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Immunology: Conjugate Vaccines Explained

The document discusses polysaccharide vaccines and the reasons for conjugating them to proteins. Specifically, it notes that vaccines containing polysaccharide capsules from bacteria like Haemophilus influenzae type B, meningococcus, and pneumococcus are commonly conjugated to proteins. This is done to promote T helper cell activation, switching, and immunologic memory formation. By conjugating the polysaccharide to a protein, it converts the T cell independent antigen to a T cell dependent one, allowing for the development of immunologic memory against these encapsulated organisms.

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268 views3 pages

Immunology: Conjugate Vaccines Explained

The document discusses polysaccharide vaccines and the reasons for conjugating them to proteins. Specifically, it notes that vaccines containing polysaccharide capsules from bacteria like Haemophilus influenzae type B, meningococcus, and pneumococcus are commonly conjugated to proteins. This is done to promote T helper cell activation, switching, and immunologic memory formation. By conjugating the polysaccharide to a protein, it converts the T cell independent antigen to a T cell dependent one, allowing for the development of immunologic memory against these encapsulated organisms.

Uploaded by

ridin007
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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9/17/2013 6:28:00 PM VACCINE HaemophIlus influenza type Bpolysaccharide capsule conjugated with the protein The vaccine administered

contains the polysaccharide conjugated with diphtheria toxioid These vaccines protect against SH I N (ENCAPSULATED ORGANISMS) Why are you commonly conjugating to proteins? BECAUSE IN their original form they are not? Vaccines coniaining polypeptide capsule such as (meningococcal vaccine, Pneumovax, H influenza type B are commonly conjugated protein to promote T HELPER cell activation, switching and FORMATION OF IMMUNOLOGIC MEMORY We want to conjugate organisms with proteins so develop memory against them. In order to do so we need to take oraganism which is (conjugated polysaccharide) which is T independent and as soon as we add a protein to it, the polysaccharide protein combo will become T dependent thus memory can take place in the future VACCINE TYPES (A) T cell independent polysaccharide organisms Strep Pneumo Neisseria Meningiditides H influenza B Neisseria meningitides outer membrane complex tetanus toxin mutagens non-toxic. DIPTHERIA TOXIN VACCINE TYPE( B) Protein carriers

Immunology

S H I N are encapsulated bacteria capsules + protein carriers = HAPTENS vaccine = polysaccharide + carrier proteins

VACCINE TYPE( B) Protein carriers 1. mutagens non-toxic. DIPTHERIA TOXIN Neisseria meningitides outer membrane complex 2. tetanus toxin or

9/17/2013 6:28:00 PM 1)

9/17/2013 6:28:00 PM 2)

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