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Hibiscus Sabdariffa: Used Part Disorders Model Mechanisms and Potential of Actions Ref

The document discusses the traditional medicinal uses of Hibiscus sabdariffa, detailing its effects on various disorders such as reproduction, inflammation, cancer, and diabetes, along with the mechanisms of action involved. It highlights the potential herb-drug interactions and pharmacokinetic changes when co-administered with conventional medications, emphasizing the need for caution. The findings suggest that while Hibiscus sabdariffa has beneficial health effects, its simultaneous use with certain drugs may lead to adverse outcomes.

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7 views1 page

Hibiscus Sabdariffa: Used Part Disorders Model Mechanisms and Potential of Actions Ref

The document discusses the traditional medicinal uses of Hibiscus sabdariffa, detailing its effects on various disorders such as reproduction, inflammation, cancer, and diabetes, along with the mechanisms of action involved. It highlights the potential herb-drug interactions and pharmacokinetic changes when co-administered with conventional medications, emphasizing the need for caution. The findings suggest that while Hibiscus sabdariffa has beneficial health effects, its simultaneous use with certain drugs may lead to adverse outcomes.

Uploaded by

arpan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Kamyab, et al.

Table 2. Hibiscus sabdariffa in traditional medicine and the relative mechanisms of actions.

Used part Disorders Model Mechanisms and potential of actions Ref.


45
Whole part Reproduction Rat Decrease in testicular protein concentration
Biochemical effects on reproductive hormones such as 29
HSC Reproduction Rat
testosterone, luteinizing hormone, and prolactin
Aqueous extract Reproduction Rat Effect on male reproductive system 30

Improves postprandial vascular function


Inflammation, CVD, Blood 31
HSC Human and CVD risk reduction, improves postprandial FMD of the
Lipids
brachial artery
Inhibition of melanoma cell growth, migration, and tube
35
Aqueous extract Cancer, Melanoma Murine formation in vitro as well as inhibition of presence of lung
metastasis and subcutaneous tumor growth
Inhibition of various food-borne pathogens as well as both 36
Aqueous extract Antibacterial activity Food
gram-positive and gram-negative pathogens
37
Dried calyx Anti-angiogenic Chick embryo Binds to (VEGFR2) and impedes its activity
38
Aqueous extract Cancer of gastric cavity Human p38 MAPK/FasL cascade pathway and p53 phosphorylation
39
HLE Prostate cancer Human (HLE) acts as an apoptosis inducer in LNCaP cells
Dried flower Leukemia Human Apoptosis inducer, RB phosphorylation, and Bcl-2 protein 40

Sour Tea Diabetes Human Lipid profiling 41

Polyphenol Increased catalase glutathione activity and reduced lipid 43


Nephropathy Human
extract peroxidation
Ethyl acetate EFHS significantly enhanced cholinergic system, 44
Cognitive Rat
extract hyperphosphorylation tau signaling, and antioxidant
FMD: Flow-mediated dilatation, CVD: cardiovascular disease, HSC: Hibiscus sabdariffa calyces, VEGFR2: vascular endothelial growth
factor receptor 2, HLE: H. sabdariffa L. leaf extract

Hibiscus sabdariffa Pharmacokinetics animal models.49 The aqueous extract of HS lowered Tc


Several patients take herbs along with their medications. better than simvastatin and improved antihyperlipidemic
Such practice may result in either beneficial or harmful activity when co-administered at low doses in an animal
herb-drug interactions. Accordingly, some studies model.50 Research results have also revealed that patients
have reported that HS consumption can change the should avoid the simultaneous usage of a HS herbal
pharmacokinetics and potential efficacies of prescribed beverage and hydrochlorothiazide (HCT) diuretics to
medicines.46 Among the best-defined health benefits of H. control hypertension.51 An innovative study showed that
sabdariffa L. is the control of high blood pressure. Some co-administration of Z. officinale or H. sabdariffa with
patients taking conventional antihypertensive drugs may amlodipine increased its pharmacodynamic response.52
also consume H. sabdariffa L. extracts.46,47 It has been An original study revealed that the herb-drug interaction
shown that co-administration of HS aqueous extract can between Z. officinale-losartan and H. sabdariffa-losartan
change the pharmacokinetic profile of captopril; for that could occur in rats.53 In general, the simultaneous use of
reason, its co-administration should be avoided.48 Several herbal and synthetic medicines can have either positive or
studies have indicated that HS extracts can reduce the toxic effects (Figure 3).
levels of TG, Tc, LDLc, and LDLc/HDLc in humans and

Figure 3. Positive or toxic effects because of simultaneous use of herbal and synthetic medicines.

509 | Pharmaceutical Sciences, 2022, 28(4), 506-516

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