인용 2

인용 2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1P4Q, 1R8U
식별자
에일리어스	인용 2, ASD8, MRG-1, MRG1, P35SRJ, VSD2, Cbp/p300과 글루/Asp 리치 카르복시 말단 도메인 2와의 상호 작용
외부 ID	OMIM: 602937 MGI: 1306784 HomoloGene: 4433 GenCard: 인용 2
유전자 위치(인간)
크르.	6번 염색체(인간)
끝.	139,374,648 bp
유전자 위치(마우스)
크르.	10번 염색체(쥐)
끝.	17,601,422 bp
RNA발현패턴
	상단 표시 위치:
	자궁내막간질세포; ; 위점막; ; 니플; ; 좌측 자궁관; ; 오른쪽 폐; ; 갑상선; ; 갑상선 좌엽; ; 인간의 음경; ; 골수 세포; ; 신장수질;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	GO:0001105 트랜스크립션코액티베이터 액티비티; GO:0001106 전사 코어프레서 액티비티; GO:0001131, GO:000115, GO:0001130, GO:0001204 DNA결합전사인자액티비티; 크로마틴 결합; LBD 도메인바인딩; GO:0001948 단백질 결합; 히스톤아세틸전달효소결합; 단백질 도메인 특이 결합;
셀룰러 컴포넌트	세포질; 핵; 핵소체; 단백질 함유 복합체;
생물학적 과정	좌우 중배엽 비대칭 결정에 관여하는 결절 신호 경로; 부신 피질 형성; 형질전환성장인자β수용체신호경로의 양성조절; 세포 분화; 저산소증에 대한 반응; 전사조절, DNA템플릿화; 세포유착의 양성조절; 배아심관좌우패턴형성; 심실중격형성; 유출로 형태 형성; 아포토시스 과정의 음성 조절; RNA중합효소II에 의한 전사 음성 조절; 비장의 발달; 유전자 발현 음성 조절; 전사, DNA 템플릿; 유체 전단 응력에 대한 반응; 에스트로겐에 대한 반응; 전사의 양성 조절, DNA 템플릿화; 다세포 생물 발달; 심장 발달; 좌우 대칭의 결정; 유전자 발현 양성 조절; 세포이동부조절; 세포주기의 양성조절; 동물 기관 형성 조절; 성별 결정 시스템; 페르옥시좀증식기활성수용체신호경로양조절; 간발달성; 좌우 패턴 형성; 저산소증에 대한 RNA 중합효소 II 프로모터로부터의 전사 음성 조절; 세포군 증식; 전사 음성 조절, DNA 템플릿; 좌/우축 사양; 남성 생식선 발달의 양성 조절; RNA중합효소II에 의한 전사의 양성 조절; RNA중합효소II에 의한 전사; 핵산 촉진 전사의 양성 조절; RNA중합효소II에 의한 전사조절;
	출처:아미고 / QuickGO
맞춤법
	10370
	17684
	ENSG00000164442
	ENSMUSG000039910
	문제 99967
	O35740
	NM_006079; NM_001168388; NM_001168389
	NM_010828
	NP_001161860; NP_001161861; NP_006070
	NP_034958
	위키데이터
인간 보기/편집	마우스 표시/편집

Cbp/p300-상호작용 트랜스활성화제 2는 CITED2 ^[5]^[6]^[7]유전자에 의해 인체 내에서 부호화되는 단백질이다.

상호 작용

인용된 2는 ^[8]^[9]^[10]^[11]EP300, LHX2,^[11] TFAP2A ^[9]^[10]및 WT1과 ^[12]상호 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000164442 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000039910 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shioda T, Fenner MH, Isselbacher KJ (Oct 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12298–303. Bibcode:1996PNAS...9312298S. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
^ Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S (Nov 1999). "Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1". Genomics. 61 (3): 307–13. doi:10.1006/geno.1999.5970. PMID 10552932.
^ "Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2".
^ Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (Jan 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes & Development. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100.
^ ^a ^b Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". The Journal of Biological Chemistry. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
^ ^a ^b Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (Mar 2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
^ ^a ^b Glenn DJ, Maurer RA (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". The Journal of Biological Chemistry. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
^ Val P, Martinez-Barbera JP, Swain A (Jun 2007). "Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage". Development. 134 (12): 2349–58. doi:10.1242/dev.004390. PMID 17537799.

추가 정보

Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS (Feb 2007). "CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor". The Journal of Endocrinology. 192 (2): 459–65. doi:10.1677/JOE-06-0083. PMID 17283246.
Shioda T, Fenner MH, Isselbacher KJ (Dec 1997). "MSG1 and its related protein MRG1 share a transcription activating domain". Gene. 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
Sun HB, Zhu YX, Yin T, Sledge G, Yang YC (Nov 1998). "MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity". Proceedings of the National Academy of Sciences of the United States of America. 95 (23): 13555–60. Bibcode:1998PNAS...9513555S. doi:10.1073/pnas.95.23.13555. PMC 24857. PMID 9811838.
Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (Jan 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes & Development. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100.
Glenn DJ, Maurer RA (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". The Journal of Biological Chemistry. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (Mar 2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". The Journal of Biological Chemistry. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cellular & Developmental Biology. Animal. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMC 3225227. PMID 12762840.
Yokota H, Goldring MB, Sun HB (Nov 2003). "CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear". The Journal of Biological Chemistry. 278 (47): 47275–80. doi:10.1074/jbc.M304652200. PMID 12960175.
Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S (Dec 2003). "Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene". The EMBO Journal. 22 (23): 6299–309. doi:10.1093/emboj/cdg595. PMC 291836. PMID 14633989.
Tien ES, Davis JW, Vanden Heuvel JP (Jun 2004). "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator". The Journal of Biological Chemistry. 279 (23): 24053–63. doi:10.1074/jbc.M401489200. PMID 15051727.
Sperling S, Grimm CH, Dunkel I, Mebus S, Sperling HP, Ebner A, Galli R, Lehrach H, Fusch C, Berger F, Hammer S (Dec 2005). "Identification and functional analysis of CITED2 mutations in patients with congenital heart defects". Human Mutation. 26 (6): 575–82. doi:10.1002/humu.20262. hdl:11858/00-001M-0000-0010-8560-F. PMID 16287139. S2CID 24646760.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Chou YT, Yang YC (Jul 2006). "Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads and Cited2 coding region". The Journal of Biological Chemistry. 281 (27): 18451–62. doi:10.1074/jbc.M601720200. PMID 16675452.
Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC (Oct 2007). "Cited2, a coactivator of HNF4alpha, is essential for liver development". The EMBO Journal. 26 (21): 4445–56. doi:10.1038/sj.emboj.7601883. PMC 2063472. PMID 17932483.

외부 링크

UCSC Genome Browser에서 인용된 2 인간 유전자 위치.
UCSC Genome Browser에서 인용된 2 인간 유전자 상세.

인간 염색체 6번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000164442 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000039910 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8901575-5] Shioda T, Fenner MH, Isselbacher KJ (Oct 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12298–303. Bibcode:1996PNAS...9312298S. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.

[pmid10552932-6] Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S (Nov 1999). "Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1". Genomics. 61 (3): 307–13. doi:10.1006/geno.1999.5970. PMID 10552932.

[entrez-7] "Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2".

[pmid9887100-8] Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (Jan 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes & Development. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100.

[pmid12586840-9] Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". The Journal of Biological Chemistry. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.

[pmid11744733-10] Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (Mar 2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.

[pmid10593900-11] Glenn DJ, Maurer RA (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". The Journal of Biological Chemistry. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.

[pmid17537799-12] Val P, Martinez-Barbera JP, Swain A (Jun 2007). "Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage". Development. 134 (12): 2349–58. doi:10.1242/dev.004390. PMID 17537799.

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인용 2

네임스페이스

더

목차

상호 작용

레퍼런스

추가 정보

외부 링크