R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a

Sixth Semester B. Pharm Degree Examination – 18-12-2020

Time: Three Hours Max. Marks: 75 Marks

PHARMACOLOGY - III
Q.P. CODE: 5024
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.

LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks

1. Classify anti ulcer agents with examples. Write mechanism of action and therapeutic uses of PPIs.
2. Classify Penicillins. Write mechanism of action, adverse effects and uses of Penicillin– G.

3. Classify antitubercular agents. Explain mechanism of action of INH and Rifampicin.

SHORT ESSAYS (Answer any Seven) 7 x 5 = 35 Marks

4. What is bronchial asthma? Classify drugs used in its treatment.
5. Classify antibiotics on the basis of mechanism of action along with examples.
6. Write mechanism of action and uses of streptomycin.
7. Write mechanism of action, adverse effects and uses of Zidovudin.
8. Write a flow chart showing life cycle of plasmodium species.
9. Describe mechanism of action and therapeutic uses of alkylating agents.
10. Explain mechanism of action and uses of cyclosporine.
11. Outline the steps involved in the elimination of orally ingested poisons.
12. Explain the terms acute, subacute and chronic toxicity studies along with their purpose.

SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks

13. Enlist non systemic antacids.
14. Write uses of expectorants and Antitussives.
15. What are nasal decongestants? Give examples.
16. Mention four classes of antibiotics acting by inhibiting cell wall synthesis.
17. Mention the drugs used for treatment of filariasis.
18. Mention common causative organisms for UTI.
19. Enlist corticosteroids.
20. What is teratogenecity? Give an example.
21. Mention four biological rhythms.
22. What is biological clock?

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 R a jiv G a n d h i U n iv e r s i t y o f H e a l t h S c ie n c e s , K a r n a t a k a
SixthSemesterB.PharmDegreeExamination– 18-Mar-2021

Time:ThreeHours Max.Marks:75Marks

PHARMACOLOGY-III
Q.P.CODE: 5024
Your answers should be specific to the questionsasked.
Draw neatlabeleddiagramswherever necessary.
All theQuestions are compulsory

LONGESSAYS 2x10=20Marks

1. Classify antiemeticswith examples. Explainmechanism of actionandusesof domperidone.

OR
Write sources, mechanism of action, adverse effects and therapeutic uses of tetracyclines.

2. Classify antifungal agents with examples. Write mechanism of action, adverse effects and therapeutic uses of
Triazoles.

SHORTESSAYS 7x5=35Marks
3. Mentionxanthine derivatives and write their mechanism of antiasthmatic action.
OR
Write a noteoncauses and preventionof antimicrobial resistance.
4. Write mechanism of actionandmerits of cotrimoxazole.
OR
Describe mechanism of actionof chloroquine.
5. Classify antiviral andantiretroviral agents withexamples.
6. Write mechanism of actionandadverseeffectsof methotrexate.
7. Write mechanism of action, adverse effectsand usesof corticosteroids.
8. Outline the steps involved in the management of acute poisonings.
9. Write clinical symptoms of heavymetalspoisonings. Add a note ontheir antidotes.

SHORTANSWERS 10x2=20Marks

10. Mentionfour Antidiarrheals.

11. List respiratory stimulants.

12. Mentionfour antitussive agents.

13. Mentionfour classesof antibiotics acting byinhibitingproteinsynthesis.

14. Mention four malarial parasites.

15. Write causativeorganismsanddrugof choice for syphilisandgonorrhoea.

16. Enlistfour immunostimulants.

17. Mentionantidotesfor morphineand organophosphorouspoisonings.

18. Mentiondrugsaffected bycircadianrhythm.

19. What are infradian rhythms? Give anexample.

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 R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
SixthSemesterB.PharmDegreeExamination– 16-Nov-2021

Time:ThreeHours Max.Marks:75Marks

PHARMACOLOGY-III
Q.P.CODE:5024
Your answersshouldbespecific to the questions asked.
Drawneat labeled diagrams wherevernecessary.
All theQuestions are compulsory.

LONGESSAYS 2x10=20Marks

1. Classify semi synthetic penicillinswithexamples? Discuss antimicrobial spectrum, mechanismof actionand usesof
ampicillin.
OR
Classify antifungal agentswithexamples.Discuss anti-fungal spectrum, mechanism of actionanduses of systemic
Triazoles.

2. Classify anti-emetics withexamples. Write mechanism of action, adverse effectsand usesof domperidone

SHORTESSAYS 7x5=35Marks
3. What are respiratory stimulants?Explainpharmacology of anyone.
OR
Explainrationale behindcombined therapyof antimicrobial agents withexamples.
4. Classify tetracyclineswith examples. Explainwhytetracyclinescauses discolorationof teeth.
OR
Classify antiviral agentswith examples. Write mechanismof action and usesof Zidovudin.
5. Classify anthelmintic agents withexamples. Write mechanism of actionof Benzimidazoles.
6. Write mechanism of action, adverse effects and usesof methotrexate.
7. What are Immunosupressants and immunostimulants? Giveexamples.Writetheir applications.
8. Explain about elimination of orally ingested poison.
9. Explainthe terms carcinogenicity and Mutagencity withexamples.

SHORTANSWERS 10x2=20Marks
10. What are antacids? Write their uses.
11. What are the differencesbetweenexpectorants and Antitussives?
12. Mentionmast cell stablizers.
13. What isSuperinfection? Give examples.
14. Mention types of leprosy.
15. Mentioncommon causative organism of sexually transmitteddiseases.
16. What are monoclonal antibodies used forimmunosuppression.
17. Write antidotes formorphine and leadpoisoning.
18. What iscircadianrhythm?
19. Explainthe term Chronopharmacology.
R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
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 R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
SixthSemesterB.PharmDegreeExamination– 16-Jun-2022

Time:ThreeHours Max.Marks:75Marks

PHARMACOLOGY-III
Q.P.CODE:5024
Your answersshouldbespecific to the questions asked.
Drawneat labeled diagrams wherevernecessary.
All theQuestions are compulsory.

LONGESSAYS 2x10=20Marks

1. What are laxatives and purgatives?Classify them withexamples.Write the mechanism of actionandusesof saline
cathartics.
OR
What are aminoglycoside antibiotics? Write the antimicrobial spectrum, mechanismof action, adverse reactions and
therapeuticusesof streptomycin.

2. Classify antifungal agentswithexamples.Writethemechanismof action, adverse reactions and therapeutic uses of

amphotericinB.

SHORTESSAYS 7x5=35Marks
3. What are mucolytics? Give examples. Write mechanism of actionof Bromohexine.
OR
What are polyene antibiotics? Give examples. Enlist theirtherapeutic uses.
4. What are sulfonamides? Classifythem withexamples.
OR
Classify antiviral agentswith examples. Write the mechanismof action, adverseeffectsandtherapeuticusesof
zidovudine.

5. Write the mechanism of actionandusesof chloroquine.

6. Classify alkylating agents and write theirmechanismof action.
7. Classify Immunosupressantswith examples, write the mechanism of actionof tacrolimus.
8. Write the signs, symptoms and treatment of morphine poisoning.
9. Explainmutagenicityand chronic toxicity withsuitable examples.

SHORTANSWERS 10x2=20Marks
10. What are appetizers? Give examples.
11. What are nasal decongestants?Give examples.
12. What are the Differences betweenbronchial asthma and COPD?
13. Givefour reasonsfor combineduse of antibiotics.
14. Outline mechanism of action of metronidazole.
15. Mentionfour urinaryantiseptics.
16. Write adverseeffectsof Cyclosporin.
17. Write signsand symptomsof organophosphorous poisoning.
18. What iscircadianrhythm? Giveanexample of drug affectedby it.
 R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
19. Explainthe term Chronopharmacology.

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 R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
SixthSemesterB.PharmDegreeExamination– 18-Nov-2022

Time:ThreeHours Max.Marks:75Marks

PHARMACOLOGY-III
Q.P.CODE:5024
Your answersshouldbespecific to the questions asked.
Drawneat labeled diagrams wherevernecessary.
All theQuestions are compulsory.

LONGESSAYS 2x10=20Marks

1. Classify antiulcer drugs withexamples. Write the mechanism of action, adverse effectsand usesof Omeprazole.
OR
Define broad spectrum antibiotics with examples. Explain the mechanism of action, adverse effects and uses of
tetracyclines.

2. Define classify antimalarial drugswith examples. Write the mechanismof action, adverseeffectsanduses of
Artemisinin.

SHORTESSAYS 7x5=35Marks
3. What are polyene antibiotics? Give examples. Write their therapeutic uses.
OR
Classify immunosuppressantswithexamples.Writethemechanismof actionof Tacrolimus.

4. What are respiratory stimulants?Explainpharmacology of anyone.

OR
Classify antileprotic drugs withexamples. Write about Dapsone.

5. Explaincarcinogenicity andmutagenecitywith examples.

6. Classify antibiotics onthe basisof mechanism of actionwithexamples.
7. Write about mechanism of actionandtoxicityof penicillins.
8. Write about symptoms and managementof barbiturates poisoning.
9. Write about drugsused intreatmentof urinarytract infections.

SHORTANSWERS 10x2=20Marks
10. What isGray Baby syndrome?
11. What iscircadianrhythm? Giveanexample of drug affectedby it.
12. Enlist four immunostimulants.
13. Name four different classes of antibioticsacting by inhibiting proteinsynthesis.
14. Give examples for mast cell stabilizers.
15. Write antidotes formorphine and leadpoisoning.
16. What isChronopharmacology?
17. Write the mechanism of actionof alkylating agents.
18. Define Mucolyticswithexamples.
19. What are carminatives?Give examples.
R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
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 R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
SixthSemesterB.PharmDegreeExamination– 01-Jun-2023

Time:ThreeHours Max.Marks:75Marks

PHARMACOLOGY-III
Q.P.CODE:5024
Your answersshouldbespecific to the questions asked.
Drawneat labeled diagrams wherevernecessary.
All theQuestions are compulsory.

LONGESSAYS 2x10=20Marks

1. Classify drugs used in pepticulcer. Write the mechanism of actionadverse effects of proton pumpinhibitors.
OR
Classify cephalosporinswithexamples.Describe theirmechanismof actionand uses.

2. Classify antifungal agentswithexamples.Writemechanismof action, adverse effects and uses of amphotericin-B.

SHORTESSAYS 7x5=35Marks
3. Explainpharmacologyof Salbutmol.
OR
Define chemotherapy.Writeclassification of antibacterial agents.

4. Classify anti-tubercular drugs withexamples and write the mechanism of actionINH.

OR
Classify typesof anti-metabolites withexamples.

5. Write mechanism of action, adverse effects and usesof Chloroquine.

6. Classify antiamoebic agentswithexamples.Write the uses of Tinidazole.
7. Write brieflyon monoclonal antibodieswithexamples.
8. Write clinical symptoms and outline steps involved in the treatment of morphine poisoning.
9. Write brieflyon teratogenicity testswithexamples.

SHORTANSWERS 10x2=20Marks
10. What are antidiarrhoeal?Give examples.
11. What are nasal decongestantswithanexample?
12. What are mucolytics and giveone example.
13. Mentiontwo modesof antibiotic resistance.
14. What are blood schizonticides? Give one example.
15. Mentionthe first line of drug therapyfor syphilis.
16. Write the adversereactionsof tacrolimus.
17. What are the antidotes forlead andmercury?
18. What isChronopharmacology?
19. Explainthe biological rhythm.

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 R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
SixthSemesterB.PharmDegreeExamination– 06-Nov-2023

Time:ThreeHours Max.Marks:75Marks

PHARMACOLOGY-III
Q.P.CODE:5024
Your answersshouldbespecific to the questions asked.
Drawneat labeled diagrams wherevernecessary.
All theQuestions are compulsory.

LONGESSAYS 2x10=20Marks

1. Classify laxativesand purgatives withexamples. Write mechanism of actionand uses of irritant purgatives.
OR
Classify semi synthetic penicillinswithexamples.Describe theirmechanismof actionand uses.

2. Classify antiamoebic agentswithexamples.Write mechanism of action, adverse effects and usesof metronidazole.

SHORTESSAYS 7x5=35Marks
3. Explainpharmacologyof selectiveβ2 agonists.
OR
Define chemoprophylaxis.Write brieflyon itstypes along withexamples.

4. Classify Tetracyclines withexamples and write their mechanism of action.

OR
Classify typesof leprosyand antileproticagentswith examples.

5. Write mechanism of action, adverse effects and usesof amphotericin-B.

6. Classify anticancer agentswithexamples.
7. Classify immunosuppressantswithexamplesandmentiontheir uses.
8. Write clinical symptoms and outline steps involved in the treatment of barbiturates poisoning.
9. Write brieflyon special toxicity tests.

SHORTANSWERS 10x2=20Marks
10. What are antacids? Give examples.
11. Discusstheadverse drug reactionsof bromhexine.
12. What are the causesof COPD?
13. What are adverseeffectsof corticosteroids?
14. What is treatment for urinary tract infection?
15. Mentionone sexual transmitted diseasesandtreatment.
16. Write adverseeffectsof rifampicin.
17. Mentionantidotes forarsenicand lead.
18. Classificationof anti malarial agents.
19. Explaingenotoxicity.

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 R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
SixthSemesterB.PharmDegreeExamination– 12-Jun-2024

Time:ThreeHours Max.Marks:75Marks

PHARMACEUTICALBIOTECHNOLOGY
Q.P.CODE:5027
Your answersshouldbespecific to the questions asked.
Drawneat labeled diagrams wherevernecessary.
All theQuestions are compulsory.

LONGESSAYS 2x10=20Marks

1. Describe any three methods of enzyme immobilization. Illustrate the applications of immobilised enzymes in
medicine and production of pharmaceuticals.
OR
Describe the productionof insulinbyrecombinant DNAtechnology.

2. Describe the different methods of fermentation. Explain the production of griseofulvin by fermentation technology
witha neatlabelledflowchart.

SHORTESSAYS 7x5=35Marks
3. Describe the productionand uses of penicillinase.Listout advantages of productionof enzymesfrommicrobial
sources.
OR
Explainthe production of hepatitisB vaccinebyrDNA technology.

4. What are restriction enzymes? Explainthetypesandtheirrole in geneticengineering.

OR
Explaindifferent types of mutations.

5. Describe the productionof monoclonal antibodies by hybridoma technology.

6. Outline the general method for the preparation of bacterial toxoids.
7. What are vaccines? Classify the typeswithexamples.
8. Describe the Southernblot testwith itsapplications.
9. What istransduction? Explain the methods.

SHORTANSWERS 10x2=20Marks
10. List out anyfour applicationsof enzymes inmedicine.
11. Write anyfour advantagesof immobilised enzymes.
12. What iscellular immunity?
13. What isprotected fermentation?
14. What isimmune suppression?Give two examples for immunosuppressive agent.
15. Write anyfour properties of Immunoglobulin G.
16. What are the conditionsfor storage of official vaccines?
17. What are Transposons?
18. Write anytwoapplications of ELISA.
19. What do you meanby conjugationandtransformation?
R a ji v G a n d h i U n i v e r s i t y o f H e a l t h S c i e n c e s , K a r n a t a k a
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