IGLL1

IGLL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2H32, 2H3N, 2LKQ
Dynodwyr
Cyfenwau	IGLL1, 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, immunoglobulin lambda like polypeptide 1
Dynodwyr allanol	OMIM: 146770 HomoloGene: 131669 GeneCards: IGLL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • immunoglobulin receptor binding • GO:0003823, GO:0051635 antigen binding Cydrannau o'r gell • blood microparticle • bilen • external side of plasma membrane • immunoglobulin complex, circulating • extracellular region Prosesau biolegol • B cell receptor signaling pathway • phagocytosis, recognition • positive regulation of B cell activation • phagocytosis, engulfment • innate immune response • defense response to bacterium • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • complement activation, classical pathway • leukocyte migration Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3543	n/a
Ensembl	ENSG00000128322	n/a
UniProt	P15814	n/a
RefSeq (mRNA)	NM_020070 NM_152855 NM_001369906	n/a
RefSeq (protein)	NP_064455 NP_690594 NP_001356835	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGLL1 yw IGLL1 a elwir hefyd yn Immunoglobulin lambda like polypeptide 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q11.23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGLL1.

• IGO

14.1

• AGM2
• IGL1
• IGL5
• IGLL
• IGVPB
• CD179b
• VPREB2
• IGLJ14.1

Llyfryddiaeth

• "Autosomal recessive agammaglobulinemia associated with an IGLL1 gene missense mutation. ". Ann Allergy Asthma Immunol. 2016. PMID 27576013.
• "Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. ". Acta Crystallogr D Biol Crystallogr. 2002. PMID 11976493.
• "Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway. ". Blood. 2000. PMID 10887125.
• "Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. ". J Immunol. 2000. PMID 10799888.
• "Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia.". J Exp Med. 1998. PMID 9419212.