FSTL1

FSTL1
식별자
에일리어스	FSTL1, FRP, FSL1, MIR198, follistatin like 1, OCC-1, OCC1, tsc36
외부 ID	OMIM: 605547 MGI: 102793 HomoloGene: 5144 GenCard: FSTL1
유전자 위치(인간)
크르.	3번 염색체(인간)
끝.	120,450,993 bp
유전자 위치(마우스)
크르.	16번 염색체(쥐)
끝.	37,656,876 bp
RNA발현패턴
	상단 표시 위치:
	자궁내막간질세포; ; 아킬레스건; ; 평활근 조직; ; 담낭; ; 흉부 대동맥; ; 상행 대동맥; ; 우관상 동맥; ; 좌관상동맥; ; 좌측 자궁관; ; 상부 신경;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	GO:0001948 단백질 결합; 칼슘 이온 결합; 헤파린 결합;
셀룰러 컴포넌트	세포외 영역; 세포외 엑소좀; 세포외 공간; 소포체내강;
생물학적 과정	기아에 대한 반응; BMP 시그널링 패스; 발육 후 단백질 수식; 세포단백질대사과정;
	출처:아미고 / QuickGO
맞춤법
	11167
	14314
	ENSG00000163430
	ENSMUSG000022816
	문제 12841
	질문 62356
	NM_007085
	NM_008047
	NP_009016
	NP_032073
	위키데이터
인간 보기/편집	마우스 표시/편집

Follistatin 관련 단백질 1은 FSTL1 유전자에 ^[5]^[6]^[7]의해 인체 내에서 암호화되는 단백질이다.

구조.

이 유전자는 BMP-4 결합 ^[8]단백질인 폴리스타틴과 유사한 단백질을 암호화한다.BMP-4 및 TGF-β1에는 결합하지만 Activin ^[8]A에는 결합하지 않습니다.FS 모듈(10개의 보존된 시스테인 잔기를 포함하는 모피스타틴 유사 배열), 카잘형 세린 단백질 분해효소 억제제 도메인, 2개의 EF 핸드 도메인 및 Von Willebrand 인자 유형 C ^[7]도메인을 포함한다.

임상적 의의

발전

FSTL1은 폐발달,^[8]^[11]^[12] 요관발달, ^[13]중추신경계발달,^[11] 골격발달 등의 ^[9]^[10]발달에 관여한다.

관절염

이 유전자 제품은 류마티스 ^[7]관절염과 관련된 자가항원으로 생각됩니다.

FSTL1은 관절염 병리학에 중요한 염증 매개체를 상향 조절하며, FSTL1의 혈청 수치는 ^[14]^[15]^[16]관절염의 심각도와 상관관계가 있다.

심혈관 질환

FSTL1 단백질은 심장 보호 역할을 하는 것으로 보입니다.FSTL1은 압력^[17] 과부하 후 비대를 약화하고 허혈/^[18]재류 마우스 또는 돼지 모델에서 심근 허혈/재류 손상을 방지했다.근육 유래 Fstl1은 ^[19]부상에 대응하여 혈관 재모델링을 조절합니다.

FSTL1은 심근경색 후 재생을 자극할 수 있는 가능한 치료제로서 뚜렷한 능력을 가지고 있는 것으로 나타났다.심근경색 후 FSTL1로 실험동물(쥐와 돼지)을 치료하는 것은 적어도 부분적으로 정상적으로 분할되지 않는 심장 근육^[20] 세포의 복제를 자극함으로써 심장 기능을 점진적으로 회복시켰다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000163430 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022816 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zwijsen A, Blockx H, Van Arnhem W, Willems J, Fransen L, Devos K, Raymackers J, Van de Voorde A, Slegers H (Nov 1994). "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue". European Journal of Biochemistry. 225 (3): 937–46. doi:10.1111/j.1432-1033.1994.0937b.x. PMID 7957230.
^ Tanaka M, Ozaki S, Osakada F, Mori K, Okubo M, Nakao K (Sep 1998). "Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases". International Immunology. 10 (9): 1305–14. doi:10.1093/intimm/10.9.1305. PMID 9786430.
^ ^a ^b ^c "Entrez Gene: FSTL1 follistatin-like 1".
^ ^a ^b ^c Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W (Apr 2011). "Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development". Proceedings of the National Academy of Sciences of the United States of America. 108 (17): 7058–63. Bibcode:2011PNAS..108.7058G. doi:10.1073/pnas.1007293108. PMC 3084141. PMID 21482757.
^ Umezu T, Yamanouchi H, Iida Y, Miura M, Tomooka Y (Mar 2010). "Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium". Proceedings of the National Academy of Sciences of the United States of America. 107 (10): 4601–6. Bibcode:2010PNAS..107.4601U. doi:10.1073/pnas.0909501107. PMC 2842048. PMID 20176958.
^ Sylva M, Moorman AF, van den Hoff MJ (Mar 2013). "Follistatin-like 1 in vertebrate development". Birth Defects Research. Part C, Embryo Today. 99 (1): 61–9. doi:10.1002/bdrc.21030. PMID 23723173.
^ ^a ^b Sylva M, Li VS, Buffing AA, van Es JH, van den Born M, van der Velden S, Gunst Q, Koolstra JH, Moorman AF, Clevers H, van den Hoff MJ (3 August 2011). "The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis". PLOS ONE. 6 (8): e22616. Bibcode:2011PLoSO...622616S. doi:10.1371/journal.pone.0022616. PMC 3149603. PMID 21826198.
^ Xu J, Qi X, Gong J, Yu M, Zhang F, Sha H, Gao X (2012). "Fstl1 antagonizes BMP signaling and regulates ureter development". PLOS ONE. 7 (4): e32554. Bibcode:2012PLoSO...732554X. doi:10.1371/journal.pone.0032554. PMC 3317656. PMID 22485132.
^ Yang Y, Liu J, Mao H, Hu YA, Yan Y, Zhao C (Oct 2009). "The expression pattern of Follistatin-like 1 in mouse central nervous system development". Gene Expression Patterns. 9 (7): 532–40. doi:10.1016/j.gep.2009.07.001. PMID 19595790.
^ Chaly Y, Marinov AD, Oxburgh L, Bushnell DS, Hirsch R (Apr 2012). "FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression". Arthritis and Rheumatism. 64 (4): 1082–8. doi:10.1002/art.33422. PMC 3276726. PMID 22006268.
^ Chaly Y, Blair HC, Smith SM, Bushnell DS, Marinov AD, Campfield BT, Hirsch R (Jul 2015). "Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells". Annals of the Rheumatic Diseases. 74 (7): 1467–73. doi:10.1136/annrheumdis-2013-204822. PMID 24641944. S2CID 31184311.
^ Chaly Y, Fu Y, Marinov A, Hostager B, Yan W, Campfield B, Kellum JA, Bushnell D, Wang Y, Vockley J, Hirsch R (May 2014). "Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages". European Journal of Immunology. 44 (5): 1467–79. doi:10.1002/eji.201344063. PMC 4004659. PMID 24470197.
^ Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K (Oct 2011). "Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload". Proceedings of the National Academy of Sciences of the United States of America. 108 (43): E899–906. doi:10.1073/pnas.1108559108. PMC 3203781. PMID 21987816.
^ Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T (Oct 2012). "Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models". Circulation. 126 (14): 1728–38. doi:10.1161/CIRCULATIONAHA.112.115089. PMC 3548325. PMID 22929303.
^ Miyabe M, Ohashi K, Shibata R, Uemura Y, Ogura Y, Yuasa D, Kambara T, Kataoka Y, Yamamoto T, Matsuo K, Joki Y, Enomoto T, Hayakawa S, Hiramatsu-Ito M, Ito M, Van Den Hoff MJ, Walsh K, Murohara T, Ouchi N (Jul 2014). "Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury". Cardiovascular Research. 103 (1): 111–20. doi:10.1093/cvr/cvu105. PMC 4834864. PMID 24743592.
^ Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P (Sep 2015). "Epicardial FSTL1 reconstitution regenerates the adult mammalian heart". Nature. 525 (7570): 479–85. Bibcode:2015Natur.525..479W. doi:10.1038/nature15372. PMC 4762253. PMID 26375005.

추가 정보

Vertegaal AC, Kuiperij HB, van Laar T, Scharnhorst V, van der Eb AJ, Zantema A (Dec 2000). "cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells". FEBS Letters. 487 (2): 151–5. doi:10.1016/S0014-5793(00)02339-5. PMID 11150499. S2CID 44781190.
Ciarmela P, Florio P, Sigurdardottir M, Toti P, Maguer-Satta V, Rimokh R, Altomare A, Tosi P, Petraglia F (Aug 2004). "Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma". European Journal of Endocrinology. 151 (2): 251–7. doi:10.1530/eje.0.1510251. PMID 15296481.
Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Ehara Y, Sakurai D, Tsuchiya N, Nakano K, Tanaka Y, Yamaguchi A, Tokunaga K (2005). "Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility". Clinical and Experimental Rheumatology. 22 (6): 707–12. PMID 15638044.
Liu S, Wang L, Wang W, Lin J, Han J, Sun H, Guo H, Sun R, Wu Q (Apr 2006). "TSC-36/FRP inhibits vascular smooth muscle cell proliferation and migration". Experimental and Molecular Pathology. 80 (2): 132–40. doi:10.1016/j.yexmp.2005.07.005. PMID 16256108.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

외부 링크

PDB for UniProt: Q62356(Mouse Pollistatin 관련 단백질 1)에서 PDBe-KB에 제공되는 모든 구조 정보의 개요.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000163430 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000022816 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7957230-5] Zwijsen A, Blockx H, Van Arnhem W, Willems J, Fransen L, Devos K, Raymackers J, Van de Voorde A, Slegers H (Nov 1994). "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue". European Journal of Biochemistry. 225 (3): 937–46. doi:10.1111/j.1432-1033.1994.0937b.x. PMID 7957230.

[pmid9786430-6] Tanaka M, Ozaki S, Osakada F, Mori K, Okubo M, Nakao K (Sep 1998). "Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases". International Immunology. 10 (9): 1305–14. doi:10.1093/intimm/10.9.1305. PMID 9786430.

[entrez-7] "Entrez Gene: FSTL1 follistatin-like 1".

[PNAS-8] Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W (Apr 2011). "Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development". Proceedings of the National Academy of Sciences of the United States of America. 108 (17): 7058–63. Bibcode:2011PNAS..108.7058G. doi:10.1073/pnas.1007293108. PMC 3084141. PMID 21482757.

[9] Umezu T, Yamanouchi H, Iida Y, Miura M, Tomooka Y (Mar 2010). "Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium". Proceedings of the National Academy of Sciences of the United States of America. 107 (10): 4601–6. Bibcode:2010PNAS..107.4601U. doi:10.1073/pnas.0909501107. PMC 2842048. PMID 20176958.

[Sylva-10] Sylva M, Moorman AF, van den Hoff MJ (Mar 2013). "Follistatin-like 1 in vertebrate development". Birth Defects Research. Part C, Embryo Today. 99 (1): 61–9. doi:10.1002/bdrc.21030. PMID 23723173.

[Sylva_2011-11] Sylva M, Li VS, Buffing AA, van Es JH, van den Born M, van der Velden S, Gunst Q, Koolstra JH, Moorman AF, Clevers H, van den Hoff MJ (3 August 2011). "The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis". PLOS ONE. 6 (8): e22616. Bibcode:2011PLoSO...622616S. doi:10.1371/journal.pone.0022616. PMC 3149603. PMID 21826198.

[12] Xu J, Qi X, Gong J, Yu M, Zhang F, Sha H, Gao X (2012). "Fstl1 antagonizes BMP signaling and regulates ureter development". PLOS ONE. 7 (4): e32554. Bibcode:2012PLoSO...732554X. doi:10.1371/journal.pone.0032554. PMC 3317656. PMID 22485132.

[13] Yang Y, Liu J, Mao H, Hu YA, Yan Y, Zhao C (Oct 2009). "The expression pattern of Follistatin-like 1 in mouse central nervous system development". Gene Expression Patterns. 9 (7): 532–40. doi:10.1016/j.gep.2009.07.001. PMID 19595790.

[pmid22006268-14] Chaly Y, Marinov AD, Oxburgh L, Bushnell DS, Hirsch R (Apr 2012). "FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression". Arthritis and Rheumatism. 64 (4): 1082–8. doi:10.1002/art.33422. PMC 3276726. PMID 22006268.

[pmid24641944-15] Chaly Y, Blair HC, Smith SM, Bushnell DS, Marinov AD, Campfield BT, Hirsch R (Jul 2015). "Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells". Annals of the Rheumatic Diseases. 74 (7): 1467–73. doi:10.1136/annrheumdis-2013-204822. PMID 24641944. S2CID 31184311.

[pmid24470197-16] Chaly Y, Fu Y, Marinov A, Hostager B, Yan W, Campfield B, Kellum JA, Bushnell D, Wang Y, Vockley J, Hirsch R (May 2014). "Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages". European Journal of Immunology. 44 (5): 1467–79. doi:10.1002/eji.201344063. PMC 4004659. PMID 24470197.

[17] Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K (Oct 2011). "Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload". Proceedings of the National Academy of Sciences of the United States of America. 108 (43): E899–906. doi:10.1073/pnas.1108559108. PMC 3203781. PMID 21987816.

[18] Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T (Oct 2012). "Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models". Circulation. 126 (14): 1728–38. doi:10.1161/CIRCULATIONAHA.112.115089. PMC 3548325. PMID 22929303.

[19] Miyabe M, Ohashi K, Shibata R, Uemura Y, Ogura Y, Yuasa D, Kambara T, Kataoka Y, Yamamoto T, Matsuo K, Joki Y, Enomoto T, Hayakawa S, Hiramatsu-Ito M, Ito M, Van Den Hoff MJ, Walsh K, Murohara T, Ouchi N (Jul 2014). "Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury". Cardiovascular Research. 103 (1): 111–20. doi:10.1093/cvr/cvu105. PMC 4834864. PMID 24743592.

[20] Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P (Sep 2015). "Epicardial FSTL1 reconstitution regenerates the adult mammalian heart". Nature. 525 (7570): 479–85. Bibcode:2015Natur.525..479W. doi:10.1038/nature15372. PMC 4762253. PMID 26375005.

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