RGS7
RGS7G단백질 시그널링 7의 조절제는 RGS7 [5][6]유전자에 의해 인체 내에서 부호화되는 단백질이다.
RGS7은 Gi/o결합 GPCR의 범용 억제제 역할을 하는 뇌에서 고농축된다.RGS7은 GTPase 활성화 단백질(GAP)이다.G단백질에 대한 GTP 가수분해를 가속화하여 빠른 불활성화를 결정하고 [7]GPCR 시그널링의 세포내 길항제 역할을 한다.
상호 작용
RGS7은 다음과 상호작용하는 것으로 나타났습니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000182901 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026527 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell. 84 (1): 115–25. doi:10.1016/S0092-8674(00)80998-8. PMID 8548815. S2CID 7815240.
- ^ "Entrez Gene: RGS7 regulator of G-protein signalling 7".
- ^ Anderson GR, Posokhova E, Martemyanov KA (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics. 54 (1–3): 33–46. doi:10.1007/s12013-009-9052-9. PMC 2827338. PMID 19521673.
- ^ Levay K, Cabrera JL, Satpaev DK, Slepak VZ (Mar 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. Bibcode:1999PNAS...96.2503L. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.
- ^ Posner BA, Gilman AG, Harris BA (Oct 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
- ^ a b Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (June 11, 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.
- ^ Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. Bibcode:1999PNAS...96.6371K. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.
- ^ Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861.
추가 정보
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- Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T (1999). "RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents". J. Biol. Chem. 274 (14): 9899–904. doi:10.1074/jbc.274.14.9899. PMID 10092682.
- Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. Bibcode:1999PNAS...96.6371K. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.
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