Exp. No.
-14 Date:
Aim: To prepare and submit 10gm of Effervescent granules.
Reference:
Mehta R.M., Dispensing Pharmacy, Vallabh Prakashan, New Delhi, 2017; 127
Subrahmanyam C.V.S., Thimmasetty. J, Prabhushankar G.L., Laboratory manual of Pharmaceutics.
Vallabh Publication, Delhi, 2019; 88
Requirements:
Apparatus Required:
Mortar & pestle, weigh balance sieve shaker, China dish etc.
Chemical Required:
Sodium phosphate, sodium bicarbonate, tartaric acid.
Principle:
Effervescent preparation provides effervescence of CO2 gas when added to water by a chemical
reaction between alkali metal carbonates or bicarbonates with tartaric acid or citric acid. This
preparation is intended to be dissolved in water before it is being taken orally. The CO2 gas is released
as a result of acid-base reaction. The preparation is advised to be taken while effervescence.
Formula:
Sl. No. Ingredients Official formula Working Required quantities
formula
1 Sodium phosphate 0.9gm
2 Sodium bicarbonate 2.1gm
3 Tartaric acid 1.1gm
4 Citric acid 0.7gm 10gm
Calculation:
Procedure:
Citric acid is mixed with sodium phosphate and tartaric acid.
Add sodium bicarbonate to the above mixture and mix it gently.
The final powdered mixture is placed in a China dish previously heated on water bath.
Stir the mixture with the help of a spatula constantly still it becomes damp mass.
Pass damp mass through sieve number 8.
Dry granules at a room temperature not exceeding 540C.
Pass dry granules through appropriate sieve.
Pack dry uniform sized granules in a wide mouthed bottle.
Dose: Each 5g contains sodium phosphate 1g.
Storage: Stored in air tight container in a cool place,
Use: Saline purgative and mild diuretic.
Label:
EFFERVESCENT GRANULES
10gm
Composition:
Sodium phosphate BATCH NO. MFG. DATE:
Sodium bicarbonate
Tartaric acid
MFG. LIC. NO.: EXPIRY DATE:
Citric acid
Category: Saline purgative and Mild diuretic
FOR INTERNAL USE ONLY.
Use: Saline purgative and Mild diuretic
Storage: Stored in a well closed air tight container in a cool place and temperature not exceeding
250C
MFG BY: ABCD Batch: Roll No.:
Report:
Exp. No.-15 Date:
Aim: To prepare and submit 30gm of Dusting powder.
Reference:
Mehta R.M., Dispensing Pharmacy, Vallabh Prakashan, New Delhi, 2017; 115
Requirements:
Apparatus Required: Mortar & pestle, weigh balance, sieve shaker etc.
Chemical Required: Purified talc, starch, zinc oxide
Principle:
Dusting powders are usually mixtures of two or more substances in fine powder intended for external
use. Starch possess binding as well as good flow property which helps the powder to flow easily,
spread uniformly and cling to the skin on application. Talc is natural mineral substance zinc oxide is
protectant.
Formula:
Sl. No. Ingredients Official formula Working formula Required quantities
1 Purified talc 1gm
2 Starch 0.5gm
3 Zinc oxide 0.5gm 30gm
Calculation:
Procedure:
Weigh the required quantity of purified talc and zinc oxide.
Mix zinc oxide with starch and incorporate purified talc.
Mix thoroughly and pass the mixed powder through a sieve no.120 to remove gritty particles.
After sieving whole of the powder must be again slightly mixed.
Pack the powder to protect it from air, moisture and contamination.
Storage: Store in a well closed container and should be kept in a cool place.
Category: Antiseptic dusting powder.
Caution: Do not apply on raw (or) weeping surface.
Direction: For external use only.
Use: Antiseptic.
Label:
DUSTING POWDER
30gm
Composition:
Purified talc BATCH NO. MFG. DATE:
Starch
Zinc oxide MFG. LIC. NO.: EXPIRY DATE:
Category: Antiseptic
FOR EXTERNAL USE ONLY.
Use: Antiseptic
Storage: Store in a well closed container and should be kept in a cool place.
MFG BY: ABCD Batch: Roll No.:
Report:
