NME1

NME1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1JXV, 1UCN, 2HVD, 2HVE, 3L7U, 4ENO
식별자
에일리어스	NME1, AWD, GAAD, NB, NBS, NDKA, NDPKA, NM23-H1, NME/NM23 뉴클레오시드2인산인산화효소1
외부 ID	OMIM : 156490 MGI : 97355 HomoloGene : 128514 GenCard : NME1
유전자 위치(인간)
크르.	17번 염색체(인간)
끝.	51,412,428 bp
유전자 위치(마우스)
크르.	11번 염색체(쥐)
끝.	93,859,347 bp
RNA발현패턴
	상단 표시 위치:
	전전두피질; ; 시상하부; ; 브로드만 9구역; ; 상전두회; ; 랑게르한스 섬; ; 신경절 융기; ; 고유 해마; ; 대상회; ; 부록; ; 전두극;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	트랜스페라아제 활성; 뉴클레오티드 결합; 디옥시리보핵산가수분해효소활성; 리보솜소형 서브유닛결합; GTP 바인딩; 금속 이온 결합; 키나아제활성; GO:0001948 단백질 결합; 동일단백질결합; ATP 결합; 마그네슘 이온 결합; 뉴클레오시드2인산인산화효소활성; RNA결합; RNA중합효소II전사조절영역배열특이적DNA결합; 외가닥 DNA결합; 중간 필라멘트 결합; 효소결합; 단백질인산화효소결합; 감마 튜브린 결합;
셀룰러 컴포넌트	러플막; 세포외 엑소좀; 핵; 세포질; 미토콘드리아 외막; 중심체; 세포; 중간 필라멘트; 막; 세포질핵주위영역; 미토콘드리아; 미엘린 칼집;
생물학적 과정	UTP생합성법; 아포토시스 과정 조절; 세포 분화; 핵산염기 함유 소분자 상호 변환; CTP생합성법; 엔도사이토증; 인산화; 상피세포 증식의 양성 조절; 뉴클레오티드 대사 과정; 뉴클레오시드2인산인산화; 신경계의 발달; DNA결합의 양성조절; GTP생합성법; 세포군 증식의 음성 조절; DNA대사과정; 골수성 백혈구 분화 음성 조절; 유전자 발현 음성 조절; 뉴런 투영 발달의 양성 조절; 아민에 대한 반응; 해마의 발달; 테스토스테론에 대한 반응; cAMP에 대한 응답; 포도당 자극에 대한 세포 반응; 지방산에 대한 세포 반응; 수유; 유선 발달;
	출처:아미고 / QuickGO
맞춤법
	4830
	18102
	ENSG00000239672
	ENSMUSG000037601
	P15531
	P15532
	NM_198175; NM_000269
	NM_008704; NM_001378854
	NP_000260; NP_937818
	NP_032730; NP_001365783
	위키데이터
인간 보기/편집	마우스 표시/편집

뉴클레오시드2인산인산화효소A는 사람에게 NME1 ^[5]유전자에 의해 코드되는 효소이다.전이 억제제라고 생각됩니다.

기능.

이 유전자(NME1)는 고도로 전이된 세포에서 mRNA 전사 수준이 감소했기 때문에 확인되었다.뉴클레오시드2인산인산화효소(NDK)는 'A'(이 유전자에 의해 암호화됨)와 'B'(NME2에 의해 암호화됨) 이소형식으로 이루어진 헥사머로서 존재한다.이 유전자의 돌연변이는 공격적인 신경아세포종에서 확인되었다.이 유전자에 대해 서로 다른 아이소폼을 코드하는 두 개의 전사 변형이 발견되었다.이 유전자와 인접한 다운스트림 유전자(NME2)의 동시 전사는 자연발생 전사물(NME1-NME2)을 생성하며, NME2는 각각의 개별 유전자 ^[6]생성물과 동일성을 공유하는 배열로 이루어진 융합단백질을 암호화한다.

상호 작용

NME1은 다음과 상호작용하는 것으로 나타났습니다.

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뉴클레오시드이인산인산화효소

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000239672 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000037601 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dooley S, Seib T, Engel M, Theisinger B, Janz H, Piontek K, Zang KD, Welter C (February 1994). "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1". Hum. Genet. 93 (1): 63–6. doi:10.1007/bf00218915. PMID 8270257. S2CID 6373221.
^ "Entrez Gene: NME1 non-metastatic cells 1, protein (NM23A) expressed in".
^ Du J, Hannon GJ (December 2002). "The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1". Nucleic Acids Res. 30 (24): 5465–75. doi:10.1093/nar/gkf678. PMC 140054. PMID 12490715.
^ Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C (June 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. 277 (23): 20895–902. doi:10.1074/jbc.M200200200. PMID 11919189.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
^ Chakravarti D, Hong R (March 2003). "SET-ting the stage for life and death". Cell. 112 (5): 589–91. doi:10.1016/s0092-8674(03)00151-x. PMID 12628178. S2CID 16423565.
^ ^a ^b Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.
^ Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (February 1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID 9480811.

추가 정보

Freije JM, MacDonald NJ, Steeg PS (1998). "Nm23 and tumour metastasis: basic and translational advances". Biochem. Soc. Symp. 63: 261–71. PMID 9513729.
Roymans D, Willems R, Van Blockstaele DR, Slegers H (2002). "Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis". Clin. Exp. Metastasis. 19 (6): 465–76. doi:10.1023/A:1020396722860. PMID 12405283. S2CID 21876557.
Tee YT, Chen GD, Lin LY, Ko JL, Wang PH (2006). "Nm23-H1: a metastasis-associated gene". Taiwan J Obstet Gynecol. 45 (2): 107–13. doi:10.1016/S1028-4559(09)60206-0. PMID 17197349.
Gilles AM, Presecan E, Vonica A, Lascu I (1991). "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme". J. Biol. Chem. 266 (14): 8784–9. PMID 1851158.
Leone A, McBride OW, Weston A, Wang MG, Anglard P, Cropp CS, Goepel JR, Lidereau R, Callahan R, Linehan WM (1991). "Somatic allelic deletion of nm23 in human cancer". Cancer Res. 51 (9): 2490–3. PMID 2015608.
Hailat N, Keim DR, Melhem RF, Zhu XX, Eckerskorn C, Brodeur GM, Reynolds CP, Seeger RC, Lottspeich F, Strahler JR (1991). "High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification". J. Clin. Invest. 88 (1): 341–5. doi:10.1172/JCI115299. PMC 296039. PMID 2056128.
Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker E, Margulies IM, King CR, Liotta LA, Steeg PS (1989). "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development". Nature. 342 (6246): 177–80. doi:10.1038/342177a0. PMID 2509941. S2CID 4340066.
Wang L, Patel U, Ghosh L, Chen HC, Banerjee S (1993). "Mutation in the nm23 gene is associated with metastasis in colorectal cancer". Cancer Res. 53 (4): 717–20. PMID 7916650.
Chang CL, Zhu XX, Thoraval DH, Ungar D, Rawwas J, Hora N, Strahler JR, Hanash SM, Radany E (1994). "Nm23-H1 mutation in neuroblastoma" (PDF). Nature. 370 (6488): 335–6. doi:10.1038/370335a0. hdl:2027.42/62612. PMID 8047138. S2CID 4356706.
MacDonald NJ, De la Rosa A, Benedict MA, Freije JM, Krutsch H, Steeg PS (1993). "A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential". J. Biol. Chem. 268 (34): 25780–9. PMID 8245015.
Postel EH, Berberich SJ, Flint SJ, Ferrone CA (1993). "Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis". Science. 261 (5120): 478–80. doi:10.1126/science.8392752. PMID 8392752.
Sudbrak R, Golla A, Hogan K, Powers P, Gregg R, Du Chesne I, Lehmann-Horn F, Deufel T (1993). "Exclusion of malignant hyperthermia susceptibility (MHS) from a putative MHS2 locus on chromosome 17q and of the alpha 1, beta 1, and gamma subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect" (PDF). Hum. Mol. Genet. 2 (7): 857–62. doi:10.1093/hmg/2.7.857. PMID 8395939. S2CID 86750140. Archived from the original (PDF) on 2020-02-07.
MacDonald NJ, Freije JM, Stracke ML, Manrow RE, Steeg PS (1996). "Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells". J. Biol. Chem. 271 (41): 25107–16. doi:10.1074/jbc.271.41.25107. PMID 8810265.
Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.
Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID 9480811.
Schaertl S, Konrad M, Geeves MA (1998). "Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis". J. Biol. Chem. 273 (10): 5662–9. doi:10.1074/jbc.273.10.5662. PMID 9488696.
Willems R, Van Bockstaele DR, Lardon F, Lenjou M, Nijs G, Snoeck HW, Berneman ZN, Slegers H (1998). "Decrease in nucleoside diphosphate kinase (NDPK/nm23) expression during hematopoietic maturation". J. Biol. Chem. 273 (22): 13663–8. doi:10.1074/jbc.273.22.13663. PMID 9593706.
Manda R, Kohno T, Matsuno Y, Takenoshita S, Kuwano H, Yokota J (1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display". Genomics. 61 (1): 5–14. doi:10.1006/geno.1999.5939. PMID 10512675.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000239672 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000037601 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8270257-5] Dooley S, Seib T, Engel M, Theisinger B, Janz H, Piontek K, Zang KD, Welter C (February 1994). "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1". Hum. Genet. 93 (1): 63–6. doi:10.1007/bf00218915. PMID 8270257. S2CID 6373221.

[entrez-6] "Entrez Gene: NME1 non-metastatic cells 1, protein (NM23A) expressed in".

[pmid12490715-7] Du J, Hannon GJ (December 2002). "The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1". Nucleic Acids Res. 30 (24): 5465–75. doi:10.1093/nar/gkf678. PMC 140054. PMID 12490715.

[pmid11919189-8] Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C (June 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. 277 (23): 20895–902. doi:10.1074/jbc.M200200200. PMID 11919189.

[pmid16189514-9] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid11042679-10] Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.

[pmid12628186-11] Chakravarti D, Hong R (March 2003). "SET-ting the stage for life and death". Cell. 112 (5): 589–91. doi:10.1016/s0092-8674(03)00151-x. PMID 12628178. S2CID 16423565.

[pmid8858107-12] Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.

[pmid9480811-13] Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (February 1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID 9480811.

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[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

Search

NME1

네임스페이스

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목차

기능.

상호 작용

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레퍼런스

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Search

NME1

기능.

상호 작용

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레퍼런스

추가 정보

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