호모 사피엔스 종의 단백질 코드 유전자
치아 가 없는 단백질 상동성 은 DTL [5] [6] 유전자 에 의해 인간에게 암호화되는 단백질 이다.
상호 작용 DTL(gene)은 P21 과 [7] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000143476 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000037474 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation" . J Biol Chem . 276 (20): 17083–91. doi :10.1074/jbc.M010802200 PMID 11278750 . ^ "Entrez Gene: DTL denticleless homolog (Drosophila)" .^ Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex" . Genes Dev . 22 (18): 2496–506. doi :10.1101/gad.1676108 . PMC 2546691 PMID 18794347 .
추가 정보 Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes" . Cell Cycle . 5 (15): 1719–29. doi :10.4161/cc.5.15.3150 PMID 16861890 . Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage" . Cell Cycle . 5 (15): 1675–80. doi :10.4161/cc.5.15.3149 PMID 16861906 . Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1" . Mol. Cell . 23 (5): 709–21. doi :10.1016/j.molcel.2006.08.010 PMID 16949367 . Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol . 8 (11): 1277–83. doi :10.1038/ncb1490 . PMID 17041588 . S2CID 22180568 . Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA (2006). "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint" . Genes Dev . 20 (22): 3117–29. doi :10.1101/gad.1482106 . PMC 1635147 PMID 17085480 . Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC (2007). "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma" . Cell Cycle . 5 (22): 2676–87. doi :10.4161/cc.5.22.3500 PMID 17106265 .