CYP2E1

CYP2E1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z
Dynodwyr
Cyfenwau	CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1
Dynodwyr allanol	OMIM: 124040 HomoloGene: 68089 GeneCards: CYP2E1
EC number	1.14.13.n7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • oxygen binding • arachidonic acid epoxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • monooxygenase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • enzyme binding • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • steroid hydroxylase activity • Hsp70 protein binding • Hsp90 protein binding Cydrannau o'r gell • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • bilen • intrinsic component of endoplasmic reticulum membrane • Golgi membrane • Reticwlwm endoplasmig • mitocondria • cytoplasm • mitochondrial inner membrane Prosesau biolegol • steroid metabolic process • epoxygenase P450 pathway • response to ozone • heterocycle metabolic process • response to organonitrogen compound • monoterpenoid metabolic process • xenobiotic metabolic process • response to ethanol • triglyceride metabolic process • carbon tetrachloride metabolic process • halogenated hydrocarbon metabolic process • benzene metabolic process • long-chain fatty acid biosynthetic process • response to bacterium • organic acid metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1571	n/a
Ensembl	ENSG00000130649	n/a
UniProt	P05181	n/a
RefSeq (mRNA)	NM_000773	n/a
RefSeq (protein)	NP_000764	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP2E1 yw CYP2E1 a elwir hefyd yn Cytochrome P450 2E1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q26.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP2E1.

• CPE1
• CYP2E
• P450-J
• P450C2E

Llyfryddiaeth

• "CYP2E1 Gene Polymorphisms Related to the Formation of Coronary Artery Lesions in Kawasaki Disease. ". Pediatr Infect Dis J. 2017. PMID 28650933.
• "Cytochrome P450 2E1 increases the sensitivity of hepatoma cells to vitamin K2. ". Int J Oncol. 2017. PMID 28339022.
• "Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies. ". Medicine (Baltimore). 2016. PMID 27787372.
• "Meta-analysis of CYP2E1 polymorphisms in liver carcinogenesis. ". Dig Liver Dis. 2017. PMID 27637154.
• "CYP2E1 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis.". Eur Arch Otorhinolaryngol. 2017. PMID 27491320.