ARF GTPase 활성 단백질 GIT2 는 인간에게 GIT2 유전자 에 의해 암호화된 효소 다.[5] [6] [7]
함수 이 유전자는 GIT 단백질 계열의 한 구성원을 인코딩한다. GIT 단백질은 G단백질 결합 수용체 키나아제와 상호작용하며 ADP-리보실화 인자(ARF) GTPase-활성화 단백질(GAP) 활동을 가지고 있다. 이 유전자는 광범위한 대체 스플라이싱을 거친다; 비록 10개의 대본 변형이 설명되었지만, 전체 길이 순서는 오직 4개의 변종에 대해서만 결정되었다. 다양한 이소 형태는 ARF GAP 활성과 G 단백질 결합 수용체 키나제2 결합에 관한 기능적 차이를 가진다.[7]
모형 유기체 모델 유기체 는 GIT2 기능 연구에 사용되어 왔다.Git2 라고Gt(XG510)Byg [15] [16] 녹아웃 마우스 라인은 웰컴 트러스트 생거 연구소 (Wellcome Trust Sanger Institute)에서 관심 있는 과학자들에게 질병 의 동물 모델을 생성하고 배포하는 고투입 돌연변이 유발 프로젝트의 일환으로 생성되었다.[17] [18] [19]
수컷과 암컷은 삭제 효과를 판단하기 위해 표준화된 표현식 화면 을 거쳤다.[13] [20] Git2 가 부족한 생쥐는 생존력이나 생식력 에 큰 결함이 없어 추가 검사를 실시했으며 4개의 유의한 표현형식 이 보고됐다.[21] [22] [13] [20]
상호작용 GIT2는 GIT1 과 상호작용 하는 것으로 나타났다.[23]
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