MCQs
Itraconazole
All of the following questions concerning the azole antifungal drugs are
correct EXCEPT:
A. Some of these agents inhibit cytochrome P450 enzymes and cause
the plasma concentration of certain co-administered drugs to build up.
B. Ketoconazole (Nizoral) has a greater likelihood of disrupting the
synthesis of sex steroids than either itraconazole (Sporanox) or
fluconazole (Diflucan).
C. Both ketoconazole and itraconazole require gastric acidity for
adequate oral absorption.
D. In the clinical setting, itraconazole and fluconazole are gradually
being replaced by ketoconazole.
All of the following questions concerning the azole antifungal drugs are
correct EXCEPT:
A. Some of these agents inhibit cytochrome P450 enzymes and cause
the plasma concentration of certain co-administered drugs to build up.
B. Ketoconazole (Nizoral) has a greater likelihood of disrupting the
synthesis of sex steroids than either itraconazole (Sporanox) or
fluconazole (Diflucan).
C. Both ketoconazole and itraconazole require gastric acidity for
adequate oral absorption.
D. In the clinical setting, itraconazole and fluconazole are
gradually being replaced by ketoconazole.
6. All of the following questions concerning specific antifungal drugs
are correct EXCEPT:
A. Itraconazole (Sporanox) is the agent of choice for chronic
suppression of Histoplasmosis in immunocompromised patients.
B. Itraconazole's excellent penetration into the CSF allows its use
for treatment of fungal infections in the central nervous system.
C. Itraconazole is approved for treatment of onychomycoses.
D. Both ketoconazole and itraconazole can both cause cardiac
toxicity when co-administered with astemizole, a long-acting
antihistamine.
6. All of the following questions concerning specific antifungal drugs are
correct EXCEPT:
A. Itraconazole (Sporanox) is the agent of choice for chronic
suppression of Histoplasmosis in immunocompromised patients.
B. Itraconazole's excellent penetration into the CSF allows its
use for treatment of fungal infections in the central nervous
system.
C. Itraconazole is approved for treatment of onychomycoses.
D. Both ketoconazole and itraconazole can both cause cardiac toxicity
when co-administered with astemizole, a long-acting antihistamine.
Select the single best answer from the following statements
about antifungal azoles.
A. Itraconazole (Sporanox) is approved for single-dose
treatment of vaginal yeast infections.
B. Ketoconazole (Nizoral) is least likely to disturb
synthesis of testosterone.
C. Ketoconazole does not require gastric acidity for
adequate oral absorption.
D. Fluconazole's pharmacokinetic properties are virtually
equivalent after IV and oral administration.
Select the single best answer from the following statements
about antifungal azoles.
A. Itraconazole (Sporanox) is approved for single-dose
treatment of vaginal yeast infections.
B. Ketoconazole (Nizoral) is least likely to disturb
synthesis of testosterone.
C. Ketoconazole does not require gastric acidity for
adequate oral absorption.
D. Fluconazole's pharmacokinetic properties are
virtually equivalent after IV and oral administration.
All of the following questions concerning specific antifungal drugs
are correct EXCEPT:
A. Itraconazole (Sporanox) is the agent of choice for chronic
suppression of Histoplasmosis in immunocompromised patients.
B. Itraconazole's excellent penetration into the CSF allows its use
for treatment of fungal infections in the central nervous system.
C. Itraconazole is approved for treatment of onychomycoses.
D. Both ketoconazole and itraconazole can both cause cardiac
toxicity when co-administered with astemizole, a long-acting
antihistamine.
All of the following questions concerning specific antifungal drugs are
correct EXCEPT:
A. Itraconazole (Sporanox) is the agent of choice for chronic
suppression of Histoplasmosis in immunocompromised patients.
B. Itraconazole's excellent penetration into the CSF allows its
use for treatment of fungal infections in the central nervous
system.
C. Itraconazole is approved for treatment of onychomycoses.
D. Both ketoconazole and itraconazole can both cause cardiac toxicity
when co-administered with astemizole, a long-acting antihistamine.
