File:Protein detoxification pathway.jpg
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Summary
[edit]DescriptionProtein detoxification pathway.jpg |
English: Protein detoxification pathway
Protein arginine methylation is performed by a class of enzymes termed protein arginine methyltransferases (PRMT), which specifically methylate protein-incorporated L-arginine (L-Arg) residues to generate protein incorporated monomethylarginine (L-MMA), asymmetric dimethylarginine (ADMA), or symmetric dimethylarginine (SDMA). Upon proteolytic cleavage of arginine-methylated proteins, free intracellular MMA, ADMA, or SDMA are generated. Free L-Arginine can be metabolized by arginases to L-ornithine and urea, or by nitric oxide synthases (NOS) to NO and L-citrulline. Free methylarginines can also be released to the extracellular space by cationic amino acid transporters (CAT) to induce distinct biological effects, undergo hepatic metabolism, or renal excretion. MMA and ADMA, but not SDMA can be converted to L-citrulline and mono- or diamines by a class of intracellular enzymes called dimethylarginine dimethylaminohydrolases (DDAH). Most importantly, MMA and ADMA, but not SDMA, act as potent endogenous inhibitors of NOS enzymes. |
Source | Ttingate (talk) (Uploads) |
Author | Dr Trevor Tingate |
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Licensing
[edit]Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.http://www.gnu.org/copyleft/fdl.htmlGFDLGNU Free Documentation Licensetruetrue |
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Original upload log
[edit]Transferred from en.wikipedia to Commons using For the Common Good.
Date/Time | Dimensions | User | Comment |
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02:04, 28 June 2010 | 3,000 × 2,250 (281,182 bytes) | w:en:Ttingate (talk | contribs) | rotein arginine methylation is performed by a class of enzymes termed protein arginine methyltransferases (PRMT), which specifically methylate protein-incorporated L-arginine (L-Arg) residues to generate protein incorporated monomethylarginine (L-MMA), as |
00:27, 28 June 2010 | 3,000 × 2,250 (281,182 bytes) | w:en:Ttingate (talk | contribs) | |
00:24, 28 June 2010 | 3,000 × 2,250 (281,182 bytes) | w:en:Ttingate (talk | contribs) | |
02:02, 25 June 2010 | 3,000 × 2,250 (281,182 bytes) | w:en:Ttingate (talk | contribs) | |
00:54, 25 June 2010 | 960 × 720 (52,221 bytes) | w:en:Ttingate (talk | contribs) | Dr Trevor Tingate MD MBBS |
04:40, 22 June 2010 | 965 × 725 (99,244 bytes) | w:en:Ttingate (talk | contribs) | redo |
04:28, 22 June 2010 | 1,680 × 1,050 (75,599 bytes) | w:en:Ttingate (talk | contribs) | Zakrzewicz, D. From arginine methylation to ADMA: A novel mechanism with therapeutic potential in chronic lung diseases Pulmonary Medicine 2009;9:1471-2466 Methylarginine metabolism. Protein arginine methylation is performed by a class of enzymes terme |
File history
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current | 17:43, 10 December 2016 | 3,000 × 2,250 (275 KB) | OgreBot (talk | contribs) | (BOT): Reverting to most recent version before archival | |
17:43, 10 December 2016 | 960 × 720 (51 KB) | OgreBot (talk | contribs) | (BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-25 00:54:15 by Ttingate | ||
17:43, 10 December 2016 | 965 × 725 (97 KB) | OgreBot (talk | contribs) | (BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-22 04:40:18 by Ttingate | ||
17:43, 10 December 2016 | 1,680 × 1,050 (74 KB) | OgreBot (talk | contribs) | (BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-22 04:28:08 by Ttingate | ||
15:58, 8 December 2016 | 3,000 × 2,250 (275 KB) | Jon Kolbert (talk | contribs) | Transferred from en.wikipedia: see original upload log above |
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