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Biochemistry

Notes biochemistry

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13 views60 pages

Biochemistry

Notes biochemistry

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anjalith3111
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© © All Rights Reserved
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ET Ts anbelfer indicator for | insignificant «| Geesaie of MS) cron baine renal preter “ond more pecig/eably clomeute Can be ved to menmuren GFR. gromero lai f tHes Wen uren ] az 4 [GER is: messured s evey as period ok 24 bixe Val “Uren Chearence i 1 BR Tass rs, TF ANS Oring iS itolleded vey _o 24 br 1 wer denreicen ig Me bypotieticals ant 0 | fetied ond. blend Sample. 1s vcatlected. Tre blood. fpr wowth “kiddy cleans Urea cont of creakinine is measured bob I ~ Aint . Wag, Une: 04 WELL OS 9 Hee ‘serene Sadyple » © this ig waenavved toy voensuring {ha cone Ty sme armel venge oF creatinine: Cheavence % yea im bleed Cones nS Urea te Une, ig Por washes St toi 120 inet fran Le fond owt. of uring | excvected ih over 1 - S - = AF Fe 1s mL fmnin woo Hs very [A hoo. iwteywal hs ppretes ee vain voli Ts very T - Ne [ete metare “vve, cheavence frist te ~~ | poet is imade. fo wold vine sone! 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GS =} ~—_— [itt “veabsoxplion ob Yo tobulan level is et G : et - el +2 _ _ > i: a fov a suitable candidate to meniore GFR: iteyabion mast of (fee piteraki Fea. elechvolyles one — | obsoreed shock ab the febolar eal bul Tolan clemence equals to GFR» Yu problem ot the tobvlan level will So “Te! messure Me “iuulin clenrentey It Gash’ | resbtt Tn non absovprou 2 excessive loss is iwkroduced iM fre wleed by menu of 4 of -electyalyfes’ im rive - - Slow continveus fafusion te wiailrtevs | a Slesidy" tone oof Viaudia pe bleods [os Sexo electrolytes trot one mensvred fev Hats Tai ig done by pret Reppin Bomt_of LOT iwolin Tn 280md GL Mormal saline Ob. Ono. = “per a) Serum gediom level (Nat) —) (BST to LMG mmols/L inpocd at avvate of 9Omb fin fo actieve! dosived cones Then Fore of 10% jwulia te SOO me ot: saline [rpesed ot atete of Umb [mec by vhaldain Ao dogived cone: sae Y 1 “sy is a Oni opps of Me GRR AL i pelo wormal | ulin tenvence shouss on Urpaived — Stemerutar ee : : B Serr electrolyte Sexve_ geno. “THe _punpote oh te leidweny tobe fusk waley balance ond excigalsn but olin” hy rrniatoim the’ etectvelyte'ikalexce: af our’ loody- [7 Kityey s aebiedy Yeabitvb ov excrebe. etertioly fed _to waive the electrolye badnce ob the boedy - [eh Serum patoaion Level CK) = Be tS momols [e+ tl Serum chbvide! Level Site LOT mmals JL = “Test el Ly pHa pies & Conc.) Test + Tn cme of oakey shortage: mW the becly) the eidvey is oble to conc. 3 + This 1s deme bey imeresdmy The veabsnsplio of sosley te gemewlds filbeke ot Wwe PobulahY levet 9) S8e ie egpert the measwre of Ghe ability of to ‘kidney ty comerve tooter ore: 2 Conserve waley: ond cocoate urine is) a measure of Fobuldn function t Ty By twit fest, the fabio ty nob atiowed fo Jake any food Oy toakev oftey te eventing &§ 4 meals The Rhvt Sovine samples famed Vrooom Aelita alg Oo fobeten - sin the napraling ore Collected fo Healy I th bow: Co ig messuvey. ~ \ my ‘Allan teat [Dring Atourain teat Ls Tha vwormel person yi te specie gravity sane ab | Cec) of at test dot te sample Vahotlel ig olao brow as) micioalbumin Test: + L Ls be -Obove, [D295 oF above + Tye re 1's below L026, dobulor dysperction ia present - i i f Pepese Teh DivoHiow “Tea = SES + Te Gilutiw teat) ie alte a» wenaove oF qunclioning ef Yobules: Th ene of fluid 1 | [Te Deteck emily Kidney digense [+ Menitoy Eidney Healthy i Wale = vise individoatse . VU uertoad jm soy BS the, fbules veabsord leasey amt: of wootes , Yeauibing mm |extreton dg {Type ot Teats : o t of diluted vine - | _ fags oak pe Gubjek vis pak one ek urine Teast =) Meswres atbumin to creatine yalio CACR)- [Fes ais a ovenughe peat and Yan a7 a oo Wage Te mada to drink (200 me %. ety? + Duby Urine collechon =) Menauves fotel albus — excreted fa 240 ieee Te Timed Urine Collection =) tyensvres albumyn over RE | okey Vover peviod Of 0 oe etl [Than the urine: Samples - ane) collected: wery eth | 4 bse i hour ere er ate SE Se et sneered Yond” obleost ove of te Sampled t 1 Chnvid have. & Spee gravity, of (008 or et. et: | leays phen of the “Surples have Hor ee of el > 3 1 i [> Daa by_colledtin =} Cilleck urine over J Duchy setllectior= “Procedure bs Vimed Glledtin =) Gallect vine ae specified Gd period: EA L klvey > 7 [Neimat merges | C vo [2 Normal ACR Ley ai 30mg lo. ¥ Lives Fonckien Teak => Se Liver panchion teat ave a qrup of feats dene 0, I I 1 [te Fos! up pes in si woot Soong Ta! 3 [eats + Blewaked levels waa equate foster Tealing » Regular onthe 2 possible Oddi Honnl pe = E Fock apyedlg aoe | ; 1 Hers alborsinera = 30 300 9Yq- ui i atihies of ; oeypalbominovia — Gwester +? [ros aay fins sobre ae Ag "| saivioes sons cin” centtatnn calaobeagecitte Hea | Uvey cons: “Te access alt tre chino | copabitiies of (fe iver suck dy f- [+ Dhysicot Exercise — Con thevense ooo Toole the? + Nijbjobion Gtabus — Atpect ovine cones + vector ~ ow Ferery — non jmevense level LT Sy meconveticg vavious Pleara proteins tude ob = Albuin™ 9 proMexombin Hrak ont Syntresized etl> [ey te Uvex, ond alas te Upids ‘ DEAlesH os —_Cextaiu droge | imparck vyeav lig + Conelanion | + Gayentiol pwr eorky detection 2 manager oF {oe ae Vbisenae meaning Yao Vovinus plasma ei et 3 ; Ties function fests ant a igyoup of feats cave Bt [P Yo accedy to functional “Capacity of He [eo Sytrele obitity 6 Wo Wer is eueutd by jrofeina: Te Secretory | Exoretory biti by (exposes teak piape one Toscan Tee devon Uline level a} Serum bilwbin = st eanjogated g _ z unconjugated The tommon Feats tok paver part of ra © Uver_fyonchiow feat poyle one” geyom e. | i [= wilistouie: gels Confgated wonconf vg eked [eb etal Sevom pproleind B jatbunvin’ gfebelin yak | Total serum proteins OT albumin globo lin. T - ay = - Toyobo, Uvex enewmed 2 proterondlin Hua. ; =a erent protirenb a Farr erage ae 7 . j\ Tomy awivianed - Fy Ra commen mehard ol mésaoring serom 6 Tata totes >. ALB) Cate T/LOM Ylisobim level Te Bisee meted & el ye ainsi oy & pron leek 18 © tee Sqidl: ge T The total Fe Total derory atlounae lev 1S BS hy "f Sq dt 19 fee warmal Terge for albumin qlowolim: robo) 1S).bD bo eS er © Li} ___t aed > T re I The, exploivation about ead of the pellewing feats Ono 04. follows ub Tene of Me end products of Gmahowl wormaled yahoa CR) @ tH oned "por manauring "fae pre hvombin G j ay is, I yee heme. 3 el : is _yolno ealeved pigment - ¢ bige megabalianm cond is derived wa tee heme. xt OF Fe hemoglobin moletute 2 tran cnivad C4 -— (bron poeple doses — Gat, 2 prop cel Al t “he eanmnow fests tok pow part of FAC et [ee SrA Moree C Te rama Gamma Ast, Ata ge tT [+ Liver plays por bot vole, Mm fhe Front opi doses — tnt Ti een a) T moka eivin of bilinolin: te breokdou y aber of “bilivolein _Apler the trerk tou » of heme portion of the. hemagiatei. > | Coneonju gated Vilivubin ) ig traatuble_ Common Teat_jpr Lever fonchion Test 1g ee eR Pape [ TIE Is brava ftwed faene the site! of RGC 2 emule i: T pene breellown Suet os! to spleen tot iter hor & tanfugation! bifd ite aller TRE ee Wier] TE 1s Confegotesd atte « geen sel twits 8 neip cof ene _ eg ____ Sr giseovemy | “vena pores’ “ a 2 | Qerenhak ufo SSD Awe be SEO wer” The i vot fle ep T Ee} eeug ete bite Te Tod Noiaze sulfpnitfe oud + a i adivwa @ howe coued divest _bilivol 2 | Fer uneeujygated ov feeble voli 1S eed to divcelve ie TW couqetion makes bilivebin water else Vad Hus Conjugated tnivovia (8 €onb [rot wait! sloble Y we _ excreted jato Wile + Tile mesdoring 6s T tabs OSES for Hie Yen to occu * Tels Pilivubim , we mesayve total 2 eonfogeked a 3 T waetasd ig to Tudiret metrod’ fev _| Tui tivubin (-Dixeck bilinubin) 8 catoulate [rmmenauring _billrvbin levels a He bis | fo. [toot conjugated & once jugeted tonive| he fhe iMdivect > bitixvbia toy, sobobrackivg, divect {pee too total: fore serues bilirolora —_ Galobelin “projeima 2 Albu [By Tetol Sesum TS _vansmal org oF billrabin igi= cig Oe ep ere, wales vital | yh ploamo nce proaure _} Seth vilivebin = | | Unemnjugated Wilirbin b= Gonagaled Vlivulghvs= ol te Ot wag ld ee Tovel oto trad of 2 Id Anise: 14 | biirvetetn | te He wn joundic jr (a — | steed ey Sie &. aie hte og cay apeeied awed imam lS iS ‘gyrthenised. by sha Wer ond el ee gerowe olbomie aver USO okie bitty te ter re various” menu. Te Sao tommors nnetrod: ob meadeving Serum ed {irolaiv' i inzin” (i jin 20 Hi: efaniic asd to vt Yue colo Te bivtyooi” Fake ore bilivbla Yue dalouk __ggy | “RI 1S meas ved » Culbyine~ J i tensity ob BROS eS iam oy _ ®& [piste level ond 0 movmally Ia toa wage Lb 2S glide $ [1 Tre mormal range oF “album 3 qlebulh Prothrna bie je olatting” “autos “Tl ond | ite ochre wi ie trem bin 7 ata d catted clatting U fetor Tate SDB Tig vat rine” pep de jloviveyen “fo | tohich emverte, {oni . | mobo iy b2 WEE But pith Y hapabe y {| | dyspunchon , Sw Voto weteds oronvda | s. I. Th fe cuntuosined tH fe Liver: And bow Ht we yptach fuschia of Liv oy [prothremien “aebiviky i’ plnawia” “[e vSed bo Caw fren, r . . S macaguye Hee Sy thehie fenckin of. Uvey- —}—— = ect! I z Lt Te mecsuse Serum atbymin tre brvmoeresol pe [se Prottrsmbin Hime ts mensoved by taking [aren mathnd ued Aton ix tae —— Eee | Woman pleama prom blood ifrt hms bear wire of bmmocwesal areen of o Slightly G asidia ph givea “0 “illow “gvtan fe bi | gra” enbanes ce 3 oa PT tee density ob tals colour ie chper died on 45 lL yne pou albumin ie uo, ample - Tit tafansibpP ft ead of a sonuateng at Te vas “Heong to bivrek oe | + ProWeombin ig a farms dn iw portent part at Lola ee mea Rg [Bis tee sero Sie he “dedbiodin of | [collected in the Y tobe tontaining citrate a4 od anticoagulant: ri + The prottvombin Hee dipyeve fm accordance te I fre enatybiecal metteod aed +) Nene to compouiate for HW’ Gewmahanat movmalized Liver eneymes Olonig sith bilivubin vase Ho wange Csmmouty mensrred’ favemefer measured ia _fhe tive (ion fesbs “Theaa ereymes [ane heputia ia” origin ond troy one leaked epobic. Cells - I Livey oreymes (one weosred to get Ton idk of) tho. Cellutan inavit on! te liver ond one imcremed a velde vaviely ot + An lucvense Mm AD py GALT levels bunts condita such ss viral nepatiks | fone ok an imavit to tae Uvex pavenchyma ne} s chivrhoss of Liver : "i p L rhos's ol ery ote Hse Alt ig ware thecip'e mowkes of ; hapolic iwjuty than MST 04 AST elevation The tommonly meagvved Soret one is clo geen Mm tardiec Hssve fapyry ~ _ Tramaolysis 2 mudele | Hysue S g “Fransardnages —> ASTCSGOT), ALT(SGPT) Frama peptidases > Gtr T “Phecphubye —> ALP a e =! evel of trandem waded [+ Tor memdure te eotatyzed by Ham 16 covpleat “te _dodailed @xplaination about each of He Cweqmeg abe os ‘follows | Hoe Teach Te a yeah Mm wWeR (MAH Ds used vp yeaviting in Change ta ae phoh metre inkersiby when vend dt Ye UV wonye, ot 2 Tosprinests I a pb A group of Sreymes Heb brenapen Yee _gmine qe Pom Br anine add i x keto ald Con verb into at amine atid wiile cerveleae tee oraimo atid inky keto acid hy ee Ov Wuehe method » bo) “Trenajpepdoses “The bronjomivenes Wap abt “measured in the. iver_punchioa test ane ALT! ond AST. the cis Olawe amito trons pehode CAT) ond Aspartate ominatrondjains® (AST) - + eo wormul Tevet of ALT 2 AGT inte Th wckde (Gert) wowith ty brown 04 Crommo Gale bene [2 TYR Joep Hidase y,) auco tron Qreyme peuple to Gilerry biliary bee ond & wore ee indicator of cholestasis one Enlai ond damage ‘a fo sbilian: a pba: bag Speci ye ker tind fe oaised eh _einaske, | Subthinieal damage rai * biliaiy tree + [Sts normat, ge isstn bf Ot v2 Tul: ps [eS Bepalaga = 3 ee dade ALP I wach Te noun jos Alkaline { pre spratese - [eo Ze igo Wypyologe Trak yemoves phosphates fpow au kinds of molecules such a4 voters , publertides ay. Th Ve foved iw pebts thaiag toe billvasiy tysiene, boon aviye iv it Lael it indjcabve “ot Saeape ko Has” ilies trtedue to cneleatatis. ¢ FIYROLD => [+ me Wayreid glad is a bviteryly shaped wrdornte qand frat 73 normally located [in wo lower front _of Aro decks “THe void '§ jo’ is te make fhyreid hormones } Th may be dug to Stove _blotle! tag lc duth By lwhumepabie” abginithion w i ehivn “pt Me bilinyy ohenneld- 2 Th ig oho Round I pplatonta 2 bones Newer BE tee Mas leveh ic’ ayo increased in grou nildyen ia thom toned _undexgo body ure ener ts “Paget's disease in bo - 29 JT eneetaing “Os y(t shfeutake vodbmost bond: fori speupie ert profes tse levek sof Hroge ove proteins Chas Here cor Ohawges Ive how much’ “bioad! 2 Ta [_meshovediy “The pout Ten 89 TS 1s fhe _horwrord quok WS Unbound /2 able te enter S$ ogpect tae ape iene uae =~ % Comninn Teal jar “Toyrid” Fonchton “Te no Te RA is Pdawe- “colori ebsltally oko Loot Lory th, Cs ee Ass Sain Jols oa dpa fo Wenuwre Nowe bavnones \ rl ee ae | i OO eit uz ery sts whith are yeadily available ancl wrdeby used, es bub wet aut ave” useaul tall dihvabions Tests ane done to doatuahe Yeproid fpechon voit prevents TE Jno vadking enough TSH fo Stimulate the tayreid+ ¢q whith Metude he. falleusivg :~ g Ca Tn Texts oy Reverse 13 by Ta Terts i= [TH te ee tt poy of Huyverd Lernrone | jyetab menguyes He bound ond fsa hoynco@ Cam ree TC) paditehive Tete Upke — [9 profess dipper - Y Gigs ENR Tu pup Mciedy Teds eit z oe Coys Tests: Jefe gisbulinn peg dratabig fr “Ye bleed A ei lt Change wten binding : : Snes N Tre debied “expnivakion okouk cask oF Fe Cy TAF fpan [i] memgneg Weak te mab bore {plowing Fests ore od follows i= et a [ge Ti werchee 18 gent Taw had Hsved aE 1 St 13@ & TSH tekst ay 5 ay [eo Mukg measure jpwe Ta — elmer a prao TH i ry - f - — a DC ETA) or foun” “TH index (FTE) — move [The beat voy te inihaly feat fayvoid es Se Sele vous ite iia lave futon i¢ “Re aeasuve Vike TSH tevel mK CL ay [Va bleed Sample Changeg fm TSM level mn @ tt | serve oF an War Sudlem . if Te A Wigh TSN [evel fedicates that He Ae tow TSH ond avis fanchibating” wher checked with “TSH « The finding ot an elevated TSH and [ow = v Fi oy REE fediewtes primicoay atu roldigens L } low FT on PTE alo indicates Ugpottyroidiawe » Eleweted TSH is due to provlem Thyroid gard» wrile low [ Haywid qtond ts vot making enoyeh a - yee t- 7 1 Hagreid Lavoe + Tha opposite /foatron FOI jo Vwhien PAR TSH fevel tt foe) esvertly a TH duo to problem ie fp Roilasay toad +e juditates tak the tapeid és podtlg foo wach Haaneid bron’ Ni ina [ ou abusvmality im the am eae ete + A tow TSH with an Chevoted FT oy FTI individsabs wn Coie hyper vein peerd s AR tebe Tip eachive = Nae oe ) Sp tess ane often sepa Fe Ta ynosis Ter Some veers “Tai #8 prodoted worelty in on to datexeaiva ht 1, paarsbody! bh oot, 1 Shan sen deqradad I Ww perPuyreidisen geoesity ~ ok tee hyper feral dit [ o Pabienrs who ont. Wyperteyroi voll howe, Moveked TS Wwe + ge individuals gsi! colha a Lee TSM, Only Hat Ts) is wr? —eteneked ond tee FT Te FTE is wormed eines se ro globu live i= Ty a _proteit pradoted 4 [eis Testing voveby, iy veld vee & Vopetainoid_footient Siwce Mit ig Mae Coat fest ee pega or) plot tome 2208 obs Prabionks tan be A | ae a cela ond Hunsid cancey Fewerty Wypebupeld eI Wig hi CLS ond low Tie I Eta en TDD: bok Woe Sovak TS - ——| | > TEr ts nob & amenduse oF Hayuord -fynchon, s Be Se end ih oct nt ding tsi eonced ]___when the wold ig stl resent 1 f Free! Tals nesible , but ss —resavcement_ot Tee ee fee - l a a e, : — : (Fe Gee aplen Sp Ha bay way gS + Becauas Ty contains fodine 1 the Myreid retects OS wn foreign iuvaders , tothe eff _ tnd rast poll a (axge amt Poa bakericn ond Y wifuses by destroy a [7 trese invedons “ryit' Gubpthances “ens LAS | cm abpropivake omb= of Ta | entitvadiies _jorodoced_Ly blesd ceils ein? | | Luma oa Luyrafplnocaploa Sj) 2 |e The Puyeid tay develiped a vow achive | Bs. mechanism fer deirg Mus Tewigfore , Hu | a ees Oe eared hig” Cog om + Th many patients sits hypo tr raidicn = on Lea pb Hay idigne bynepbee cubed react I fadividvel gwallow a smath amt: “of os te Heyvald and male > [ledine ) we fs" radsoachive* qusti bodies “pana ~ Huyroid. 6 oe proteins i Se er docby fe brake etl Townes Hee fedicd goes. By mensoring te * Tusa common audibeliby ano Hey r0/ 0) ele an oF vadieackivity tatTis taken Sp by a the Wyreid glend Crediaachive indine—optake | peroxidage ovttiedss 9 thu glebulin {| I [antibody " Meanuring level of’ fayanid “81 cantly “aaakee dobemdna wnelyex | ewithiboadeA may as ; Hee rig i ie GuneKoning. gore To amcao' of tae Hcyreld —pYs bles el} 5 te a ie xj _ gerald | al! [of ven nig AALU is gear ia individuals hase ~TSM and FT: ono sahol tet, vi obouk Me of) o— ae jad is overachive C hyper Myreid’en z T pekust Heuyeid puvehan ov’ Jevely. A et 9 atte tHe BATU ig seen in individuals wwate, [eijwxont autibady “thot way be' Lovie PT tp tid god if udondtive Cioypottepssidiors) _ EP client lt MyperBapibten iy @ Lg a a Sey een Weiaplor ostibesy C7SZ) 0 @ [3 yy a edlow fo BARU) a Wapuid seme - ip Tbe sbolaived p vosich dhawws & foichore of fee _ hy Radioactive Tedint Djpfabee io : Epi ord pid vocals wok parks of Fe ef | roid have taken yp “te iodine» I al, a ao) t ari [ | gb intesne it, Tyroid at x "i R Tor wionen aha i eps to fegraid —jumekiow best i= F [hae one wien wom madicakions tho i hi com afpect thyroid function featng + en [emer ee 7 a | Some examples dncide, i uv ihe = a ; elt Free fuyrnxine 0:4 = 199 Leal ob. Ciitbenh is ls te eg |o Snet eee ; na T Sodtoa a Whi Combe pills, Orie Premanwy, Soo j eae aie 2a 45 bal Tocome high levels of bhel 2 ts. TS © cu a eae g . z ig veeedtan ealiogues Tecrenae Tee a el + ¢ He binding protemas) Tn those St (Ors | hayveid simak 24-3: FO miu] fea ei pee ae pee et aS ee J. Te. por, Hopeeid enoboakion ) tole! coil! ti? I ypiedtly be tn Hee smormak trary ~ fond Lear ee ET IS eaneaE pS : Se LY Yay (by Bio c 5 H [ = i wit [Anti i <4b fmt j 5 onde: ee - —— r aa a aaa ae ST ae ef | onbiloodi Cigale) |. sel a72 7 ; ; ol | = op several Womold: pwicbion : Feats. Fo — . - aetciaria UO oppesh abwormal, when toy we a @ 7 ful we hase as uf Jock veveal in blood: Gistin, saould, wo E et: = ont 8 - E 2 day a blood I aaa 7 - be taken fev mye Logger blbo et ° oe Nayak “Tpeid Lexels = HI 3 | ess finite ____Ronge. = = a zz Ere tuposin ac t= Lg fat — > i — ey | | pss eur a wbsi2 gy Jd at Ton { a = 4p £ ze [hit oda May one = Bob ng ge TY HEME. CATA tt | cevom? rane Ce a P | Sins x et is some? Free_triin do tayroni 4 o c TM OL FUE S$ ¢ Heme ig _cxiten vayibus brolegese 0 functions incladiiig Op brongport pa blood, electron Y brawu for in neibnebion - f kedowe Jf M20— in coll» A r 44 tH te I * Remlahan > Heme synthesis is negulated | ivDhive Mm the | load) Te com vesule Irom OvioUd: iundentying -condivons , [nelading ff es J KX Tetredoction of Heme Cotadallm : = eR || Hence calebnlion ig fre | fivoecad by coe heme rs component of heemoglobiny and ofret heme containing profeind is byeken dows re oe ae ata se solve is 0 aes The oe vhabae Occurs pe Decenjigated tile cpilixolsin binds to athumin, protein jhe bleed and is transported 4\ Conjugation i wu the Liver ilivabin: jg epay'eg Pe ge glutivanis acid by ye emerge UDP — ! glu Won glk pa 6, enaleiing tt pf at pastnatid grap par gtoobamase. P4850 — Onze lgoattranatloshion —= Henne vegulafes Ye eh caved “By basket daly ETS oO te te te ata urobilinnger: Some oft 1k enaverte ot ays Wi jing, lay owt “Aburibecl ond excreted by Mat |) thy Hires nity bia od cain sahil Gide 12 itil Boyett a pe | pkilinngan ht converted Yo steveobilin, mf Some rot x ade of _ Tot paubbeds in ita gaas giving 2 —] Hat proteins oo Seep [Stool its be enlov V ei -9 ins 0v—_ennattg ef omit ae al 1. TE rus: foranede it veasenbel” fo sthe- bodys — @ LES as = Seki seed pea ee gh Typstean falas and ps_fpeaont tet accumulate t I me? an vil tiyeglin ally be ond is brea kdanin 9. tnohinne ¢Derdnae 1°. Neuerojabil NADPH. opndsats Hig | ds “Gy a ea % Heme Suntresig in Liver : ~ 9 rs Heme _Syntitas eS F Sra es pfs in the Lie le_bephlig we te o ata. Nn af | nee foray ale plaae darn I Tepe ct Nene: Liver conbming “Me c ihe wi ALASE4S hich 1 exforeadedh sa ¥ i i : spleox vatieh - sinvelvess Seue veut Stepd '— eit ws? el i Les [| + Druga increase ALAS EA ach i Ped th Memes oxygennge «Recline t= 4 £££ 8 ne nacbilt ; Sse | i fo CP 80sec ts heme: i | i — F T £ et} mak ee — tee ; ma ; tyatieals of ALALEL He sgyntboet Sopa +> <1. we [is nea a a [ oroteins psd vole heme asd * herd ree | ivet ond CO - el — TG) Canersion of Bilan to Bilfsbin s= a | + Henin deeveodes Hoe synttoay Qe eee | yatintiscie din BS Sioeydi ge y WD Ry | Bitinetdin a geenns—tetan pasate bile eS eaduee the _sy ntaeal 2 pigmen is Sula sepyuonttyy re deed to ——§ " maka. A Fe tintin pe ets constr ty — | teapot of Hye ereymes ALAS L ~ Teg 1) tae entry inne tail wredoclage + Nilivulaite cpa to adda hued ve g. AE ig | is tel folate tena avid tan be [ov as —brovtported to fe Liver move Cedily | « poy | as Sp co Lah egepiie aietacton al Slain el + Lal iYorois dial ~H = foxou_thot Stan be. excvetedt fbi» Tas © iy 9 frien ancicle ; c | - > [ot we gitvie ciel * illacabin AE terse cpndabe 8 oo} ie tna ay nei fatya— | annus Seappaneabs ob bene. cegeadabiaa 6 a : pe ee Iu eels of tre elitulo¥ndorreliaf @ Ly —}-)—Heaie it oni aa ¢ ~ ahed “sydem, —Liser_and inbediine. ef tert a i conan | : | prodasing, Hoe. nent tetanfpynsle biliverdin | Bs retin St) a dA tO» bstvabe —> Heme, NADPH, 2 00P — alveu~ A id d sienic acid « LE : ; Lt Produck =? on ilinegen (exeveled fw { reroute dete a reduckede,Hfardineag bilson The —__ t € i 3) Prnduchs of degandabion uc._o chs {9 celular sed fsstcbinnd fen ___§ 1 sect lation nachos Stathers of hew ne ‘addibinaed iment hrs 9—____a1d_ane involved »in various cri ete ebtiitarx event. La\ Heme doqradotin« 16 believed to be oe evoluHoxavily — comserved Yeafrnge to ovidative stout: ee pT Sp a highs pleats, lnente, —is_lovelsen dion Cy te te foley colli proteda play Hechrrsmae ra ee rae ee Yes] poses ce oui a a eh Sk atyat, ik tk mtctebalibed tote Light = waiexo (ton be iE cadade wt yg ore Byer _ the produchinn of venchive oxygen i Bee ees ene aidabina ana © bugh a) a cl aay tale 9p — fe teehisieat_ onal, — a lta ging net al a 4 i of. jowrdhieg a He hembalolin ot aging ved ood cally > 0 d 7 : =~ pp . a wl UGT — Upp:= glvevveni is Ltrendponose [arnén > atiline Kin wont glvcuventda Ippoi.=? ia dial J Toit reny tani Hoe. cuit ot He liver to sony nied secrete. bilivubin edull rae ta buildup Pr x toms of Saundic a 7 “Pp ts crekina af qd —veuoval of Uilivmbie--eauaing “tite a —- sania ty wippbnns a founder wane 7 vest shviziss Sign 0 fusadive iS yellows tige fo “Hae sein “at fhe shin is usually jist nobitea le — eee ten gt nae av ow. e_Hend dad fit “nepate Shased eg — “Tis a b a Suit | shiv jellousiing. a the totritos fea af the, ty? [eyes 160 fier move noticenble + Ig Tis intenupts: teen fees of bite’ sone tee liver. “Tae oil containing Y Comps gated: bilirn blu remelna ia ine Live? imiteod of. being exore ted= el I 6 Crilbert’s~ Syndrome /= 2 af 2 [re clippevont typos of Tanndiee are os Tut ig con ivmertted tnudehion thal pepo ——@£T onatal Union i jie ability of oxrgmnes 0. process fre. eh — Neonatal ‘Taide se Py exevehinn “ot bile” et. [ec at | 5 very comuernn is lowe loodoies Ee - 1 el othe foe opady'Heus of Hoe fellowes = = ennnot be. vemoved. st tte. fo fee \aidaespa- WE ts wally atiaed by ives ilove vey (diene 7 hepatitis or by “taking eevtain tube. of medisabioad- 5 BY -Heerolyb'e, Taundiieo eNOS [Se ig cused wrene tro merch bilirubin is produced oslo vesulh pho lange : [nos RBC being broker dasa -— That - — ol Gane! due ty 0 Wes henna uarelaked to pina bin, ionene Hee i : —¢e I ‘ ar latin: Noi feo lneimg gecvered out of E I % ito Liver pois vedu/t' og tse tire liver celta » “ek? | bopatii' B,C .D ox E vires + It - = poe alan dlovetop 0 et wesult of oyiw Leng _ 4} Crighey = Nes} Suwdbennae ‘= =a | ' jer or Lowy period i inboni dina eT oagects tho emupmre res pousi ble Uv . “6 . 5 . excess bile up. “ty bibivu bie 3 % Cowes of Jainabioo '- hi | TR | e ame of Me causes of jowndiee ote od = Fay Gamer's Syad ai Hp wed! = = 7 > Tr lt e. r T 7 * ; Hivvhi i f > [te te condita ton oppecks apfovox 37 pt "4 | K a an inhewbed at I wondivan tat adver.ctly ogpects Moe too oh bilivwteta 1 Hee. | tone i eae 2 a ay veoson , ven, et yp nity nh srry _—to punta’ . ea - property Connnk a 6h id ot it | the excedy t [and “process fhe excietion of. i) joumdica- Tavrdien toatl, @ | + iil! eouge — curt maa vesolt of & Sobevete, galls RA” 3S) Neonatal Taundite : - 1 epuctiHow woudl caused c- buildufa 6’ py \ he - : - . bilixwbia or prevents tae. bi fees Ss { RR is very, enaeeese allen —eosnunl SPF Lior fore portly $ disposing. 0 wt s§— 7 TT bilivtt in eb — ys - at+ (Fiver nat oiag_ fly dewebefed «itch ! I At : Lotlive bin « “2 (A pilin metabolicm in he Srtes hie ped ‘ ce ehchigatn aed ia! aa? + Poxpose i= Detests the freseuce of a tnofugated loihirubin ja Line. + Siquviticous i my ip canee— . - 4 we 1 . Fare CQ) Positive ovine bilivwbin jidieates pre. ae 9-8) rine tol =~ Goss uated! _bikimatiia po pressnce._of Yeypicably feo jin pre —hopaLie jowadieo. vse neosjoycted Wwilirubsn ’/ elevated ond! Unk extreted ia omnia go | % Blond rweatiqation of Taundioo '= a | | Blond investigations one sageectiat chingnosivcy ~ fanndice oud celermaiit J, I DG . e 1 Biliruble Levels = Te Allatine Pérosphale (ALP) ofevatror < 2 . dirwbes ile! duet obsbrithinn ++ Rowpose i- Meosuye tre level nf tol, am 1 ms ties : Ie 2 Glw if 7. ia fre blood > : | elevadinn inditates bile duck obctruc trae ot e 3 I br Oholinl relubed livey di'sease Tc pronteo. = Lite i ati [ in level docrease iedirated chrawie 5 “Tato toiltutin Slevalsbn tine jovrcbice a | 1 ey_a. Sew fuer age « oy paste hepatic. jrwadice + a eh [eo Protacombin Hime CPT) prblengatiou sygyesks Ss a Hers i ing pecker yore! al | > |

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