Safety Data Sheet
According to EC Directive 91/155/EEC
Date of issue:
Supersedes edition of
1.
10.12.2004
20.01.2004
Identification of the substance/preparation and of the company/undertaking
Identification of the product
Catalogue No.:
100012
Product name:
Acetone for gas chromatography SupraSolv
Use of the substance/preparation
Reagent for analysis
Company/undertaking identification
2.
Company:
Merck KGaA * 64271 Darmstadt * Germany * Phone: +49 6151 72-0
Emergency telephone No.:
Please contact the regional Merck representation
in your country.
Composition/information on ingredients
Synonyms
Dimetyl ketone, 2-Propanone
CAS-No.:
M:
Formula Hill:
Chemical formula:
3.
67-64-1
58.08 g/mol
C3H6O
CH3COCH3
EC-Index-No.:
EC-No.:
606-001-00-8
200-662-2
Hazards identification
Highly flammable. Irritating to eyes. Repeated exposure may cause skin dryness or cracking. Vapours
may cause drowsiness and dizziness.
4.
First aid measures
After inhalation: fresh air. Consult doctor if feeling unwell.
After skin contact: wash off with plenty of water. Remove contaminated clothing.
After eye contact: rinse out with plenty of water with the eyelid held wide open. Call in
ophtalmologist.
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free.
Immediately call in physician.
The Safety Data Sheets for catalog items are also available at www.chemdat.info
Page 1 of 6
Merck Safety Data Sheet
According to EC Directive 91/155/EEC
Catalogue No.:
Product name:
5.
100012
Acetone for gas chromatography SupraSolv
Fire-fighting measures
Suitable extinguishing media:
CO2, foam, powder.
Special risks:
Combustible. Vapours heavier than air. Forms explosive mixtures with air at ambient temperatures.
Beware of backfiring. Development of hazardous combustion gases or vapours possible in the event of
fire.
Special protective equipment for fire fighting:
Do not stay in dangerous zone without self-contained breathing apparatus.
Other information:
Prevent fire-fighting water from entering surface water or groundwater. Cool container with spray
water from a save distance. Contain escaping vapours with water.
6.
Accidental release measures
Person-related precautionary measures:
Avoid substance contact. Do not inhale vapours/aerosols. Ensure supply of fresh air in enclosed
rooms.
Environmental-protection measures:
Do not allow to enter sewerage system; risk of explosion!
Procedures for cleaning / absorption:
Take up with liquid-absorbent material (e.g. Chemizorb ). Forward for disposal. Clean up affected
area.
7.
Handling and storage
Handling:
Notes for prevention of fire and explosion:
Keep away from sources of ignition. Take measures to prevent electrostatic charging.
Notes for safe handling:
Work under hood . Do not inhale substance. Avoid generation of vapours/aerosols.
Storage:
Tightly closed in a well-ventilated place, away from sources of ignition and heat. At +15C
to +25C.
8.
Exposure controls/personal protection
Specific control parameter
EC
Name
Value
Acetone
500 ml/m3
1210 mg/m3
Personal protective equipment:
Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.
The Safety Data Sheets for catalog items are also available at www.chemdat.info
Page 2 of 6
Merck Safety Data Sheet
According to EC Directive 91/155/EEC
Catalogue No.:
Product name:
100012
Acetone for gas chromatography SupraSolv
Respiratory protection:
required when vapours/aerosols are generated. Filter AX (EN 371)
Eye protection:
required
Hand protection:
In full contact:
butyl rubber
0.7 mm
> 480 Min.
Glove material:
Layer thickness:
Breakthrough time:
In splash contact:
natural latex
0.6 mm
> 10 Min.
Glove material:
Layer thickness:
Breakthrough time:
The protective gloves to be used must comply with the specifications
of EC directive 89/686/EEC and the resultant standard EN374, for
example KCL 898 Butoject (full contact), 706 Lapren (splash contact).
The breakthrough times stated above were determined by KCL in
laboratory tests acc. to EN374 with samples of the recommended glove
types.
This recommendation applies only to the product stated in the safety
data sheet and supplied by us as well as to the purpose specified by
us. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the
supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Industrial hygiene:
Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face
after working with substance. Work under hood . Do not inhale substance.
9.
Physical and chemical properties
Form:
Colour:
Odour:
liquid
colourless
fruity
pH value
at 395 g/l H2O
(20 C)
5-6
Viscosity dynamic
Melting point
Boiling point
Ignition temperature
Flash point
Explosion limits
(20 C)
0.32
-95.4
(1013 hPa)
56.2
465
< -20
2.6
Vol%
lower
upper
Vapour pressure
Relative vapour density
Density
Solubility in
water
log Pow:
Bioconcentration factor
mPa*s
13
Vol%
(20 C)
233
2.01
hPa
(20 C)
0.79
g/cm3
(20 C)
soluble
-0.24
c.c.
(experimental)
0.69
The Safety Data Sheets for catalog items are also available at www.chemdat.info
Page 3 of 6
Merck Safety Data Sheet
According to EC Directive 91/155/EEC
Catalogue No.:
Product name:
100012
Acetone for gas chromatography SupraSolv
10. Stability and reactivity
Conditions to be avoided
Warming.
Substances to be avoided
alkali hydroxides, halogens, halogenated hydrocarbons / alkali hydroxides, halogen-halogen compounds,
oxidizing agent (i.a. CrO3, peroxi compounds, nitric acid, nitrating acid), halogen oxides, alkali
metals, nitrosyl compounds, metals, ethanolamine.
Hazardous decomposition products
no information available
Further information
light-sensitive; sensitive to air.
unsuitable working materials: various plastics, rubber.
explosible with air in a vaporous/gaseous state
11. Toxicological information
Acute toxicity
LC50 (inhalation, rat): 76 mg/l /4 h.
LD50 (dermal, rabbit): 20000 mg/kg.
LD50 (oral, rat): 5800 mg/kg.
Specific symptoms in animal studies:
Eye irritation test (rabbit): Irritations.
Skin irritation test (rabbit): Irritations.
The literature data available to us do not conform with the labelling prescribed by the
EC. The EC has dossiers which have not been published.
Subacute to chronic toxicity
Sensitization:
Sensitization test (guinea pig): negative.
Noncarcinogenic in animal experiments.
Mutagenicity (mammal cell test): negative. (in vitro)
Bacterial mutagenicity: Salmonella typhimurium: negative.
No impairment of reproductive performance in animal experiments.
Further toxicological information
After inhalation of vapours: mucosal irritations, drowziness, drowsiness, absorption.
After skin contact: Slight irritations. Drying-out effect resulting in rough and chapped skin.
After eye contact: Irritations. Risk of corneal clouding.
After swallowing: gastrointestinal complaints, absorption
After absorption: headache, salivation, nausea, vomiting, dizziness, narcosis, coma.
Further data
The product should be handled with the care usual when dealing with chemicals.
The Safety Data Sheets for catalog items are also available at www.chemdat.info
Page 4 of 6
Merck Safety Data Sheet
According to EC Directive 91/155/EEC
Catalogue No.:
Product name:
100012
Acetone for gas chromatography SupraSolv
12. Ecological information
Biologic degradation:
Biodegradation: 91 % /28 d;
Readily biodegradable.
Behavior in environmental compartments:
Distribution: log p(o/w): -0.24 (experimental).
No bioaccumulation is to be expected (log P(o/w) <1).
Ecotoxic effects:
Biological effects:
Fish toxicity: L.macrochirus LC50: 8300 mg/l /96 h.
Daphnia toxicity: Daphnia magna EC50: 12600-12700 mg/l /48 h.
Maximum permissible toxic concentration:
Algeal toxicity: Sc.quadricauda IC5: 7500 mg/l /8 d;
Bacterial toxicity: M.aeruginosa EC5: 530 mg/l /8 d; Ps.putida EC5: 1700 mg/l /16 h;
Protozoa: E.sulcatum EC5: 28 mg/l /72 h.
Further ecologic data:
Degradability:
BOD5: 1.85 g/g;
COD: 2.07 g/g;
TOD: 2.20 g/g.
No ecological problems are to be expected when the product is handled and used with due care and
attention.
13. Disposal considerations
Product:
Chemicals must be disposed of in compliance with the respective national regulations. Under
www.retrologistik.de you will find country- and substance-specific information as well as
contact partners.
Packaging:
Merck product packaging must be disposed of in compliance with the country-specific regulations
or must be passed to a packaging return system. Under www.retrologistik.de you will find special
information on the respective national conditions as well as contact partners.
14. Transport information
Road & Rail ADR, RID
UN 1090 ACETON, 3, II
Inland waterway ADN, ADNR not tested
Sea IMDG-Code
UN 1090 ACETONE, 3, II
Ems
F-E S-D
Air CAO, PAX
ACETONE, 3, UN 1090, II
The transport regulations are cited according to international regulations and in the form
applicable in Germany . Possible national deviations in other countries are not considered.
The Safety Data Sheets for catalog items are also available at www.chemdat.info
Page 5 of 6
Merck Safety Data Sheet
According to EC Directive 91/155/EEC
Catalogue No.:
Product name:
100012
Acetone for gas chromatography SupraSolv
15. Regulatory information
Labelling according to EC Directives
Symbol:
F
Xi
Highly flammable
Irritant
R-phrases:
11-36-66-67
S-phrases:
9-16-26
EC-No.:
200-662-2
Highly flammable. Irritating to eyes. Repeated
exposure may cause skin dryness or cracking.
Vapours may cause drowsiness and dizziness.
Keep container in a well-ventilated place. Keep
away from sources of ignition - No smoking. In case
of contact with eyes, rinse immediately with plenty
of water and seek medical advice.
EC label
16. Other information
Reason for alteration
Chapter 4: first aid measures.
General update.
Regional representation:
This information is given on the authorised Safety Data Sheet
for your country.
The information contained herein is based on the present state of our knowledge. It
characterizes the product with regard to the appropriate safety precautions. It does not
represent a guarantee of the properties of the product.
The Safety Data Sheets for catalog items are also available at www.chemdat.info
Page 6 of 6
