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Teratogen S.Y

Teratogens are substances that can cause abnormalities in a developing fetus when ingested by the mother, with examples including synthetic drugs like thalidomide. Various plant constituents such as alkaloids and coumarins are identified as teratogenic, affecting the fetus during early gestation. Specific plants like Indigofera and Leucaena contain teratogenic compounds that can lead to severe developmental issues in livestock and other animals.

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6 views5 pages

Teratogen S.Y

Teratogens are substances that can cause abnormalities in a developing fetus when ingested by the mother, with examples including synthetic drugs like thalidomide. Various plant constituents such as alkaloids and coumarins are identified as teratogenic, affecting the fetus during early gestation. Specific plants like Indigofera and Leucaena contain teratogenic compounds that can lead to severe developmental issues in livestock and other animals.

Uploaded by

mnabonita912
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Teratogens:

• Teratogens are defined as substances


when ingested by the mother, can cause
abnormalities in the developing fetus.
• Synthetic drug: thalidomide
Teratogens:

• These teratogens act for a short period


and early during gestation period.
• Hence these plant components
disappear in the offspring when the
abnormalities become apparent.
Teratogens:
• Teratogenic constituents of plants include:
1. Alkaloids
2. Coumarins
3. Lignans
4. Macrolides
5. Nitriles
6. Terpenoids
7. Toxic amino acids
Most of them contains nitrogen.
Plant source Constituent Teratogenic effects
Leguminosae:
1. Indigofera Indospicine • Indospicine, a non-proteinogenic
spicata analogue of arginine,
• Occurs only in indigofera plants
• Accumulates in the tissues of
animals grazing on them.
• HepG2 ctytotoxicity
6-amidino-2- • Cleft palate and embryo lethality in
aminohexanoic acid rats
2. Leucaena Mimosine: Toxic to livestock, teratogenic in pigs
leucocephala- & rat.
mimosa spp.

4.Loco plants: Unknown Contains


Astragalus 1. Osteolathyrogens- substances
lentiginosus ingested through mother’s milk.
2. Teratogens causing excessive
flexure of carpal joints/
contracted tendons
Plant source Constituent Teratogenic effects
5. Lupinus sericeus Quinolizidine alkaloids: Results in cracked calf
cytisine anagyrine disease

Umbelliferae: coniline • Alkaloidal teratogen,


1.Conium maculatum • Results in cracked calf
disease
Compositae: Pyrrolizidine alkaloids: teratogen in rats, utero
1.Senecio spp. lasiocarpine, retrorsine deaths in calves
Solanaceae: Pyridine alkaloids Skeleton deformalitions in
1. Nicotiana spp. pig
Companulaceae
1. Lobella spp
Sapindaceae: Hypoglycin A Hypoglycemic in humans,
Blighia sapida(Akee) teratogen in rats,
fruits &seeds Twice a toxic as hypoglycin B

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