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Atenolol is a selective beta-1 adrenergic receptor blocker used to treat cardiovascular conditions such as hypertension, angina, and arrhythmias. It works by decreasing heart rate, oxygen demand, and renin secretion, thereby lowering blood pressure. Dosage varies based on the condition, with specific guidelines provided for hypertension, angina, myocardial infarction, and arrhythmias.

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4 views5 pages

Cardio

Atenolol is a selective beta-1 adrenergic receptor blocker used to treat cardiovascular conditions such as hypertension, angina, and arrhythmias. It works by decreasing heart rate, oxygen demand, and renin secretion, thereby lowering blood pressure. Dosage varies based on the condition, with specific guidelines provided for hypertension, angina, myocardial infarction, and arrhythmias.

Uploaded by

Duran Justine
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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DRUG THAT AFFECTS THE CARDIOVASCULAR SYSTEM

• Primarily target the heart, blood vessels, and


blood pressure to treat various conditions such as
hypertension, heart failure, arrhythmias, and ischemic
heart disease. Below are the main categories of drugs
that influence the cardiovascular system.

These medications play vital roles in managing


cardiovascular health, either by directly affecting heart
function or modifying factors like blood pressure and
cholesterol.
ATENOLOL
Atenolol Overview:
Atenolol is a beta-blocker used in the treatment of several
cardiovascular conditions. It is a selective beta-1 adrenergic
receptor blocker, meaning it primarily affects the heart rather
than the lungs or peripheral blood vessels. This makes it useful for
controlling heart rate, reducing blood pressure, and managing
heart-related

1. DOSAGE:
The dosage of Atenolol depends on the condition being treated.
Below are general guidelines:
· Hypertension (High Blood Pressure):
 Initial dose: 25-50 mg once daily.
 Maintenance dose: 50-100 mg once daily.
• Angina Pectoris (Chest Pain):
 Initial dose: 50 mg once daily.
o Maintenance dose: 50-100 mg once daily.
 Acute Myocardial Infarction (Heart Attack):
o Initial IV dose: 5 mg over 5 minutes, followed by 5 mg
after 10 minutes if well-tolerated.
 Oral dose: 50 mg orally 10 minutes after the last IV
dose, then 50 mg twice daily for 1-2 days, followed by
100 mg once daily for maintenance.
• Arrhythmias (Irregular Heartbeat):
 Dose varies; typically 50-100 mg per day depending
on response.
Note: Always adjust the dose according to the patient's
response and medical condition.

2. Mechanism of Action:
Atenolol works by selectively blocking beta-1 adrenergic receptors
primarily in the heart. This leads to:
• Decreased heart rate (negative chronotropy): Reduces the
number of heart beats per minute.
• Decreased oxygen demand: As a result of the reduced heart workload.
• Reduced renin secretion: This contributes to lowering blood pressure by
reducing angiotensin II production, which causes vasoconstriction and
fluid retention.
• Since Atenolol is beta-1 selective, it has less effect on the beta-2
receptors found in the lungs and vascular smooth muscle, which helps
avoid bronchospasm (as opposed to non-selective beta-blockers).

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