Scribd
Upload
7 views2 pages

Clinical Types of JRA:: Juvenile Rheumatoid Arthritis

Juvenile rheumatoid arthritis (JRA) is an autoimmune disease characterized by joint pain and stiffness lasting over three weeks, with peaks in children aged 1-3 and 8-12 years, and is more common in girls. It has three clinical types: pauciarticular, polyarticular, and systemic, each with varying joint involvement and outcomes. Diagnosis involves blood tests and imaging, while treatment includes NSAIDs, corticosteroids, and methotrexate to manage inflammation.

Uploaded by

moahammm37t
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
7 views2 pages

Clinical Types of JRA:: Juvenile Rheumatoid Arthritis

Juvenile rheumatoid arthritis (JRA) is an autoimmune disease characterized by joint pain and stiffness lasting over three weeks, with peaks in children aged 1-3 and 8-12 years, and is more common in girls. It has three clinical types: pauciarticular, polyarticular, and systemic, each with varying joint involvement and outcomes. Diagnosis involves blood tests and imaging, while treatment includes NSAIDs, corticosteroids, and methotrexate to manage inflammation.

Uploaded by

moahammm37t
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 2

Juvenile rheumatoid arthritis

JRA definition:
Arthralgia > 3weeks > 3 months.
Autoimmune disease: Girls > boys
1-3 years old peak & 8-12 years old peak
Clinical types of JRA:
 Pauciarticular
 Polyarticular
 Systemic type
Clinical picture:
Joint pain
Joint stiffness
Slow progression
Restriction of movement
Confused with trauma or fall
Signs of inflammation: hot, tender, swelling
With time (growth plate) leg length discrepancy
Pauciarticular JRA:
 < 5 joints in 1st 6 months
 Large joints Polyarticular JRA:
 Uveitis +++  > 5 joints in 1st 6 months Systemic JRA:
 ANA +  Small joints  Varies joints usually medium
 RF –  Uveitis +  Varies number usually > 5
 Outcome: excellent 90%  ANA +  Uveitis +
complete remission  RF +  ANA --
 Some systemic  RF –
Investigations: manifestations can occur  Systemic manifestations:
Blood samples:  Outcome: good 50%  High fever with salmon patch,
 Hb recession& 50% disability anemia, failure to thrive
 WBCs  Hepatosplenomegaly in 70% of
cases
 PMN
 Pleuritis& pericarditis can occur
 ESR
 RF + joint destruction
 ANA + irido-cyclitis
 Annual F/up slit lamb for the eyes

Head of pediatric department: Dr. Noura Noraddin


Radiology:
 Osteopenia
 Bony proliferation
 Bone erosion at articular surface
Invasive procedures:
 Synovial fluid aspiration to exclude septic arthritis
WBC < 50.000, Mainly lymphocytes
Differential diagnosis:
Diagnosis of exclusion
Arthritis for at least 6 weeks
Exclude ALL, lymphoma, cancer, SCA,
RF, septic, reactive, trauma, hemophilia
Treatment:
 Reduce inflammation by NSAID
 Bridge therapy by corticosteroids
 Methotrexate weekly for specific cases
 Anti-tumor necrosis factor: etanrecept, infliximab, adalimumab

Head of pediatric department: Dr. Noura Noraddin

You might also like