RBP1

RBP1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	5HA1, 5HBS, 5H8T, 5H9A
식별자
에일리어스	RBP1, CRABP-I, CRBP, CCRBPI, RBPC, 레티놀결합단백질1
외부 ID	OMIM: 180260 MGI: 97876 HomoloGene: 2175 GeneCard: RBP1
유전자 위치(인간)
크르.	3번 염색체(인간)
끝.	139,539,829 bp
유전자 위치(마우스)
크르.	9번 염색체(쥐)
끝.	98,328,628 bp
RNA발현패턴
	상단 표시 위치:
	망막 색소 상피; ; 우측 자궁관; ; 췌장체; ; 우부신; ; 뇌하수체 전엽; ; 좌부신; ; 담낭; ; 좌측 자궁관; ; 랑게르한스 섬; ; 태아;
	상단 표시 위치:
	시신경; ; 망막 색소 상피; ; 내측 신경절 융기; ; 심내막 쿠션; ; 외경동맥; ; 내경동맥; ; 방실 밸브; ; 상악 융기; ; 선조 혈관; ; 배꼽;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	지질 결합; 레티놀 결합; 레티노이드 결합; 망막 결합; 전트랜스레티놀결합;
셀룰러 컴포넌트	핵소체; 세포질; 세포; 지질액적;
생물학적 과정	레티노인산생합성법; 레티노이드 대사 과정; 비타민 A 대사 과정; 지질 항상성;
	출처:아미고 / QuickGO
맞춤법
	5947
	19659
	ENSG00000114115
	ENSMUSG000046402
	P09455
	Q00915
	NM_002899; NM_001130992; NM_001130993; NM_001365940
	NM_011254
	NP_001124464; NP_001124465; NP_002890; NP_001352869
	NP_035384
	위키데이터
인간 보기/편집	마우스 표시/편집

RBP1로도 알려진 레티놀 결합 단백질 1, 세포는 RBP1 ^[5]^[6]^[7]유전자에 의해 인간에게 암호화되는 단백질이다.

기능.

RBP1은 레티놀(비타민 A 알코올)을 간 저장 부위에서 말초 조직으로 운반하는 데 관여하는 운반 단백질입니다.비타민 A는 성장, 생식, 상피조직의 분화와 시력에 필요한 지용성 비타민이다.이 유전자는 각각 24, 59, 33, 16개의 아미노산 잔류물을 코드하는 4개의 엑손(exon)을 가지고 있다.두 번째 개입 배열만 21kb의 유전자 ^[5]중 19kb를 차지한다.

임상적 의의

세포 레티놀결합단백질-1(CRBP-1)은 레티놀의 생체이용률 조절을 통해 자궁내막세포의 분화상태 유지에 기여한다.반대로 CRBP-1의 손실은 자궁내막암 ^[8]발병과 관련이 있다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG0000011415 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000046402 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: RBP1 retinol binding protein 1, cellular".
^ Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ (September 1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. doi:10.1016/S0021-9258(19)47422-X. PMID 1654334.
^ De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L (1998). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 226–7. doi:10.1159/000015107. PMID 9858824. S2CID 46851294.
^ Orlandi A, Ferlosio A, Ciucci A, Francesconi A, Lifschitz-Mercer B, Gabbiani G, Spagnoli LG, Czernobilsky B (June 2006). "Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications". Mod. Pathol. 19 (6): 797–803. doi:10.1038/modpathol.3800586. PMID 16575402.

추가 정보

Herr FM, Ong DE (1992). "Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins". Biochemistry. 31 (29): 6748–55. doi:10.1021/bi00144a014. PMID 1322170.
Siegenthaler G, Tomatis I, Chatellard-Gruaz D, et al. (1992). "Expression of CRABP-I and -II in human epidermal cells. Alteration of relative protein amounts is linked to the state of differentiation". Biochem. J. 287. ( Pt 2) (2): 383–9. doi:10.1042/bj2870383. PMC 1133176. PMID 1332671.
Aström A, Tavakkol A, Pettersson U, et al. (1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. doi:10.1016/S0021-9258(19)47422-X. PMID 1654334.
Wei LN, Mertz JR, Goodman DS, Nguyen-Huu MC (1990). "Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression". Mol. Endocrinol. 1 (8): 526–34. doi:10.1210/mend-1-8-526. PMID 2856408.
Colantuoni V, Cortese R, Nilsson M, et al. (1985). "Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein". Biochem. Biophys. Res. Commun. 130 (1): 431–9. doi:10.1016/0006-291X(85)90435-8. PMID 2992469.
Nilsson MH, Spurr NK, Lundvall J, et al. (1988). "Human cellular retinol-binding protein gene organization and chromosomal location". Eur. J. Biochem. 173 (1): 35–44. doi:10.1111/j.1432-1033.1988.tb13963.x. PMID 3356192.
Sherman DR, Lloyd RS, Chytil F (1987). "Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3209–13. doi:10.1073/pnas.84.10.3209. PMC 304838. PMID 3472205.
Kooistra T, Lansink M, Arts J, et al. (1995). "Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells". Eur. J. Biochem. 232 (2): 425–32. doi:10.1111/j.1432-1033.1995.425zz.x. PMID 7556191.
Jaconi S, Rose K, Hughes GJ, et al. (1995). "Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure". J. Lipid Res. 36 (6): 1247–53. doi:10.1016/S0022-2275(20)41132-0. PMID 7666002.
Liu W, Hellman P, Li Q, et al. (1997). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells". Biochem. Biophys. Res. Commun. 229 (3): 922–9. doi:10.1006/bbrc.1996.1903. PMID 9005841.
Sundaram M, Sivaprasadarao A, DeSousa MM, Findlay JB (1998). "The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor". J. Biol. Chem. 273 (6): 3336–42. doi:10.1074/jbc.273.6.3336. PMID 9452451.
De Baere E, Speleman F, Van Roy N, et al. (1999). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 226–7. doi:10.1159/000015107. PMID 9858824. S2CID 46851294.
Christensen EI, Moskaug JO, Vorum H, et al. (1999). "Evidence for an essential role of megalin in transepithelial transport of retinol". J. Am. Soc. Nephrol. 10 (4): 685–95. doi:10.1681/ASN.V104685. PMID 10203351.
Skowyra D, Zeremski M, Neznanov N, et al. (2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex". J. Biol. Chem. 276 (12): 8734–9. doi:10.1074/jbc.M007664200. PMID 11118440.
Folli C, Calderone V, Ottonello S, et al. (2001). "Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3710–5. doi:10.1073/pnas.061455898. PMC 31117. PMID 11274389.
Orlandi A, Francesconi A, Clément S, et al. (2002). "High levels of cellular retinol binding protein-1 expression in leiomyosarcoma: possible implications for diagnostic evaluation". Virchows Arch. 441 (1): 31–40. doi:10.1007/s00428-001-0576-7. PMID 12111198. S2CID 195243470.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cvetković D, Williams SJ, Hamilton TC (2003). "Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer". Clin. Cancer Res. 9 (3): 1013–20. PMID 12631600.
Hosaka B, Park SI, Felipe CR, et al. (2004). "Predictive value of urinary retinol binding protein for graft dysfunction after kidney transplantation". Transplant. Proc. 35 (4): 1341–3. doi:10.1016/S0041-1345(03)00380-4. PMID 12826154.
Schmitt-Gräff A, Ertelt V, Allgaier HP, et al. (2003). "Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival". Hepatology. 38 (2): 470–80. doi:10.1053/jhep.2003.50321. PMID 12883492. S2CID 23904734.

인간 염색체 3번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG0000011415 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000046402 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RBP1 retinol binding protein 1, cellular".

[pmid1654334-6] Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ (September 1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. doi:10.1016/S0021-9258(19)47422-X. PMID 1654334.

[pmid9858824-7] De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L (1998). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 226–7. doi:10.1159/000015107. PMID 9858824. S2CID 46851294.

[pmid16575402-8] Orlandi A, Ferlosio A, Ciucci A, Francesconi A, Lifschitz-Mercer B, Gabbiani G, Spagnoli LG, Czernobilsky B (June 2006). "Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications". Mod. Pathol. 19 (6): 797–803. doi:10.1038/modpathol.3800586. PMID 16575402.

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RBP1

네임스페이스

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목차

기능.

임상적 의의

레퍼런스

추가 정보