Hematology
Long answer
A 56 year old presented to the OPD with history of weakness and
distension of abdomen. On examination he was pale with moderate
splenomegaly CBC done showed Hb-8gms% platelet count 8 lakhs cell/cumm,
Total count-1,15,000 cells/cumm with Eosinophils-18%
a) What is your probable diagnosis? Give reason it? (2) CML
b) Explain in brief its etiopathogenesis and phases of above condition?(4)
c) Outline its laboratory investigations? (4)
A 32-year-old female presented with severe pallor and history of easy
fatiguability and lassitude to the OPD. Routine CBC showed Hb-4gms% Total
count-1.45x109/dl, Platelet count is 30,000 Cells/cumm. Peripheral smear
showed: Many atypical WBC’s with auer rods
a) What is your probable diagnosis? Give reason (2) AML
b) Mention in brief its FAB classification (3)
c) Describe in brief lab diagnosis and prognostic factors (5)
A 55-year-old lady presented with features of fatigue, weakness and
multiple bone pains. Skeletal x-ray revealed multiple osteolytic lesions in the
skull and vertebrae. Peripheral smear showed plenty of mature and immature
plasma cells.
a)What is the most likely diagnosis? (2) Multiple myeloma
b)Explain the pathophysiological basis of this condition(4)
c)Adda note on the laboratory diagnosis and complications of this condition(4)
A 58 year old man presented with fever, fatigue and weakness. On
examination pallor present. Per abdomen examination showed massive
splenomegaly. CBC was done. Total Leucocyte Count was markedly elevated
with basophils – 5%.
i) What is the probable diagnosis? Give reasons (2) CML
ii) Describe the peripheral smear, bone marrow findings of the
condition (4)
iii) Mention the chromosomal aberration of this condition (2)
iv) What are the clinical phases of this condition? (2)
A 12 year old boy with history of multiple episodes of retroperitoneal hematoma
and intramuscular hematoma in thigh and with now he presented with painful
knee swelling following trauma.
a. What is the probable diagnosis (2) Hemophilia
b. Etiopathogenesis and clinical features of above condition (4)
c. Complete lab diagnosis with reason (4)
Short answer
1) Classification and morphological features of Hodgkin’s lymphoma
2) Etiopathogensis and lab diagnosis of megaloblastic anemia
3) Platelet functional disorders
4) Classify hemolytic anemias
5) Explain in brief lab diagnosis and complications of multiple myeloma.
6) Describe Peripheral smear and bone marrow findings in megaloblastic anemia
7) Describe different types of Reed-Sternberg cell with the help of diagrams
8) Describe pathogenesis and Clinical features of ITP
9) Explain in brief, how to counsel a voluntary blood donor, recently diagnosed as
retro positive during Transfusion transmitted infection screening.
10) Lab diagnosis of Multiple Myeloma
11) Describe in brief pathogenesis and lab diagnosis of sideroblastic Anemia
12) Mention four causes of Pancytopenia
13) FAB classification of AML
14) Enumerate the clinical features and laboratory diagnosis of sickle cell anemia
15) Describe in brief lab diagnosis of multiple myeloma.
16) Classify hemolytic anemia.
17) Megaloblastic anemia.
18) Describe etiopathogenesis and lab diagnosis of idiopathic thrombocytopenic purpura.
19) Risk factors and prognostic markers of acute myeloid leukemia
20) What is Reticulocyte? Mention the stains used to demonstrate reticulocyte
21) Mention any 4 causes for Pancytopenia
22) Define thrombocytopenia. Write the normal range
23) Mention the differences between lymphoblast and myeloblast.
24) Classify Hodgkin lymphoma.
25) Explain in detail about Glanzmann thrombasthenia and Bernard- Soulier syndrome.
26) Write a note on Immune thrombocytopenia.
27) Draw microscopic picture of Megaloblastic anemia.
