Pharmaceutical Properties of Sour Tea: Treatment for Hypertension
solid phase extraction‐capillary electrophoresis‐mass potential of Hibiscus sabdariffa L. Biomed Pharmacother.
spectrometry (time‐of‐flight/ion trap). Electrophoresis 2020;127:110153. doi:10.1016/j.biopha.2020.110153
2008;29(13):2852-61. doi:10.1002/elps.200700819 35. Su C-C, Wang C-J, Huang K-H, Lee Y-J, Chan W-M,
24. Serban C, Sahebkar A, Ursoniu S, Andrica F, Chang Y-C. Anthocyanins from Hibiscus sabdariffa
Banach M. Effect of sour tea (Hibiscus sabdariffa calyx attenuate in vitro and in vivo melanoma
L.) on arterial hypertension: A systematic review cancer metastasis. J Funct Foods. 2018;48:614-31.
and meta-analysis of randomized controlled trials. doi:10.1016/j.jff.2018.07.032
J Hypertens. 2015;33(6):1119-27. doi:10.1097/ 36. Lim H-W, Seo K, Chon J, Song K-Y, editors.
HJH.0000000000000585 Antimicrobial activity of Hibiscus sabdariffa L. (roselle)
25. Herrera-Arellano A, Miranda-Sánchez J, Ávila-Castro powder against food-borne pathogens present in dairy
P, Herrera-Álvarez S, Jiménez-Ferrer JE, Zamilpa products: Preliminary study. J Dairy Sci Biotechnol.
A, et al. Clinical effects produced by a standardized 2020;38(1):37-44. doi:10.22424/jdsb.2020.38.1.37
herbal medicinal product of Hibiscus sabdariffa on 37. Joshua M, Okere C, O’Donnell Sylvester MY, Precious
patients with hypertension. A randomized, double- O, Dluya T, Um J-Y, et al. Disruption of angiogenesis
blind, lisinopril-controlled clinical trial. Planta Med. by anthocyanin-rich extracts of Hibiscus sabdariffa.
2007;73(1):6-12. doi:10.1055/s-2006-957065 Int J Sci Eng. 2017;8(2):299-307. doi:10.14299/
26. Herrera-Arellano A, Flores-Romero S, Chavez-Soto ijser.2017.02.009
M, Tortoriello J. Effectiveness and tolerability of a 38. Lin H-H, Huang H-P, Huang C-C, Chen J-H, Wang C-J.
standardized extract from Hibiscus sabdariffa in patients Hibiscus polyphenol-rich extract induces apoptosis in
with mild to moderate hypertension: A controlled human gastric carcinoma cells via p53 phosphorylation
and randomized clinical trial. Phytomedicine. and p38 mapk/fasl cascade pathway. Mol Carcinog.
2004;11(5):375-82. doi:10.1016/j.phymed.2004.04.001 2005;43(2):86-99. doi:10.1002/mc.20103
27. Salem MA, Zayed A, Beshay ME, Mesih MMA, 39. Lin H-H, Chan K-C, Sheu J-Y, Hsuan S-W, Wang C-J,
Khayal RFB, George FA, et al. Hibiscus sabdariffa L.: Chen J-H. Hibiscus sabdariffa leaf induces apoptosis
phytoconstituents, nutritive, and pharmacological of human prostate cancer cells in vitro and in vivo.
applications. Adv Tradit Med. 2021;22:497–507. Food Chem. 2012;132(2):880-91. doi:10.1016/j.
doi:10.1007/s13596-020-00542-7 foodchem.2011.11.057
28. Ismail A, Ikram EHK, Nazri HSM. Roselle (Hibiscus 40. Tseng T-H, Kao T-W, Chu C-Y, Chou F-P, Lin
sabdariffa L.) seeds nutritional composition protein W-L, Wang C-J. Induction of apoptosis by hibiscus
quality and health benefits. Food. 2008;2(1):1-16. protocatechuic acid in human leukemia cells via
29. Nwabufo CK, Olusanya O. Biochemical effect of reduction of retinoblastoma (rb) phosphorylation and
Hibiscus sabdariffa calyx extracts on the reproductive bcl-2 expression. Biochem Pharmacol. 2000;60(3):307-
hormones of male wistar rat. Adv Appl Sci Res. 15. doi:10.1016/S0006-2952(00)00322-1
2017;8(2):38-41. 41. Effects of sour tea (Hibiscus sabdariffa) on lipid profile
30. Ali BH, Al-Lawati I, Beegam S, Ziada A, Al Salam and lipoproteins in patients with type II diabetes.
S, Nemmar A, et al. Effect of Hibiscus sabdariffa J Altern Complement Med. 2009;15(8):899-903.
and its anthocyanins on some reproductive doi:10.1089/acm.2008.0540
aspects in rats. Nat Prod Commun 2012;7(1):41-4. 42. Mozaffari-Khosravi H, Jalali-Khanabadi B, Afkhami-
doi:10.1177/1934578X1200700115 Ardekani M, Fatehi F, Noori-Shadkam M. The effects
31. Abubakar SM, Ukeyima MT, Spencer JP, Lovegrove of sour tea (Hibiscus sabdariffa) on hypertension
JA. Acute effects of Hibiscus sabdariffa calyces on in patients with type II diabetes. J Hum Hypertens.
postprandial blood pressure, vascular function, 2009;23(1):48-54.
blood lipids, biomarkers of insulin resistance and 43. Lee W-C, Wang C-J, Chen Y-H, Hsu J-D, Cheng
inflammation in humans. Nutrients. 2019;11(2):341. S-Y, Chen H-C, et al. Polyphenol extracts from
doi:10.3390/nu11020341 Hibiscus sabdariffa linnaeus attenuate nephropathy
32. Sung H, Ferlay J, Siegel RL, Laversanne M, in experimental type 1 diabetes. J Agric. Food Chem.
Soerjomataram I, Jemal A, et al. Global cancer statistics 2009;57(6):2206-10. doi:10.1021/jf802993s
2020: Globocan estimates of incidence and mortality 44. Seung TW, Park SK, Kang JY, Kim JM, Park SH, Kwon
worldwide for 36 cancers in 185 countries. CA: Cancer BS, et al. Ethyl acetate fraction from Hibiscus sabdariffa
J Clin. 2021;71(3):209-49. doi:10.3322/caac.21660 L. Attenuates diabetes-associated cognitive impairment
33. Ferlay J, Colombet M, Soerjomataram I, Mathers C, in mice. Int Food Res J. 2018;105:589-98. doi:10.1016/j.
Parkin D, Piñeros M, et al. Estimating the global cancer foodres.2017.11.063
incidence and mortality in 2018: Globocan sources 45. Ali BH, Al-Lawati I, Beegam S, Ziada A, salam SA,
and methods. Int J Cancer. 2019;144(8):1941-53. Nemmar A, et al. Effect of hibiscus sabdariffa and its
doi:10.1002/ijc.31937 anthocyanins on some reproductive aspects in rats.
34. Laskar YB, Mazumder PB. Insight into the molecular Nat Prod Commun. 2012;7(1):1934578X1200700115.
evidence supporting the remarkable chemotherapeutic doi:10.1177/1934578X1200700115
Pharmaceutical Sciences, 2022, 28(4), 506-516 | 514
