호모사피엔스 종의 단백질 코딩 유전자
GIPC1 식별자 별칭 GIPC1 외부 ID OMIM : 605072 MGI : 1926252 호몰로진 : 21167 GeneCard : GIPC1 직교체 종 인간 마우스 엔트레스 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 위치(UCSC) Cr 19: 14.48 – 14.5Mb Chr 8: 84.38 – 84.39Mb PubMed 검색[3] [4] 위키다타
가족, 멤버 1 (GIPC1 )을 포함하는 GIPC PDZ 도메인 은 인간에서 GIPC1 유전자 에 의해 인코딩 되는 단백질이다.[5] [6] [7] GIPC는 원래 G단백질신호 조절에 관여하는 단백질인 RGS-GAIP의 C단말기에 특별히 결합하는 것으로 확인되었다.[5] GIPC는 "GAIP Interactiving 단백질 C-terminus"의 약자다. RGS 단백질은 'G단백신호 조절기'이고, RGS-GAIP는 'Gαi/Gαq용 GTPase 활성제 단백질'로, Gα 단백질의 두 가지 주요 아종이다. 인간 GIPC1 분자는 분자 크기의 아미노산 333개 또는 약 36kDa이며, 특정 단백질-단백질 상호작용을 매개하는 콤팩트 단백질 모듈인 중앙 PDZ 영역 으로 구성되어 있다. RGS-GAIP 단백질은 이 영역과 상호작용을 하며 많은 다른 단백질은 여기 또는 GIPC1 분자의 다른 부분에서 상호작용을 한다. 그 결과 GIPC1은 여러 다른 그룹에 의해 독립적으로 발견되었으며, 시넥틴, C19orf3, RGS19IP1 등을 포함한 다양한 대체 이름을 가지고 있다. 세 개의 멤버로 구성된 포유류에서 GIPC1 유전자 계열이 형성되어 있어 최초 발견되는 유전자 계열은 현재 일반적으로 GIPC1이라고 불리고 있으며, 나머지 두 종은 GIPC2와 GIPC3로 명명되었다.[8] 3개의 인간 단백질은 단백질 순서에서 약 60%가 동일하다. GIPC1 has been shown to interact with a variety of other receptor and cytoskeletal proteins including the GLUT1 receptor, ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4, SEMA4C/semaphorin-4 and HTLV-I Tax. 그러므로 GIPC 계열 단백질의 일반적인 기능은 G 단백질 신호 전달과 막 번역에 관여하는 단백질 사이의 특정한 상호작용을 매개하는 것으로 보인다.
상호작용 GIPC1은 다음과 상호 작용하는 것으로 나타났다.
액티닌, [9] 알파1 ,ADRB1 ,[10] 글루트1 ,[9] ITGA5 ,[11] ITGA6 ,[11] KIF1B ,[9] LRP1 ,[12] LRP2 ,[12] [13] [14] LHCGR ,[15] MYO6 ,[16] [17] RGS19 ,[18] TPBG [19] TYRP1 .[20] 참고 항목 패밀리가 포함된 GIPC PDZ 도메인, 멤버 2, GIPC2
패밀리가 포함된 GIPC PDZ 도메인, 멤버 3, GIPC3
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000123159 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000019433 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b De Vries L, Lou X, Zhao G, Zheng B, Farquhar MG (November 1998). "GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP" . Proc. Natl. Acad. Sci. U.S.A . 95 (21): 12340–5. Bibcode :1998PNAS...9512340D . doi :10.1073/pnas.95.21.12340 PMC 22833 PMID 9770488 . ^ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (March 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins" . Oncogene . 16 (5): 643–54. doi :10.1038/sj.onc.1201567 PMID 9482110 . ^ "Entrez Gene: GIPC1 GIPC PDZ domain containing family, member 1" .^ Katoh M (2002). "GIPC gene family (Review)". Int. J. Mol. Med . 9 (6): 585–9. doi :10.3892/ijmm.9.6.585 . PMID 12011974 . ^ a b c Bunn RC, Jensen MA, Reed BC (April 1999). "Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton" . Mol. Biol. Cell . 10 (4): 819–32. doi :10.1091/mbc.10.4.819 . PMC 25204 PMID 10198040 . ^ Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ (July 2003). "GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation" . J. Biol. Chem . 278 (28): 26295–301. doi :10.1074/jbc.M212352200 PMID 12724327 . ^ a b Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B" . J. Biol. Chem . 276 (39): 36535–42. doi :10.1074/jbc.M105785200 PMID 11479315 . ^ a b Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction" . J. Biol. Chem . 275 (33): 25616–24. doi :10.1074/jbc.M000955200 PMID 10827173 . ^ Petersen HH, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek AJ, Willnow TE (February 2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule" . J. Cell Sci . 116 (Pt 3): 453–61. doi :10.1242/jcs.00243 PMID 12508107 . ^ Lou X, McQuistan T, Orlando RA, Farquhar MG (April 2002). "GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function" . J. Am. Soc. Nephrol . 13 (4): 918–27. doi :10.1681/ASN.V134918 PMID 11912251 . ^ Hirakawa T, Galet C, Kishi M, Ascoli M (December 2003). "GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR" . J. Biol. Chem . 278 (49): 49348–57. doi :10.1074/jbc.M306557200 PMID 14507927 . ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 : 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . ^ Aschenbrenner L, Lee T, Hasson T (July 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries" . Mol. Biol. Cell . 14 (7): 2728–43. doi :10.1091/mbc.E02-11-0767 . PMC 165672 PMID 12857860 . ^ Lou X, Yano H, Lee F, Chao MV, Farquhar MG (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways" . Mol. Biol. Cell . 12 (3): 615–27. doi :10.1091/mbc.12.3.615 . PMC 30968 PMID 11251075 . ^ Awan A, Lucic MR, Shaw DM, Sheppard F, Westwater C, Lyons SA, Stern PL (January 2002). "5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis". Biochem. Biophys. Res. Commun . 290 (3): 1030–6. doi :10.1006/bbrc.2001.6288 . PMID 11798178 . ^ Liu TF, Kandala G, Setaluri V (September 2001). "PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)" . J. Biol. Chem . 276 (38): 35768–77. doi :10.1074/jbc.M103585200 PMID 11441007 . 추가 읽기 Katoh M (2002). "GIPC gene family (Review)". Int. J. Mol. Med . 9 (6): 585–9. doi :10.3892/ijmm.9.6.585 . PMID 12011974 . Hasson T (2003). "Myosin VI: two distinct roles in endocytosis" . J. Cell Sci . 116 (Pt 17): 3453–61. doi :10.1242/jcs.00669 PMID 12893809 . Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H (1996). "A pancreatic cancer-specific expression profile". Oncogene . 13 (8): 1819–30. PMID 8895530 . De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits" . Proc. Natl. Acad. Sci. U.S.A . 93 (26): 15203–8. Bibcode :1996PNAS...9315203D . doi :10.1073/pnas.93.26.15203 PMC 26381 PMID 8986788 . Bunn RC, Jensen MA, Reed BC (1999). "Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton" . Mol. Biol. Cell . 10 (4): 819–32. doi :10.1091/mbc.10.4.819 . PMC 25204 PMID 10198040 . Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF" . J. Biol. Chem . 274 (20): 14137–46. doi :10.1074/jbc.274.20.14137 PMID 10318831 . Cai H, Reed RR (1999). "Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1" . J. Neurosci . 19 (15): 6519–27. doi :10.1523/JNEUROSCI.19-15-06519.1999 PMC 6782790 PMID 10414980 . Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction" . J. Biol. Chem . 275 (33): 25616–24. doi :10.1074/jbc.M000955200 PMID 10827173 . Gao Y, Li M, Chen W, Simons M (2000). "Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration". J. Cell. Physiol . 184 (3): 373–9. doi :10.1002/1097-4652(200009)184:3<373::AID-JCP12>3.0.CO;2-I . PMID 10911369 . Von Kap-Herr C, Kandala G, Mann SS, Hart TC, Pettenati MJ, Setaluri V (2000). "Assignment of PDZ domain-containing protein GIPC gene (C19orf3) to human chromosome band 19p13.1 by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet . 89 (3–4): 234–5. doi :10.1159/000015621 . PMID 10965131 . S2CID 85292825 . Lou X, Yano H, Lee F, Chao MV, Farquhar MG (2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways" . Mol. Biol. Cell . 12 (3): 615–27. doi :10.1091/mbc.12.3.615 . PMC 30968 PMID 11251075 . Liu TF, Kandala G, Setaluri V (2001). "PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)" . J. Biol. Chem . 276 (38): 35768–77. doi :10.1074/jbc.M103585200 PMID 11441007 . Ligensa T, Krauss S, Demuth D, Schumacher R, Camonis J, Jaques G, Weidner KM (2001). "A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor" . J. Biol. Chem . 276 (36): 33419–27. doi :10.1074/jbc.M104509200 PMID 11445579 . Tani TT, Mercurio AM (2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B" . J. Biol. Chem . 276 (39): 36535–42. doi :10.1074/jbc.M105785200 PMID 11479315 . Blobe GC, Liu X, Fang SJ, How T, Lodish HF (2001). "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC" . J. Biol. Chem . 276 (43): 39608–17. doi :10.1074/jbc.M106831200 PMID 11546783 . Awan A, Lucic MR, Shaw DM, Sheppard F, Westwater C, Lyons SA, Stern PL (2002). "5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis". Biochem. Biophys. Res. Commun . 290 (3): 1030–6. doi :10.1006/bbrc.2001.6288 . PMID 11798178 . El Mourabit H, Poinat P, Koster J, Sondermann H, Wixler V, Wegener E, Laplantine E, Geerts D, Georges-Labouesse E, Sonnenberg A, Aumailley M (2002). "The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits". Matrix Biol . 21 (2): 207–14. doi :10.1016/S0945-053X(01)00198-6 . PMID 11852236 . Lou X, McQuistan T, Orlando RA, Farquhar MG (2002). "GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function" . J. Am. Soc. Nephrol . 13 (4): 918–27. doi :10.1681/ASN.V134918 PMID 11912251 .