Kinesin 유사 단백질 KIF22 는 인간에게 KIF22 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
이 유전자에 의해 암호화된 단백질은 키네신 유사 단백질 계열의 일원이다. 이 단백질군은 세포 내에서 오르간젤을 운반하고 세포분열 시 염색체를 움직이는 미세관 의존형 분자모터다. 이 단백질의 절반인 C단말기가 DNA를 결합하는 것으로 밝혀졌다. Xenopus homological을 사용한 연구는 은유 염색체 정렬과 유지관리에 필수적인 역할을 제안한다.[7]
상호작용 KIF22는 SIAH1 과 상호작용 하는 것으로 나타났다.[8]
임상 관련성 이 유전자의 돌연변이는 관절 이완과 함께 스폰딜로피메타피질이형성증 같은 발달장애를 일으키는 것으로 나타났다.[9]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000079616 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000030677 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T (April 1996). "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle" . EMBO J . 15 (3): 457–67. doi :10.1002/j.1460-2075.1996.tb00378.x . PMC 449964 PMID 8599929 . ^ Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human" . Proc Natl Acad Sci U S A . 98 (13): 7004–11. Bibcode :2001PNAS...98.7004M . doi :10.1073/pnas.111145398 PMC 34614 PMID 11416179 . ^ a b "Entrez Gene: KIF22 kinesin family member 22" .^ Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis" . Oncogene . 19 (52): 5997–6006. doi :10.1038/sj.onc.1204002 PMID 11146551 . ^ Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ (December 2011). "Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type" . Am. J. Hum. Genet . 89 (6): 760–6. doi :10.1016/j.ajhg.2011.10.015 . PMC 3234366 PMID 22152677 . 추가 읽기 Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". 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Genomics . 52 (3): 374–7. doi :10.1006/geno.1998.5452 . PMID 9790757 . Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics . 60 (3): 295–308. doi :10.1006/geno.1999.5927 . PMID 10493829 . Funabiki H, Murray AW (2000). "The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement" . Cell . 102 (4): 411–24. doi :10.1016/S0092-8674(00)00047-7 PMID 10966104 . S2CID 3010084 . Antonio C, Ferby I, Wilhelm H, et al. (2000). "Xkid, a chromokinesin required for chromosome alignment on the metaphase plate" . Cell . 102 (4): 425–35. doi :10.1016/S0092-8674(00)00048-9 PMID 10966105 . S2CID 17113314 . Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis" . Oncogene . 19 (52): 5997–6006. doi :10.1038/sj.onc.1204002 PMID 11146551 . Levesque AA, Compton DA (2001). "The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles" . J. Cell Biol . 154 (6): 1135–46. doi :10.1083/jcb.200106093 . PMC 2150818 PMID 11564754 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Yajima J, Edamatsu M, Watai-Nishii J, et al. (2003). "The human chromokinesin Kid is a plus end-directed microtubule-based motor" . EMBO J . 22 (5): 1067–74. doi :10.1093/emboj/cdg102 . PMC 150335 PMID 12606572 . Shiroguchi K, Ohsugi M, Edamatsu M, et al. (2003). "The second microtubule-binding site of monomeric kid enhances the microtubule affinity" . J. Biol. 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