Practical 6: ORS powder
Powder: These are solid dosage forms of drugs in a finely divided form and intimately mixed.
Classification:
     1. Class I: A. Simple: Containing only one ingredient.
                  B. Compound: Containing more than one ingredient.
     2. Class II: powders enclosed in sachets/capsules.
     3. Class III: Compressed powder.
     4. Class IV: Granular effervescent powder.
     5. Class V: Powders used for external use. E.g. tooth powder.
Packing: in paper or bulk container.
Advantage of packing: Easy to administer and dispense. Accurate quantity is measured and
is more stable.
Exercise: Prescribe and dispense one powder packer of oral rehydration solution (ORS) for a
child aged nine years suffering from moderate dehydration due to diarrhea.
Apparatus: Dispensing balance, weight box, mortar and pestle, paper, thread
Prescription:
                                                                              Dr. B.K. Mehta, BDS,
                                                                    Add.-D-18/B, Medical Campus,
                                                                                Reg. No.- G-41334
                                                                      Date- 26-10-2018, Jamnagar
For,
Mr. K. C. Joshi.
Age-9 year, Male
Add. – Patel colony, 10/3, Akshardham
Jamnagar.
RX
                                        Gm or ml
Sodium chloride                         2    6
Potassium chloride                      1    5
Trisodium citrate                       2    9
Glucose                                 13   5
Mix and prepare. Divide in five packets each weighing 4.1 grams.
Direction: Dissolve the content of one packet in glassful of water and to be given in sips ½ to
1 hrly.
                                                                    Dr. B.K. Mehta, BDS,
                                                                    Reg. No.- G-41334
Procedure:
   ● First weight 2.6 gram of sodium chloride with the help of dispensing balance and then
     transfer it into mortar and triturate it finely. Then transfer the powder in a piece of
     paper.
   ● Likewise weight Potassium chloride (1.5 gram), Trisodium citrate (2.9 gram) and
     Glucose (13.5 gram) one by one triturate them and transfer into separate paper.
   ● Then in ascending order of their weight e.g. potassium chloride, sodium chloride,
     trisodium citrate and glucose is transferred to mortar and mixed properly.
   ● Then make five packets, each packet weighing 4.1 gm. Close and wrap all the five
     packets in a big packet and label it.
Uses:
        It is used as a replacement therapy to compensate fluid and electrolyte for the patient
suffering from mild to moderate dehydration due to diarrhea, vomiting, etc.
Mechanism of action:
   1. Sodium chloride: Sodium helps in absorption of water. Sodium and chloride both
      maintains electrolyte balance.
   2. Potassium chloride: To replenish lost potassium and chloride.
   3. Trisodium citrate: Sodium helps in absorption of water. Citrate compensates acidosis
      by forming HCO3- in liver.
   4. Glucose: Each molecule of glucose helps in absorption of equal amount of absorption
      of sodium via Na+ - Glucose cotransporter operating in ileum.
                                        LABEL
                                      POWDER
                                                                     Date- 26-10-2018
                                                                              Jamngar
For,
Mr. K. C. Joshi.
Age-9 year, Male
Add. – Patel colony, 10/3, Akshardham
Jamnagar.
Direction: Dissolve the content of one packet in glassful of water and to be given in
sips ½ to 1 hrly.
Pharmacy lab,
MPSGMC,
Jamnagar
                                                                           Pharmacist,
                                                                                 Sign