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Pathology OSPE Charts

The document presents a series of clinical case charts detailing various patients with symptoms and laboratory findings indicative of different medical conditions. Each chart includes questions regarding probable diagnoses, findings in peripheral smears, causes of the conditions, and differences between related medical terms. The cases cover a range of hematological disorders, including anemia, leukemias, and thrombosis.
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0% found this document useful (0 votes)
251 views10 pages

Pathology OSPE Charts

The document presents a series of clinical case charts detailing various patients with symptoms and laboratory findings indicative of different medical conditions. Each chart includes questions regarding probable diagnoses, findings in peripheral smears, causes of the conditions, and differences between related medical terms. The cases cover a range of hematological disorders, including anemia, leukemias, and thrombosis.
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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CHART-1

20 year female weakness. fatiguability,


month.
breathlessness since 1
H/O pica on examination- pallor +++
Koilonychia +
Clinical findings - Tachypnoea.

Q1. Give probable diagnosis? (1)mark

02. Mention four findings in


peripheral
smear of this condition. (2)marks

Q3. Enumerate four causes of this condition.


(2)marks
CHART-2

40year female with strict vegetarian diet- with increasing


fatigue, lethargy and muscle weakness.
On examination red beefy tongue and tingling numbness in
lower legs.
Her CBCshow: Hb -10.69 gm/dl,
TLC 2100 /cmm
MCV- 132fl

Platelet- 80,000/cmm.
Q1. What is your probable diagnosis? (1)mark
Q2. Mention findings in peripheral
smearof thiscondition. (2)marks
Q3. Enumerate causes of this condition. (2)marks
CHART3

22yr old male with problems of long duration anaemia. He showed


mild features of icterus and spleenomegaly.
Blood investigations: Hb: 9gm/dl
Peripheral smear shows fragmented rbc's
Total bilirubin 5mg/dl
Indirect bilirubin 4.8mg/di

Q1. What is the most likely diagnosis in this individual? (1)mark

Q2. Enumerate cause of above diagnosis? (2)marks

Q3. Mention two differences between conjugated and (2)marks


unconjugated bilirubin.
CHART -4

15 yr male with complaints of bleeding from nose & gums.


Mild splenomegaly +.
Mld hepatomegaly +.
No lymphadenopathy.
P.S.->35% blast and few Auer rods.

1)What is probable diagnosis? (1) mark

2)'What is blast cell count in P.S or bone marrow for diagnosis of


this condition (2)marks

3) Write twodifferences between leukemoid reaction


andCML. (2) marks
CHART-5

72 YROLD MALE
PRESENTED WITH INCREASING FATIGUE. He is found to
have multiple enlarged
lymphnode which are non tender with
hepatosplenomegaly.
On P.S- Normocytic Normochromic Anaemia.
Hemogram - Hb- 10.29 gm/dl
Platelet - 78000/cmm
TLC 72 000 /cmm
DLC Monomorphic population of mature B cells -92%
Neutrophils- 6%
Monocytes - 2%

Q1. What is your probable diagnosis? (1) mark

Q2. Write differences between Myloblast and Lymphoblast? (2) marks

CLL. (2) marks


Q3. Write 2 differences between ALL and
CHART-6

56year male presents with severe backache.


-Urine shows evidence of Bencé Jones protein
-Sr. electrophoresis spike
immunoglobulin (1gm)
-Bone marrow shows - plasma cell proliferation.

Q1. What is most likely diagnosis? (1) mark

Q2. Write two positive investigations to confirm the


diagnosis? (2) marks

03. What are Bence Jones proteins?


(2) marks
CHART-7
10year male having historyof spontaneous haemorrhage in
knee joint.
Lab investigation - prolonged activated partial
thromboplastin time,
Platelet count- Normal,
Bleeding time - Normal &
PT-Normal
Q1. What is probable diagnosis? (1) mark

Q2. What is etiology? (2) marks

Q3. Mention normal range of bleeding time and


time.
clotting
(2) marks
CHART-8
65year female bedridden having history of right femur
fracture
operated for that but bedridden for two months. Pain,
redness in right calf area since& days. swelling,
Investigation: PT increased.
Protein Cactivity decreased.
Protein Sactivity decreased.
Fasting plasma Homocysteine is decreased.
Venous colour drop of right leg vein show
thrombosis in popliteal vein extending up to great
vein. sephanous

Q1. What is your probable diagnosis according to


and investigation?
above history
(1) mark

Q2. Name any 2 Vit.K dependent factors. (2)marks

Q3. Name 2 screening test for above diagnosis. (2) marks


CHART-9
9years female presented with facial bone expansion with prominent
cheek bones.

Xray skull- Hair on end appearance


On examination,

Massive splenomegaly.
CBC- 6gm%

TLC-6000/cmm. DLC- P-56%, L-44%


PS- Microcyte++ Hypochromia++ Anisopoikilocytosis+
Target cell+ Nucleated RBCs + Polychromatic RBCS+ Tear
drop cells+
Reticulocyte count increased.

1) What isyour diagnosis?


(1) mark

2) Which type of anaemia seen in above


case.and mention the
investigation to confirm the diagnosis? (2) marks

3) Mention 2 causes of
splenomegaly. (2) marks
CHART -10

Syr male puffiness of face, swelling over body since one month. On
examination: generalized edema (Anasarca)
Clinical findings: Anaemia- Microcytic hypochromic type.
Urine examination: Foamy urine
Protein +++

Microscopy urine shows: Waxy cast


Serum cholesterol level: 300 mg/dl(Increased)
Serum triglyceride levels increased.

Q1. Give probable diagnosis. (1)mark

Q2. Give relevant investigations with positive findings. (2) marks

Q3.Give clinical features which constitute this disorder. (2) marks

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