아연 핑거 단백질 Eos는 IKZF4 [5] [6] 단백질 이다.
Eos를 포함한 Ikaros(ZNFN1A1; MIM 603023) 계열의 전사 인자는 림프구에서 발현되며 림프구 발달 제어에 관여한다. [OMIM [6]
상호 작용 IKZF4는 CTBP1 [7] [5] [8] IKZF1 과 대화하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000123411 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002578 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities" . J Biol Chem . 275 (49): 38347–54. doi :10.1074/jbc.M005457200 PMID 10978333 . ^ a b "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)" .^ Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem . Germany. 269 (23): 5885–92. doi :10.1046/j.1432-1033.2002.03313.x . ISSN 0014-2956 . PMID 12444977 . ^ Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system" . FEBS Lett . NETHERLANDS. 447 (1): 76–80. doi :10.1016/S0014-5793(99)00265-3 ISSN 0014-5793 . PMID 10218586 . S2CID 28898354 .
추가 정보 Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Bao J, Lin H, Ouyang Y, et al. (2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos". Nat. Neurosci . 7 (11): 1250–8. doi :10.1038/nn1342 . PMID 15494726 . S2CID 1964177 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Perdomo J, Crossley M (2003). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem . 269 (23): 5885–92. doi :10.1046/j.1432-1033.2002.03313.x . PMID 12444977 . Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros" . J. Biol. Chem . 277 (31): 27697–705. doi :10.1074/jbc.M201694200 PMID 12015313 . Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 8 (2): 85–95. doi :10.1093/dnares/8.2.85 PMID 11347906 . Honma Y, Kiyosawa H, Mori T, et al. (1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system" . FEBS Lett . 447 (1): 76–80. doi :10.1016/S0014-5793(99)00265-3 PMID 10218586 . S2CID 28898354 .