CDC5L

CDC5L
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2DIM, 2DIN
식별자
에일리어스	CDC5L, CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1, 세포분할사이클5와 같은
외부 ID	OMIM : 602868 MGI : 1918952 HomoloGene : 13291 GenCard : CDC5L
유전자 위치(인간)
크르.	6번 염색체(인간)
끝.	44,450,425 bp
유전자 위치(마우스)
크르.	17번 염색체(쥐)
끝.	45,744,663 bp
RNA발현패턴
	상단 표시 위치:
	정자; ; 경골; ; 내장글로부페리더스; ; 이차 난모세포; ; 양수; ; 상완 이두근; ; 브로드만 23구역; ; 안검결막; ; 중측두회; ; 내장 흉막;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; 단백질인산가수분해효소1결합; 류신 지퍼 도메인 결합; WD40 반복 도메인바인딩; GO:0001948 단백질 결합; 전사 코어 프레서 결합; 단백질인산화효소결합; 배열특이적 DNA결합; GO:0001200, GO:0001133, GO:0001201 DNA결합전사인자활성, RNA중합효소II 특이적; RNA결합; RNA중합효소II전사조절영역배열특이적DNA결합; GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA결합전사활성화제, RNA중합효소II 특이적;
셀룰러 컴포넌트	세포질; 핵반점; 촉매제2단계 스플라이세오솜; 막; Prp19 복합체; 핵소체; 단백질-DNA복합체; 세포질핵주위영역; DNA복제인자A복합체; 스플라이소좀복합체; 핵; U2형 촉매 2단계 스플라이세오솜;
생물학적 과정	mRNA 스플라이싱, 스플라이싱 경유; 신경증식인자 자극에 대한 세포반응; 전사조절, DNA템플릿화; mRNA 처리; 섬유아세포증식인자 자극에 대한 세포반응; 전사, DNA 템플릿; 인터류킨-2에 대한 세포반응; 프로락틴에 대한 세포 반응; DNA 손상 자극에 대한 세포 반응; 보르트마닌에 대한 세포반응; GO:0007067 유사분열세포 사이클; 세포 주기; DNA복구; 세포 분화; RNA 스플라이싱; RNA중합효소II에 의한 전사조절; RNA중합효소II에 의한 전사; RNA중합효소II에 의한 전사의 양성 조절;
	출처:아미고 / QuickGO
맞춤법
	988
	71702
	ENSG000096401
	ENSMUSG000023932
	Q99459
	Q6A068
	NM_001253
	NM_152810
	NP_001244
	NP_690023
	위키데이터
인간 보기/편집	마우스 표시/편집

세포분열주기 5상 단백질은 CDC5L ^[5]^[6]^[7]유전자에 의해 인체 내에서 암호화되는 단백질이다.

기능.

이 유전자에 의해 코드된 단백질은 G/M 전환에 중요한₂ 세포 주기 조절 장치인 Chrisoscharomyces pombe cdc5 유전자 제품과 유의미한 유사성을 공유합니다.이 단백질은 세포주기₂ G/M 진행의 양성 조절제 역할을 하는 것으로 입증되었다.또한 최소 5개의 추가 단백질 인자를 포함하고 사전 mRNA 스플라이싱의 ^[7]두 번째 촉매 단계에 필요한 비-snRNA 스플라이싱의 필수 성분으로 확인되었다.

상호 작용

CDC5L은 다음 제품과 상호 작용하는 것으로 나타났습니다.

「」를 참조해 주세요.

G2/M 체크 포인트

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000096401 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000023932 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Groenen PM, Vanderlinden G, Devriendt K, Fryns JP, Van de Ven WJ (Apr 1998). "Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia". Genomics. 49 (2): 218–29. doi:10.1006/geno.1998.5254. PMID 9598309.
^ Bernstein HS, Coughlin SR (Feb 1997). "Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling". The Journal of Biological Chemistry. 272 (9): 5833–7. doi:10.1074/jbc.272.9.5833. PMID 9038199.
^ ^a ^b "Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)".
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Ajuh P, Lamond AI (Nov 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Research. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297.
^ Ajuh P, Sleeman J, Chusainow J, Lamond AI (Nov 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". The Journal of Biological Chemistry. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. PMID 11544257.
^ Leonard D, Ajuh P, Lamond AI, Legerski RJ (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/s0006-291x(03)01486-4. PMID 12927788.

추가 정보

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
Heaney JP, Jacobson A (Aug 1975). "Simplified control of upper abdominal hemorrhage from the vena cava". Surgery. 78 (2): 138–41. PMID 1154257.
Hirayama T, Shinozaki K (Nov 1996). "A cdc5+ homolog of a higher plant, Arabidopsis thaliana". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 13371–6. doi:10.1073/pnas.93.23.13371. PMC 24100. PMID 8917598.
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Bernstein HS, Coughlin SR (Feb 1998). "A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry". The Journal of Biological Chemistry. 273 (8): 4666–71. doi:10.1074/jbc.273.8.4666. PMID 9468527.
Ohi R, Feoktistova A, McCann S, Valentine V, Look AT, Lipsick JS, Gould KL (Jul 1998). "Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes". Molecular and Cellular Biology. 18 (7): 4097–108. doi:10.1128/mcb.18.7.4097. PMC 108994. PMID 9632794.
Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Sep 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
Burns CG, Ohi R, Krainer AR, Gould KL (Nov 1999). "Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13789–94. doi:10.1073/pnas.96.24.13789. PMC 24143. PMID 10570151.
Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M (Aug 2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". The Journal of Biological Chemistry. 275 (33): 25411–7. doi:10.1074/jbc.M001676200. PMID 10827081.
Lei XH, Shen X, Xu XQ, Bernstein HS (Dec 2000). "Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein". Journal of Cell Science. 113. 113 (24): 4523–31. doi:10.1242/jcs.113.24.4523. PMID 11082045.
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (May 2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nature Biotechnology. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Ajuh P, Sleeman J, Chusainow J, Lamond AI (Nov 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". The Journal of Biological Chemistry. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. PMID 11544257.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (Apr 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Liu L, Gräub R, Hlaing M, Epting CL, Turck CW, Xu XQ, Zhang L, Bernstein HS (2004). "Distinct domains of human CDC5 direct its nuclear import and association with the spliceosome". Cell Biochemistry and Biophysics. 39 (2): 119–32. doi:10.1385/CBB:39:2:119. PMID 14515018. S2CID 22472390.

외부 링크

UCSC Genome Browser의 인간 CDC5L 게놈 위치 및 CDC5L 유전자 세부 정보 페이지.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000096401 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000023932 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9598309-5] Groenen PM, Vanderlinden G, Devriendt K, Fryns JP, Van de Ven WJ (Apr 1998). "Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia". Genomics. 49 (2): 218–29. doi:10.1006/geno.1998.5254. PMID 9598309.

[pmid9038199-6] Bernstein HS, Coughlin SR (Feb 1997). "Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling". The Journal of Biological Chemistry. 272 (9): 5833–7. doi:10.1074/jbc.272.9.5833. PMID 9038199.

[entrez-7] "Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)".

[pmid11101529-8] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid14576297-10] Ajuh P, Lamond AI (Nov 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Research. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297.

[pmid11544257-11] Ajuh P, Sleeman J, Chusainow J, Lamond AI (Nov 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". The Journal of Biological Chemistry. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. PMID 11544257.

[pmid12927788-12] Leonard D, Ajuh P, Lamond AI, Legerski RJ (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/s0006-291x(03)01486-4. PMID 12927788.

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CDC5L

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목차

기능.

상호 작용

「」를 참조해 주세요.

레퍼런스

추가 정보

외부 링크

Search

CDC5L

기능.

상호 작용

「 」를 참조해 주세요.

레퍼런스

추가 정보

외부 링크

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