1.
A 52 yrs/M presented with chest pain that is radiating to his left
shoulder, left arm and back. ECG showed ST segment elevation.
Postmortem findings of the C/S of heart is given below
1. What is the diagnosis?
2. What is the special stain used to demonstrate this condition?
3. What are the early light microscopic findings?
4. Name the biochemical markers used for diagnosis of this
condition?
5. What are the complications of this condition?
MYOCARDIAL INFARCTION
A 52 yrs/M presented with chest pain that is radiating to his left
shoulder, left arm and back. ECG showed ST segment elevation.
Postmortem findings of the C/S of heart is given below
1. What is the diagnosis?
2. What is the special stain used to demonstrate this condition?
3. What are the early light microscopic findings?
4. Name the biochemical markers used for diagnosis of this
condition?
5. What are the complications of this condition?
ANSWERS:
1. Myocardial Infarction
2. Triphenyl tetrazolium chloride
3. ½-4hrs- waviness of the cardiac fibres at the border, 4-12hrs- early
coagulative necrosis, edema and hemorrhage is seen.
4. Cardiac Troponin T ,cardiac Troponin I, Creatine kinase-MB
5. Myocardial rupture, arrhythmias, contractile dysfunction , mural
thrombus, infarct expansion
2. A 36 years/M presented with unilateral swelling of right lower limb.
O/E: There was non- pitting edema and thickening of the skin of the left
lower limb. He also had swollen lymph nodes in the right inguinal
region. Peripheral smear finding is shown.
:
1. What is the diagnosis ?
2. Name the different species that cause this condition ?
3. What is the mode of transmission of this condition?
4. Where will you look for the causative agent in peripheral and in
which power?
5. What is the lung condition related to this disease and characteristic
finding in lungs ?
FILARIASIS
A 36 years/M presented with unilateral swelling of right lower limb.
O/E: There was non- pitting edema and thickening of the skin of the left
lower limb. He also had swollen lymph nodes in the right inguinal
region. Peripheral smear finding is shown.
1. What is the diagnosis ?
2. Name the different species that cause this condition ?
3. What is the mode of transmission of this condition?
4. Where will you look for the causative agent in peripheral and in
which power?
5. What is the lung condition related to this disease and characteristic
finding in lungs?
ANSWERS
1. Filariasis
2. Wuchereria Bancrofti, Brugia Malayi
3. Mosquitoes
4. Parasite should be screened mainly at the tail, body and along the
sides of the smear, in low power magnification.
5. Tropical Pulmonary Eosinophilia and Meyer Kouwenaar bodies
3. A 63 years male presented with fatigue, weight loss, shortness of
breath, bowel disturbances, cardiac failure, increased blood pressure and
proteinuria.
Abdominal fat aspirate showed deposition
of homogenous, eosinophilic material.
1. What is the diagnosis?
2. Name some forms of the etiological factor of the above diagnosis?
3. What is the characteristic appearance in infrared spectroscopy ?
4. What are the special techniques available to demonstrate this
diagnosis and the characteristic appearance?
5. What is the morphological appearance of this condition in spleen?
AMYLOIDOSIS
A 63 years male presented with fatigue, weight loss, shortness of breath,
bowel disturbances, cardiac failure, increased blood pressure and
proteinuria.
Abdominal fat aspirate showed deposition of homogenous, eosinophilic
material.
1. What is the diagnosis?
2. Name some forms of the etiological factor of the above diagnosis?
3. What is the characteristic appearance in infrared spectroscopy?
4. What are the special techniques available to demonstrate this
diagnosis and the characteristic appearance?
5. What is the morphological appearance of this condition in spleen?
ANSWERS:
1. Amyloidosis
2. Amyloid light chain, beta2 microglobulin, transthyretin, amyloid
associated protein, Aβ protein
3. Beta pleated sheet appearance
4. Congo red stain- amyloid appears pink or red color,
under polarized light congo red stained amyloid shows aplle green
birefringence
5. Sago spleen- deposition of amyloid in splenic follicle
Lardaceous spleen-map-like areas in spleen due to fusion of
amyloid deposits in the splenic follicle
