PTTG1

PTTG1
식별자
에일리어스	자매염색체분리 PTTG1, EAP1, HPTG, PTTG, TUTR1, 뇌하수체종양전환1, PTTG1조절제, 시큐린, ECRAR
외부 ID	OMIM : 604147 MGI : 1353578 HomoloGene : 3110 GenCard : PTTG1
유전자 위치(인간)
크르.	5번 염색체(인간)
끝.	160,428,739 bp
유전자 위치(마우스)
크르.	11번 염색체(쥐)
끝.	43,317,078 bp
RNA발현패턴
	상단 표시 위치:
	이차 난모세포; ; 신경절 융기; ; 정자; ; 결석골; ; 골수; ; 모낭; ; 구강; ; 직장; ; 갑상선 좌엽; ; 흉선;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	펩티드가수분해효소억제활성; 시스테인형 엔도펩티드가수분해효소억제제활성; GO:0001131, GO:000115, GO:0001130, GO:0001204 DNA결합전사인자액티비티; SH3 도메인바인딩; GO:0001948 단백질 결합; GO:0001200, GO:0001133, GO:0001201 DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	세포질; 핵; 세포;
생물학적 과정	염색체 분리; 염색체 구성; 상동 염색체 분리; DNA 손상 자극에 대한 세포 반응; 세포 분열; 정자 형성; 세포 주기; 아나phase-complex-의존성 이화 과정; DNA복구; 전사조절, DNA템플릿화; 펩티드가수분해효소활성음성조절; 엔도펩티드가수분해효소활성음성조절; RNA중합효소II에 의한 전사조절; RNA중합효소II에 의한 전사; 유사분열 자매 염색체 분리 음성 조절; 유비퀴틴의존성 단백질 이화 과정;
	출처:아미고 / QuickGO
맞춤법
	9232
	30939
	ENSG00000164611
	ENSMUSG000020415
	O95997; Q6IAL9
	Q9CQJ7
	NM_004219; NM_001282382; NM_001282383
	NM_001131054; NM_013917; NM_001362799
NP_001269311; NP_001269312; NP_004210; NP_001269311.1; NP_001269312.1;
	NP_004210.1
	NP_001124526; NP_038945; NP_001349728
	위키데이터
인간 보기/편집	마우스 표시/편집

시큐린은 인간의 PTTG1 ^[5]^[6]^[7]유전자에 의해 암호화되는 단백질이다.

기능.

암호화된 단백질은 효모 세큐르신 단백질의 상동체이며, 세퍼린이 자매 염색체 분리를 촉진하는 것을 방지합니다.APC가 활성화될 때까지 세퍼린과 관련된 Anaphase-Promoting Complex(APC) 기판입니다.유전자 생성물은 체외변형 활성과 체내 종양유전 활성을 가지며, 다양한 종양에서 유전자가 고도로 발현된다.본 유전자 생성물은 2개의 PXXP 모티브를 포함하고 있으며, 이는 형질전환 및 종양유전 활성과 기초섬유아세포 성장인자 발현 자극에 필요하다.APC에 의한 열화에 필요한 파괴 박스(D 박스)도 포함되어 있습니다.암호화된 단백질의 산성 C 말단 영역은 트랜스활성화 도메인으로 작용할 수 있다.유전자 생성물은 부분적으로 ^[7]핵에 위치하지만 주로 세포질 단백질이다.

상호 작용

PTTG1은 다음 제품과 상호 작용하는 것으로 나타났습니다.

규정

유사분열 중에 CDK1은 Ser-165에서 ^[12]PTTG1을 인산화한다.PTTG1은 사이클린 의존성 키나제 억제제 PHA-848125에 ^[13]반응하여 흑색종 세포에서 하향 조절된다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000164611 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000020415 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Domínguez A, Ramos-Morales F, Romero F, Rios RM, Dreyfus F, Tortolero M, Pintor-Toro JA (Oct 1998). "hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG". Oncogene. 17 (17): 2187–93. doi:10.1038/sj.onc.1202140. PMID 9811450.
^ Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S (Jan 1999). "Structure, expression, and function of human pituitary tumor-transforming gene (PTTG)". Molecular Endocrinology. 13 (1): 156–66. doi:10.1210/me.13.1.156. PMID 9892021.
^ ^a ^b "Entrez Gene: PTTG1 pituitary tumor-transforming 1".
^ ^a ^b Pei L (Jan 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". The Journal of Biological Chemistry. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854.
^ Romero F, Multon MC, Ramos-Morales F, Domínguez A, Bernal JA, Pintor-Toro JA, Tortolero M (Mar 2001). "Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase". Nucleic Acids Research. 29 (6): 1300–7. doi:10.1093/nar/29.6.1300. PMC 29753. PMID 11238996.
^ Bernal JA, Luna R, Espina A, Lázaro I, Ramos-Morales F, Romero F, Arias C, Silva A, Tortolero M, Pintor-Toro JA (Oct 2002). "Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis". Nature Genetics. 32 (2): 306–11. doi:10.1038/ng997. PMID 12355087. S2CID 1770399.
^ Chien W, Pei L (Jun 2000). "A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product". The Journal of Biological Chemistry. 275 (25): 19422–7. doi:10.1074/jbc.M910105199. PMID 10781616.
^ Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M (Jan 2000). "Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product". Oncogene. 19 (3): 403–9. doi:10.1038/sj.onc.1203320. PMID 10656688. S2CID 21958836.
^ Caporali S, Alvino E, Levati L, Esposito AI, Ciomei M, Brasca MG, Del Bufalo D, Desideri M, Bonmassar E, Pfeffer U, D'Atri S (Sep 2012). "Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125". Biochemical Pharmacology. 84 (5): 598–611. doi:10.1016/j.bcp.2012.06.004. PMID 22704958.

추가 정보

Yu R, Melmed S (2004). "Pituitary tumor transforming gene: an update". Molecular Pathology of the Pituitary. Frontiers of Hormone Research. Vol. 32. pp. 175–85. doi:10.1159/000079044. ISBN 3-8055-7740-0. PMID 15281346.
Tfelt-Hansen J, Kanuparthi D, Chattopadhyay N (Jun 2006). "The emerging role of pituitary tumor transforming gene in tumorigenesis". Clinical Medicine & Research. 4 (2): 130–7. doi:10.3121/cmr.4.2.130. PMC 1483889. PMID 16809406.
Pei L (Jan 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". The Journal of Biological Chemistry. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854.
Kakar SS (1999). "Assignment of the human tumor transforming gene TUTR1 to chromosome band 5q35.1 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 83 (1–2): 93–5. doi:10.1159/000015139. PMID 9925941. S2CID 28589466.
Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S (Feb 1999). "Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas". The Journal of Clinical Endocrinology and Metabolism. 84 (2): 761–7. doi:10.1210/jc.84.2.761. PMID 10022450.
Lee IA, Seong C, Choe IS (May 1999). "Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene". Biochemistry and Molecular Biology International. 47 (5): 891–7. doi:10.1080/15216549900201993. PMID 10365261. S2CID 22575138.
Kakar SS, Jennes L (1999). "Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis". Cytogenetics and Cell Genetics. 84 (3–4): 211–6. doi:10.1159/000015261. PMID 10393434. S2CID 38980080.
Zou H, McGarry TJ, Bernal T, Kirschner MW (Jul 1999). "Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis". Science. 285 (5426): 418–22. doi:10.1126/science.285.5426.418. PMID 10411507.
Kakar SS (Nov 1999). "Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG)". Gene. 240 (2): 317–24. doi:10.1016/S0378-1119(99)00446-1. PMID 10580151.
Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M (Jan 2000). "Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product". Oncogene. 19 (3): 403–9. doi:10.1038/sj.onc.1203320. PMID 10656688. S2CID 21958836.
Chien W, Pei L (Jun 2000). "A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product". The Journal of Biological Chemistry. 275 (25): 19422–7. doi:10.1074/jbc.M910105199. PMID 10781616.
Ishikawa H, Heaney AP, Yu R, Horwitz GA, Melmed S (Feb 2001). "Human pituitary tumor-transforming gene induces angiogenesis". The Journal of Clinical Endocrinology and Metabolism. 86 (2): 867–74. doi:10.1210/jcem.86.2.7184. PMID 11158059.
Zur A, Brandeis M (Feb 2001). "Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis". The EMBO Journal. 20 (4): 792–801. doi:10.1093/emboj/20.4.792. PMC 145417. PMID 11179223.
Romero F, Multon MC, Ramos-Morales F, Domínguez A, Bernal JA, Pintor-Toro JA, Tortolero M (Mar 2001). "Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase". Nucleic Acids Research. 29 (6): 1300–7. doi:10.1093/nar/29.6.1300. PMC 29753. PMID 11238996.
Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C (May 2001). "Securin is required for chromosomal stability in human cells". Cell. 105 (4): 445–57. doi:10.1016/S0092-8674(01)00340-3. PMID 11371342. S2CID 16188959.
Hilioti Z, Chung YS, Mochizuki Y, Hardy CF, Cohen-Fix O (Sep 2001). "The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner". Current Biology. 11 (17): 1347–52. doi:10.1016/S0960-9822(01)00399-2. PMID 11553328. S2CID 11420259.
Waizenegger I, Giménez-Abián JF, Wernic D, Peters JM (Aug 2002). "Regulation of human separase by securin binding and autocleavage". Current Biology. 12 (16): 1368–78. doi:10.1016/S0960-9822(02)01073-4. PMID 12194817. S2CID 18316557.
McCabe CJ, Boelaert K, Tannahill LA, Heaney AP, Stratford AL, Khaira JS, Hussain S, Sheppard MC, Franklyn JA, Gittoes NJ (Sep 2002). "Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors". The Journal of Clinical Endocrinology and Metabolism. 87 (9): 4238–44. doi:10.1210/jc.2002-020309. PMID 12213878.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000164611 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000020415 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9811450-5] Domínguez A, Ramos-Morales F, Romero F, Rios RM, Dreyfus F, Tortolero M, Pintor-Toro JA (Oct 1998). "hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG". Oncogene. 17 (17): 2187–93. doi:10.1038/sj.onc.1202140. PMID 9811450.

[pmid9892021-6] Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S (Jan 1999). "Structure, expression, and function of human pituitary tumor-transforming gene (PTTG)". Molecular Endocrinology. 13 (1): 156–66. doi:10.1210/me.13.1.156. PMID 9892021.

[entrez-7] "Entrez Gene: PTTG1 pituitary tumor-transforming 1".

[pmid9915854-8] Pei L (Jan 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". The Journal of Biological Chemistry. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854.

[pmid11238996-9] Romero F, Multon MC, Ramos-Morales F, Domínguez A, Bernal JA, Pintor-Toro JA, Tortolero M (Mar 2001). "Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase". Nucleic Acids Research. 29 (6): 1300–7. doi:10.1093/nar/29.6.1300. PMC 29753. PMID 11238996.

[pmid12355087-10] Bernal JA, Luna R, Espina A, Lázaro I, Ramos-Morales F, Romero F, Arias C, Silva A, Tortolero M, Pintor-Toro JA (Oct 2002). "Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis". Nature Genetics. 32 (2): 306–11. doi:10.1038/ng997. PMID 12355087. S2CID 1770399.

[pmid10781616-11] Chien W, Pei L (Jun 2000). "A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product". The Journal of Biological Chemistry. 275 (25): 19422–7. doi:10.1074/jbc.M910105199. PMID 10781616.

[12] Ramos-Morales F, Domínguez A, Romero F, Luna R, Multon MC, Pintor-Toro JA, Tortolero M (Jan 2000). "Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product". Oncogene. 19 (3): 403–9. doi:10.1038/sj.onc.1203320. PMID 10656688. S2CID 21958836.

[13] Caporali S, Alvino E, Levati L, Esposito AI, Ciomei M, Brasca MG, Del Bufalo D, Desideri M, Bonmassar E, Pfeffer U, D'Atri S (Sep 2012). "Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125". Biochemical Pharmacology. 84 (5): 598–611. doi:10.1016/j.bcp.2012.06.004. PMID 22704958.

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PTTG1

네임스페이스

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목차

기능.

상호 작용

규정

레퍼런스

추가 정보