Manuscript
Manuscript
Hua Yu
Mental Health Center of West China Hospital, Sichuan University
Mingli Li
Mental Health Center of West China Hospital, Sichuan University
Zhixiong Li
The Third Department of Clinical Psychology, Karamay Municipal People's Hospital
Weiyi Xiang
The West China College of Medicine, Sichuan University
Yiwen Yuan
ental Health Center of West China Hospital, Sichuan University
Yaya Liu
Mental Health Center of West China Hospital, Sichuan University
Zhe Li
Mental Health Center of West China Hospital, Sichuan University
jay_li@163.comCorresponding Author
Zhenzhen Xiong
School of Nursing, Chengdu Medical College
18981776039@163.comCorresponding Author
DOI:
10.21203/rs.3.rs-20397/v2
SUBJECT AREAS
Psychiatry Psychology
KEYWORDS
COVID-19, Psychological distress, Coping style, Social support, Cross-sectional
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Abstract
Background
The purpose of this study was to investigate the psychological status of the general population in
mainland China during the outbreak of coronavirus disease 2019 (COVID-19), and to explore the
factors influencing psychological distress, in order to provide the basis for further psychological
intervention programs.
Methods
We administered three questionnaires on-line to a convenience sample of the general population from
different regions of mainland China from February 1 to February 4, 2020. We used the Mandarin
versions of the six-item Kessler psychological distress scale (K6), the Simplified Coping Style
Questionnaire (SCSQ), and the Social Support Rating Scale (SSRS). We also collected demographic
data and other information related to the COVID-19 outbreak. Multivariate binary logistic regression
Results
Of 1607 respondents, 1588 returned valid questionnaires and were included in the analysis. Nearly
one quarter (22.8%) had high levels of psychological distress (K6 score ≥ 13). Individuals with higher
psychological distress spent more time searching for information about COVID-19, had a history of
contact with epidemic areas, more frequently adopted a negative coping style, and reported less
Conclusions
The COVID-19 outbreak in China has a great impact on the mental health status of the general
population. Positive coping strategies and increased social support are significantly correlated with
decreased psychological distress, and may serve as the basis for psychological interventions.
Background
An outbreak of infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), initially
called novel coronavirus (2019-nCoV), began on December 8, 2019, when several cases of pneumonia
of unknown etiology were reported in Wuhan, Hubei province, China [1]. In the early stages of this
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pneumonia, severe acute respiratory infection symptoms can occur, with some patients rapidly
developing acute respiratory distress syndrome, acute respiratory failure, and other serious
complications [2]. As of March 11, 2020, the total number of patients in China with confirmed
coronavirus disease 2019 (COVID-19) was 80,955, of which 67,773 were in Hubei province, and the
total number of COVID-19-associated deaths was 3,162 [3] . At the end of January 2020, the World
Health Organization declared the COVID-19 outbreak in China as a public health emergency of
international concern.
Infectious diseases cause significant psychological distress, both in the general public and in health
professionals [4]. The emergence of COVID-19 has parallels with the pandemic of human
immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS), the severe
acute respiratory syndrome (SARS) outbreak or the threat of an avian influenza pandemic, all of which
caused substantial concern among health authorities, the media, and the general public [5]. As a life-
threatening disease, we can consider COVID-19 outbreak as a specific stress. Psychosocial responses
towards infectious disease outbreaks are variable and can range in intensity, including feelings of
anxiety, a sense of shame, failure or weakness of the individual and society; an underestimation of
likelihood of survival; an overestimation of likelihood of infection [6]; an urge to take flight from the
outbreak; excessive, inappropriate adoption of precautionary measures; and increased demand for
healthcare services during a critical shortage [7]. Few epidemiological data are available on mental
health problems and psychiatric morbidity among those suspected or diagnosed with COVID-19 and
among the health professionals treating them. Therefore the best strategies to respond to mental
Previous research indicated that coping styles and social support are moderating variables in the
relationship between stress and distress [9]. Coping strategies refer to the specific efforts, both
behavioral and psychological, that people employ to master, tolerate, reduce, or minimize stressful
events [10]. Coping styles can be positive, i.e. stress-reducing, or negative, i.e., stress-enhancing
[11]. Positive coping has been associated with well-being, while negative coping is often related to
psychological distress [12]. When confronted with a single stressor or constellation of stressors,
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individuals are forced to consider their coping resources and select a coping response accordingly.
The constellation of stressors, coping resources, and coping responses determines the extent to
In addition to coping strategies, effective social support can protect individuals from developing
mental health problems when they experience stressors [13]. Social support can be defined as a
series of support measures accessible to an individual through their social relationships with other
individuals, groups, and the larger community [14]. Since Durkheim first established that social
support has a positive effect on health [15], many researchers have found that this support can serve
as a mediator between stress and psychological problems [16]. An investigation of 1016 SARS
patients in 17 provinces in China confirmed the utility of social support, with different types of support
influencing different aspects of SARS-related stress [17]. That study revealed that social support
directly impacted panic and cognition , and relatives or friends were a source of greater social support
[17]. The beneficial effects of social support on psychological well-being have been widely studied and
well documented across patients with various illnesses [18, 19]. It is reasonable to assume that social
support may similarly help Chinese people during the COVID-19 outbreak, generally regarded as a
The severity of the psychological burden that COVID-19 places on the general population was not
clear at the onset of the outbreak, and a model to guide successful interventions was lacking. Little is
known about how Chinese are coping with the COVID-19 stressor. Here we aimed to investigate the
psychological status of the general population in the early stages of the COVID-19 outbreak, and to
explore factors influencing psychological stress. We also examined major relationships between
stressors and coping, as well as support systems available to the general population. Our results may
Methods
Study participants and questionnaires
The study population comprised Chinese living in mainland China. The snowball sampling method was
used to invite potential study participants. Through the WeChat messaging App, the investigators
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invited an initial group of 10 individuals to participate, who were chosen to ensure broad
representation of age, gender, education level, occupation and city. This first set of invitees then
forwarded the invitations to 10 of their contacts whom they considered suitable, and this second set
forwarded the invitation in the same way. Participants filled in anonymous basic information online via
the Questionnaire Star (https://www.wjx.cn), and as long as they did not report a history of serious
mental illness, they were asked to provide informed consent and were able to continue to the three
questionnaires (see below). The study was approved by the Ethics Committee of West China Hospital,
Sichuan University. Invitees were allowed to complete the survey from 4 p.m. on February 1, 2020
Instruments
information about sex, age, educational level, occupation, family residence location, and family
income. The questionnaire also asked about infection with SARS-CoV-2 (in the respondent or
relatives), time spent searching for information about the virus everyday, history of contact with the
epidemic area (Wuhan City), and presence of cases in the respondent’s community (Table 1).
5
Characteristic Mean±SD Subgroup n (%)
≥60 50 (3.10)
No 1332 (83.9)
Then participants filled out the Mandarin versions of the six-item Kessler psychological distress scale
(K6), the Simplified Coping Style Questionnaire (SCSQ), and the Social Support Rating Scale (SSRS).
The Mandarin version of the K6, which has been validated in the World Mental Health Survey [20],
comprises six questions that ask respondents to rate how frequently they have felt ‘nervous’,
‘hopeless’, ‘restless or fidgety’, ‘so depressed that nothing could cheer you up’, ‘everything was an
effort’, or ‘worthless’ during the past 30 days [21]. Items are rated on a five-point scale, with 0
6
indicating an absence of the symptom and 4 indicating that the symptom was always present during
the past 30 days. The final K6 score can range from 0 to 24, with higher scores (≥13) indicating
The SCSQ [23], based on the 'Ways of Coping' questionnaire [24], is a 20-item self-report that
includes dimensions of active coping (12 items) and passive coping (8 items). Responses are given on
a four-point Likert scale (0=never; 3=very often). The instrument has been used frequently in China,
The SSRS is a 10-item self-report that assesses the level of an individual’s social support over the past
year [25]. This measure consists of three subscales: subjective support (4 items), objective support (3
items), and utilization of support (3 items). Subjective support refers to perceived social support,
meaning that people feel supported, cared for and helped by family members, friends and colleagues
[e.g., Question: How many close friends do you have? Responses: (1) None, (2) 1-2, (3) 3-5, or (4) 6 or
more]. Objective support refers to visible, practical and direct support (e.g., financial or other tangible
resources that you received when you needed help). The utilization of support reflects the degree of
social support used [Question: How do you get help when in need? Responses: (1) I am self-reliant, (2)
I seldom ask for help from others, (3) I sometimes ask for help from others, or (4) I often ask for help
from relatives and friends]. The total SSRS score ranges from 12 to 66 points, with higher scores
indicating higher level of social support. The SSRS has shown good reliability and validity, with
Quality control
Only one set of surveys was accepted from the same Internet Protocol address, and surveys were not
accepted if the time to complete all questionnaires was less than 120 seconds. Surveys did not
Statistical analysis
All statistical analyses were performed using SPSS 21 (IBM, Armonk, NY, USA). Exploratory data
analysis was conducted using frequencies for categorical variables and mean values for continuous
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Differences in demographic characteristics, coping style and social support between respondents who
suspected or did not suspect that they themselves had COVID-19 were assessed for significance using
To identify predictors of high psychological distress, we classified respondents into those with high
psychological distress (K6 score ≥13) and those with low psychological distress (K6 score ≤12) [21].
To identify factors influencing high psychological distress among respondents who did not suspect
that they had COVID-19, we performed simple binary logistic regression and backward stepwise
multiple logistic regression. The dependent variable was the dichotomous classification of low or high
psychological distress. The model was constructed with the following covariates: age, sex,
educational level, family income coefficient (total family income/number of family members),
residence location (Hubei province or other), history of contact with the epidemic area (Wuhan City)
or not, time spent searching for information about COVID-19 per day, and questionnaire scores for
positive coping style, negative coping style, subjective support, objective support and utilization of
support. The least significant variables were removed one at a time until only significant variables (P
Logistic regression was not performed on data from respondents who suspected that they had COVID-
Results
Study population
A total of 1607 people submitted survey responses, taking a mean of 10.7±7.57 min to complete all
questionnaires. Three people finished in fewer than 120 seconds, and 16 did not finish all
questionnaires. After excluding these individuals, 1588 respondents (33.1% men) were included in the
final analysis. Their average age was 33.7±12.0 years, 8.3% had at most a senior high school level of
education, 22.1% had a technical qualification, 56.7% had a bachelor’s degree, and 12.9% had a
postgraduate qualification. A total of 8.8% of respondents were from Hubei province, the initial area
of the COVID-19 outbreak. Fewer than a quarter of participants (16.1%) were suspected of having
COVID-19, 20.3% had a history of contact with the epidemic area, and 20.8% lived in communities
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where COVID-19 cases had been reported. Nearly one third (32.5%) of respondents spent more than 4
h per day searching for information about COVID-19 (Table 1). Of the 1588 respondents, 22.8% had
high levels of psychological distressK6 score ≥ 13). Mean scores were as follows: positive coping
style, 20.7±9.42; negative coping style, 9.02±4.18; subjective social support, 19.4± 6.72; objective
Table 2. Psychological distress, coping style and social support in the study cohort (n =
1588).
respondents who suspected or did not suspect that they had COVID-19
Only one of 256 respondents with suspected infection showed low psychological distress, indicating
that suspected cases in our sample had high psychological distress. In contrast, only around 8% of
respondents without suspected infection had high psychological distress. Respondents with or without
suspected infection were different in demographic characteristics: those with suspected infection
were younger (mean age, 21.2±5.51), and they had lower family income (0.62 ±0.34), higher
education level, and more contact with Wuhan City. Compared to respondents without suspected
infection, those with suspected infection also spent more time searching for information about COVID-
19, rarely used any coping style to deal with the stressor, and had less social support (Table 3).
between respondents who suspected or did not suspect that they had COVID-19.
9
Suspected Not suspected df t/χ2 P-value
(n = 256) (n = 1332)
coefficient
lower
community
COVID-2019 (h/day)
≥8 28 (10.9) 84 (6.30)
Positive coping style 5.50 (2.62) 23.58 (7.20) 1090.88 70.51 <0.001
style
10
Social Support Rating Scale
Binary logistic regression identified three factors that predicted high psychological distress among our
respondents without suspected infection: spending >4h daily searching for information about COVID-
19 (OR for 5-6 h, 6.91; OR for 7-8 h, 8.78; OR for >8 h, 9.07, all P< 0.001), history of contact with the
epidemic area (OR=4.36, P < 0.001), and negative coping style (OR=1.12, P=0.002).
The binary logistic regression also identified four factors that predicted low psychological distress:
positive coping style (OR=0.87, P<0.001), objective support (OR=0.79, P=0.045), subjective support
These regression analyses did not include the following factors: age, sex, education level, family
income coefficient, residence location, or presence of COVID-19 cases in the respondent’s community,
because they did not correlate significantly with psychological distress (Supplementary Table 1).
Table 4. Factors predicting high psychological distress in respondents who did not suspect
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95% CI OR β P-value
Lower Upper
epidemic area
Noa 1.0
(h/day)
1-2a 1.0
Coping style
Social support
a Reference group.
Discussion
This appears to be the first study to examine psychological distress in the general population in
mainland China during the COVID-19 outbreak, and to investigate factors associated with that
distress. The results of the present study show that in December 2019, when there were significant
public concerns about the new coronavirus pandemic outbreak, 22.8% of our participants reported
high levels of psychological distressK6 score ≥13). Respondents with suspected infection reported
higher levels of psychological distress than those without suspected infection, and the two groups
differed in several sociodemographic variables, coping styles and support systems. Among those
without suspected infection, factors significantly associated with high distress were a history of
contact with the epidemic area, spending >4h per day searching for information about COVID-19, a
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negative coping style and lower social support.
The present study was conducted during the first two weeks of the COVID-19 outbreak, since human-
to-human transmission was announced on January 20, 2020 [26]. In our study, 22.8% of participants
had high psychological distress based on the cut-off score of 13 [27]. The prevalence of high
psychological distress in our cohort is much higher than the prevalence of high psychological distress
among the general population in Australia (8.0%) [28], undergraduates in China (4.0%) [27] and
workers in Japan (10.8%) [29]. These findings suggest that COVID-19 outbreak places a substantial
burden on the mental health of the general population in China. Therefore urgent measures are
The high psychological distress among nearly all respondents with suspected infection may indicate
higher probability of having a severe mental illness [30]. Compared with respondents without
suspected infection, those with suspected infection used less positive coping styles and more
negative coping styles during the outbreak; they also had lower objective social support, subjective
social support and utilization of social support. Some demographic factors were also associated with
higher risk of psychological distress, such as younger age and less income. We hypothesize that
young people may feel that they have less social support because they have lower income [31], which
For respondents without suspected infection, an active coping style and social support were
protective factors against psychological distress in our regression model. On the other hand, time
spent searching for information about the outbreak, a history of contact with individuals from Wuhan
City, travelling to or living in Wuhan City during the outbreak, and negative coping styles were risk
factors of high psychological distress. We performed regression modeling of data only from
participants without suspected infection, and we excluded sociodemographic variables that did not
correlate significantly with psychological distress in this subgroup (see Supplementary Table 1).
Compared to respondents without a history of contact with individuals from Wuhan City, those with a
history of contact and who had traveled to or lived in Wuhan within one month before the survey were
at 4.36-fold higher risk of high psychological distress. This is not surprising, since COVID-19 was first
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observed in Wuhan. News coverage of the COVID-19 outbreak in Wuhan initially focused on the high
infectivity and fatality, potentially creating fear and panic. In addition, in order to decrease the risk of
disease transmission, Wuhan authorities suspended public transport indefinitely from January 23,
2020. A range of measurements were urgently adopted, such as early identification and isolation of
suspected and diagnosed cases, contact tracing and monitoring, collection of clinical data and
biological samples from patients, dissemination of regional and national diagnostic criteria and expert
treatment consensus, establishment of isolation units and hospitals, and prompt provision of medical
supplies and dispatching of external expert teams to Hubei province [32]. The process of SARS-CoV-2
infection control and prevention involves the use of personal protective equipment, quarantine, and
isolation, all of which may be further associated with fear and anxiety. It is reasonable to conclude
that under these circumstances, the general population is under substantial stress and may need
Respondents without infection who showed high psychological distress (K6 score ≥13) also showed a
higher frequency of negative coping style, such as problem-avoidance, fantasy, self-blame, and
asking for help from others. This result is consistent with a meta-analysis reporting a strong
association between negative coping style and depression [33]. Previous research [34] indicated that
coping styles can affect how a stressful event is perceived and how it is managed. Since coping can
involve “all efforts to manage taxing demands, without regard to their efficacy or inherent value”
[34], it is not necessarily associated with a good outcome. Our findings are consistent with other
studies that associate higher stress with greater use of emotion-oriented and social diversion-oriented
coping [35].
We found that active coping style and higher social support were protective factors against
psychological distress in the early stages of the COVID-19 outbreak. Our results emphasize the need
to research coping strategies in the general public and interventions to teach coping during epidemic
outbreaks. Such work may lay a solid foundation for individuals to cope positively and actively with
various stress factors and circumstances [36]. In general, strong social support exerts weak to
moderate effects on the relationship between stressors and distress [37]. As an external resource
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available to individuals under stress, social support functions as a buffer to improve psychological
condition [38]. Indeed, a lack of social support can itself be a source of stress, leading to a long-term
feeling of loneliness [39]. Social support can improve individual coping ability and resilience,
indirectly buffering the individual from daily life and mitigating stress reactions [36]; consistently, we
Our findings also suggest that media reports about how the government is fighting the outbreak, how
to protect oneself from COVID-19, and how many suspected infections and cases were reported every
day can engender intense confusion and panic in the general population. We suggest that the public
should limit the time they spend searching for COVID-19 information to fewer than 4h per day.
Limitations
There are several limitations in our study. First, a potential selection bias existed in our online survey.
Elderly are more susceptible to the SARS-CoV-2 virus, but only 3.1% of our sample was older than 60
years, so our results may not be representative of the segment of society at greatest risk of mental
Second, we did not assess whether and how respondents were engaging in prevention; preventive
self-behaviors can also mediate stress levels [40]. Finally, our study design was cross-sectional and so
could not capture changes in psychological distress and its predictors over the course of the COVID-
19 outbreak. At one year after the SARS outbreak, survivors still had elevated stress levels and
disturbing levels of psychological distress [30]. Therefore the long-term psychological implications of
Conclusions
The COVID-19 outbreak in China is substantially affecting the mental health of the general population.
Mental health interventions should be implemented in a timely manner for individuals with suspected
infection. Our results showed that positive coping strategies and increased social support significantly
correlated with lower psychological distress. This suggests that the general population, especially
those directly affected by the epidemic, should be taught active coping strategies and be encouraged
to seek and maintain social support [41]. We believe that efficient mental healthcare in the national
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public health emergency system will empower China and the world during the campaign to contain
Abbreviations
COVID-19: Coronavirus disease 2019; K6: Six-item Kessler psychological distress scale; SCSQ:
Simplified Coping Style Questionnaire; SSRS: Social Support Rating Scale; SARS-CoV-2: Severe acute
immunodeficiency virus; AIDS: Acquired immune deficiency syndrome; ORs: Odds ratios
Declarations
Acknowledgments
The authors would like to thank all of their coworkers of West China Hospital, National Clinical
Research Center for Geriatrics, Karamay Municipal People's Hospital, The West China College of
Medicine and School of Nursing, Chengdu Medical College, on this survey for their skillful
contributions.
Authors’ Contributions
ZL and ZZX had the idea for and designed the study and had full access to all of the data in the study
and take responsibility for the integrity of the data and the accuracy of the data analysis. HY and MLL
drafted the paper. MLL did the analysis. ZZL, WYX, YWY, and YYL collected the data. All authors agree
to be accountable for all aspects of the work in ensuring that questions related to the accuracy or
integrity of any part of the work are appropriately investigated and resolved. All authors critically
revised the manuscript for important intellectual content and gave final approval for the version to be
published.
The identified data used in this study can be made available upon necessary request. Inquiries of the
This study was conducted in accordance with the ethical standards put forth in the Declaration of
Helsinki. Informed consent was obtained from the participates via the Questionnaire Star before they
16
were able to continue to the survey. The study was approved by the Ethics Committee of West China
Not applicable.
Competing interests
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Supplementary Files
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supplementary tables-submit.docx
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