1. Which out of the following enzymes cleavage a carbon-carbon bond in the pathway of glycolysis?
A. Aldolase
B. Glyceraldehyde-3-P dehydrogenase
C. Enolase
D. Phosphoglycerate kinase
E. Phosphoglycerate mutate
2. A patient has chronic obstructive pulmonary disease, enough oxygen is not reaching her tissue. All of
the following are expected except
A. The ETS chain would be inhibited
B. Glycolysis would be activated by a low ATP/ADP ratio
C. More than normal amount of ATP will be synthesized
D. Concentration of NADH and pyruvate would be lower than normal
E. More than normal of lactate would be produced
3. The precursor to glycogen in the glycogen synthase reaction is
A. Glucose 1 phosphate
B. Glucose 6 phosphate
C. UDP Glucose
D. UTP Glucose
E. None of the above
4. Which of the following steps from glycolysis is performed by a different enzyme in gluconeogenesis?
A. Isomerase
B. Phosphofructokinase
C. Glyceraldehyde-3-P dehydrogenase
D. Enolase
E. Aldolase
5. Fructose 2,6 biphosphate
A. Inhibits phosphofructokinase
B. Activates fructose 1,6 biphosphatase
C. Activates phosphofructokinase
D. Inhibits fructose 1,6 biphosphatase
E. C and D are both correct
6. Which of the following is not a mechanism for altering the flux of metabolites through the rate
determining steps of a pathway?
A. Covalent modification of the enzyme
B. Genetic control of the enzyme concentration
C. Diffusional coupling between adjacent active site.
D. Allosteric control of the enzyme activities
E. Coordinate regulation of synthetic and degradative steps in the same pathway.
7. The breakdown of glycogen to form glucose occurs:
A. In the liver by phosphorolysis
B. In the muscle by phosphorolysis
C. In the liver by hydrolysis
D. In the muscles by hydrolysis
E. A and B are both correct.
8. The active form of glycogen __ is phosphorylated, the active form of glycogen__ is dephosphorylated
A. Hydrolase, dehydrogenase
B. Dehydrogenase, hydrolase
C. Hydrolase, semi synthase
D. Phosphorylase, synthase
E. Synthase, Phosphorylase
9. Which statement is false regarding the citric acid cycle
A. It occurs in the mitochondrial matrix for eukaryotes
B. 6 GTP molecules would be produced starting with 3 glucose molecules
C. Oxygen is directly required for the citric acid cycle to occur
D. All of these
E. Another name for it is the Krebs cycle
10. Within the Krebs cycle, L-malate and NAD+ come together to form oxaloacetate, NADH, and H+.
What type of chemical reaction is responsible for this step in the cycle?
A. Decarboxylation
B. Dehydration
C. Oxidation
D. Hydration
E. None of the above
11. If the Krebs cycle is overstimulated, the body will produce too much of which of the following
molecules?
A. Acetyl CoA
B. Oxygen
C. Carbon dioxide
D. Pyruvate
E. Glucose
12. Where is the Krebs cycle carried out in eukaryotic cells?
A. Nucleus
B Cytosol
C. Mitochondrial matrix
D. Inner membrane of the mitochondria
E. All of the above
13. Product of Krebs cycle essential for oxidative phosphorylation is _______
A. NADPH and ATP
B. Acetyl CoA
C. CO2 and oxaloacetate
D. NADH and FADH2
E. None of the above
14. Which of the intermediate of the Kreb’s cycle is utilised in the formation of amino acids?
A. Citric acid
B. Malic acid
D. 𝛼-ketoglutaric acid
C. Isocitric acid
E. None of the above
15. 7. Which of the following is not formed during the Krebs cycle?
A. Lactate
B. Isocitrate
C. Succinate
D. Both (a) and (b)
E. All of the above
16. The entry of pyruvate into the TCA cycle is inhibited by the presence of a high cellular concentration
of
A. Pyruvate
B. NADH
C. Coenzyme A
D. AMP
E. All of above
17. FAD is reduced in which of the reaction of the Kreb’s cycle?
A. Isocitrate to oxaloacetate
B. Succinyl CoA to Succinate
C. Fumarate to malate
D. Succinate to fumarate
E. All of the above
18. Which of the following is the first complex (Complex I) of ETS?
A. NADH dehydrogenase
B. Cytochrome aa3
C. Cytochrome bc1
D. ATP synthase
E. None of the above
19. Ubiquinone transfers its electrons to
A. Complex I
B. Complex II
C. ATP Synthase
D. Cytochrome C
E. NADH Dehydrogenase
20. Which of the following step is the rate-limiting step of the pentose phosphate pathway?
A. Transketolase
B. Transaldolase
C. Glucose-6-P dehydrogenase
D. Phosphogluconate dehydrogenase
E All of the above
21. Insulin activates the pentose phosphate pathway.
Which of the following enzyme is activated by insulin action?
A. Transketolase
B. Glucose-6-P dehydrogenase
C. Transaldolase
D. Phosphogluconate dehydrogenase
E Glucose 6 phosphatase
22. Glucose-6-Phosphate dehydrogenase is allosterically inhibited by:
A. Acetyl CoA
B. Citrate
C Glucose
d) Fructose
23. Which of the following statements about gluconeogenesis is correct?
A. Pyruvate is first converted to phosphoenolpyruvate by phosphoenolpyruvate carboxykinase
B. Fructose 1, 6-biphosphatase converts fructose 1, 6-bisphosphate into fructose 1-phosphate
C. Glucose 6-phosphatase hydrolyzes glucose 6-phosphate to release glucose into the blood
D. Glucose 6-phosphatase hydrolyzes glucose 6-phosphate and is found in liver and muscle
24. What is the main source of glucose carbons for gluconeogenesis?
A. Guanine
B. Alanine
C. Cysteine
D. Threonine
25. Gluconeogenesis involves the conversion of ____________
A. Glucose to pyruvate
B. Pyruvate to glucose
C. Phosphoenolpyruvate to glucose
D. Pyruvate to fructose
26. The entry of pyruvate into the TCA cycle is inhibited by the presence of a high cellular concentration
of
(a) Pyruvate
(b) NADH
(c) Coenzyme A
(d) AMP
27. FAD is reduced in which of the reaction of the Kreb’s cycle?
(a) Isocitrate to oxaloacetate
(b) Succinyl CoA to Succinate
(c) Fumarate to malate
(d) Succinate to fumarate
