CD247 molecule (Q21102029)

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mammalian protein found in Homo sapiens

CD247
T-cell receptor T3 zeta chain
T-cell antigen receptor complex, zeta subunit of CD3
TCR zeta chain
CD3zeta chain
T-cell surface glycoprotein CD3 zeta chain
CD247 antigen, zeta subunit
CD3Z antigen, zeta polypeptide (TiT3 complex)

Language	Label	Description	Also known as
English	CD247 molecule	mammalian protein found in Homo sapiens	CD247 T-cell receptor T3 zeta chain T-cell antigen receptor complex, zeta subunit of CD3 TCR zeta chain CD3zeta chain T-cell surface glycoprotein CD3 zeta chain CD247 antigen, zeta subunit CD3Z antigen, zeta polypeptide (TiT3 complex)

Statements

1 reference

13 November 2019

UniProt protein ID

T-cell surface glycoprotein CD3 zeta subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20963

Phosphorylated immunoreceptor signalling ITAM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

19 references

8 April 2019

BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

End-binding protein 1 controls signal propagation from the T cell receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Mechanism of activation for Zap-70 catalytic activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Interaction between the SH2 domains of ZAP-70 and the tyrosine-based activation motif 1 sequence of the zeta subunit of the T-cell receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

The adaptor protein SAP directly associates with CD3ζ chain and regulates T cell receptor signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Alternative modes of binding of proteins with tandem SH2 domains

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Peptide microarrays for the detection of molecular interactions in cellular signal transduction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

The Transmembrane Adaptor Protein SIT Inhibits TCR-Mediated Signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Identification of substrates of human protein-tyrosine phosphatase PTPN22

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

transmembrane signaling receptor activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

identical protein binding

determination method or standard

2 references

protein homodimerization activity

determination method or standard

3 references

8 April 2019

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

protein tyrosine kinase binding

determination method or standard

1 reference

8 April 2019

Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

determination method or standard

1 reference

8 April 2019

The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

alpha-beta T cell receptor complex

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

plasma membrane

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

A new subunit of the human T-cell antigen receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Five novel antigens illustrate shared phenotype between mouse thymic stromal cells, thymocytes, and peripheral lymphocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

T cell receptor complex

determination method or standard

3 references

8 April 2019

A new subunit of the human T-cell antigen receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

8 April 2019

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

T cell receptor complex

determination method or standard

4 references

1 January 2018

A new subunit of the human T-cell antigen receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

1 January 2018

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

biological process

mitigation of host defenses by virus

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

Fc-gamma receptor signaling pathway involved in phagocytosis

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

regulation of immune response

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

protein homotetramerization

determination method or standard

1 reference

8 April 2019

Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

protein homotrimerization

determination method or standard

1 reference

8 April 2019

Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

adaptive immune response

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

immune system process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

interleukin-2 production

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

positive regulation of protein localization to cell surface

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963

determination method or standard

T cell receptor signaling pathway

determination method or standard

3 references

Phosphorylated immunoreceptor signalling ITAM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20963

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

7 March 2020

1 reference

7 March 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000354782

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354782

ENSP00000375969

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000375969

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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