. Chem. 259: 4038-42,
1984.

129. Rapoport, R.M., Murad, F.: Effect of cyanide on nitrovasodilator-induced relaxation, cyclic GMP
accumulation and guanylate cyclase activation in rat aorta. Europ. J. Pharm. 104: 61-70, 1984.
Ferid Murad, M.D., Ph.D.
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130. Pearl, R.G., Rosenthal, M.H., Murad, F., Ashton, J.P.A.: Aminophylline potenitates sodium
nitroprusside-induced hypotension in the dog. Anesthesiology 61: 712-15, 1984.

131. Winquist, R.M., Faison, E.P., Waldman, S.A., Schwartz, K., Murad, F., Rapoport, R.M.: Atrial
natriuretic factor elicits an endothelium independent relaxation and activates particulate guanylate
cyclase in vascular smooth muscle. Proc. Nat. Acad. Sci. 81: 7661-64, 1984.

132. Waldman, S.A., Rapoport, R.M., Murad, F.: Atrial natriuretic factor selectively activates particulate
guanylate cyclase and elevates cyclic GMP in rat tissues. J. Biol. Chem. 259: 14332-334, 1984.

133. Rapoport, R.M., Draznin, M.B., Murad, F.: Mechanisms of adenosine triphosphate-, thrombin-,
and trypsin-induced relaxation of rat thoracic aorta. Circ. Res. 55: 468-79, 1984.

134. Garieppy, J., O'Hanley, P.D., Waldman, S.A., Murad, F., Schoolnik, G.K.: A common antigenic
determinant found in two functionally unrelated classes of cysteine-rich toxins. J. Expt'l. Med.
160: 1253-58, 1984.

135. Winquist, R.J., Faison, E.P., Napier, M., Vanden, R., Waldman, S.A., Murad, F., Rapoport, R.M.:
The effects of atrial natriuretic factor on vascular smooth muscle. In Vascular Neuroeffector
Mech., J.A. Beaven, editor, Elsevier/North Holland, Amsterdam 349-53, 1984.

136. Murad, F., Rapoport, R.M., Fiscus, R.R.: Role of cyclic GMP in relaxations of vascular smooth
muscle. J. of Card. Pharm. 7, Supplement 3, S111-18, 1985.

137. Waldman, S.A., Rapoport, R.M., Fiscus, R.R., Murad, F.: Effects of antriopeptin on particulate
guanylate cyclase from rat adrenal. Biochim. Biophys. Acta. 845: 298-303, 1985.

138. Rapoport, R.M., Schwartz, K., Murad, F.: Effect of Sodium-Potassium-pump inhibitors and
membrane depolarizing agents on sodium nitroprusside-induced relaxation and cyclic Guanosine
Monophosphate accumulation in rat aorta. Circ. Res. 57: 164-70, 1985.

139. Gilman, A.G., Goodman, L.S., Rall, T.W., Murad, F. (editors) The Pharmacological Basis of
Therapeutics, seventh edition, Macmillan, New York, 1985.

140. Murad, F., Haynes, R.C.: Hormones and Hormone Antagonists. In The Pharmacological Basis of
Therapeutics, seventh edition, Eds., A.G. Gilman, L.S. Goodman, T.W. Rall and F. Murad,
Macmillan, New York, pp. 1360-62, 1985.

141. Murad, F., Haynes, R.C.: Adenohypophyseal hormones and related substances, Chapter 59, in
The Pharmacological Basis of Therapeutics, seventh edition, Eds., A.G. Gilman, L.S. Goodman,
T.W. Rall and F. Murad, Macmillan, New York, pp. 1362-88, 1985.

142. Haynes, R.C., Murad, F.: Thyroid and antithyroid drugs, Chapter 60, in The Pharmacological
Basis of Therapeutics, seventh edition, Eds., A.G. Gilman, L.S. Goodman, T.W. Rall and F. Murad,
Macmillan, New York, pp. 1389-11, 1985.

143. Murad, F., Haynes, R.C.: Estrogens and progestins, Chapter 61, in The Pharmacological Basis of
Therapeutics, seventh edition, Eds., A.G. Gilman, L.S. Goodman, T.W. Rall and F. Murad,
Macmillan, New York, pp. 1412-39, 1985.

144. Murad, F., Haynes, R.C.: Androgens and anabolic steroids, Chapter 62, in The Pharmacological
Basis of Therapeutics, seventh edition, Eds., A.G. Gilman, L.S. Goodman, T.W. Rall and F. Murad,
Macmillan, New York, pp. 1412-39, 1985.
Ferid Murad, M.D., Ph.D.
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145. Haynes, R.C., Murad, F.: Adrenocorticotropic hormones: Adrenocortical steroids and their
synthetic analogs. Inhibitors of adrenocortical steroid biosynthesis, Chapter 63, in The
Pharmacological Basis of Therapeutics, seventh edition, Eds., A.G. Gilman, L.S. Goodman, T.W.
Rall and F. Murad, Macmillan, New York, pp. 1459-89, 1985.

146. Haynes, R.C., Murad, F.: Agents affecting calcification: Calcium parathyroid hormone, calcitonin
vitamin D, and other compounds, Chapter 65, in The Pharmacological Basis of Therapeutics,
seventh edition, Eds., A.G. Gilman, L.S. Goodman, T.W. Rall and F. Murad, Macmillan, New
York, pp. 1517-43, 1985.

147. Murad, F. Gilman, A.G.: Drug Interactions, Appendix III, in The Pharmacological Basis of
Therapeutics, seventh edition, Eds., A.G. Gilman, L.S. Goodman, T.W. Rall and F. Murad,
Macmillan, New York, pp. 1734-50, 1985.

148. Rapoport, R.M., Schwartz, K., Murad, F.: Effects of Na+, K+-pump inhibitors and membrane
depolarizing agents on acetylcholine-induced endothelium-dependent relaxation and cyclic GMP
accumulation in rat aorta. Eur. J. Pharm. 110: 203-09, 1985.

149. Rapoport, R.M., Waldman, S.A., Schwartz, K., Winquist, R.J., Murad, F.: Effects of atrial
natriuretic factor, sodium nitroprusside and acetylcholine on cyclic GMP and relaxation in rat aorta.
Eur. J. Pharm. 115: 219-29, 1985.

150. Fiscus, R.R., Rapoport, R.M., Waldman, S.A., Murad, F.: Atriopeptin II elevates cyclic GMP,
activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta.
Biochim. Biophy. Acta. 846: 179-84, 1985.

151. Leitman, D.C., Waldman, S.A., Rapoport, R.M., Murad, F.: Specific atrial natriuretic factor
receptors mediate increased cyclic GMP accumulation in cultured bovine aortic endothelial and
smooth muscle cells. Trans. Assoc. Amer. Phys. 98: 243-52, 1985.

152. Waldman, S.A., Chang, L.Y., Murad, F.: A two-step procedure for obtaining highly purified
particulate guanylate cyclase from rat lung. Prep. Biochem. 15: 103-19, 1985.

153. Murad, F.: Effects of phosphodiesterase inhibitors and the role of cyclic nucleotides in smooth
muscle relaxation. In Antiasthma Xanthines and Adenosine, Eds., K.E. Andersson and C.G.A.
Persson, Excerpta Medica, Amsterdam, pp. 10-15, 1985.

154. Leitman, D.C., Murad, F.: Comparison of binding and cyclic GMP accumulation by atrial natriuretic
peptides in endothelial cells. Biochim. Biophys. Acta. 885: 74-9, 1986.

155. Leitman, D.C., Fiscus, R.R., Murad, F.: Forskolin, phosphodiesterase inhibitors and cyclic AMP
analogs inhibit proliferation of cultured bovine aortic endothelial cells. J. Cell Physiol. 127: 237-
43, 1986.

156. Murad, F.: Cyclic guanosine monophosphate as a mediator of vasodilation. J. Clin. Invest. 78: 1-
5, 1986.

157. Kuno, T., Kamisaki, Y., Waldman, S.A. Garieppy, J., Schoolnik, G.K., Murad, F.: Characterization
of the receptor for heat-stable enterotoxin from E. Coli in rat intestine. J. Biol. Chem. 261: 1470-
76, 1986.

158. Murad, F., Waldman, S.A., Fiscus, R.R., Rapoport, R.M.: Regulation of cyclic GMP synthesis and
the interactions with calcium. J. Card. Pharm. Supplement 8: S57-60, 1986.
Ferid Murad, M.D., Ph.D.
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159. Waldman, S.A., Kuno, T., Kamisaki, Y., Chang, L.Y., Garieppy, J., O'Hanley, P.D., Schoolnik,
G.K., Murad, F.: Intestinal receptor for heat-stable enterotoxin of E. Coli is tightly coupled to a
novel form of particulate guanylate cyclase. Infect. and Immun. 51: 320-26, 1986.

160. Kuno, T., Andresen, J.W., Kamisaki, Y., Waldman, S.A., Chang, L.Y., Saheki, S., Leitman, D.C.,
Nakane, M., Murad, F.: Co-purification of an atrial natriuretic factor receptor and particulate
guanylate cyclase from rat lung. J. Biol. Chem. 261: 5817-23, 1986.

161. Leitman, D.C., Andresen, J.W., Kuno, T., Kamisaki, Y., Chang, J., Murad, F.: Identification of
multiple binding sites for atrial natriuretic factor by affinity cross-linking in cultured endothelial cells.
J. Biol. Chem. 261: 11650-55, 1986.

162. Kamisaki, Y., Saheki, S., Nakane, M., Palmieri, J., Kuno, T., Chang, B., Waldman, S.A., Murad, F.:
Soluble guanylate cyclase from rat lung exists as a heterodimer. J. Biol. Chem. 261: 7236-41,
1986.

163. Bennett, B., Hayward, D., Murad, F.: Effects of the D and L stereoisomers of isoidide dinitrate on
relaxation and cyclic GMP accumulation in rat aorta and comparison to glyceryl trinitrate. J. of
App. Card. 1: 203-90, 1986.

164. Waldman, S.A., Rapoport, R.M., Ginsburg, R., Murad, F.: Desensitization to nitroglycerin in
vascular smooth muscle from rat and human. Biochem. Pharm. 35: 3525-31, 1986.

165. Rapoport, R.M., Winquist, R.J., Baskin, E.P., Baison, E.P., Waldman, S.A., Murad, F.: Effects of
atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aorta. Eur. J. Pharm. 120: 123-
26, 1986.

166. Rapoport, R.M., Ginsburg, R., Waldman, S.A., Murad, F.: Effects of atriopeptins on relaxation and
cyclic GMP levels in human coronary artery in vitro. Eur. J. Pharm. 124: 193-96, 1986.

167. Draznin, M.B., Rapoport, R.M., Murad, F.: Myosin light chain phosphorylation in contraction and
relaxation of intact rat thoracic aorta. Int'l. J. Biochem. 18: 917-28, 1986.

168. Kamisaki, Y., Waldman, S.A., Murad, F.: The involvement of catalytic site thiol groups in the
activation of soluble guanylate cyclase by sodium ntiroprusside. Arch. Biochem. Biophys. 251:
709-14, 1986.

169. Leitman, D.C., Andresen, J.W., Kuno, T., Kamasaki, Y., Chang, J., Murad, F.: Identification of two
binding sites for atrial natriuretic factor in endothelial cells: Evidence for a receptor subtype
coupled to guanylate cyclase. Trans. Assoc. Phys. 99: 104-13, 1986.

170. Fiscus, R.R., Robles, B.T., Waldman, S.A., Murad, F.: Atrial natriuretic factors stimulate
accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC-12 rat pheochromocytoma cell
cultures. J. Neurochem. 48: 522-528, 1987.

171. Leitman, D.C., Agnost, V.L., Tuan, J.J., Andresen, J.W., Murad, F.: Atrial natriuretic factor and
sodium nitroprusside increase cyclic GMP in cultured rat lung fibroblasts by activating different
forms of guanylate cyclase. Biochem. 244: 69-74, 1987.

172. Rapoport, R.M., Waldman, S.A., Ginsburg, R., Molina, C.R., Murad, F.: Effects of glyceryl trinitrate
on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and
human coronary artery. J. Card. Pharm. 10: 82-89, 1987.
Ferid Murad, M.D., Ph.D.
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173. Leitman, D.C., Murad, F.: Atrial natriuretic factor receptor heterogeniety and stimulation of
particulate guanylate cyclase and cyclic GMP accumulation. Endocrin. and Metab. Clin. in No.
Amer. 16: 79-105, 1987.

174. Molina, C., Andresen, J.W., Rapoport, R.M., Waldman, S.A., Murad, F.: The effects of in vivo
nitroglycerin therapy on endothelium-dependent and -independent relaxation and cyclic GMP
accumulation in rat aorta. J. Card. Pharm., 10: 371-378, 1987.

175. Murad, F., Waldman, S.A., Molina, C.R., Bennett, B.M., Leitman, D.C.: Regulation and role of
guanylate cyclase-cyclic GMP in vascular relaxation. Proceedings of the Second International
Symposium on Cellular Endocrinology. Mech. of Signal Transduction by Hormones and Growth
Factors, Alan R. Liss, New York, 1987.

176. Waldman, S.A., Murad, F.: Cyclic GMP synthesis and function. Pharm. Rev. 39: 163-96, 1987.

177. Schroeder, H., Leitman, D.C., Hayward, L.D., Bennett, B.M., Murad, F.: Cultured rat lung
fibroblasts as a model for organic nitrate-induced cyclic GMP accumulation and activation of
guanylate cyclase. J. App. Card. 2: 301-11, 1987.

178. Murad, F., Leitman, D.C., Bennett, B.M., Molina, C.R., Waldman, S.A.: Regulation of guanylate
cyclase by atrial natriuretic factor and the role of cyclic GMP in vasodilation. Amer. J. Med. Sci.
249: 139-143, 1987.

179. Murad, F.: Role of cyclic GMP in the mechanism of action of ntirovasodilators, atrial peptides and
other agents. Proc. Third Symposium on Nitrates, Excerpta Medica, Ltd., 1987.

180. Murad, F., Waldman, S., Molina, C., Bennett, B. and Leitman, D. Regulation and role of guanylate
cyclase-cyclic GMP in vascular relaxation. Progress in Clinical and Biological Research 249: 65-
76, 1987.

181. Fiscus, R., Murad, F.: A procedure for investigating cyclic GMP-dependent protein kinase
activation in intact tissues. In Methods in Enzymology: Hormone Action, Cyclic Nucleotide Action
and Degradation, J.D. Corbin and R.A. Johnson, Eds., Academic Press Vol. 159, 150-159, 1988.

182. Rapoport, R.M., Murad, F.: The role of cyclic GMP in endothelium-dependent relaxation of
vascular smooth muscle. In Endothelium-Derived Vasoactive Factors, Ed., P. Vanhoutte, Humana
Press, New Jersey, pp 219-239, 1988.

183. Rapoport, R.M., Murad, F.: Effects of ethacrynic acid and cystamine on sodium nitroprusside
induced relaxation, cyclic GMP levels and guanylate cyclase activity in rat aorta. Gen. Pharm. 19:
61-65, 1988.

184. Murad, F.: Round Table on Cyclic GMP and atrial natriuretic factor. Adv. Cyc. Nucl. and Pro.
Phosphor. Res. 21: 101-103, 1988.

185. Schroeder, H., Leitman, D.C., Bennett, B.M., Waldman, S.A., Murad, F.: Glyceryl trinitrate induced
desensitization of guanylate cyclase in cultured rat lung fibroblasts. J. Pharm. and Exper. Ther.
245: 413-418, 1988.

186. Bennett, BM., Schroeder, H., Hayward, L.D., Murad, F.: Effect of in vitro organic nitrate tolerance
on relaxation, cyclic GMP accumulation and guanylate cyclase activation by glyceryl trinitrate and
the enantiomers of isoidide dinitrate. Circ. Res. 63: 693-701, 1988.
Ferid Murad, M.D., Ph.D.
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187. Murad, F., Leitman, D.C., Bennett, B.M., Molina, C.R., Waldman, S.A.: Role of guanylate cyclase
and cyclic GMP in the actions of ANF. In Proceedings of the Second World Congress on
Biologically Active Atrial Peptides, New York, May 1987. Advances in Atrial Peptide Research,
Vol. II, 53-60, Ed., J.H. Laragh and B. Brenner, Raven Press, New York, 1988.

188. Leitman, D.C., Andressen, J.W., Catalano, R.M., Waldman, S.A., Tuan, J.J., Murad, F.: Atrial
natriuretic peptide binding, cross-linking and stimulation of cyclic GMP accumulation and
particulate guanylate cyclase activity in cultured cells. J. Biol. Chem. 263: 3720-28, 1988.

189. Murad, F.: The mechanism of relaxation of EDRF: Similarities of the effects of EDRF and
nitrovasodilators on cyclic GMP formation and vascular relaxation. Proc. of the Tenth Int'l.
Congress of Pharm., 1988.

190. Murad, F.: Atrial natriuretic peptide, endothelium-dependent vasodilators and nitrovasodilators:
Role of guanylate cyclase and cyclic GMP in their actions . In Proc. of XIIth European
Symposium on Hormones and Cell Regulation, Vol. 165, J. Libbey & Co., Ltd., France., pp.
3-12, 1988.

191. Leitman, D.C., Agnost, V.L., Catalano, R.M., Schroeder, H., Waldman, S.A., Bennett, B.M., Tuan,
J.J., Murad, F.: Atrial natriuretic peptide, oxytocin and vasopressin increase cyclic Guanosine 3',
5'-monophosphate in LLC-PK1 kidney epithelial cells. Endocrinology, 122, 1478-85, 1988.

192. Myers, B.D., Petersen, C., Molina, C., Tomlanovich, S.J., Newton, L., Nitkin, R., Sandler, H.,
Murad, F.: Role of cardiac atria in the human renal response to changing plasma volume. Amer.
J. Physiol. 254: F562-573, 1988.

193. Molina, C.R., Fowler, M.B., McCrary, S., Peterson, C., Myers, B.D., Schroeder, J.S., Murad, F.:
Hemodynamic, renal and endocrine effects of atrial natriuretic peptide infusion in severe heart
failure. J. Amer. Col. Card. 12: 175-186, 1988.

194. Murad, F.: The role of cyclic GMP in the mechanism of action of nitrovasodilators, endothelium-
dependent agents and atrial natriuretic peptide. Biochemical Society Transactions 16, 490-92,
1988.

195. Song, D.L., Kohse, K., Murad, F.: Brain natriuretic factor: Augmentation of cellular cyclic GMP,
activation of particulate guanylate cyclase and receptor binding. FEBS Lett. 1, 125-29, 1988.

196. Nakane, M., Saheki, S., Kuno, T., Ishii, K., Deguchi, T., Murad, F.: Molecular cloning of a cDNA
coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung. Biochem. Biophys.
Res. Commun. 157: 1139-1147, 1988.

197. Waldman, S.A., Murad, F.: Biochemical mechanisms underlying vascular smooth muscle
relaxation: The guanylate cyclase-cyclic GMP system. J. Cardiovasc. Pharmacol. 12: Suppl. 5,
S115-S118, 1988.

198. Leitman, D.C., Molina, C.R., Waldman, S.A., Murad, F.: Atrial natriuretic peptide receptors and the
guanylate cyclase-cyclic GMP system. Proc. of the UCLA Symposium on Atrial Natriuretic
Factor in Biological and Molecular Aspects of Atrial Factors, UCLA Symposia on Molecular and
Cellular Biology, 81: 36-59, 1988.

199. Murad, F., Leitman, D., Waldman, S. Chang, C.H., Hirata, M., Kohse, K.: Effects of
nitrovasodilators, endothelium-dependent vasodilators and atrial peptides on cGMP. Proc. Cold
Spring Harbor Symposium on Quantitative Biology, Signal Transduction, 53: 1005-1009,
1988.
Ferid Murad, M.D., Ph.D.
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200. Bennett, B.M., Molina, C.R., Waldman, S.A., Murad, F.: Cyclic nucleotides and protein
phosphorylation in vascular smooth muscle relaxation. In Physiology and Pathophysiology of the
Heart, Ed., N. Sperelakis, Kluwer Academic Publishers, Boston, pp. 825-846, 1989.

201. Rapoport, R.M., Ashraf, M., Murad, F.: Effects of melittin on endothelium-dependent relaxation
and cyclic GMP levels in rat aorta. Circ. Res. 64: 463-473, 1989.

202. Ishii, K., Murad, F.: ANP relaxes bovine tracheal smooth muscle and increases cGMP. Amer. J.
Physiol.: Cell Physiol. , 25: C495-C500, 1989.

203. Waldman, S.A., Rapoport, R.M., Fiscus, R.R., Leitman, D.C., Chang, L.Y., Murad, F.: Regulation
of particulate guanylate cyclase by atriopeptins: Relation between peptide structure, receptor
binding and enzyme kinetics. Biochim. Biophys. Acta, 999, 157-162, 1989.

204. Waldman, S.A., Leitman, D.C., Chang, L.Y., Murad, F.: Comparison of particulate guanylate
cyclase in cells with and without atrial natriuretic peptide receptor binding activity. Mol. Cell
Biochem., 90, 19-26, 1989.

205. Hirata, H., Chang, C.H., Murad, F.: Stimulatory effects of atrial natriuretic factor on
phosphoinositide hydrolysis in cultured bovine aortic smooth muscle cells. Biochem. Biophys.
Acta. 1010: 346-351, 1989.

206. Murad, F.: Modulation of the guanylate cyclase-cGMP system by vasodilators and the role of free
radicals as second messengers. Proc. of the NATO Advanced Studies Institute on Vascular
Endothelium: Receptors and Transduction Mechanisms. Porto Carros, Greece, June, 1988,
in Vascular Endothelium, eds. J.D. Catravas, C.N. Gillis and U.S. Ryan, pp 157-164, Plenum Pub.,
1989.

207. Bennett, B.M., Leitman, D.C., Schroder, H., Kawamoto, J.H., Nakatsu, K., Murad, F.: Relationship
between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured
cell lines. J. Pharmacol. Expt'l. Therap. 250: 316-323, 1989.

208. Murad, F.: Mechanisms for hormonal regulation of the different isoforms of guanylate cyclase.
Proc. of the 40th Mosbach Colloquium on Molecular Mechanisms of Hormone Action, eds.
Y, Gehring, E. Helmreich and G. Schultz, Springer, Heidelberg, April 1989. pp 186-194, 1989.

209. Ishii, K., Gorsky, L., Förstermann, U., Murad, F.: Endothelium-derived relaxing factor (EDRF):
The endogenous activator of soluble guanylate cyclase in various types of cells. J. Applied
Cardiology, 4, 505-512, 1989.

210. Waldman, S.A., Murad, F.: Atrial natriuretic peptides: Receptors and second messengers.
BioEssays, 10, 16-19, 1989.

211. Förstermann, U., Ishii, K., Gorsky, L.D., Murad, F.: The cytosol of N1E-115 neuroblastoma cells
synthesizes an EDRF-like substance that relaxes rabbit aorta. Naunyn Schmiedbergs Arch.
Pharmacol., 340: 771-774, 1989.

212. Leitman, D.C ., Murad, F.: Structure and function of atrial natriuretic peptide receptor subtypes.
Atrial Natriuretic Peptides, Chapter 7, pp. 77-93. Eds., R. Quirion and W.K. Samson, CRC
Press, 1990.
Ferid Murad, M.D., Ph.D.
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213. Chang, C.H., Kohse, K.P., Chang, B., Hirata, M., Jiang, B., Douglas, J., Murad, F.:
Characterization of ATP-stimulated guanylate cyclase activation in rat lung membranes. Biochem
Biophys Acta 1052: 159-165, 1990.

214. Hirata, M., Kohse, K., Chang, C.H., Ikebe, T., Murad, F.: Mechanism of cyclic GMP inhibition of
inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells.
J. Biol. Chem., 265: 1268-1273, 1990.

215. Murad, F.: Drugs used in the treatment of angina: organic nitrites, calcium channel blockers and

β-adrenergic antagonists. In Pharmacological Basis of Therapeutics, VIII Edition, chapter 32; eds.
A.G. Gilman, T.W. Rall, A. Nies and P. Taylor, pp.764-783, 1990.

216. Murad, F.: Hormones and Hormone Antagonists. In Pharmacological Basis of Therapeutics, VIII
Edition, Section XV, eds. A.G. Gilman, T.W. Rall, A. Nies and P. Taylor, pp.1332-1333, 1990.

217. Kuret, J., Murad, F.: Adenohypophyseal hormones and related substances. In Pharmacological
Basis of Therapeutics, VIII Edition, Chapter 56, eds. A.G. Gilman, T.W. Rall, A. Nies and P.
Taylor, pp. 1334-1360, 1990.

218. Murad, F., Kuret, J.: Estrogens and progestins. In Pharmacological Basis of Therapeutics,
chapter 58, eds. A.G. Gilman, T.W. Rall, A. Nies and P. Taylor, pp. 1384-1412, 1990.

219. Murad, F., Ishii, K.: Hormonal regulation of the different isoforms of guanylate cyclase: EDRF is a
ubiquitous activator of soluble guanylate cyclase. Proc. of the First Internat. Symp. on
Endothelium-Derived Vasoactive Factors. Philadelphia, PA, 1989. eds. G.M. Rubanyi and P.
Vanhoutte, Karger, Basel, pp. 151-165, 1990.

220. Fiscus, R.R., Kim, D.D., Wong, Y., Maslowski, R.J., Robles, B.T., Kuno, T., Murad, F.: Atrial
natriuretic peptide causes calcium-dependent increases in cyclic GMP levels in discrete regions of
rat brain. J. Neurochem.,1990.

221. Saheki, S., Kuno, T. Takeuchi, N., Murad, F.: Radiation inactivation target size analysis of soluble
guanylate cyclase. Biochim. Biophys. Acta 1051: 306-309, 1990.

Τ
222. Ishii, K., Chang, B., Kerwin, J.F., Huang, Z.J., Murad, F.: N -Nitro-L-Arginine: A potent inhibitor
of Endothelium-derived relaxing factor formation. Europ. J. Pharmacol. 176: 219-223, 1990.

223. Murad, F., Ishii, K., Gorsky, L., Förstermann, U., Kerwin, J.F., Heller, M.: Endothelium-derived
relaxing factor is a ubiquitous intracellular second messenger and extracellular paracrine
substance for cyclic GMP synthesis. Proc. of the International Meeting on Nitric Oxide from L-
Arginine: A Bioregulatory System. London, September, 1989, eds., S. Moncada and E.A.
Higgs, Chapter 32, pp 301-315, 1990.

224. Murad, F., Ishii, K., Förstermann, U., Gorsky, L., Kerwin, J., Pollock, J., Heller, M.: EDRF is an
intracellular second messenger and autacoid to regulate cyclic GMP synthesis in many cells.
Proc. of the VII International Conf. on Cyclic Nucleotides, Calcium and Protein
Phosphorylation. Adv. Cyclic Nucl. Res. 24: 441-448, 1990.

225. Gorsky, L., Förstermann, U., Ishii, K., Murad, F.: Production of an EDRF-like activity in the cytosol
of N1E-115 neuroblastoma cells. FASEB Journal, 4: 1494-1500, 1990.
Ferid Murad, M.D., Ph.D.
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226. Förstermann, U., Gorsky, L., Pollock, J., Ishii, K., Schmidt, H.H.H.W., Heller, M., Murad, F.:
Hormone induced biosynthesis of Endothelium-derived relaxing factor-Nitric oxide-like material in
N1E-115 neuroblastoma cells requires calcium and calmodulin. Molecular Pharmacology,. 38,
7-13, 1990.
w
227. Ishii, K., Kerwin, J., Murad, F.: N -nitro-L-arginine: A potent inhibitor of the L-arginine-dependent
soluble guanylate cyclase activation pathway in LLC-PK1 cells. Canadian J. Pharmacol., 68: 749-
751, 1990.

228. Förstermann, U., Gorsky, L., Pollock, J., Schmidt, H.H.H.W., Heller, M., Murad, F.: Regional
distribution of EDRF/NO synthesizing enzyme in rat brain. Biochem. Biophys. Res. Commun.,
168, 727-732, 1990.

229. August, T., Anders, M.W., Murad, F., Nies, A., editors. Advances in Pharmacology, Academic
Press, Inc., Vol. 21, pp 1-302, 1990.
230. Nakane, M., Arai, K., Saheki, S., Kuno, T., Buechler, W., Murad, F.: Molecular cloning and
expression of cDNAs coding for soluble guanylate cyclase from rat lung. Journal of Biol. Chem.,
265: 16841-16845, 1990.

231. Murad, F., Pollock, J.S., Schmidt, H.H.H.W., Förstermann, U., Ishii, K., Heller, M., Gorsky, L.:
Characterization and purification of a rat brain enzyme which catalyzes the formation of an EDRF-
like factor from L-arginine. Eur. J. Pharmacol., 183, 647-648, 1990.

232. Förstermann, U., Gorsky, L., Pollock, J.S., Schmidt, H.H.H.W., Ishii, K., Heller, M., Murad, F.:
Subcellular localization and regulation of the enzymes responsible for EDRF synthesis in
endothelial cells and N1E 115 neuroblastoma cells. Eur. J. Pharmacol., 183, 1625-1626, 1990.

233. Horio, Y., Murad, F.: Solubilization of guanylate cyclase from bovine rod outer segments and
++
effects of Ca and nitro compounds. Journal of Biol. Chem., 266: 3411-3415, 1991.

234. Waldman, S.A., Leitman, D.C., Murad, F.: Immunoaffinity purification of soluble guanylate
cyclase.Methods in Enzymology, (Corbin, J.D. and Johnson, R.A., Eds., Academic Press), 195,
391-396, 1991.

235. Leitman, D.C., Waldman, S.A., Murad, F.: Identification of atrial natriuretic peptide receptors in
cultured cells. Methods in Enzymology, (Corbin, J.D. and Johnson, R.A., Eds., Academic
Press), 195, 436-446, 1991.

236. Waldman, S.A., Leitman, D.C., Murad, F.: Co-purification of an atrial natriuretic peptide receptor
and particulate guanylate cyclase. Methods in Enzymology, (Corbin, J.D. and Johnson, R.A.,
Eds., Academic Press), 195, 397-404, 1991.

237. Leitman, D.C., Chang, C.H., Kohse, K.P., Hirata, M., Song, D.L., Waldman, S.A., Murad, F.:
Signal transduction pathways of atrial natriuretic peptide receptor subtypes. Proc. of the Internat.
Symposium on ANP, 1988 Kyoto, Japan, (eds. H. Matsuo and H. Imusa) pp. 149-164, 1991.

238. Ishii, K., Chang, B., Kerwin, J.F., Wagenaar, F.L., Huang, Z.J., Murad, F.: Formation of EDRF in
porcine kidney epithelial LLC-PK1 cells: An Intra- and intercellular messenger for activation of
soluble guanylate cyclase, J. Pharmacol. Expt'l. Therap. 256: 38-43, 1991.

239. Fiscus, R.R., Zhou, H.L., Wong, Y., Hon, C.D., Ali, S., Joyce, C.D., Murad, F.: Calcitonin gene-
related peptide-induced cyclic AMP, cyclic GMP and vasorelaxant responses in rat thoracic aorta
are antagonized by EDRF blockers. Neuropeptides 20, 133-143, 1991.
Ferid Murad, M.D., Ph.D.
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240. Förstermann, U., Pollock, J., Schmidt, H.H.H.W., Heller, M., Murad, F.: Calmodulin-dependent
endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and
cytosolic fractions of bovine aortic endothelial cells. Proc. Nat. Acad. Sci., 88, 1788-1792, 1991.

241. Schmidt, H.H.H.W., Pollock, J., Nakane, M., Gorsky, L., Förstermann, U., Heller, M., Murad, F.:
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proc. Nat. Acad.
Sci. 88, 365-369, 1991.

242. Chen, J., Chang, B., Williams, M., Murad, F.: Sodium Nitroprusside, a source of nitric oxide,
induces degeneration of cultured rat striatal neurons. Neuro. Report, 2, 121-123, 1991.

243. Ishii, K., Warner, T., Sheng, H., Murad, F.: Endothelin-1 stimulates cyclic GMP formation in
porcine kidney epithelial cells via activation of the L-arginine-dependent soluble guanylate cyclase
pathway. J. Cardiovasc. Pharmacol. 17 (Suppl. 7), S246-S250, 1991.

244. Sheng, H., Ishii, K., Murad, F.: Generation of an EDRF-like substance in bovine tracheal smooth
muscle. Amer. J. Physiol., Lung Cell Molec. Physiol., 260, L489-493, 1991.

245. Ishii, K., Sheng, H., Warner, T., Förstermann, U., Murad, F.: A simple and sensitive bioassay
method for detection of EDRF with RFL6 rat lung fibroblasts. Amer. J. Physiol., 261, H598-603,
1991.

246. Förstermann, U., Schmidt, H.H.H.W., Pollock, J.S., Heller, M., Murad, F.: Enzymes synthesizing
guanylyl cyclase activating factor (GAF) in endothelial cells, neuroblastoma cells and rat brain. J.
Cardiovasc. Pharmacol., 17 (Sup3), 557-564, 1991.

247. Buechler, W.A., Nakane, M., Murad, F.: Expression of soluble guanylate cyclase activity requires
both enzyme subunits. Biochem. Biophys. Res. Commun., 174, 351-357, 1991.

248. Mitchell, J.A., Förstermann, U., Warner, T.D., Pollock, J.S., Schmidt, H.H.H.W., Heller, M., Murad,
F.: Endothelial cells have a particulate enzyme system responsible for EDRF formation:
Measurement by vascular relaxation. Biochem. Biophys. Res. Commun., 176, 1417-1423,
1991.

249. Horio, Y. and Murad, F.: Purification of guanylyl cyclase from bovine rod outer segments.
Biochim. Biophys. Acta, 1133, 81-88, 1991.

250. Pollock, J.S., Förstermann, U., Mitchell, J.A., Warner, T.D., Schmidt, H.H.H.W., Nakane, M.,
Murad, F.: Purification and characterization of particulate EDRF synthase from cultured and native
bovine aortic endothelial cells. Proc. Nat. Acad. Sci. USA, 88, 10480-10484, 1991.

251. Mitchell, J.A., Sheng, H. Förstermann, U., Murad, F.: Characterization of nitric oxide synthases in
non-adrenergic, non-cholinergic nerve containing tissue from the rat anococcygenus muscle. Brit.
J. Pharmacol., 104, 289-291, 1991.

252. Förstermann, U., Schmidt, H.H.H.W., Pollock, J.S., Sheng, H., Mitchell, J.A., Warner, T.D.,
Nakane, M., Murad, F.: Isoforms of EDRF/NO synthase: Characterization and purification from
different cell types. Biochem. Pharmacol., 42, 1849-1857, 1991.

253. August, J.T., Anders, M.W., and Murad, F., editors, Advances in Pharmacology, Vol. 22, pp 1-374,
Academic Press, 1991.
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254. Mitchell, J.A., Pollock, J.S., Nakane, M., Warner, T.D., Kerwin, J.F., Wagenaary, F., Förstermann,
U., and Murad, F.: Hydroxy-L-arginine is a substrate for the constitutive NO synthase purified from
endothelial cells and brain: Comparison with L-arginine. In: Biology of Nitric Oxide, S. Moncada,
M.A. Marletta, J.B. Hibbs and E.A. Higgs, eds., 2, pp 66-68, 1991.

255. Mitchell, J.A., Kohlhaas, K.L., Warner, T.D., Matsumoto, T., Pollock, J.S., Förstermann, U., and
Murad, F.: Simultaneous induction by sytokines of NADPH-dependent diaphorase and NO
synthase in endothelium-denuded rat aorta. In: Biology of Nitric Oxide, S. Moncada, M.A.
Marletta, J.B. Hibbs and E.A. Higgs, eds., 1, pp. 213-215, 1991.

256. Sheng, H., Mitchell, J.A., Nakane, M., Schmidt, H., Pollock, J.S., Warner, T.D., Förstermann, U.,
and Murad, F.: Characterization of nitric oxide synthase from non-adrenergic non-cholinergic
nerves in rat anococcygeus and bovine retractor penis muscle. In: Biology of Nitric Oxide, S.
Moncaca, M.A. Marletta, J.B. Hibbs and E.A. Higgs, eds., 2, pp 119-121, 1991.

257. Pollock, J.S., Mitchell, J.A., Warner, T.D., Schmidt, H., Nakane, M., Förstermann, U., and Murad,
F.: Purification of NO synthase from endothelial cells. In: Biology of Nitric Oxide, S. Moncada,
M.A. Marletta, J.B. Hibbs and E.A. Higgs, eds., 2, pp 108-111, 1991.

258. Förstermann, U., Schmidt, H., Pollock, J.S., Sheng, H., Mitchell, J.A., Warner, T.D., Nakane, M.,
and Murad, F.: Characterization and classification of constitutive and inducible isoforms of NO
synthase in various cells. In: Biology of Nitric Oxide, S. Moncaca, M.A. Marletta, J.B. Hibbs and
E.A. Higgs, eds., 2, pp 21-23, 1991.

259. Nakane, M., Mitchell, J.A., Förstermann, U., Murad, F.: Phosphorylation by calcium calmodulin-
dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase.
Biochem. Biophys. Res. Com. , 180, 1396-1402, 1991.

260. Schmidt, H.H.H.W., Murad, F.: Purification and characterization of a human NO synthase.
Biochem. Biophys. Res. Com., 181, 1372-1377, 1991.
261. Ishii, K., Warner, T.D., Sheng, H., Murad, F.: Endothelin increases cyclic GMP in LLC-PK1
porcine kidney epithelial cells via formation of an endothelium-derived relaxing factor-like
substance. J. Pharmacol. Expt'l. Therap. 259, 1102-1108, 1991.

262. Sheng, H., Mitchell, J., Nakane, M., Schmidt, H., Pollock, J., Warner, T., Förstermann, U. and
Murad, F.: Characterization of nitric oxide synthase from nonadrenergic, noncholinergic nerves in
rat anococcygeus and bovine retractor penis muscles -- In: Proceedings of Biology of Nitric
Oxide - 2nd International meeting, London, pp 119-121, 1991.

263. Hu, Z.W., Honda, K., Murad, F., Hoffman, B.: Prolonged exposure to catecholamines enhances
sensitivity of vascular smooth muscle to relaxation by sodium nitroprusside and atriopeptin in rat
aorta. J. Pharmacol. Expt'l. Therap. 260, 756-761, 1992.

264. Yonemara, N., Ishii, K., Murad, F., Raffin, T.: Atriopeptin-induced increases in endothelial cell
permeability are associated with elevated cyclic GMP levels. Amer. J. Physiol. 263: Lung
Cellular & Molec. Physiol. 7, L363-369, 1992.

265. Schmidt, H.H.H.W., Warner, T.D., Förstermann, U., Murad, F.: Regulation and subcellular location
of nitric oxide synthases in RAW 264.7 macrophanges. Molec. Pharmacol. 41, 615-624, 1992.

266. Warner, T.D., Schmidt H.H.H.W., Murad, F.: Interactions of endothelin and EDRF in bovine native
endothelial cells: Selective effects of endothelin-3. Amer. J. Physiol, 262, H1600-H1605, 1992.
Ferid Murad, M.D., Ph.D.
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267. Warner, T., Mitchell, J.A., D'Orleans-Juste, P., Ishii, K., Förstermann, U., Murad, F.:
Characterization of endothelin-converting enzyme from endothelial cells and rat brain: Detection
of the formation of biologically active endothelin-1 by rapid bioassay. Mol. Pharmacol, 41, 399-
403, 1992.

268. Schmidt, H.H.H.W., Smith, R.M., Nakane, M. , Murad, F.: Calcium calmodulin-dependent nitric
oxide synthase Type I-- a biopterin-flavo-protein with calcium calmodulin-independent diaphorase
and reductase activities. Biochem., 31, 3243-3249, 1992.

269. Förstermann, U., Schmidt, H.H.H.W., Murad, F.: Induced RAW 264.7 macrophages express
soluble and particulate nitric oxide synthase: Inhibition by transforming growth factor-∃. Eur. J.
Pharmacol., 225, 161-165, 1992.

270. Sheng, H., Schmidt, H.H.H.W., Nakane, M., Mitchell, J., Pollock, J., Förstermann, U., Murad,F.:
Characterization and localization of nitric oxide synthase in non-adrenergic non-cholinergic nerves
from bovine retractor penis muscles. Brit. J. Pharmacol., 106, 768-773, 1992.

271. Schmidt, H.H.H.W., Warner, T., Ishii, K., Sheng, H., Murad, F.: Insulin secretion in pancreatic ∃
cells caused by L-arginine derived nitric oxide. Science, 255, 721-723, 1992.

272. Mitchell, J.A., Kohlhaas, K., Matsumoto, T., Pollock, J., Förstermann, U., Warner, T.D., Schmidt,
H.H.H.W., Murad, F.: Induction of NADPH dependent diaphorase and NO synthase acivity in
aortic smooth muscle and cultured macrophages. Molec. Pharmacol., 41, 1163-1168, 1992.

273. Warner, T.D., Budzik, G., Mitchell, J.A., Huang, Z.J., Murad, F.: Detection by bioassay and
specific ELISA of phosphoramidon-inhibitable endothelin-converting activity in brain and
endothelium. J. Cardio. Pharm., 20, S19-S21, 1992..

274. Schmidt, H.H.H.W., Gagne, G., Nakane, M., Pollock, J., Miller, M., and Murad, F.: Mapping of
neural NO synthase in the rat suggests frequent colocalization with NADPH diaphorase but not
soluble guanylyl cyclase and novel paraneural functions for nitrinergic signal transduction. J.
Histochem. Cytochem., 40, 1439-1456, 1992.

275. August, J.T., Anders, M.W., and Murad, F., editors, Advances in Pharmacology, Vol 23, 1-346,
Academic Press, 1992.

276. Murad, F., Förstermann, U., Nakane, M., Schmidt. H.H.H.W., Pollock, J., Sheng, H., Matsumoto,
T., Warner, T., Mitchell, J., Tracey, R., Buechler, W.: The nitric oxide-cyclic GMP signal
transduction pathway in vascular smooth muscle preparations and other tissues, Japanese
Journal of Pharmacology, 58, 150-157, 1992.

277. Warner, T., Förstermann, U., Ishii, K., Mitchell, J., Nakane, M., Pollock, J., Schmidt, H.H.H.W.,
Sheng, H., and Murad, F.: Bioassay for EDRF/NO by accumulation of cyclic GMP in RFL-6 fetal
rat lung fibroblasts. NeuroProtocols, 1, 117-123, 1992.

278. Hassall, C., Saffrey, M., Belai, A., Hoyle, C., Moules, E., Moss, J., Schmidt, H.H.H.W., Murad, F.,
Förstermann, U., and Burnstock, G.: Nitric oxide synthase immunoreactivity and NADPH
diaphorase activity in a subpopulation of intrinsic neurons of the guinea pig heart, Neurosci. Lett.,
143, 65-68. 1992.

279. Saffrey, M., Hassall, C., Hoyle, C., Belai, A., Moss, J., Schmidt, H.H.H.W., Förstermann, U.,
Murad, F., and Burnstock, G.: Nitric oxide synthase and NADPH diaphorase in cultured myenteric
neurons, Neuroreports, 3, 333-336, 1992.
Ferid Murad, M.D., Ph.D.
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280. Belai, A., Schmidt, H.H.H.W., Hoyle, C., Hassall, C., Saffrey, M., Moss, J., Förstermann, U.,
Murad, F., and Burnstock, G.: Colocalization of nitric oxide synthase and NADPH diaphorase in
the myenteric plexus of the rat gut. Neurosci. Lett., 143, 60-64, 1992.

281. Schmidt, H.H.H.W., Warner, T., and Murad, F.: The double-edged role of endogenous nitrogen
oxides.The Lancet, 339, 986, 1992.

282. Warner, T., Schmidt, H., Kuk, J., Mitchell, J., and Murad, F.: Human brain contains a
metalloprotease that converts big endothelin-1 to endothelin-1 and is inhibited by phosphoramidon
and EDTA. Brit. J. Pharmacol. 106, 505-506, 1992.

283. Sheng, H., Hughes, M., Murad, F., and Briggs, C.: Evidence that nitric oxide mediates the cyclic
GMP response to synaptic activity in the rat superior cervical ganglion. Brain Res. 597, 343-345,
1992.

284. Matsumoto, T., Mitchell, J., Schmidt, H., Kohlhaas, K., Warner, T., Förstermann, U., and Murad,
F.: Nitric oxide synthase in ferret brain: Localization and characterization. Brit. J. Pharmacol.
107, 849-852, 1992.

285. Pollock, J., Nakane, M., Förstermann, U., and Murad, F.: Particulate and soluble bovine
endothelial nitric oxide synthases are structurally similar proteins yet different from soluble brain
nitric oxide synthase. J. Cardiovasc. Pharmacol. 20, (S-12), S50-S53, 1992.

286. Schmidt, H.H.H.W., Pollock, J., Nakane, M., Förstermann, U., and Murad, F.: Calcium-calmodulin
regulated nitric oxide synthases. Cell Calcium, 13, 427-434, 1992.

287. Warner, T., Budzik, G., Mitchell, J., and Murad, F.: Regional differences in endothelin-converting
enzyme activity in rat brain: Inhibition by phosphoramidon and EDTA. Brit. J. Pharmacol. 106,
123-127, 1992.

288. Pollock, J., Klinghofer, V., Förstermann, U. and Murad, F.: Endothelial nitric oxide synthase is
myristylated. FEBS. Lett. 309, 402-404, 1992.

289. Wilcox, C., Welch, J., Murad, F., Gross S., Taylor, G., Levi, R. and Schmidt H.: Nitric oxide
synthase in macula densa regulates glomerular capillary pressure. Proc. Nat. Acad. Sci. 89,
11993-11997, 1992.

290. Schmidt, H.H.H.W., Warner, T., Ishii, K., Sheng, H. and Murad, F.: Role of NO in insulin secretion.
Science, 1992.

291. Welch, W., Schmidt, H., Murad, F., Gross, S., Taylor, G., Levi, R. and Wilcox, C.: Nitric oxide
synthase in maculadensa: localization and functional studies -- In: Biology of Nitric Oxide:
Physiologic and Clinical Aspects. Eds. Moncada, S., Marletta M., Hibbs, J. and Higgs E.A.
Portland Press, London, 243-245, 1992.

292. Murad, F., Förstermann, U., Nakane, M., Pollock. J., Schmidt, H.H.H.W., Matsumoto, T., Tracey,
W.R., and Buechler, W.: Isoforms of nitric oxide synthase and the nitric oxide-cyclic GMP signal
transduction system. Proc. NATO-ASI Conference on Vascular Endothelium, Rhodes,
Greece, June, 1992, J. Catravas, A. Callow, & U. Ryan, eds., NATO ASI Series, Vol. 257; pp 73-
80, Plenum Publishers, 1993.

293. Murad, F., Förstermann, U., Nakane, M., Pollock, J., Tracey, W.R., Matsumoto, T. and Buechler,
W.: The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular
communication. Adv. Second Messenger Phosphoprotein Res. 28, 101-109, 1993.
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294. Nakane, M., Schmidt, H.H.H.W., Pollock, J., Förstermann, U. and Murad, F.: Cloned human brain,
nitric oxide synthase is highly expressed in skeletal muscle. FEBS. Lett. 316, 175-180, 1993.

295. Pollock, J., Nakane, M., Buttery, L., Martinez, A., Springall, D., Polak, J., Förstermann, U. and
Murad, F.: Characterization and localization of endothelial nitric oxide synthase using specific
monoclonal antibodies. Amer. J. Physiol. 265, C1379-C1387, 1993.

296. Mitchell, J.A., Kohlhaas, K.L., Sorrentino, R., Warner, T.D., Murad, F. and Vane, J.R.: Induction of
calcium-independent nitric oxide synthase in the rat mesentery: Possible role in the hypotension
associated with sepsis. Brit. J. Pharmacol. 109, 265-270, 1993.

297. Sheng, H., Gagne, G., Matsumoto, T., Miller, M., Förstermann, U. and Murad, F.: Nitric oxide
synthase in bovine superior cervical ganglion. J. Neurochem. 61, 1120-1126, 1993.

298. Murad F.: Nitric Oxide. In: Amer. Heart Assoc. Hypertension Primer, J. Isso and H. Black, eds.,
pp 27-28, 1993.

299. Murad, F.: The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular
communication. In: Recent Progress Hormone Res. Ed: Bardin, C.W., Academic Press, San
Diego, 49, pp 239-248, 1994.

300. Wendland, B., Schweizer, F., Ryan, T., Nakane, M., Murad, F., Smith, S., Scheller, R. and Tsien,
R.: Existence of nitric oxide synthase in rat hippocampal pyramidal cells. Proc. Nat. Acad. Sci.
90, 2151-2155, 1994.

301. Murad, F., editor. Cyclic GMP Synthesis, Metabolism and Function, In: Adv. in Pharmacol., Vol.
26, pp 1-335, Academic Press, 1994.

302. Murad, F.: Introduction and some historical comments. In: Cyclic GMP Synthesis, Metabolism
and Function, Adv. in Pharmacol., Vol. 26, F. Murad, ed., Academic Press, Chapter 1, pp 1-5,
1994.

303. Nakane, M. and Murad, F.: Cloning of guanylyl cyclase isoforms. In: Cyclic GMP Synthesis,
Metabolism and Function, Adv. in Pharmacol., Vol. 26, F. Murad, ed., Academic Press, Chapter
2, pp 7-18, 1994.

304. Murad, F.: Regulation of cytosolic guanylyl cyclase by nitric oxide: The nitric oxide-cyclic GMP
signal transduction system. In: Cyclic GMP Synthesis, Metabolism and Function, Adv. in
Pharmacol, Vol. 26, F. Murad, ed., Academic Press, Chapter 3, pp 19-33, 1994.

305. Leitman, D., Waldman, S. and Murad, F.: Regulation of particulate guanylyl cyclase by natriuretic
peptides and E.Coli enterotoxin. In: Cyclic GMP Synthesis, Metabolism and Function, Adv. in
Pharmacol., Vol. 26, F. Murad, ed., Academic Press, Chapter 4, pp 67-86, 1994.

306. Warner, T., Mitchell, J., Sheng, H. and Murad, F.: Effects of cyclic GMP on smooth muscle
relaxation. In: Cyclic GMP Synthesis, Metabolism and Function, Adv. in Pharmacol., Vol. 26, F.
Murad, ed., Academic Press, Chapter 8, pp 171-194, 1994.

307. Hirata, M. and Murad, F.: Inter-relationships of cyclic GMP, inositol phosphates and calcium. In:
Cyclic GMP Synthesis, Metabolism and Function, Adv. in Pharmacol., Vol. 26, F. Murad, ed.,
Academic Press, Chapter 11, pp 195-216, 1994.
Ferid Murad, M.D., Ph.D.
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308. Murad, F.: Future Directions. In: Cyclic GMP Synthesis, Metabolism and Function, Adv. in
Pharmacol., Vol. 26, F. Murad, ed., Academic Press, Chapter 14, pp 321-324, 1994.

309. Tracey, R., Pollock, J., Murad, F., Nakane, M. and Förstermann, U.: Identification of an
endothelial-like Type III nitric oxide synthase in LLC PK1 kidney epithelial cells. Amer. J.
Physiol. 226, C22-C28, 1994.

310. Murad, F.: The nitric oxide-cyclic GMP signal transduction system. Proc. of the Fourth Intl.
Symp. on Endothelium-Derived Factors and Vascular Functions, Tokyo, Dec., 1993, T.
Masaki, ed., Excerpto Medica, pp 29-37, 1994.

311. Murad, F.: The role of nitric oxide in modulating guanylyl cyclase. Neurotransmission, Vol. X,
1-4, 1994.

312. Murad, F.: The nitric oxide-cyclic GMP signal transduction system. In: Proc. of the Medicine
Group Therapeutic Adv. Meeting, 1994.

313. August, T., Anders, M.W. and Murad, F., editors, Advances in Pharmacology, Volumes 21-34,
Academic Press.

314. Sheng, H., Ishii, K., Förstermann, U. and Murad, F.: Mechanism of bradykinin-induced cyclic GMP
accumulation in bovine tracheal smooth muscle. Lung, 173, 373-383, 1995.

315. Murad, F.: The nitric oxide-cyclic GMP signal transduction system. In: Proc. of the 38th OHOLO
Conference on Biochemical, Pharmacological and Clinical Aspects of Nitric Oxide, Eilat, Israel,
April, 1994, (B.A. Weissman, N. Allan, & S. Shapiro, eds.), Plenum, 1995.

316. Xie, J., Roddy, P., Rife, T., Murad, F., and Young, A.: Two closely linked but separate promoters
for human neuronal nitric oxide synthase gene transcription. Proc. Natl. Acad. Sci. 92, 1242-
1246, 1995.

317. Buechler, W.A., Singh, S., Aktas, J., Muller, S., Murad, F., and Gerzer, R.: High level expression
of biologically active soluble guanylyl cyclase using the baculovirus system is strongly heme-
dependent. Advances in Pharmacology, Volume 34, pp.293-303, Academic Press, 1995.

318. McDonald, L.J. and Murad, F.: Nitric oxide and cyclic GMP signaling. Advances in Pharmacology,
Volume 34, pp. 263-275, Academic Press,1995.

319. Young, A.P., Murad, F., Vaessin, H., Xie, J., and Rife, T.: Transcription of the human neuronal
nitric oxide synthase gene in the CNS is mediated by multiple promoters. Advances in
Pharmacology, Volume 34, pp. 91-112, Academic Press, 1995.

320. Papapetropoulos, A., Marczin, N., Mora, G., Milici, A., Murad, F., and Catravas, J.: Regulation of
vascular smooth muscle soluble guanylate cyclase activity, mRNA and protein levels by cyclic
AMP-elevating agents. Hypertension. 26:696-704, 1995.

321. Ignarro, L. and Murad, F. (eds), Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic
Implications. Advances in Pharmacology, 34:1-516, Academic Press, 1995.

322. Papapetropoulos, A., Go, C., Murad, F., and Catravas, J.: Mechanisms of tolerance to sodium
nitroprusside in cultured rat aortic smooth muscle cells. Brit. J. Pharmacol. 117:147-155, 1996.
Ferid Murad, M.D., Ph.D.
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323. Papapetropoulos, A., Abou-Mohamed, G., Marczin, N., Murad, F., Caldwell, R., and Catravas, J.
Down regulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to
endotoxin and interleukin - 1B. Brit. J. Pharmacol. 118:1359-1366, 1996.

324. McDonald, L. and Murad, F.: Nitric oxide and cyclic GMP signaling. Proc. Soc. Expt'l. Biol. and
Medicine, 211:1-6, 1996.

325. Murad, F.: Signal transduction using nitric oxide and cyclic guanosine monophosphate. J. Amer.
Med. Assoc. 276: 1189-1192, 1996.

326. Murad, F. What are the molecular mechanisms for the antiproliferative effects of nitric oxide and
cyclic GMP in vascular smooth muscle? Circulation 95, 1101-1103, 1997.

327. Zanardo, R., Costo, E., Ferreira,H.,Antunes, E., Martins,A., Murad, F., and de Nucci, G.
Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system
in rat peritoneal eosinophils. Proc. Nat. Acad. Sci. USA 94, 14111-14114, 1997.

328. August, J.T., Anders, M.W., Murad, F., Coyle, J.T., editors: Advances in Pharmacology, volumes
35-43, Academic Press, 1996-1998.

329. Murad, F. Nitric oxide signaling: Would you belive that a simple free radical could be a second
messenger, autocoid, paracrine substance, neurotransmitter and hormone? Recent Progress in
Hormone Research, 53, 43-60, 1998.

330. Kamisaki, Y., Wada, K., Bian, K., Balabanli, B., Davis, K., Martin, E., Behbod, F., Lee, Y-C., and
Murad, F. An enzyme activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc.
Nat. Acad. Sci. USA 95, 11584-11589, 1998.

331. Murad, F. and Webb, C. Nitric Oxide. Chapter 19. Amer. Heart Assoc. Hypertension Primer.
Eds. J. Isso and H. Black, pp. 44-46, 1998.

332. Murad, F. Nitric oxide synthases in RBI Handbook of Receptor Classification and Signal
Transduction, editor K. J. Watling, 3rd edition, pp. 148-149, 1998.

333. Murad, F. Discovery of some of the biological effects of nitric oxide and its role in cellular
signaling. Nobel Lecture, Bioscience Reports 19, 133-154, 1999; Les Prix Nobel, The Nobel
Prizes, 1998, pp. 273-307, 1999.

334. Bian, K., Davis, K., Kuret, J., Binder, L., and Murad, F. Nitrotyrosine formation with endotoxin-
induced kidney injury detected by immunochemistry. Amer. J. Physiology: Renal Physiology
277: F33-F40, 1999.

335. Murad, F. Discovery of some of the biological effects of nitric oxide and its role in cell signaling.
(Die Entdeckung einiger biologischer Wirkungen von Stickstoffmonoxid und seiner Rolle fur die
Zellkommunikation (Nobel-Vortrag), Angewandte Chemie 38, 1857-1868, 1999.

336. Kamisaki, Y., Martin, E., and Murad, F. Protein nitration and regulation in physiological functions,
Zikken – Igaku, Experimental Medicine, Yodosha Co. Ltd., Tokyo, 17: No. 8, 918-923, 1999.

337. Murad, F. Cellular signaling with nitric oxide and cyclic GMP. In Proc. of the Basic and Clinical
Aspects of Nitric Oxide meeting, March, 1999, Iguacu, Brazil. Brazilian J. of Medical and
Biological Research 32: 1317-1327, 1999.
Ferid Murad, M.D., Ph.D.
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338. Balabanli, B., Kamisaki, Y., Martin, E., and Murad, F. Requirements for heme and thiols for the
nonezymatic modification of nitrotyrosine. Proc. Nat. Acad. Sci. USA 96, 13136-13141, 1999.

339. Martin, E., Davis, K., Bian, K., Lee, Y.C., and Murad, F. Cellular signaling with NO and cyclic
GMP. Seminars in Perinatology 24, 2-6, 2000.

340. Kildsgaard, J., Hollmann, T.J., Matthews, K.W., Bian, K., Murad, F., and Wetsel, R.A. Cutting
edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-
inflammatory role for C3a in endotoxin-shock. J. Immunol. 165, 5406-5409, 2000.

341. Sharina, I., Krumenacker, J., Martin, E., and Murad, F. Genomic organization of alpha1 and beta1
subunits of mammalian soluble guanylyl cyclase genes. Proc. Nat. Acad. Sci. 97, 10878-10883,
2000.

342. Lee, Y.C., Martin, E. and Murad, F. Human recombinant soluble guanylyl cyclase: Expression,
purification, and regulation. Proc. Nat. Acad. Sci. 97, 10763-10768, 2000.

343. Chen, Z.J., Miao, Z.H., Chang, G.D., Hughes, B., Vetter, M., Dulin, N., Murad, F., Douglas, J. and
Chang, C.H. Molecular cloning of a regulatory protein for membrane-bound guanylyl cyclase GCA
Biochem Biophy Res Commun 278(1):106-11, 2000.

344. Murad, F. Discovery of some of the biological effects of nitric oxide and its role in cell signaling.
Science and technology development: A retrospective view over the past century and a
perspective look into the future. pp. 86-96. Editor in Chief: Lu, Yongxiang, ShangHai Education
Press, ShangHai, 2000.

345. Ishii, N., Patel, K.P., Lane, P.H., Taylor, T., Bian, K., Murad, F., Pollock, J.S., and Carmines, P.K.
Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus. J.
Amer. Soc. Nephrology 12, 1630-1639, 2001.

346. Bian, K., and Murad, F. Diversity of endotoxin-induced nitrotyrosine formation in macrophage –
endothelium rich tissue. Free Radical Biology and Medicine 31, 421-429, 2001.

347. Mendes, R.V., Martins, A.R., de Nucci, G., Murad, F., and Soares, F.A. Expression of nitric oxide
synthase isoforms and nitrotyrosine immunoreactivity by B-cell non-Hodgkin’s lymphomas and
multiple myeloma. Histopathology. 39 , 172-178, 2001.

348. Krumenacker, J., Hyder, S. and Murad, F. Estradiol rapidly inhibits soluble guanylyl cyclase
expression in rat uterus. Proc. Nat. Acad. Sci. 98, 717-722, 2001.

349. Mailman, D., Guntuku, S., Bhuiyan, B. and Murad, F. Organ sites of LPS-induced nitric oxide
production in the anesthetized rat. Nitric Oxide: Biology and Chemistry. 5, 243-251, 2001.

350. Davis, K., Martin, E., Turko, I. and Murad, F. Novel effects of nitric oxide, Annual Review of
Pharmacology and Toxicology. 41, pp. 203-236, 2001.

351. Marcondes, S., Turko, I., and Murad, F. Nitration of succinyl Co-A:3-oxoacid CoA transferase in
rats following endotoxin administration. Proc. Nat. Acad. Sci. 98, 7146-7151, 2001.

352. Seminara, A.R., Krumenacker, J.S., and Murad, F. Signal transduction with nitric oxide, guanylyl
cyclase and cyclic GMP. Nitric Oxide: Basic Research and Clinical Applications, NATO Science
Series, 317, 5-22, 2001.
Ferid Murad, M.D., Ph.D.
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353. Murad, F. Nitric oxide synthases in RBI Handbook of Receptor Classification and Signal
Transduction, editor Keith Watling, 4th edition, pp. 176-177, 2001.

354. Hanafy, K., Krumenacker, J.S. and Murad, F. Nitric oxide, nitrotyrosine and cyclic GMP in signal
transduction. Proceedings of the Vascular Biology Conference, Cracow, Poland, May, 2001.
Medical Science Monitor, 7 (4), 801-819, 2001.

355. Turko, I., Marcondes, S., and Murad, F. Diabetes-associated nitration of tyrosine and inactivation
of succinyl-CoA:3-oxoacid CoA transferase. Physiol. Amer. J. Physiol., Heart Circ 281, H2289-
H2294, 2001.

356. Krumenacker, J.S., Hanafy, K.A. and Murad, F. Regulation of nitric oxide and soluble guanylyl
cyclase. Proc. of the Symposium on Neuroprotection and the Eye. San Antonio, Texas, March,
2001. Brain Research Bulletin 62, 505-515, 2004

357. Martin, E., Lee, Y.C., and Murad, F. YC-1 activation of human soluble guanylyl cyclase has both
heme-dependent and heme—independent components. Proc. Nat. Acad. Sci. 98, 12938-12942,
2001.

358. Bian, K., Zhong, M., Harari, Y., Weisbrodt, N., and Murad, F. Down regulation of inducible nitric
oxide synthase by an IL4Rα/Stat6-dependent and T-cell independent pathway during parasite-
induced gut inflammation. Mol. Pharmacol. 59(4):939-47, 2001.

359. Turko, I., and Murad, F. Protein nitration in cardiovascular diseases. Pharmacological Reviews
54, 619-634, 2002.

360. Bian, K., and Murad, F. Nitric oxide (NO) – Biogeneration, regulation, and relevance to human
diseases. Frontiers in Bioscience 8, 264-278, 2003.

361. Adewuya, O., Irie, Y., Bian, K., Onigu-Otite, E., and Murad, F. Mechanism of vasculitis and
aneurysms in a mouse model of Kawasaki Diseased: Role of nitric oxide. Nitric Oxide: Biology
and Chemistry 8, 15-25, 2003.

362. Murad, F. The excitement and rewards of research with our discovery of some of the biological
effects of nitric oxide. Circulation Research 92:339-41, 2003.

363. Irie, Y., Saeki, M., Kamisaki, Y., Martin, E., and Murad, F. Histone H1.2 is a substrate for
denitrase, an activity that reduces nitrotyrosine immunoreactivity in protein. Proc. Nat. Acad. Sci.
100, 5634-5639, 2003.

364. Bian, K., Gao, Z., Weisbrodt, N., and Murad, F. The nature of heme/iron-induced protein tyrosine
nitration. Proc. Nat. Acad. Sci. 100, 5712-5717, 2003.

365. Turko, I., and Murad, F. Quantitative protein profiling in heart mitochondria from diabetic rats. J.
Biol. Chem. 278, 35844-35849, 2003.

366. Turko, I., Li, L., Aulak, K., Stuehr, D., Chang, R., and Murad, F. Protein tyrosine nitration in the
mitochondria from diabetic mouse heart. J. Biol. Chem. 278, 33972-33977, 2003.

367. Martin, E., Sharina, I., Kots, A., and Murad, F. A constitutively activated mutant of human soluble
guanylyl cyclase. Implication for the mechanism of soluble guanylyl cyclase activation. Proc. Nat.
Acad. Sci. 100, 9208-9213, 2003.
Ferid Murad, M.D., Ph.D.
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368. Jurasz, P., Alonso, D., Castro-Blanco, S., Radomski, M.W. and Murad, F. Generation and role of
angiostatin in human platelets. Blood. 102(9): 3217-23, 2003.

369. Sharina I, Martin E, Thomas, A., Davis, K. and Murad F. CCAAT binding factor regulates
expression of the β1 subunit of soluble guanylyl cyclase gene in the BE2 human neuroblastoma
cell line. Proc. Nat. Acad. Sci. 100 (20), 11523-8, 2003.

370. Ruiz-Stewart, I., Tiyyagura, S.R., Kazerounian, S., Pitari, G.M., Schulz, S., Martin, E., Murad, F.,
and Waldman, S.A. Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell
metabolism. Proc. Nat. Acad. Sci. 101, 37-42, 2004.

371. Hanafy KA, Martin, E. and Murad F. CCTη: A novel soluble guanylyl cyclase interacting protein. J.
Biol. Chem. 279, 46946-46953, 2004.

372. Murad F. Some highlights of a 47 year career in research. Cellular and Molecular Life Sciences
62, 1-3, 2005.

373. Martin, E., Czamecki K, Jayaraman, V., Murad, F. and Kincaid, J.R. Resonance Raman and
infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase. J. Amer.
Chem. Soc. 127, 4625-4631, 2005.

374. Bian, K., Zhang, M., Harari, Y., Lai, M., Weisbrodt, N. and Murad, F. Helminth regulation of host
IL-4Rd/Stat 6 signaling: Mechanism underlying NOS-2 inhibition by Tripinella spiralis. Proc. Nat.
Acad. Sci. 102, 3936-3941, 2005.

375. Bian, K., Yong, M., Harari, Y., Lai, M., Weisbrodt, N. and Murad, F. Helminth regulation of host IL-
4Rα/Stat6 signaling. Mechanism underlying NOS-2 inhibition by trichinella spiralis. Proc. Nat.
Acad. Sci. 102(11) 3936-41, 2005.

376. Deng, W., Li, C., Liao, L., Zhao, Z., Ge, W., You, S., Deng, H., Zhao, R., and Murad, F. Bone
marrow-derived cells give rise to skin cells and regenerate skin tissue. Engrafted bone marrow-
derived flk-(1+) mesenchymal stem cells regenerate skin tissue. Tissue Eng. 11(1-2), 110-9,
2005.

377. Martin E, Berka V, Tsai AL and Murad F. Soluble guanylyl cyclase: The nitric oxide receptor.
Methods in Enzymology 396, 478-492, 2005

378. Turko IV and Murad F. Mapping sites of tyrosine nitration by matrix-assisted laser
desorption/ionization mass spectroscopy. Methods in Enzymology 396, 266-275, 2005.

379. Krumenacker J, Katsuki S, Kots A, and Murad F. Differential expression of genes involved in
cGMP-dependent nitric oxide signaling in murine embryonic stem cells (ES) and ES cells-derived
cardiomyocyte precursors. Nitric Oxide (In Press), 2005.

380. Krumenacker, J., Kots, A., and Murad, F. Effects of c-Jun kinase inhibitor anthrax[1,9-cd]
pryazole-6(2H)-one (SP600125) on soluble guanylyl cyclase α1 gene regulation and cGMP
synthesis. Amer. J. Physiol-Cell Physiology. (In Press).

381. Bian, K. and Murad, F. Nitric oxide biology and atherosclerosis. Atherosclerosis Research. (In
Press).

382. Murad, F. Looking into the future advances of medical research. Houston Medical Magazine.
(In Press).
Ferid Murad, M.D., Ph.D.
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383. Martin, E., Sharina, I., Seminara AR., Krumenacker, J. and Murad, F. Nitric oxide cell signaling
mediated by aGMP in Nitric oxide, Cell signaling and Gene Expression. (In Press).

384. Adewuya O, and Murad F. Kawasaki syndrome. Encyclopedia Reference of Molecular

Mechanisms of Disease. (In Press).

385. Bian, K., Murad, F. Nitric oxide biology and atherosclerosis. Atherosclerosis Research.
(In Press)

386. Gocman, C., Buyahnacor, H., Kots, A., Murad, F., Kiroglu O and Kuman E. The relaxant activity of
4, 7-dimethyl-1, 2, 5-oxadiazolo [3, 4-d] piridozine 1, 5, 6-tioxide in the mouse corpus cavernosum.
J. of Pharmacology and Exp. Therapeutics (Accepted), 2005.

387. Murad, F., and R. Barber. A hypothesis about cellular signaling with nitric oxide in the earliest life
forms in evolution. Nitric Oxide (Submitted)

388. Sullivan, J.C., Loomis, E.D., Collins, M., Murad, F., Imig, J.D., Inscho, E.W., and Pollock, J.S.
Effect of age on vascular reactivity and oxidative stress in mesenteric arteries from male and
female rats. AJP: Regulatory. Amer. J. Physiol. (Submitted).

389. Rossini, L., Martin, E., Zhong, M., and Murad, F. Nitration of inducible nitric oxide synthase
tyrosine residues in RAW 264.7 macrophages. Pharmacological Res. (Submitted).

390. Kots A, Postnikov, A., Betin, V, Bulgaria, T., Martin, E. and Murad F. Hsp 90 binds to soluble
guanylyl cyclase and protects it from inhibition. J. Biol. Chem. (Submitted).

391. Lee, YC, Murad, F and Martin E. Putative dimerization domain of soluble guanylyl cyclase
mediates the activation signal. J. Biol. Chem. (Submitted).

392. Nedopasov, A., Beda, N., Pimenova, T., Martin, E., and Murad, F. Diazotyrosine as a derivatized
product of nitrotyrosine and aminotyrosine residues of peptides and proteins. Proc. Nat. Acad.
Sci., (Submitted).

393. Turko,I.V, Thompson, L. and Murad F. Protein profiling in liver peroxisomes from WY 14643-
treated rats. Mass spectrometry-based relative quantification of proteins using stable isotope
labeling with do and d3 acrylamides. Mol. Phar. (Submitted).

394. Yoneda, M., Wada, K., Fujita, K., Kirikoshi, H., Saitoh, S., Nakane, D., Blumberg, R., Kamisaki, Y.,
Murad, F., and Nakajimo, A. Strong involvement of nitric oxide derivatives on the pathogenesis of
nonalcoholic steatohepatitis. Lancet (Submitted).

395. Bian, K., Li, J., Ren, Z., Zhang, A., Murad, F., and McCutcheon, I. Activation of Stat 3 and Stat 1
DNA binding in human meningioma cells by GP 130 cytokines and insulin-like growth factor-1.
Tumor Biology (Submitted).

396. Zhu, H., Bian, K., Murad, F., Y.I. Geng (editor). Nitric oxide accelerated the recovery from burn
wound. J. of Investigative Dermatology (Submitted).

397. Seminara, A.R., Sharina, I.G., Jarvis, W.D., and Murad, F. Nitric oxide-induced expression of
MAPK-ERK kinase kinase 1 (MEKK1) in activated murine macrophages. (Proc. Nat. Acad. Sci.).
(In preparation).
Ferid Murad, M.D., Ph.D.
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Abstracts and Presentations at National and International Meetings (excludes

numerous university and industry seminars and lectures)

1. Murad, F., Rall, T.W., Sutherland, E.W.: Formation of adenosine 3', 5'-phosphate by particulate
preparations of ventricular muscle. Fed. Proc. 19:192, 1960.

2. Murad, F.: An inhibitor of adensine 3', 5'-phosphate in heart and liver extracts. Fed. Proc. 24:
150, 1965.

3. Murad, F.: Effect of glucagon on heart. New Eng. J. Med. 279: 434-435, 1968.

4. Manganiello, V., Murad, F., Vaughan, M.: Effect of cyclic 3', 5'-GMP on lipolysis in fat cells. Fed.
Proc. 28: 876, 1969.

5. Murad, F., Manganiello, V., Vaughan, M.: Effect of cyclic 3', 5'-GMP on cyclic 3', 5'-AMP levels in
fat cells. J. Clin. Invest. 48: 59a, 1969.

6. Murad, F., Brewer, H.B., Vaughan, M.: Effects of thyrocalcitonin on cyclic AMP formation by rat
kidney. Clin. Res. 17: 591, 1969.

7. Murad, F., Manganiello, V., Vaughan, M.: Hormone effects of cyclic 3', 5'-AMP accumulation and
lipolysis during fat cell incubations. Clin. Res. 18: 461, 1970.

8. Stossel, T., Murad, F., Vaughan, M.: Regulation of glycogenolysis in polymorphonuclear

leukocytes. Clin. Res. 18: 417, 1970.

9. Murad, F.: Factors which influence the accumulation and action of cyclic AMP. Presented at the
Gordon Conference on "Cyclic AMP", August, 1970.

10. Simopoulos, A., Pak, C.Y., Kattwinkel, J., Murad, F., di Sant-Agnese, P., Bartter, F.: Calcium
metabolism and parathyroid function in cystic fibrosis. Presented at the American Pediatric
Society Meeting, May, 1971.

11. Murad, F.: Diagnostic application of cyclic nucleotide levels. Presented at the Gordon Conference
on "Cyclic AMP", June, 1971.

12. Murad, F.: Is there a role for extracellular cyclic nucleotides in clinical medicine? Presented at the
Gordon Conference on "Chemistry, Physiology and Structure of Bones and Teeth", June, 1971.

13. Murad, F., Pak, C.Y., Thomas, E.: Urinary excretion of cyclic 3', 5'-AMP as a diagnostic test for
altered parathyroid function. Presented at the Intl. Conference on Physiology and Pharmacology
of Cyclic AMP, Milan, Italy, July, 1971.

14. Middler, S., Pak, C., Murad, F., Bartter, F.: Thyrocalcitonin and calcium infusions in the treatment
of osteoporosis. The 53rd Annual Meeting of the Endocrine Society, San Francisco, California,
June, 1971

15. Murad, F., Shen, L.C., Larner, J.: Effect of glucagon on rat diaphragms. Fed. Proc. 31: 889,
1972.

16. Murad, F., Thomas, E., Lapsley, R.: Practolol, propranolol and dichloroisoproterenol blockade of
epinephrine .
Ferid Murad, M.D., Ph.D.
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17. Thomas, E., Murad, F., Looney, W.: Cyclic AMP and cyclic GMP levels in Morris hepatomas of
various growth rates. Presented at the meeting of the American Society for Cell Biology at St.
Louis, Missouri, November, 1972. Jour. of Cell Biol. 55: 259a, 1972.

18. Murad, F., Pak, C.Y.: Clinical application of cyclic AMP levels. Presented at the Fifth Int.
Congress on Pharmacology, San Francisco, California, July, 1972.

19. Murad, F., Weitzman, R., Pak, C.Y.: Urine levels of cyclic AMP and cyclic GMP in parathyroid
disorders. Presented at the 164th National American Chemical Society, New York, August, 1972.

20. Simopoulos, A., Taussig, L., Murad, F., Arnaud, C.D., di Sant-Agnese, P., Kattwinkel, J., Bartter,
F.: Parathyroid function in patients with cystic fibrosis. Ped. Res. 6: 355, 1972.

21. Weitzman, R., Murad, F.: Effects of aminophylline, chlorpropamide and parathyroid extract on
plasma and urinary cyclic AMP in pseudohypoparathyroidism. Clin. Res. 21: 89, 1973.

22. Weitzman, R., Murad, F.: Effects of phosphodiesterase inhibition on urine cyclic AMP and
phosphate after parathyroid extract in pseudohypoparathyroidism. Clin. Res. 21: 58, 1973.

23. Moss, W., Johanson, A., Selden, R., Murad, F.: Urinary excretion on cyclic nucleotides in children.
Clin. Res. 21: 45, 1973.

24. Murad, F.: Cyclic AMP levels in tracheal preparations: Effects of epinephrine, theophylline and
prostaglandin E1. Clin. Res. 21: 73, 1973.

25. Weitzman, R., Murad, F., Owen, J.: Cyclic nucleotide metabolism in pseudohypoparathyroidism.
55th Annual Meeting of the Endocrine Society, Chicago, Illinois, June 20-22, 1973.

26. Kimura, H., Thomas, E., Murad, F.: Effects of decapitation, ether and pentobarbital on cyclic AMP
and cyclic GMP levels in rat tissues. Fed. Proc. 32: 680, 1973.

27. Murad, F.: Clinical studies and application of cyclic AMP. Presented at the 25th National Meeting
of the American Association of Clinical Chemists, July, 1973, New York.

28. Murad, F.: Clinical studies with cyclic nucleotides. Presented at the 27th Post Graduate Assembly
in Anesthesiology, New York, December 9-11, 1973.

29. Murad, F., Kimura, H.: Cyclic GMP levels in incubations of guinea pig tracheal rings. Clin. Res.
22: 47a, 1974.

30. Kimura, H., Murad, F.: Evidence for two forms of guanylate cyclase in rat heart. Fed. Proc. 33:
179, 1974.

31. Kimura, H., Murad, F.: Guanylate cyclase activity in various rat tissues. Fed. Proc. 33: 385, 1974.

32. Larner, J., Huang, L.C., Brooker, G., Murad, F., Miller, T.B.: Inhibitor of protein kinase formed in
insulin treated muscle. Fed. Proc. 33: 261, 1974.

33. Muffleman, D.W., Mundy, J.C., Schrank, J.P., Murad, F.: The effect of exercise on cyclic AMP and
cyclic GMP in human plasma and urine. Clin. Res. 22: 476a, 1974.
Ferid Murad, M.D., Ph.D.
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34. Murad, F.: Mechanism of action of some bronchodilators: Cyclic nucleotide metabolism in
tracheal preparations. Presented at the Scientific Basis of Respiratory Therapy Conference,
Philadelphia, May 1, 1974.

35. Murad, F.: Different forms of guanylate cyclase. Presented at the Gordon Conference on Cyclic
AMP, June 1974.

36. Murad, F.: Role of cyclic nucleotides as "Second Messengers." Presented at the First Portonovo
Conference, Ancona, Italy, September, 1974.

37. Murad, F.: Feedback systems to regulate cyclic AMP accumulation and action. Presented at the
First Portonovo Conference, Ancona, Italy, September, 1974.

38. Kimura, H., Murad, F.: Two forms of guanylate cyclase in several rat tissues. Presented at the
Second International Conference on Cyclic AMP, Vancouver, Canada, July, 1974, in Adv. Cyc.
Nucl. Res. 5: 822, 1975.

39. Kimura, H., Murad, F.: Subcellular distribution of guanylate cyclase in rat liver. Fed. Proc. 34:
616, 1975.

40. Murad, F., Kimura, H.: Altered subcellular distribution of guanylate cyclase in regenerating and
fetal liver and in hepatoma. Fed. Proc. 34: 232, 1975.

41. Murad, F., Kimura, H., Hopkins, H.A., Looney, W.B.: Correlation of changes in urinary cyclic GMP
with changes in tumor volume of hepatoma 3924A following chemotherapy and radiotherapy.
Proc. Amer. Assoc. Cancer Res. 16: 138, 1975.

42. Murad, F.: Use of cyclic nucleotides to evaluate calcium disorders. Proceedings of the American
Pharmaceutical Association Meeting, San Francisco, April, 1975, 5: 115, 1975.

43. Kimura, H., Mittal, C.K., Murad, F.: Activation of guanylate cyclase with sodium azide. Clin. Res.
23: 324a, 1975.

44. Kimura, H., Mittal, C.K., Murad, F.: Sodium azide activation of guanylate cyclase. Proc. Internat.
Pharmacol. Meeting, Helsinki, Finland, July, 1975.

45. Larner, J., Huang, L.C., Hagen, R., Brooker, G., Murad, F.: Mechanism of insulin action on
glycogenesis. Presented at the 35th Annual Meeting of the Amer. Diabetes Assoc., June, 1975,
Diabetes 24 (Suppl. 2): 394, 1975.

46. Murad, F.: Regulation of guanylate cyclase. Presented at the Gordon Conference on Cyclic AMP,
June, 1975.

47. Curnow, R.T., Carey, R.M., Taylor, A., Johanson, A., Murad, F.: Depression of serum insulin by
somatostatin. New Eng. J. Med. 293: 723, 1975.

48. Criss, W.E., Murad, F.: Regulation of guanylate cyclase from normal and neoplastic liver and
kidney tissues. Tenth International Congress of Biochemistry, Hamburg, Germany, July, 1976.

49. Criss, W.E., Murad, F.: Increased urinary excretion of cyclic GMP in rats bearing transplantable
liver and kidney tumors. Clin. Res. 24: 31a, 1976.

50. Criss, W.E., Murad, F., Kimura, H.: Altered subcellular distribution and properties of guanylate
cyclase from transplantable liver and kidney tumors. Clin. Res. 24: 51a, 1976.
Ferid Murad, M.D., Ph.D.
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51. Kimura, H., Mittal, C.K., Murad, F.: Magnesium dependent guanylate cyclase after sodium azide.
Fed. Proc. 35: 424, 1976.

52. Murad, F.: Some clinical applications of cyclic nucleotides. Proc. of Amer. Assoc. for Clin. Chem.
28th National Meeting, August, 1976.

53. Arnold, W.P., Kimura, H., Murad, F.: Properties of guanylate cyclase in bovine pulmonary
structures. Clin. Res. 24: 463A, 1976.

54. Murad, F.: Cyclic GMP metabolism in transplantable tumors. Presented at the 25th Annual
Conference on Rutgers Bureau of Biological Res., April, 1976.

55. Katsuki, S., Murad, F.: Cyclic GMP and cyclic AMP levels during contraction and relaxation of
bovine tracheal smooth muscle. The Pharmacologist 18: 220, 1976.

56. Murad, F.: Some clinical studies with cyclic nucleotides. Presented at the Gordon Conference on
Cyclic AMP, June, 1976.

57. Murad, F.: Guanylate: Properties and Regulation. Presented at the V Intl. Congress of
Endocrinology, Hamburg, Germany, July, 1976.

58. Mittal, C.K., Murad, F.: Formation of cyclic AMP by guanylate cyclase preparations after activation
with sodium azide. Clin. Res. 25: 49a, 1977.

59. Ichihara, K., Larner, J., Kimura, H., Murad, F.: Activation of liver guanylate cyclase by bile salts
and contaminants in crude secretin and pancreozymin preparations. Clin. Res. 25: 32a, 1977.

60. Katsuki, S. Murad, F.: Effects of sodium nitroprusside, nitroglycerin and sodium azide on cyclic
GMP levels in various tissues. Clin. Res. 25: 32A, 1977.

61. Katsuki, S., Arnold, W., Mittal, C.K., Murad, F.: Stimulation of guanylate cyclase in various tissues
by sodium nitroprusside, nitroglycerin, hydroxylamine and sodium azide. Clin. Res. 25: 58a, 1977.

62. Mittal, C.K., Kimura, H., Murad, F.: Properties of a protein factor required for sodium azide
activation of guanylate cyclase. Fed. Proc. 36: 737, 1977.

63. Murad, F.: A novel scheme for guanylate cyclase activation. Presented at the Gordon Conf. on
Cyclic Nucleotides, July, 1977.

64. Murad, F.: Regulation of guanylate cyclase. Presented at the Third Intl. Conference on Cyclic
Nucleotides, New Orleans, July, 1977.

65. Murad, F.: Guanylate Cyclase: Some of its properties and regulation. Presented at the NATO
Advanced Study Institute on Cyclic Nucleotides, Milan, Italy, Sept., 1977.

66. Guerrant, R.L., Hughes, J.M., Murad, F.: Role of cyclic GMP in ST-associated diarrhea.
Presented at the CDC meeting on Cholera, Sept., 1977.

67. Mittal, C.K., Murad, F.: Formation of cyclic AMP by guanylate cyclase preparations after activation
with azide, nitro and nitroso compounds. 3rd Intl. Congress of Cyclic Nucelotides, Adv. Cyclic
Nucl. Res. 9: 742, 1978.
Ferid Murad, M.D., Ph.D.
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68. Ichihara, K., Murad, F.: Effect of starvation on guanylate cyclase activity in various rat tissues. 3rd
Intl. Congress on Cyclic Nucleotides, Adv. Cyclic Nucl. Res. 9: 743, 1978.

++
69. Sutherland, C.A., Murad, F., Rall, T.W.: Effects of Ca 5', AMP and DP on cyclic AMP-induced
activation of phosphorylase in liver extract preparations. 3rd Intl. Congress on Cyclic Nucleotides,
Adv. Cyclic Nucl. Res. 9: 774, 1978.

70. Arnold, W.P., Katsuki, S., Mittal, C.K., Murad, F.: Stimulation of guanylate cyclase by nitric oxide
gas. 3rd Intl. Congress on Cyclic Nucleotides. Adv. Cyclic Nuc. Res. 9: 743, 1978.

71. Guerrant, R.L., Hughes, J.M, Murad, F.: Effects of E. Coli heat-stable toxin on cyclic GMP in
intestine. Presented - Southern Soc. Clin. Invest., January, 1978, Clin. Res. 26: 58a, 1978.

72. Arnold, W.P., Braughler, J.M., Mittal, C.K., Murad, F.: Activation of guanylate cyclase from thiols.
Fed. Proc. 37: 390, 1978.

73. Ichihara, K., El-Zayat, M., Mittal, C.K., Murad, F.: Activation of guanylate cyclase from fibroblasts
and liver by fatty acids. Fed. Proc. 37: 341, 1978.

74. Murad, F., Mittal, C.K., Braughler, J.M.: Cyclic AMP formation by guanylate cyclase. A new
pathway for its synthesis. Presented at the Amer. Soc. Clin. Invest. Meeting, San Francisco, April,
1978. Clin. Res. 26: 531A, 1978.

75. Mittal, C.K., Murad, F.: Effects of phospholipase A2 and lipoxygenase on rat cerebral cortex
guanylate cyclase. Fed. Proc. 37: 1968, 1978.

76. Hughes, J., Murad, F., Guerrant, R.: Studies to elucidate the mechanism of action of heat-stable
enterotoxin of E. Coli. Clin. Res. 26: 524A, 1978.

77. Thorner, M.O., Kirk, C.R., Murad, F.: Dissociation of prolactin and growth hormone release from
perfused isolated rat pituitary cells in response to changes in endogenous cyclic AMP. Endocrine
Society Meeting, June, 1978.

78. Murad, F., Mittal, C.K., Arnold, W.P., Braughler, J.M.: Effect of nitro-compound smooth muscle
relaxants and other materials on cyclic GMP metabolism. Proc. of the 7th Intl. Congress of
Pharmacology, Paris, France, July, 1978.

79. Murad, F.: Cyclic GMP and Guanylate Cyclase. State of the Art Lecture, FASEB, April, 1978.

80. Murad, F.: Guanylate Cyclase. Presented at the Gordon Conference on Cyclic Nucleotides, June,
1978.

81. Hughes, J., Murad, F., Guerrant, R.: Studies of guanylate cyclase activation by heat stable
enterotoxin of E. Coli. Proc. of the Interscience Conf. on Antimicrobial Agents and Chemotherapy,
Atlanta, Georgia, Sept., 1978.

82. Murad, F.: Clinical applications of cyclic nucleotides. Presented at the Internat. Symposium on
Cyclic Nucleotides and Therapeutic Perspectives, Paris, July, 1978.

83. Murad, F.: Guanylate cyclase and cyclic GMP. Presented at the EMBO/ICRO Meeting on
Hormones, Calcium and Cyclic Nucleotides, Glasgow, Scotland, August, 1978.
Ferid Murad, M.D., Ph.D.
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84. Murad, F.: Clinical studies with cyclic nucleotides. Presented at the EMBO/ICRO Meeting on
Hormones, Calcium and Cyclic Nucleotides, Glasgow, Scotland, August, 1978.

85. Braughler, J.M., Mittal, C.K., Murad, F.: Purification of soluble guanylate cyclase from rat liver to
apparent homogeneity. Clin. Res. 26: 788A, 1978.

86. Mittal, C.K., Braughler, J.M., Murad, F.: Modulation of purified guanylate cyclase activity. Fed.
Proc. 38: 318, 1979.

87. Dohi, T., Murad, F.: Pyruvate and other metabolites increase cyclic GMP levels in rat hepatocytes
and kidney cortex. Fed. Proc. 38: 432, 1979.

88. Daniel, K.A., Thorner, M.O., Murad, F.: The role of cyclic nucleotides in the release of LH from
continuously perfused isolated rat pituitary cells. Endocrine Society Meeting, Anaheim, California,
June, 1979.

89. Murad, F.: Properties and regulation of guanylate cyclase and cyclic GMP. Presented at the
Hormone Action Gordon Conference, January, 1979.

90. Murad, F.: Cyclic nucleotides. Presented at a meeting on Cell Injury in Shock, Anoxia and
Ischemia in Easton, Maryland, Sept., 1979.

91. Murad, F.: Cyclic nucleotides. Presented at a workshop on Manganese in Metabolic Regulation,
Bethesda, Maryland, Sept., 1979.

92. Murad, F.: Effects of E. Coli heat-stable enterotoxin on cyclic GMP metabolism. Presented at the
Second Annual Meeting of the Great Neglected Diseases of Mankind, Oxford, England, October,
1979.

93. Greenberg, R.N., Chang, B., Murad, F., Guerrant, R.L.: Indomethacin and chlopromazine
inhibition of E. Coli heat-stable enterotoxin. Presented at Southern Soc. Clin. Invest., New
Orleans, January, 1980. Clin. Res. 27: 787a, 1979.

94. Greenberg, R.N., Chang, B., Murad, F. Guerrant, R.L.: Indomethacin and chlopromazine inhibition
of E. Coli heat-stable enterotoxin. Amer. Soc. Microbiol. Meeting, Miami, Florida, May, 1980.

95. Varma, M., Wilson, T.A., Murad, F., Blizzard, R.M.: Impairment of human chorionic gonadotropin-
induced cyclic 3', 5'-adenosine monophosphate formation in isolated Leydig cells of aged rats.
Endo. Soc. Meeting, June, 1980.

96. Brandwein, H.J., Lewicki, J.A., Waldman, S.A., Murad, F.: Effects of disulfides and thiols on
guanylate cyclase. Presented at Soc. Biol. Chem. Meeting, New Orleans, June, 1980, Fed. Proc.
39: 2108, 1980.

97. Wada, A., Mittal, C.K., Murad, F.: Cyclic GMP levels and -glucuronidase release from human
polymorphonuclear leukocytes. Clin. Res. 28: 498a, 1980.

98. Greenberg, R., Chang, B., Murad, F., Guerrant, R.L.: Inhibition of E. Coli heat-stable enterotoxin
by phenothiazine derivates and indomethacin. Clin. Res. 28: 369a, 1980.

99. Arnold, W.P., Marshall, W.K., Bedford, R.B., Murad, F.: Nitroprusside alters plasma levels of cyclic
GMP and cyclic AMP. Amer. Heart Assoc. Meeting, Miami, November, 1980.
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100. Greenberg, R.N., Guerrant, R.L., Chang, B., Murad, F.: Inhibition of E. Coli heat-stable enterotoxin
by quinacrine. Interscience Conf. Antimicrobial Agents and Chemotherapy, abstract 700, New
Orleans, 1980.

101. Murad, F.: Guanylate cyclase. Purification and properties. Presented at the IV International
Cyclic Nucleotide Conference, Brussels, July, 1980.

102. Waldman, S.A., Lewicki, J.A., Brandwein, H.J., Murad, F.: Solubilization, characterization and
partial purification of guanylate cyclase from particulate fractions of rat liver. Clin. Res. 28: 835,
1980.

103. Lewicki, J.A., Brandwein, H.J., Waldman, S.A., Murad, F.: Characterization and radiolabeling of
purified soluble guanylate cyclase. Clin. Res. 28: 819a, 1980.

104. Brandwein, H.J., Lewicki, J.A., Murad, F.: Production and characterization of monoclonal
antibodies to soluble guanylate cyclase from rat lung. Clin. Res. 28: 891a, 1980.

105. Greenberg, R.N., Chang, B., Murad, F., Guerrant, R.L.: Lack of effect of porcine E. Coli
enterotoxin (STb) on cyclic nucleotide metabolism. Clin. Res. 28: 830a, 1980.

106. Brandwein, H.J., Lewicki, J.A., Murad, F.: Development of monoclonal antibodies to soluble
guanylate cyclase from rat lung. Fed. Proc. 40: 664, 1981.

107. Lewicki, J.A., Brandwein, H.J., Waldman, S.A., Murad, F.: Binding of soluble guanylate cyclase
from rat lung to immobilized monoclonal antibody. Fed. Proc. 40: 664, 1981.

108. Waldman, S.A., Lewicki, J.A., Brandwein, H.J., Murad, F.: Partial purification and characterization
of particulate guanylate cyclase from rat liver. Fed. Proc. 40: 664, 1981.

109. Rapoport, R.M., Brandwein, H.J., Murad, F.: Cystamine inhibits relaxation, increases in cyclic
GMP accumulation and guanylate cyclase activation induced by nitroprusside in rat aorta. Fed.
Proc. 40: 690, 1981.

110. Greenberg, R.N., Chang, B., Sauer, K., Murad, F., Guerrant, R.L.: Effects of a third type of
Escherichia Coli enterotoxin on cyclic nucleotide metabolism. Clin. Res. 29: 385a, 1981.

111. Greenberg, R.N., Murad, F., Halterman, L., Guerrant, R.L.: Lanthanum chloride inhibition of the
secretory response to Escherichia Coli heat-stable enterotoxin (ST). Clin. Res. 29: 386a, 1981.

112. Brandwein, H., Lewicki, J.A., Murad, F.: Effect of GTP analogues on purified guanylate cyclase.
Fed. Proc. 40: 1973, 1981.

113. Arnold, W.P., Murad, F.: Interactions of nitrovasodilators with the cyclic GMP systems. 28th
Annual Association of University Anesthetics Meeting, April, 1981.

114. Arnold, W.P., Marshall, W.K., Bedford, R.F., Murad, F.: Is nitroprusside mediated by cyclic GMP?
American Society of Anesthesiologists, October, 1981.

115. Rapoport, R.M., Lewicki, J.A., Murad, F.: Cyanide inhibits relaxation, increases in cyclic GMP and
guanylate cyclase activation induced by nitroprusside in rat aorta. American Heart Association
Meeting, Dallas, Texas, November, 1981.

116. Greenberg, R.N., Murad, R., Guerrant, R.L.: Pharmacologic inhibition of the secretory response to
E. Coli heat-stable enterotoxin. U.S.-Japan Cholera Meeting, Baltimore, Maryland, October, 1981.
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117. Guerrant, R.L., Greenberg, R.N., Chang, B., Murad, F.: Studies on the mechanism of action of E.
Coli (STb): Evidence for a third type of E. Coli enterotoxin. U.S.-Japan Cholera Meeting,
Baltimore, Maryland, October, 1981.

118. Draznin, M.B., Rapoport, R.M., Murad, F.: Vascular smooth muscle protein phosphorylation
following sodium nitroprusside treatment: Possible role in smooth muscle relaxation. Clin. Res.
30: 6A, 1982.

119. Rapoport, R.M., Murad, F.: Ouabain inhibits relaxation of nitroprusside and 8-bromo-cyclic GMP in
rat aorta. Clin. Res. 30: 18A, 1982.

120. Greenberg, R.N., Kennedy, D.J., Chang, B., Murad, F., Guerrant, R.L.: Studies on the properties
and mechanisms of action of a third type of E. Coli enterotoxin (STb). Amer. Soc. for Microbiol.
Meeting, March, 1982.

121. Rapoport, R.M., Draznin, M.B., Murad, F.: Sodium nitroprusside-induced protein phosphorylation
in intact rat aorta is mimicked by 8-bromo-cyclic GMP. Clin. Res. 30: 484A, 1982.

122. Greenberg, R.N., Lonogro, A., Murad, F., Guerrant, R.L.: Stimulation of intestinal prostaglandin
secretion by a third type of E. Coli enterotoxin (STb). Clin. Res. 30: 367A, 1982.

123. Murad, F.: Cyclic nucleotides in smooth muscle. Presented at the FASEB Smooth Muscle
Conference, Saxton River, Vermont, June, 1982.

124. Rapoport, R.M., Draznin, M.B., Martinez, G.A., Murad, F.: Effect of endothelium-dependent
vasodilators on relaxation, cyclic GMP levels and protein phosphorylation in rat thoracic aorta.
Clin. Res. 31: 16A, 1983.

125. Waldman, S.A., O'Hanley, P.D., Falkow, S., Schoolnik, G.K., Murad, F.: A simple, sensitive and
quantitative in vitro assay for the detection of heat-stable enterotoxin (ST) produced by E. Coli.
Clin. Res. 31: 50A, 1983.

126. Draznin, M.B., Rapoport, R.M., Martinez, G.A., Murad, F.: Effects of norepinephrine, sodium
nitroprusside, calcium-free buffer and a calmodulin inhibitor on protein phosphorylation related to
contraction and relaxation in intact rat aorta. Clin. Res. 31: 6A, 1983.

127. Lewicki, J.A., Waldman, S.A., Chang, B., Murad, F.: Membrane-dependent regulation of soluble
guanylate cyclase by snake venom phospholipase A2. Fed. Proc. 42: 902, 1983.

128. Sinacore, M.S., Lewicki, J.A., Waldman, S.A., Murad, F.: Determination of the subcellular
distribution of guanylate cyclase in neural crest derived cultured cells using a tandem double
monoclonal antibody immunoassay. Fed. Proc. 42: 900, 1983.

129. Waldman, S.A., Lewicki, J.A., Chang, L.Y., Murad, F.: Characteristics of highly purified particulate
guanylate cyclase from rat lung. Fed. Proc. 42: 1366, 1983.

130. Rapoport, R.M., Draznin, M.B., Martinez, G.A., Murad, F.: Endothelium-dependent vascular
relaxation may be mediated through cyclic GMP-dependent protein phosphorylation. Clin. Res.
31: 526A, 1983.

131. Draznin, M.B., Rapoport, R.M., Martinez, G.A., Murad, F.: Myosin light chain dephosphorylation in
intact rat aorta treated with sodium nitroprusside: Role of cyclic GMP. Clin. Res. 31: 466A, 1983.
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132. Murad, F.: Free radicals, cyclic GMP metabolism and cell growth. Presented at the Cancer
Causation and Prevention: Biochemical Mechanisms Symposium, Washington, D.C., December,
1982.

133. Waldman, S.A., Sinacore, M.S., Lewicki, J.A., Chang, L.Y., Murad, F.: Activation of particulate
guanylate cyclase by hemin. Fed. Proc. 42: 1853, 1983.

134. Murad, F.: Physiological aspects of potassium metabolism. Presented at the Student National
Medical Association Meeting, Atlanta, April, 1983.

135. Murad, F.: Regulation and role of cyclic GMP. Presented at the Gordon Conference on Cyclic
Nucleotides, June, 1983.

136. Murad, F., Rapoport, R.M., Draznin, M.B., Fiscus, R.: Cyclic GMP-linked mechanisms for
controlling smooth muscle. Presented at the NIH workshop on Airway Smooth Muscle,
September, 1983.

137. Pearl, R.G., Rosenthal, M.H., Ashton, J.P., Murad, F.: Aminophylline potentiates sodium
nitroprusside-induced hypotension. Anesthesiology, September, 1983.

138. Fiscus, R.R., Rapoport, R.M., Murad, F.: Activation of cyclic GMP-dependent protein kinase in rat
aorta by sodium nitroprusside and endothelium-dependent vasodilator. Clin. Res. 32: 5A, 1984.

139. Murad, F.: Role of cyclic GMP in vascular smooth muscle relaxation. Presented at the Workshop
on Precapillary Vessels, Weisbaden, Germany, April, 1984.

140. Murad, F.: Endothelium-dependent and independent vascular relaxation: Role of cyclic GMP.
Presented at the Workshop on Endothelium, Cardiff, Wales, August, 1984.

141. Murad, F.: Cyclic GMP in vascular relaxation. Presented at the American Heart Association joint
meeting of the Council on Circulation and Basic Science, Snowmass, Colorado, August, 1984.

142. Murad, F.: The role of the endothelium and cyclic GMP in vascular smooth muscle relaxation.
Presented at the Second Fernand Nedee Conference, Antwerp, Belgium, October, 1984.

143. Murad, F.: Effects of treatment of hypokalemia. Presented at the Southern Med. Assoc. Meeting,
Scientific Assembly, New Orleans, November, 1984.

144. Leitman, D.C., Fiscus, R., Murad, F.: Inhibition of cultured endothelial cell proliferation by forskolin
and phosphodiesterase inhibitors. Clin. Res. 33: 12A, 1985.

145. Chang, B., Kamasaki, Y., Saheki, S., Waldman, S.A., Lewicki, J.A., Murad, F.: Rapid purification
of soluble guanylate cyclase by monoclonal antibody immunoaffinity chromatography. Fed. Proc.
44: 698, 1985.

146. Kuno, T., Waldman, S.A., Kamasaki, Y., Garieppy, J., Schoolnik, G.K., Murad, F.: Molecular
characterization of the receptor for the heat-stable enterotoxin (ST) produced by E. Coli. Fed.
Proc. 44: 1798, 1985.

147. Kamasaki, Y., Waldman, S.A., Murad, F.: Involvement of catalytic site sulfhydryls in the activation
of soluble guanylate cyclase by sodium nitroprusside. Fed. Proc. 44: 699, 1985.
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148. Chang, L.Y., Chang, B., Waldman, S.A., Murad, F.: Purification of particulate guanylate cyclase
from rat lung and production of monoclonal antibodies. Fed. Proc. 44: 698, 1985.

149. Waldman, S.A., Kuno, T., Kamasaki, Y., Chang, L.Y., Garieppy, J., Schoolnik, G.K., Murad, F.:
The ST receptor for E. Coli heat-stable enterotoxin (ST) is tightly coupled to a novel form of
particulate guanylate cyclase. Fed. Proc. 44: 698, 1985.

150. Fiscus, R.R., Robles, B.T., Rapoport, R.M., Waldman, S.A., Murad, F.: Atrial natriuretic factor
elevates cyclic GMP and activates cyclic GMP-dependent protein kinase in rat aorta: Potential
mechanism of vasodilation. Fed. Proc. 44: 698, 1985.

151. Murad, F.: The mechanism of action of nitroglycerin and other nitrovasodilators, a role for cyclic
GMP. Presented at the Science Writers Forum, Amer. Heart Assoc., Monterey, January, 1985.

152. Murad, F.: Phosphodiesterase inhibition as a mechanism of action of xanthines. Presented at the
Symposium on Antiasthms xanthines and adenosine. Copenhagen, Feb., 1985.

153. Molina, C.R., Andresen, J.W., Rapoport, R.M., Waldman, S.A., Murad, F.: The effect of in vivo
nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic
GMP accumulation in rat aorta. Clin. Res. 33:, 1985.

154. Leitman, D.C., Waldman, S.A., Kuno, T., Murad, F.: Specific atrial natriuretic factor receptors
mediate increased cyclic GMP accumulation in cultured bovine aortic endothelial and smooth
muscle cells. Clin. Res. 33: 599A, 1985.

155. Murad, F.: Regulation of cyclic GMP synthesis and the interactions with calcium. Presented at the
meeting on Cellular Calcium Control Mechanisms, Lucerne, February, 1985.

156. Murad, F., Rapoport, R.M., Waldman, S.A., Fiscus, R.R., Leitman, D.C.: The role of cyclic GMP in
endothelium-dependent, nitrovasodilator and atriopeptin mediated vascular relaxation. Presented
at the Hungarian Physiological Soc. Meeting, Budapest, July, 1985.

157. Murad, F.: Regulation of guanylate cyclase and the role of cyclic GMP in vascular relaxation.
Presented at Biochemical Pharmacology meeting of the New York Acad. Sci., Nov., 1985.

158. Murad, F.: Diuretics and potassium supplements - Solutions or problems. Presented at the
Tutorials in Medicine meeting. San Francisco, March, 1986.

159. Kuno, T., Andresen, J.W., Kamisaki, Y., Waldman, S.A., Chang, L.Y., Saheki, S., Nakane, M.
Murad, F.: Purification and characterization of particulate guanylate cyclase from rat lung. Fed.
Proc. 45: 1986.

160. Saheki, S., Kamisaki, Y., Nakane, M., Palmieri, J.A., Chang, L.Y., Kuno, T., Waldman, S.A.,
Murad, F.: Purified soluble guanylate cyclase from rat lung is a heterodimer. Fed. Proc. 45: 1986.

161. Murad, F.: Cyclic GMP as a mediator of endothelium-dependent and endothelium-independent

relaxation. Presented at the Smooth Muscle Function Symposium of the International Union of
Physiological Sciences, Banff, Canada, July, 1986.

162. Tomlanovich, S., Peterson, C., Molina, C.R., Murad, F., Nitkin, R., Myers, B.D.: Role of atrial
natriuretic hormone and cardiac nerves in renal response to hyperkolemia in man. Clin. Res. 34:
702A, 1986.
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163. Kuno, T., Andresen, J.W., Kamasaki, Y., Waldman, S.A., Saheki, S., Murad, F.: Co-purification of
atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. Clin. Res. 34:
638A, 1986.

164. Leitman, D.C., Andresen, J.W., Kuno, T., Kamisaki, Y., Chang, L.Y., Murad, F.: Identification of
two binding sites for atrial natriuretic factor in endothelial cells. Clin. Res. 34: 709A, 1986.

165. Nakane, M., Kuno, T., Murad, F.: Cloning of soluble guanylate cyclase 82,000 dalton subunit
complementary DNA from rat lung. Fed. Proc. 45: 1523, 1986.

166. Molina, C.R., Leitman, D.C., Fowler, M.B., Murad, F.: Atrial natriuretic factor release and renal
clearance in heart failure. Amer. Heart Assoc. meeting, November, 1986, Circ. 74: II-438, 1986.

167. Molina, C.R., Leitman, D.C., Fowler, M.B., Murad, F.: An in vitro bioassay for plasma human atrial
natriuretic factor using cultured endothelial cells. Amer. Heart Assoc. meeting, November, 1986,
Circ. 74:II-464, 1986.

168. Bennett, B.M., Hayward, D., Murad, F.: Stereospecificity in the action of iosoidide dinitrate.
Pharmacologist 28: 188, 1986.

169. Bennett, B.M., Hayward, D., Murad, F.: Comparison of vasodilation and tolerance development to
glycerl trinitrate and the stereoisomers of isoidide dinitrate. Amer. Heart Assoc. meeting,
November, 1986, Circ. 74: II-321, 1986.

170. Molina, C.R., Andresen, J.W., Rapoport, R.M., Murad, F.: The effect of nitroglycerin tolerance on
endothelium-dependent vascular relaxation. Amer. Heart Assoc. meeting, November, 1986, Circ.
74: II-287, 1986.

171. Fiscus, R.R., Robles, B.T., DelVecchio, R.L., Waldman, S.A., Murad, F.: Atrial natriuretic factor
stimulates cyclic GMP accumulation and efflux in C6-2B rat glioma cell cultures and these
responses are antagonized by chlorpromazine. VIth Internat. Conf. on Cyclic Nucleotides,
Calcium and Protein Phosphorylation, Bethesda, Maryland, September, 1986.

172. Murad, F.: Interactions of atrial natriuretic factor and cyclic GMP. Presented at the VIth Internat.
Conf. on Cyclic Nucleotides, Calcium and Protein Phosphorylation, Bethesda, Maryland,
September, 1986.

173. Fiscus, R.R., Robles, B.T., Murad, F.: Atrial natriuretic factor stimulates cyclic GMP accumulation
in selected regions of rat brain. Amer. Physiol. Soc. Mtg., New Orleans, Louisiana, October, 1986.
The Physiologist, 29: 156, 1986.

174. Murad, F.: Regulation and role of guanylate cyclase-cyclic GMP in vascular relaxation. Presented
at the Second Internat. Symposium on Cellular Endocrinology, Lake Placid, NY, September, 1986.

175. Murad, F.: The role of cyclic GMP in the mechanism of action of nitrovasodilators, atrial peptides
and other agents. Presented at the Symposium on Nitrates, Tokyo, Japan, October, 1986.

176. Murad, F.: Cyclic nucleotides and endothelium-derived relaxing factors. Presented at the Amer.
Physiol. Society Meeting, New Orleans, Louisiana, October, 1986.

177. Murad, F.: Atrial natriuretic factor: a new class of peptide hormones. Presented at the Center of
Molecular and Genetic Medicine Symposium, Stanford University, November, 1986.
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178. Murad, F.: Regulation of guanylate cyclase and the role of cyclic GMP in vasodilation. Presented
at the ANF Symposium, Southern Soc. Clin. Invest. Meeting, New Orleans, January, 1986.

179. Sakeki, S., Chang, L.Y., Ishii, K., Murad, F.: Subunit structure of soluble guanylate cyclase from
rat lung. Clin. Res. 35: 117A, 1987.

180. Schroeder, H., Leitman, D.C., Bennett, B.M., Murad, F.: Atrial natriuretic factor, sodium
nitroprusside and organic nitrates increase cyclic GMP and activate guanylate cyclase in cultured
rat lung fibroblasts. Clin. Res. 35: 113A, 1987.

181. Molina, C.R., Fowler, M.B., Peterson, C.A., Costard, A., Myers, B.D., Murad, F.: Hemodynamic,
renal and endocrine effects of atrial natriuretic peptide in severe congestive heart failure. Clin.
Res. 35: 642A, 1987.

182. Molina, C.R., Costard, A., Peterson, C.A., Myers, B.D., Murad, F., Fowler, M.B.: Hemodynamics,
renal and endocrine effects of atrial natriuretic peptide in severe congestive heart failure. Amer.
Society of Hypertension, New York, May, 1987.

183. Leitman, D.C., Andresen, J.W., Tuan, J.J., Catalano, R., Murad, F.: Atrial natriuretic factor
binding, cross linking and effects of cyclic GMP accumulation and particulate guanylate cyclase
activity in cultured cells. Amer. Society of Hypertension, New York, May, 1987.

184. Murad, F.: Relationships of atrial natriuretic factor receptors and guanylate cyclase. Presented at
the Angiotensin Gordon Conference, Santa Barbara, February, 1987.

185. Murad, F.: Role of guanylate cyclase and cyclic GMP in the actions of ANF. Presented at the 2nd
World Congress on Biologically Active Atrial Peptides, New York, May, 1987.

186. Murad, F.: Role of cyclic GMP in the vascular effects of atrial natriuretic factor and other
vasodilators. Presented at the Endocrinology Meeting, Indianapolis, June, 1987.

187. Murad, F.: Role of cyclic GMP in vasodilation. Presented at the Cyclic Nucleotide Gordon
Conference, June, 1987.

188. Molina, C.R., Leitman, D.C., Costard, A., Fowler, M.B., Murad, F.: Atrial natriuretic factor is
secreted as an immunoreactive but partially biactive peptide in man. Clin. Res. 35: 574A, 1987.

189. Molina, C.R., Fowler, M.B., McCrary, S., Murad, F.: Pharmacodynamic and pharmacokinetics of
two hour atrial natriuretic peptide infusions in severe congestive heart failure. Circ. 76, Suppl. IV, ,
1987. Amer. Heart Assoc. Meeting, Dallas, November, 1987.

190. Song, D.L., Wang, Y.N., Molina, C.R., Cheng, J.K., Cong, Y., Cheng, D., Murad, F.: B-Human
atrial natriuretic polypeptide in human plasma. Circ. 76: Suppl. IV, 134, 1987. American Heart
Assoc. Meeting, Dallas, November, 1987.

191. Murad, F.: Advances in vasodilator mechanisms. Presented at the 38th Annual Amer. Soc.
Pharmacol. and Exp. Therap. meeting, Honolulu, August, 1987.

192. Murad, F.: The mechanism of relaxation of EDRF: Similarities of the effects of EDRF and
nitrovasodilators on cyclic GMP formation and vascular relaxation. Presented at the Tenth Int'l.
Pharmacol. Meeting, Sydney, August, 1987.
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193. Murad, F.: Guanylate cyclase and cyclic GMP: Regulation by atrial natriuretic factor and other
vasodilators. Presented at the Symposium on Receptors and Cell Activation, Bethesda,
September, 1987.

194. Murad, F.: ANF and other vasodilators: The role of guanylate cyclase and cyclic GMP in their
action. Presented at the 12th European Symposium on Hormones and Cell Regulation, St. Odile,
France, October, 1987.

195. Murad, F.: Cyclic GMP and vasodilation. Presented at the Hughes Medical Institute Symposium
on Cyclic GMP Action, Miami, November, 1987.

196. Murad, F.: Action of EDRF in vascular smooth muscle. Presented at the Second Chepstan
Workshop on Endothelium and Vasomotor Control, Chepstow, Wales, December, 1987.

197. Murad, F.: Role of cyclic GMP in the mechanism of action of nitrovasodilators, endothelium-
dependent agents and atrial natriuretic peptide. Presented at the British Biochemical Society
Meeting, London, England, December, 1987.

198. Murad, F.: ANF receptors and the guanylate cyclase cyclic GMP system. Presented at the UCLA
Symposium on ANF. Steamboat, Colorado, January, 1988. J. Cell Biochem. 12A: 7, 1988.

199. Murad, F.: Role of cyclic GMP in smooth muscle regulation. Presented at the Meeting of the
Cellular Calcium Control Mechanisms, Basel, Switzerland, February, 1988.

200. Murad, F.: Cyclic GMP mediates the effects of atrial natriuretic factor and other vasodilators.
Presented at the Western Assoc. Phys. Meeting, Carmel, California, February, 1988.

201. Schroeder, H., Leitman, D.C., Bennett, B.M., Waldman, S.A., Murad, F.: Nitrate tolerance and its
reversal in cultured rat lung fibroblasts. Presented at the Deutsche gesellschaft fur Pharmakologie
und Toxikologie, Mainz, Germany, A 296, March, 1988.

202. Ishii, K., Murad, F.: Atrial natriuretic peptides relax bovine tracheal smooth muscle and increase
tissue cyclic GMP levels through activation of particulate guanylate cyclase. Fed. Proc. 47:A1066,
1988.

203. Song, D.L., Leitman, D.C., Molina, C.R., Murad, F.: Atrial natriuretic peptide, oxytocin and
substance P increase cyclic GMP in kidney epithelial cells. Fed. Proc. 47:A1304, 1988.

204. Bennett, B.M., Leitman, D.C., Schroeder, H., Murad, F.: Relationship between biotransformation
of glyceryl trinitrate and cyclic GMP accumulation in various cell lines. Fed. Proc. 47: A1304,
1988.

205. Murad, F.: Regulation of ANF receptors. Presented at the Gordon Conf. on Angiotensin and
Related Hormones, Oxnard, California, February, 1988.

206. Waldman, S.A., Leitman, D.C., Andresen, J., Murad, F.: Guanylate cyclase and the atrial
natriuretic factor receptor. Science 240: 805, 1988.

207. Murad, F.: Effects of vasodilators on cyclic GMP. Presented at the Cold Spring Harbor
Symposium on Signal Transduction. May, 1988.

208. Murad, F.: Modulation of guanylate cyclase by vasodilators and free radicals. Presented at the
NATO-Adv. Study Institute on Vascular Endothelium. Porto Carras, Greece, June, 1988.
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209. Murad, F.: Effects of ANF on cyclic GMP. Presented at the Internat. Symposium on ANF, Kyoto,
Japan, July, 1988.

210. Kohse, K., Song, D.L., Murad, F.: Ein nuentdecktes mitglied der ANP-familie im ZNS:
Natriuretisches gehrin-peptid (BNP). Effekte anf intrazellulares cGMP and partikeulare
guanylatzyklase sowie rezeptor bindung. Presented at the Annual Meeting, German Society of
Clinical Chemistry, Vienna, Dec., 1988.

211. Chang, C.H., Kohse, K., Chang, B., Murad, F.: Participation of protein phosphorylation in the
activation of particulate guanylate cyclase by ANP. FASEB, 3, A1005 , 1989.

212. Murad, F.: Role of cGMP-guanylate cyclase system in the action of atrial peptides and other
vasodilators. Presented at the FASEB meeting, New Orleans, Louisiana, March, 1989.

213. Murad, F.: Hormonal regulation of guanylate cyclases. Presented at the Mosbach Colloquium on
Molecular Mechanisms of Hormone Action, Germany, April, 1989.

214. Murad, F.: Regulation of the guanylate cyclase-cyclic GMP system. Presented at the Chicago
Biological Signal Transduction Symposium, Chicago, Illinois, April, 1989.

215. Murad, F.: EDRF and cyclic GMP. Presented at the First Internat. Symposium on Endothelium-
Derived Vasoactive Factors, Philadelphia, Pennsylvania, May, 1989.

216. Murad, F.: Signal transduction and cyclases. Presented at the Amer. Lung Assoc. and Amer.
Thoracic Soc. meeting, Cincinnati, Ohio, May, 1989.

217. Horio, Y., Murad, F.: Properties of retinal guanylate cyclase. Proc. 19th Neuroscience Meeting,
Oct., 1989, 205.

218. Gorsky, L.P., Huang, Z.J.., Murad, F.: Cytosolic production of an endothelium-derived relaxing
factor-like substance in N1E-115 neuroblastoma cells. Clin. Res. , 37, 878A, 1989.

219. Förstermann, U., Huang, Z.J., Murad, F.: Subcellular localization of the enzymes responsible for
the synthesis of endothelium-derived relaxing factor in endothelial cells. Clin. Res., 37, 877A,
1989.

220. Ishii, K., Chang, B., Huang, Z.J., Murad, F.: Endothelium-derived relaxing factor is produced as an
endogenous activator of soluble guanylate cyclase in porcine kidney epithelial cells. Clin. Res.,
37, 88A, 1989.

221. Förstermann, U., Ishii, K., Gorsky, L., Murad, F.: Endothelium-derived relaxing factor is a
paracrine and autocrine activator of soluble guanylate cyclase in various cell types. Presented at
the German Soc. Pharmacol. Toxicol. Meeting, Oct., 1989.

222. Murad, F., Ishii, K., Kerwin, J., Gorsky, L., Förstermann, U.: Role of EDRF in the formation of NO
and the activation of the soluble guanylate cyclase isoenzyme form. Presented at the Royal
Society Meeting on Nitric Oxide from L-Arginine, London, September, 1989.

223. Murad, F.: EDRF is an intracellular second messenger and autacoid to regulate cyclic GMP
synthesis in many cells. Presented at the 7th International Conference on Cyclic Nucleotides,
Calcium and Protein Phosphorylation, Kobe, Japan, October, 1989.
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224. Murad, F., Ishii, K.: EDRF may be a second messenger for hormonal activation of soluble
guanylate cyclase in LLC-PK1 cells. Presented at the 7th International Conference on Cyclic
Nucleotides, Calcium and Protein Phosphorylation, Kobe, Japan, October, 1989.

225. Murad,F.: Hormonal regulation of guanylate cyclase. Presented at the Soc. for Neuroscience
Meeting, Phoenix, Oct., 1989.

226. Murad, F.: Regulation of cyclic GMP in vascular preparations and other tissues - Mechanism of
action of some vasodilators. Presented at the 62nd Amer. Heart Assoc. Meeting, New Orleans,
Nov., 1989.

227. Yonemaru, M., Ishii, K., Murad, F., Raffin, T.: Atrial natriuretic peptide increases endothelial cell
monlayer permeability via a cyclic GMP-dependent mechanism. Presented at the 62nd Amer.
Heart Assoc. Meeting, New Orleans, Nov., 1989.

228. Schmidt, H.H.H.W., Pollock, J., Murad, F.: Characterization and purification of a rat brain enzyme
(system) which catalyzes the formation of and EDRF-like factor from L-arginine. Presented at the
German Society for Pharmacology and Toxicology, Spring Meeting, Mainz, March, 1990. Naunyn
Schmiedbergs Arch. Pharmacol., 341, R66, 1990.

229. Förstermann, U., Gorsky, L., Pollock, J., Schmidt, H.H.H.W., Ishii, K., Heller, M., Murad, F.:
Subcellular localization and regulation of the enzymes responsible for EDRF synthesis in
endothelial cells and N1E-115 neuroblastoma cells. Presented at IUPHAR XI Intl. Congress of
Pharmacology, Amsterdam, July, 1990.

230. Heller, M., Förstermann, U., Gorsky, L., Ishii, K., Pollock, J., Schmidt, H.H.H.W., Murad, F.:
Regulation of EDRF synthase in N1E-115 neuroblastoma cells by calmodulin and calcium.
Presented at FASEB Meeting, Washington, D.C., April, 1990.

231. Schmidt, H.H.H.W., Förstermann, U., Gorsky, L., Heller, M., Ishii, K., Pollock, J., Murad, F.:
Characterization and purification of a rat brain enzyme system catalyzing formation of EDRF from
L-arginine. Presented at FASEB Meeting, Washington, D.C., April, 1990.

232. Murad, F., Pollock, J., Schmidt, H.H.H.W., Förstermann, U., Ishii, K., Heller, M., Gorsky, L.:
Characterization and purification of a rat brain enzyme which catalyzes the formation of and
EDRF-like factor from L-arginine. Presented at IUPHAR XI Int. Congress of Pharmacology,
Amsterdam, July, 1990.

233. Heller,M., Förstermann, U., Gorsky, L., Ishii, K., Pollock, J., Schmidt, H.H.H.W., Murad, F.: EDRF
synthetase in bovine aorta endothelial cells and NIE-115 neuroblastoma cells: Subcellular
localization and regulation by calcium and calmodulin. J. Molec. & Cellular Cardiol. 22, 521,
1990.

234. Pollock, J., Schmidt, H.H.H.W., Gorsky, L., Förstermann, U., Kohlhaas, K., Huang, Z.J., Heller, M.,
Murad, F.: Characterization of a rat brain enzyme which catalyzes the formation of an EDRF-like
factor from L-arginine. Amer. Soc. Biochem. and Molec. Biol. Meeting, New Orleans, June, 1990.

235. Gorksy, L., Schmidt, H.H.H.W., Pollock, J., Förstermann, U., Kohlhaas, K., Huang, Z.J., Heller, M.,
Murad, F.: Partial purification of a rat brain enzyme which catalyzes the formation of an EDRF-like
factor from L-arginine. Amer. Soc. Biochem. and Molec. Biol. Meeting, New Orleans, June, 1990.

236. Murad, F.: Mechanisms of hormone receptor coupling to the various isoforms of guanylate
cyclase. Endocrine Society Meetings, Atlanta, June, 1990.
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237. Förstermann, U., Gorsky, L., Pollock, J., Schmidt, H.H.H.W., Heller, M., Murad, F.:
Characterization and partial purification of the enzyme responsible for EDRF/NO synthesis in NIE-
115 neuroblastoma cells. Symposium on EDRF, Antwerp, June, 1990.

238. Arneric, S., Linville, D., Kerwin, J., Murad, F.: Nitric oxide: Its role in mediating increases in
cortical cerebral blood flow elicited by electrical stimulation of the basal forebrain. Soc. for
Neuroscience Mtg., St. Louis, Oct., 1990.

239. Murad, F.: Relationships of nitric oxide free radical and cyclic GMP as second messengers.
ASPET Mtg., Milwaukee, Aug., 1990.

240. Murad, F.: Cellular mechanisms of vascular smooth muscle relaxation. ASPET Mtg., Milwaukee,
Aug., 1990.

241. Murad, F.: Biosynthesis of EDRF. ASPET Mtg., Milwaukee, Aug., 1990.

242. Chen, J., Chang, B., Heller, M., Murad, F.: Visualization of guanylate cyclase in cultured CNS
neurons. Soc. for Neuroscience Mtg., St. Louis, Oct., 1990.

243. Murad, F.: Mechanisms of nitrovasodilator tolerance and heterogenity. XII Congress of the
European Society of Cardiology, Stockholm, September, 1990.

244. Ishii, K., Warner, T.D., Sheng, H., Murad, F.: Endothelin stimulates cyclic GMP formation in
porcine kidney epithelial cells via activation of the L-arginine-dependent soluble guanylate cyclase
pathway. Presented at the Second International Conference on Endothelin, Tsukubo, Japan,
December, 1990.

245. Ishii, K., Warner, T.D., Sheng, H., Murad, F.: Endothelin increases cyclic GMP levels in LLC-PK1
porcine kidney epithelial cells via formation of an EDRF-like substance. Annual Meeting of the
Japanese Pharmacological Society, Kobe, Japan, 1991, Japanese J. Pharmacol., 55, 70, 1991.

246. Murad, F.: The interrelationships of nitric oxide and cyclic GMP as second messengers. Trends
in cardiovascular research seminars, Rome, Italy, February, 1991.

247. Förstermann, U., Pollock, J.S., Schmidt, H.H.H.W., Mitchell, J.A., Heller, M., Murad, F.:
Characterization and purification of particulate EDRF-synthase from bovine aortic endothelial cells.
FASEB J., 5, Part III, pg. A1728, 1991.

248. Buechler, W., Nakane, M., Murad, F.: Expression of soluble guanylate cyclase activity requires
both enzyme subunits. FASEB J., 5, Part I, pg. A454, 1991.

249. Sheng, H., Ishii, K., Murad, F.: Generation of an EDRF-like substance with carbachol- or
bradykinin-induced cyclic GMP accumulation in bovine tracheal smooth muscle. FASEB J., 5,
Part III, pg. A1591, 1991.

250. Huang, Z-J.,Schmidt, H.H.H.W., Warner, T.D., Murad, F.: Glucose-induced formation of arginine-
derived nitrogen oxides from HIT-T15 pancreatic ∃-cells implies a role of cyclic GMP in insulin
biosynthesis and/or secretion. FASEB J., 5, Part I, pg. A756, 1991.

251. Chang, B., Chen, J., Murad, F.: Increased expression of soluble guanylate cyclase (sGC) during
the maturation of cultured CNS neurons. FASEB J., 5, Part I, pg. A509, 1991.
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252. Nakane, M., Schmidt, H.H.H.W., Warner, T.D., Huang, Z., Murad, F.: Induction of Type II
guanylyl cyclase-activating-factor (GAF) synthase in RAW macrophages requires transcription and
de novo-protein biosynthesis. FASEB J., 5, Part I, pg. A509, 1991.

253. Mitchell, J.A., Förstermann, U., Warner, T.D., Pollock, J.S., Schmidt, H.H.H.W., Kohlhass, K.L.,
Heller, M., Murad, F.: Particulate activity is responsible for EDRF formation by native bovine
aortic endothelial cells. FASEB J., 5, Part III, pg. A1728, 1991.

254. Warner, T.D., Schmidt, H.H.H.W., Opgenorth, T.J., Murad, F.: Selective stimulation of the release
of nitrogen oxides from whole bovine aortae by endothelin-3 but not endothelin-1. FASEB J., 5,
Part III, pg. A1728 1991.

255. Dillon, T., Warner, T.D., Schmidt, H.H.H.W., Budzik, G.P., Opgenorth, T.J., Murad, F.: Stimulators
of the release of EDRF decrease the release of immunoreactive-endothelin from whole bovine
aortae. FASEB J., 5, Part II, pg. A1419, 1991.

256. Schmidt, H.H.H.W., Pollock, J.S., Förstermann, U., Murad, F.: Type I guanylyl cyclase-activating-
2+
factor (GAF) synthase from rat brain is a CA /Calmodulin-, NADPH- Tetrahydrobiopterin-
dependent homodimer. FASEB J., 5, Part III, pg. A1591, 1991.

257. Schmidt, H.H.H.W., Warner, T.D., Mitchell, J., Nakane, M., Murad, F.: Soluble synthese of
guanylyl cyclase-activating factors (Type I) and mouse macrophages (Type II). Presented at the
German Pharmacology Soc. Meeting, March, 1991.

258. Nakane, M., Schmidt, H.H.H.W., Murad, F.: Purification and molecular cloning of guanylyl cyclase
activating factor synthase. Neuroscience Meeting, November, 1991.

259. Murad, F.: Regulation of guanylate cyclase isoforms, signal transduction via chemical and
electrical messengers. Nashville, May, 1991.

260. Murad, F.: Nitric oxide regulation of cyclic GMP synthesis: An ubiquitous signal transduction
pathway. Presented at the meeting of the "Biological Role of Nitric Oxide", Baltimore, May, 1991.

261. Sheng, H., Mitchell, J.A., Nakane, M., Warner, T.D., Pollock, J.S., Förstermann, U., Murad, F.:
Characterization of NO synthase from NANC nerve containing tissues. Presented at the British
Pharmacol. meeting, Glasgow, July, 1991.

262. Mitchell, J.A., Sheng, H., Warner, T.D., Pollock, J.S., Förstermann, U., Murad, F.: Relationship
between endothelial cell activation and subsequent NO synthase activity: Inhibition by oxygen-
derived free radicals. Presented at the British Pharmacol. meeting, Glasgow, July, 1991.

263. Murad, F.: Endothelial regulation of cyclic GMP synthesis: A ubiquitous signal transduction
system. Presented at the FASEB conference on Endothelium and Cardiovascular Function,
Copper Mountain, June, 1991.

264. Mitchell, J.A., Kohlhaas, K.L., Warner, T.D., Pollock, J.S., Förstermann, U., Murad, F.:
Simultaneous induction by cytokines of NADPH-dependent diaphorase activity and NO synthase in
endothelium-denuded rat aorta. Presented at the Biology of Nitric Oxide--2nd International
meeting, London, September, 1991.

265. Sheng, H., Mitchell, J.A., Nakane, M., Schmidt, H.H.H.W., Pollock, J.S., Warner, T.D.,
Förstermann, U., Murad, F.: Characterization of NO-synthase from non-adrenergic non-
cholinergic nerves in rat anococcygeus and bovine retractor penis muscles. Presented at the
Biology of Nitric Oxide--2nd International meeting, London, September, 1991.
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266. Mitchell, J.A., Pollock, J.S., Nakane, M., Warner, T.D., Kerwin, J., Wagenaar, F., Förstermann, U.,
Murad, F.: Hydroxy-L-arginine is a substrate for constitutive NO synthase purified from endothelial
cells and brain: Comparison with L-arginine. Presented at the Biology of Nitric Oxide--2nd
International meeting, London, September, 1991.

267. Pollock, J.S., Mitchell, J.A., Warner, T.D., Schmidt, H.H.H.W., Nakane, M., Förstermann, U.,
Murad, F.: Purification of NO synthases from endothelial cells. Presented at the Biology of Nitric
Oxide--2nd International meeting, London, September, 1991.

268. Schmidt, H.H.H.W., Smith, R.M., Nakane, M., Pollock, J.S., Sheng, H., Förstermann, U., Murad,
F.: Type I NOx Synthase: Purification and immunohistochemical localization. Presented at the
Biology of Nitric Oxide--2nd International meeting, London, September, 1991.

269. Förstermann, U., Schmidt, H.H.H.W., Pollock, J.S., Sheng, H., Mitchell, J.A., Warner, T.D.,
Nakane, M., Murad, F.: Characterization and classification of constitutive and inducible isoforms of
NO synthase in various cell types. Presented at the Biology of Nitric Oxide--2nd International
meeting, London, September, 1991.

270. Mitchell, J.A., Sheng, H., Warner, T., Pollock, J., Förstermann, U. and Murad, F.: Relationship
between endothelial cell activation and subsequent NO synthase activity: Inhibition by oxygen
derived free radicals. Brit. J. Pharmacol. 105, 117, 1991.

271. Pollock, J.S., Nakane, M., Förstermann, U., Murad, F.: Characterization of monoclonal antibodies
to Type III Nitric Oxide (NO) synthase. Presented at ASBMB/Biophysical Society, Houston,
February, 1992 .

272. Schmidt, H.H.H.W., Nakane, M, Smith, R.M., Murad, F.: Characterization of Type I NO synthase
2+
from rat cerebellum: a bioptero-flavo-protein differentially regulated by Ca /Calmodulin.
Presented at ASBMB/Biophysical Society, Houston, February, 1992 .

273. Gagne, G.D., Schmidt, H.H.H.W., Nakane, M, Miller, M.F., Murad, F.: Immunohistochemical
localization of NO synthase, NADPH diaphorase, and soluble guanylyl cyclase reveals inter- and
intracellular messenger functions for NO in the CNS and paraneuronal functions in peripheral
tissues. Presented at ASBMB/Biophysical Society, Houston, February, 1992 .

274. Nakane, M., Mitchell, J., Förstermann, U., Murad, F.: Phosphorylation by calcium calmodulin-
dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase.
Presented at ASBMB/Biophysical Society, Houston, February, 1992 .

275. Schmidt, H.H.H.W., Gagne, G., Miller, M., Warner, T.D., Sheng, H., Murad, F.:
Immunohistochemical detection of NO synthase type I suggests co-localization with NADPH-
diaphorase but not soluable guanylyl cyclase, and para-neuronal functions for nitrinergic signal
transduction. Presented at the German Pharmacological Society Meeting, March, 1992 .

276. Matsumoto, T., Mitchell, J.A., Kohlhaas, K., Ritger, R., Warner, T.D., Schmidt, H.H.H.W.,
Förstermann, U., Murad, F.: Localization of nitric oxide synthase in ferret brain. FASEB, April,
1992 .

277. Förstermann, U., Pollock, J., Huang, Z., Kuk, J., Nakane, M., Murad, F.: Transforming growth
factor-∃ increases nitric oxide production in bovine aortic endothelial cells. FASEB, April, 1992 .
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278. Sheng, H., Nakane, M., Schmidt, H.H.H.W., Mitchell, J.A., Gagne, G., Miller, M., Murad, F.:
Characterization and localization of NO synthase from non-adrenergic non-cholinergic nerves from
bovine retractor penis muscle. FASEB, 6, A1298, April, 1992.

279. Huang, R., Sheng, H., Murad, F.: Formation of nitric oxide in bovine superior cervical ganglion.
FASEB, 6, A1298, April, 1992 .

280. Murad, F.: The nitric oxide-cyclic GMP signal transduction pathway in vasular preparations and
other tissues. Presented at the International Symposium on Smooth Muscle, Fukuoka, Japan,
January, 1992.

281. Murad, F.: The discovery and development of pharmaceutical agents. Presented at the Internal
Medicine Symposium, Vail, Colorado, February, 1992.

282. Pollock, J., Nakane, M., Springhall, D., Huang, Z., Mitchell, J., Warner, T., Pollock, J.,
Förstermann, U., and Murad, F.: Particulate and soluble endothelial nitric oxide synthases are
similar proteins. Presented at the 2nd International Symposium of Endothelium-Derived
Vasoactive Factors. Basel, Switzerland, April, 1992. J. Vascular Res., 29, 315, 1992.

283. Mitchell, J., Warner, T., Huang, Z., Förstermann, U., and Murad, F.: Native LDL inhibits the
release of endothelium-derived relaxing factor by reduced activity of endothelial nitric oxide
synthase. Presented at the 2nd International Symposium of Endothelium-Derived Vasoactive
Factors. Basel, Switzerland, April, 1992. J. Vascular Res., 29, 1992.

284. Hughes, M., Sheng, H., Murad, F., and Briggs, C.: Evidence that nitric oxide mediates the cyclic
GMP response to synaptic activity in the rat superior cervical ganglion. Soc. Neurosci. Meeting,
October, 1992.

285. Mitchell, J., Kohlhaas, K., Matsumoto, T., Warner, T., Pollock, J., Förstermann, U., Schmidt, H.,
and Murad, F.: NO synthase activity in the lung is species dependent. British Pharmacol. Soc.
Meeting, 1992.

286. Murad, F.: Endothelial regulation of cyclic GMP synthesis: The nitric oxide-cyclic GMP signal
transduction system. Presented at the Intl. Union Biochem. Molec. Biol. Mtg., Nagoya, Japan,
June, 1992.

287. Murad,F.: Isoforms of nitric oxide synthase and the nitric oxide-cyclic GMP signal transduction
system. Presented at the NATO Vascular Endothelium Mtg., Rhodes, Greece, June, 1992.

288. Murad, F.: The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular
communication. Presented at the 8th Intl. Conf. on Second Messengers and Protein
Phosphorylation. Glasgow, Scotland, August, 1992.

289. Murad, F.: Isoenzymes of nitric oxide synthase: The nitric oxide-cyclic GMP signal transduction
pathway in intercellular and intracellular communication. Presented at the 8th Intl. Symp. on
Calcium-Binding Proteins and Calcium Function in Health and Disease. Davos, Switzerland,
August, 1992.

290. Mitchell, J., Kohlhaas, K., Sorrentino, R., Murad, F., Warner, T. and Vane, J.: Induction of calcium-
independent nitric oxide synthase in rat mesentery during sepsis does not impair the vascular
response to vasoconstrictor agonists. Brit. J. Pharmacol.,

291 Murad, F.: Nitric oxide. Presented at the Laurention Hormone Conference, Puerto Rico,
November 1992.
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292. Ignarro, L., Sheng, H., Buga, G. and Murad F.: Distribution of neuronal NO synthase in rat penis.
FASEB, abstract 1488, April, 1993.

293. Murad, F.: The nitric oxide-cyclic GMP signal transduction system for intercellular and intracellular
communication. Presented at the Japanese Pharmacology Meeting, Yokohama, Japan, March,
1993.

294. Murad, F.: The nitric oxide - cyclic GMP signal transduction system for intercellular and
intracellular communication. Presented at the Japanese Pharmaceutical meeting, Osaka, Japan,
March, 1993.

295. Murad F.: The nitric oxide - cyclic GMP signal transduction system. Presented at the National
Institutes of Health Workshop on Nitric Oxide in the Lung. Bethesda, Maryland, April, 1993.

296. Murad, F.: The nitric oxide-cyclic GMP pathway. Presented at the Canadian Biological Societies
Meeting, WIndsor, Canada, June, 1993.

297. Murad, F.: The nitric oxide-cyclic GMP signal transduction system. Presented at the
Histochemistry Soc. Meeting, Bethesda, Maryland, Aug., 1993.

298. Murad, F.: Nitric oxide signal transduction. Presented at the Southeastern Pharmacol. Soc.
Meeting, Memphis, Tennessee, October, 1993.

299. Murad, F.: The nitric oxide-cyclic GMP signal transduction system. Presented at the Medicine
Group Therapeutic Advances Meeting, Newport Beach, California, October, 1993.

300. Murad, F.: The nitric oxide-cyclic GMP signal transduction system. Presented at the Banbury
Conference on Nitric Oxide: Molecular Mechanisms of Synthesis and Action, Cold Spring Harbor,
New York, November, 1993.

301. Murad, F.: The nitric oxide-cyclic GMP signal transduction system. Presented at the Uehara
Symposium on Endothelium-Derived Factors and Vascular Functions. Tokyo, Japan, December,
1993.

302. Murad, F.: The nitric oxide-cyclic GMP signal transduction system. Presented at the 38th Oholo
Conference on Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide, Eilat, Israel,
April, 1994.

303. Buechler, W., Aktos, J., Muller, S., Murad, F., and Gerzer, R.: Baculovirus-mediated high level
expression of a functional soluble guanylyl cyclase. Presented at the International Conf. on the
Biochemistry and Molecular Biology of Nitric Oxide, Los Angeles, California, July, 1994.

304. Murad, F.: The nitric oxide-cyclic GMP signal transduction system. Presented at the International
Conf. on the Biochemistry and Molecular Biology of Nitric Oxide, Los Angeles, California, July,
1994.

305. Young, A., Murad, F., Xie, J., Rife, T. Seiff, M., and Roddy, P.: Human neuronal nitric oxide
synthase gene transcription initiates at multiple sites involving at least two promoters. Presented
at the International Conf. on the Biochemistry and Molecular Biology of Nitric Oxide, Los Angeles,
California, July, 1994.
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306. Papapetropoulos, A., Marczin, N., Mora, G., Milici, A., Murad, F., and Catravas, J.: Regulation of
soluble guanylate cyclase activity, message and protein levels by cyclic AMP elevating agents.
Presented at the FASEB meetings, Atlanta, Georgia, April, 1995.

307. Murad, F.: Nitric oxide and cyclic GMP signaling. Presented at the Nitric Oxide Symposium,
FASEB, Atlanta, Georgia, April, 1995.

308. Murad, F.: Nitric oxide and cyclic GMP. Presented at the 9th Intl. Conf. on Second Messengers
and Phosphoproteins. Nashville, Tennessee, October, 1995.

309. Murad, F.: Nitric oxide: Its potential significance in vascular and nrueological diseases. Presented
at the Fourth International Symposium on Functional Medicine. Aspen, Colorado, May, 1997.

310. Murad, F.: Nitric oxide and cyclic GMP in cell signalling, Plenary lecture presented at the 33rd
International Congress of Physiological Sciences. St. Petersburg, Russia, July, 1997.

311. Murad, F.: Nitric oxide as a second messenger. Presented at the Recent Progress in Hormone
Research Conference, Stevenson, WA, August, 1997.

312. Murad, F.: Nitric oxide and guanylyl cyclase activation. Presented at the Endothelial Regulation of
Vascular Tone Meeting, Amer. Physiol. Soc., Fall Conference, Augusta, Georgia, Sept., 1998.

313. Murad, F.: Nitric oxide and cyclic GMP signaling, Presented at the Tenth International Conf. on
Second Messengers and Phosphoproteins, Jerusalem, Israel, November, 1998.

314. Ankoma-Sey, V., Wang, Y., Behbod, F., and Murad, F.: Reactive oxidative species during liver
injury and repair: contribution of nitrotyrosine during hepatic stellate cell activation at Amer. Assoc.
of the Study of Liver Diseases meeting in Chicago, Ilinois, November, 1998.

315. Murad, F.: Nitric oxide and cyclic GMP in cellular signaling, Nobel Lecture, Karolinska University,
Stockholm, Sweden, December, 1998.

316. Murad, F. Cellular signaling with nitric oxide and cyclic GMP. Basic and Clinical Aspects of Nitric
Oxide meeting, Iguacu, Brazil, March, 1999.

317. Murad, F. Discovery of nitric oxide and cyclic GMP signaling. UCLA Vascular Biology
Symposium, Los Angeles, California, March, 1999.

318. Murad, F. Nitric oxide production and therapeutic implications. Plenary Lecture, Amer. Soc. For
Clinical Pharmacology and Therapeutics, 100th annual meeting, San Antonio, Texas, March, 1999,

319. Murad, F. Cellular signaling with nitric oxide and cyclic GMP. Annual Biomedical Sciences
meeting, Taipai, Taiwan, April, 1999,.

320. Murad, F. Perspectives on Nitric oxide, NICHD Conference on Vasoactive Substances and free
radicals in perinatal biology. Alexandria, Virginia, May, 1999,

321. Murad, F. Nitric Oxide, Human Anatomy and Physiology Society Meeting, Baltimore, Maryland,
May, 1999,

322. Murad, F. Cellular Signaling with nitric oxide and cyclic GMP. Presented at the German
Aerospace Center symposium on Science Summit Space, Cologne, Germany, June, 1999,
Ferid Murad, M.D., Ph.D.
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323. Murad, F. Personal perspectives on nitric oxide, NASA Nitric Oxide meeting, Houston, TX,
August, 1999.

324. Murad, F. Cellular signaling with nitric oxide and cyclic GMP. Presented at the Congress on Heart
Failure, Rome, Italy, September, 1999.

325. Murad, F. Cellular signaling with nitric oxide and cyclic GMP. Presented at College Marocain
Interdisciplinaire de Couer et des Vaisseaux, Rabat, Morocco, October, 1999.

326. Carmines, P., Pollock, J.S., Ishii, N., Patel, K.P., Lane, P.H., Bian, K., and Murad, F. Tyrosine
nitration accompanies increased nitric oxide and superoxide anion production in renal cortex
during the hyperfiltration stage of diabetes mellitus. Amer. Nephrology Meeting, Miami, Florida,
November, 1999.

327. Bian, K., Harari, Y., Lai, M., Weisbrodt, N. and Murad, F. Gut mediated systemic down-regulation
of nitric oxide synthase-2 expression. Amer. Gastro. Assoc., Submitted, 1999.

328. Murad, F. Nitric oxide in cellular signaling, Amer. Nephrology meeting, Miami, Florida, November,
1999.

329. Murad, F. Cellular signaling with nitric oxide, Assoc. Academic Surgeons meeting, Philadelphia,
Pennsylvania, November, 1999.

330. Jablecki, N.T., Bian, K., Harari, Y., Lai, M., Walker, C., Weisbrodt, F. and Murad, F. The effect of
lipopolysaccharide and Trichinella spiralis on levels of inducible nitric oxide synthase (iNOS) in
jejunum and ileum of rat. Exper. Biol. Meeting, April, 2000.

331. Murad, F. Nitric oxide cell signaling. Internat. Symposium on Neuroprotection and the Eye, San
Antonio, Texas, March, 2000.

332. Murad, F. Cellular signaling with NO and cyclic GMP. Annual Meeting Assoc. Medical School
Pharmacology. Sea Island, Georgia, February, 2000.

333. Murad, F. Nitric oxide and gastrointestinal diseases, 11th Asian Pacific Congress of
Gastroenterology, Hong Kong, March, 2000.

334. Murad, F. Nitric oxide signaling. Annual meeting of the German Society for Cell Biology,
Karlsruhe, Germany, March, 2000.

335. Murad, F. Nitric oxide celular signaling. FASEB meeting lecture, San Diego, California, April,
2000.

336. Murad, F. Cellular signaling with nitric oxide. Plenary lecture. Joint meeting of Amer. Soc. Of
Clin. Invest. and American Assoc. of Physicians, Baltimore, May, 2000-06-23

337. Bian, K. Gut mediated systemic down-regulation of nitric oxide synthase-2 expression. Digestive
Disease Week and the 101st Annual Meeting of the American Gastroenterological Association,
San Diego, May, 2000.

338. Murad, F. Keynote Lecture. Nitric Oxide: A unique signaling molecule. Internat. Society for Heart
Res. Meeting, Louisville, June, 2000.
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339. Leite, J.P., Martins, A.R., Terra-Bustamante, V.C., Chimelli, L., de Nucci, G., Assirati, J.A., and
Murad, F. The reorganization of hippocampal no-ergic synapses is associated with increased
expression of soluble guanylyl cyclase immunoreactivity on CA1 pyramidal neurons in temporal
lobe epilepsy. American Epilepsy Society, San Diego, California, December, 2000.

340. Murad, F. Nitric oxide signaling. NATO meeting on Nitric Oxide, Sicily, Sept., 2000.

341. Murad, F. Medical research in the next millennium. Presented at the 2nd Chinese Hi Tech Fair
meeting, Shenzhen, China, Oct., 2000.

342. Murad, F. Cellular signaling with nitric oxide and cyclic GMP. Presented at the Nobel Symposium
Polytechnic University, Hong Kong, China, Oct., 2000.

343. Murad, F. Plenary lecture. Cellular signaling with nitric oxide and cyclic GMP. Presented at the
Twelfth International Pathogenic Neisseria Conf., Galveston, TX, Nov., 2000.

344. Bhuiyan, B.M., Murad, F., and Fant, M.E. The placental cholinergic system: localization to the
cytotrophoblast and regulation of nitric oxide. 2001 Pediatric Academic Societies Meeting, 2001.

345. Mailman, D., Gantuku, S., Bhuiyan, M.B.A., and Murad, F. Organ sites of lipopolysaccharide
(LPS)-induced nitric oxide (NO) production in the anesthetized rat. Shock Society meeting, 2001.

346. Bian, K., Harari, Y., Zhong, M., Weisbrodt, N., and Murad, F. Tissue inflammation and tyrosine
nitration: Role of nitric oxide and myeloperoxidase in nitrotyrosine formation. FASEB, 15, 190.11,
2001.

347. Bian, K., and Murad, F. Diversity of endotoxin-induced nitrotyrosine formation in macrophage-
endothelium rich tissues. FASEB, 15, 190.12, 2001.

348. Murad, F. Cellular signaling with nitric oxide and cyclic GMP. NIH Symposium on Insights into
signal transduction. Bethesda, MD, March, 2001.

349. Murad, F. Cellular signaling with NO and cyclic GMP. Japanese Soc. Legal Medical Conference,
Kurune, Japan, April, 2001.

350. Bian, K., Weisbrodt, N. and Murad, F. Ca++-channel protein nitration and intestinal smooth muscle
contractility. Amer. Gastroenterological Assoc. Meeting, Atlanta, GA, May, 2001.

351. Bian, K., Harrari, Y., Zhang, M., Lai, M., Weisbrodt, N. and Murad, F. Intestinal protein nitration
induced by myeloperoxidase. Amer. Gastroenterological Assoc. Meeting, Atlanta, GA, May, 2001.

352. Murad, F. Nitric oxide and cyclic GMP in cell signaling. Endothelial meeting, Kracow, Poland,
May, 2001.

353. Murad, F. Role of NO and cGMP in Cellular Signaling. Kyoto – Neuro 2001 Symposium, Osaka,
Japan, September, 2001.

354. Murad, F. Cardiovascular effects of nitric oxide and cyclic GMP. Presented at the 17th
International Meeting of Clinical Cardiology, Athens, Greece, May, 2002.

355. Murad F. Cellular Signaling with Nitric Oxide. Free Radical Symposium, Chicago, Illinois. May 20-
24, 2002.
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356. Bian, K., Zhong, M., Harari, Y., Weisbrodt, N., and Murad, F. Down regulation of NOS-2 by an IL-
4Rα/Stat6-dependent and T-cell independent pathway during parasite-induced gut inflammation.
103rd Annual meeting of the American Gastroenterological Assoc., San Francisco, May, 2002.

357. Murad, F. Cell Signaling with Nitric Oxide and Cyclic GMP. 25th Congress of Mexican
Ophthalmology, Morelia, Mexico, August, 2002.

358. Murad F. Cellular Signaling with Nitric Oxide and Cyclic GMP. Retreat Seminar, Department of
Physiology & Physics, University of Alabama, Birmingham, AL. October 16-18, 2002.

359. Murad, F. Nitric oxide, cyclic GMP and cell signaling. Keynote address, the Second Sino-US
Symposium, Shanghai, China, October, 2002.

360. Bian, K., Gao, Z., Weisbrodt, N., and Murad, F. The nature of heme/iron-induced protein tyrosine
nitration. Exper. Biol. Meeting, April, 2003.

361. Murad, F. Nitric oxide and cyclic GMP regulation in biology. Japanese Society of Oral
Therapeutics and Pharmacology meeting, Osaka, Japan, February, 2003.

362. Bian, K., Gao, Z., Weisbrodt, N., and Murad, F. The nature of heme/iron-induced protein tyrosine
nitration. Exper. Biol. Meeting, April, 2003.

363. Murad, F. Nitric oxide and cyclic GMP, 13th Internat. Conference on Laboratory Medicine and
10th European Conference of Clinical Molecular Biology, Capri, Italy, June, 2003.

364. Murad, F. The nitric oxide story, Canadian Soc. Clin. Pharmacol. Meeting, Ottawa, Canada,
Sepember, 2003.

365. Murad, F. Nitric oxide and cyclic GMP in cellular signaling. Islamic Academy of Science meeting,
Kuching, Malaysia, September, 2003.

366. Murad, F. Importance of animals in nitric oxide research, Amer. Assoc. Lab. Animal Science
meeting, Seattle, Washington, October, 2003.

367. Turko, L., and Murad, F. Quantitative protein profiling in heart mitochondria from diabetic rats
using stable isotope labeling with denterated acrylamide IUBMB XIX World Congress,
Montreal,Canada, October, 2003.

368. Murad, F. How does the blood vessel constrict or dilate? International Conference on Heart,
Hypertension, and Diabetes. Hyderabad, India, November, 2003.

369. Murad F. Nitric oxide in cellular signaling and drug development, International Peace Foundation
lecture series, (4 lectures). Bangkok, Chiang Mai, Khen Kaen and Song Kla, Thailand, January
2004.

370. Murad F. Application of nitric oxide research to drug development. 8th International Conference on
Business and Economic Development. Monterrey, Mexico, January, 2004.

371. Murad F. Discovery of nitric oxide and its applications for drug development. Presented at the
Houston Society for Engineering in Medicine and Biology, Houston, Feb., 2004.

372. Murad, F. Guest speaker, 26th National Arab American Medical Association meeting, Houston,
October, 2004.
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373. Murad, F. Keynote speaker, Bioastronautics meeting, Galveston, TX, Jan. 2005.

374. Murad, F. Plenary Speaker, Nitric oxide discovery and role in cell signaling and drug
development. Western Assoc. Physicians meeting, Carmel, Feb., 2005.

375. Murad, F. Keynote speaker, Society of University Surgeons meeting, Nashville, TN, Feb. 2005.

376. Seminara AR. Murad F. MEK-ERK Kinase 1 (MEKK1) transcriptional regulation by nitric oxide
(NO) in murine macrophages. XXXV International Congress of Physiological Sciences, San
Diego, CA, April 3, 2005.

377. Murad, F. Keynote speaker, Application of nitric oxide and cyclic GMP research to drug
development. First Internat. Conf. on Biological and Medical Physics, United Arab Emirates,
March, 2005.

378. Murad, F. Speaker DeLange Conference, Rice University, Frontiers of Medicine, March, 2005.

379. Murad, F., Keynote Speaker, European Metabalic Group meeting, Prague, May, 2005.

380. Murad, F., Speaker, Three Master Course Lectures, Valencia, Spain, May, 2005.

381. Murad, F., Speaker, Cyclic GMP meeting, Potsdam, Germany, June, 2005.

382. Murad, F., Lecture, Campus de Excellence meeting, Canary Islands, June, 2005.

383. Murad, F., Lecture, Annual Meeting of Association of Pakistani Physicans of North America,
Houston, TX, July 2005

384. Murad, F., Keynote Speaker, Biotech and Life Sciences Global Venture Congress, New York, NY,
August 2005.
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