CYP19A1

CYP19A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8
Dynodwyr
Cyfenwau	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, cytochrome P450 family 19 subfamily A member 1
Dynodwyr allanol	OMIM: 107910 HomoloGene: 30955 GeneCards: CYP19A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • oxygen binding • metal ion binding • monooxygenase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • electron transfer activity • oxidoreductase activity • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • steroid hydroxylase activity Cydrannau o'r gell • endoplasmic reticulum membrane • Reticwlwm endoplasmig • bilen • integral component of membrane Prosesau biolegol • estrogen biosynthetic process • androgen metabolic process • negative regulation of chronic inflammatory response • prostate gland growth • sterol metabolic process • negative regulation of macrophage chemotaxis • steroid biosynthetic process • female gonad development • female genitalia development • mammary gland development • uterus development • testosterone biosynthetic process • androgen catabolic process • positive regulation of estradiol secretion • electron transport chain Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1588	n/a
Ensembl	ENSG00000137869	n/a
UniProt	P11511	n/a
RefSeq (mRNA)	NM_000103 NM_001347248 NM_001347249 NM_001347250 NM_001347251 NM_001347252 NM_001347253 NM_001347254 NM_001347255 NM_001347256 NM_031226	n/a
RefSeq (protein)	NP_000094 NP_001334177 NP_001334178 NP_001334179 NP_001334180 NP_001334181 NP_001334182 NP_001334183 NP_001334184 NP_001334185 NP_112503	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP19A1 yw CYP19A1 a elwir hefyd yn Aromatase a Cytochrome P450 family 19 subfamily A member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP19A1.

• ARO
• ARO1
• CPV1
• CYAR
• CYP19
• CYPXIX
• P-450AROM

Llyfryddiaeth

• "Preparation of a novel antiserum to aromatase with high affinity and specificity: Its clinicopathological significance on breast cancer tissue. ". PLoS One. 2017. PMID 28489882.
• "The effects of Nobiletin, Hesperetin, and Letrozole in a combination on the activity and expression of aromatase in breast cancer cells. ". Cell Mol Biol (Noisy-le-grand). 2017. PMID 28364779.
• "Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer. ". Nat Genet. 2017. PMID 28112739.
• "Aromatase changes in depression: A postmortem and animal experimental study. ". Psychoneuroendocrinology. 2017. PMID 28024269.
• "Impact of CYP19A1 and ESR1 variants on early-onset side effects during combined endocrine therapy in the TEXT trial.". Breast Cancer Res. 2016. PMID 27825388.