adrenoceptor beta 3 (Q4897175)

http://www.ebi.ac.uk/interpro/protein/P13945

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein homodimerization activity

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

beta3-adrenergic receptor activity

IMP

1 reference

5 June 2018

Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

beta-3 adrenergic receptor binding

IMP

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

1 reference

31 October 2017

adrenergic receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

1 reference

5 June 2018

protein binding

IPI

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

beta3-adrenergic receptor activity

IPI

IMP

epinephrine binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

norepinephrine binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

1 reference

8 April 2019

receptor complex

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

3 references

8 April 2019

8 April 2019

Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

8 April 2019

integral component of plasma membrane

1 reference

5 June 2018

Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

nucleus

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

integral component of plasma membrane

adenylate cyclase-activating G protein-coupled receptor signaling pathway

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

1 reference

8 April 2019

eating behavior

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

5 June 2018

Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

response to antibiotic

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

negative regulation of multicellular organism growth

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

cell-cell signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

1 reference

5 June 2018

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Molecular characterization of the human beta 3-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

ageing

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

receptor-mediated endocytosis

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

generation of precursor metabolites and energy

1 reference

8 April 2019

Molecular characterization of the human beta 3-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

activation of adenylate cyclase activity

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

diet induced thermogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

heat generation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

brown fat cell differentiation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

response to cold

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

energy reserve metabolic process

1 reference

8 April 2019

Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

temperature homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13945&geneProductId=UniProtKB:P13945

1 reference

5 June 2018

desensitization of G protein-coupled receptor signaling pathway by arrestin

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

positive regulation of MAPK cascade

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

1 reference

8 April 2019

carbohydrate metabolic process

1 reference

8 April 2019

Molecular characterization of the human beta 3-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

G protein-coupled receptor signaling pathway

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13945

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

physically interacts with

1 reference

7445

17 August 2016

1 reference

568

17 August 2016

1 reference

569

17 August 2016

1 reference

536

17 August 2016

1 reference

505

17 August 2016

1 reference

550

17 August 2016

1 reference

551

17 August 2016

1 reference

570

17 August 2016

1 reference

554

17 August 2016

1 reference

564

17 August 2016

1 reference

547

17 August 2016

1 reference

571

English

17 August 2016

epinephrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL679

norepinephrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1437

(−)-ephedrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL211456

amibegron hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL545437

isoproterenol hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1711

carteolol hydrochloride

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201002

dipivefrin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200833

Gene Atlas image

PBB GE ADRB3 206812 at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P13945

1 reference

GPCR, rhodopsin-like, 7TM

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13945

Commons category

Beta-3 adrenergic receptor (ADRB3)

0 references

Identifiers

MeSH descriptor ID

D022702

subject named as

Receptors, Adrenergic, beta-3

0 references

MeSH tree code

D12.776.543.750.670.300.300.340.300

0 references

D12.776.543.750.695.150.300.340.900

0 references

D12.776.543.750.720.330.300.340.300

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

14 November 2015

http://www.uniprot.org/uniprot/P13945.txt?version=171

UMLS CUI

C0248722

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023