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Endometrial Carcinoma: Tamoxifen Is An Estrogen Receptor Antagonist

Tamoxifen is an estrogen receptor antagonist that can be associated with endometrial carcinoma in cases of hyperoestrogenic states like obesity, diabetes, late menopause, or prolonged use of unopposed estrogens. Endometrial carcinoma typically presents in postmenopausal women with symptoms of postmenopausal bleeding or abnormal uterine bleeding. Management involves surgical hysterectomy and staging to determine if the cancer has spread beyond the uterus.

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Maha Mukhtar
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119 views1 page

Endometrial Carcinoma: Tamoxifen Is An Estrogen Receptor Antagonist

Tamoxifen is an estrogen receptor antagonist that can be associated with endometrial carcinoma in cases of hyperoestrogenic states like obesity, diabetes, late menopause, or prolonged use of unopposed estrogens. Endometrial carcinoma typically presents in postmenopausal women with symptoms of postmenopausal bleeding or abnormal uterine bleeding. Management involves surgical hysterectomy and staging to determine if the cancer has spread beyond the uterus.

Uploaded by

Maha Mukhtar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Associated with hyperoestrogenic states:

Possible associations with:

Tamoxifen is an
estrogen receptor
antagonist

Obesity
Diabetes
Late menopause
Prolonged use of unopposed oestrogens
Estrogen secreting tumors
Long term tamoxifen

Previous pelvic irradiation


Lower parity

Etiology:

Pathology:
Usually adenocarcinoma
Spreads by invasion through myometrium
Spreads via cervical lymphatics involving
iliac and para-aortic lymph nodes
In advanced cases haematogenous spread
to lungs, liver, and bones

Mean age of presentation 56 years


80% menopausal women
Rare under the age of 40 years

Symptoms:
Post Menopausal Bleeding
Bloodstained discharge
Irregular bleeding

Management:
Surgery hysterectomy & Salpingooophorectomy
? Lymphadenectomy
In women with high grade disease - full
staging laporotomy & omental biopsy
Radiotherapy if unable to undergo surgery
& as adjuvant
Hormone therapy (progesterones) inhibit
rate of growth

Endometrial
Carcinoma

Post menopausal bleeding


should be assumed to be
endometrial Ca till proved
otherwise!

Signs:
Uterine enlargement (uncommon)
Bleeding through cervix

Investigations:
Staging:
Stage 1 - Ca confined to Uterus
Stage 2 - extension to cervix
Stage 3 - extension outside uterus but
within true pelvis
Stage 4 - involvement of the bladder,
rectum, or extension outside true pelvis

USS to assess dimensions of any tumor &


to show endometrial thickness (< 5mm
normal)

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