SAP30이라고 도 하는 Sin3A 관련 단백질 30kDa 는 SAP30 [5] 단백질 이다.
기능. 히스톤 아세틸화 는 진핵생물 유전자 발현 조절에 중요한 역할을 한다.히스톤 아세틸화 및 탈아세틸화는 멀티 서브유닛 복합체에 의해 촉매된다. 이 유전자에 의해 코드된 단백질은 SIN3A , SAP18 , HDAC1 , HDAC2, RbAp46 , RbAp48 및 기타 폴리펩타이드를 포함하는 히스톤탈아세틸라아제 복합체의 구성요소이다. 이 복합체는 코어 히스톤 옥타머 탈아세틸화에는 활성이지만, 핵염색체 히스톤 탈아세틸화에는 비활성이다. 이 유전자의 유사 유전자는 [5]
포유류는 SAP30과 70%[6] ) 라는 이름의 SAP30을 가지고 있다. SAP30과 SAP30L은 모두 잘 보존된 SAP30 단백질 패밀리를 구성한다. 또한 SAP30L은 Sin3A 코어프레셔 복합체의 여러 성분과 상호작용하여 Sin3A 및 히스톤탈아세틸화효소의 [7]
SAP30 패밀리의 단백질(SAP30 단백질)은 기능적 인 핵자 국재 신호를 가지며, Sin3A를 [7] SAP30 단백질은 N 말단 아연 의존 모듈에 의해 DNA와 배열의존적 접촉을 가지며, 이들의 산성 중심 영역은 히스톤 및 뉴클레오솜 상호작용에 기여한다. SAP30 단백질의 DNA결합은 핵 신호 발생을 지질에 의해,(PI)phosphoinositides되어 있다.[8]SAP30 단백질은 DNA와 실행 지시계 상호 반감을 상호 관계에 아연 집게 단백질과 그들의 상호 작용과 관련해 어떻게 이러한 지질은 분자 메커니즘을 예로 들고 서 있는 것처럼 보이는 첫번째 예를 제공합니다. 유전자 [8] [9]
상호 작용 SAP30은 다음 제품과 상호 작용하는 것 으로 나타났습니다.
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