RAC3

RAC3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2C2H, 2G0N, 2IC5, 2OV2, 2QME
Dynodwyr
Cyfenwau	RAC3, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), Rac family small GTPase 3
Dynodwyr allanol	OMIM: 602050 HomoloGene: 68433 GeneCards: RAC3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • GTP binding; • calcium-dependent protein binding; • GO:0001948, GO:0016582 protein binding; • GO:0006184 GTPase activity; • protein kinase binding;
Cydrannau o'r gell	• cytoplasm; • filamentous actin; • cytosol; • cell projection; • bilen; • growth cone; • Cellbilen; • soma; • perinuclear region of cytoplasm; • neuron projection; • extracellular exosome; • Cytosgerbwd; • endomembrane system; • cyrion cell; • lamellipodium; • intracellular anatomical structure;
Prosesau biolegol	• GO:0007243 intracellular signal transduction; • neuromuscular process controlling balance; • regulation of neuron maturation; • synaptic transmission, GABAergic; • cerebral cortex GABAergic interneuron development; • positive regulation of substrate adhesion-dependent cell spreading; • neuromuscular process; • cell projection assembly; • regulation of cell morphogenesis; • homeostasis of number of cells within a tissue; • positive regulation of cell adhesion mediated by integrin; • neuron projection development; • regulation of small GTPase mediated signal transduction; • actin cytoskeleton organization; • small GTPase mediated signal transduction; • GO:0000767 cell morphogenesis; • actin filament organization; • Rho protein signal transduction; • cell migration; • positive regulation of actin filament polymerization; • actin cytoskeleton reorganization; • engulfment of apoptotic cell;
	Sources:Amigo / QuickGO
Orthologau
	5881
	n/a
	ENSG00000169750
	n/a
	P60763
	n/a
	NM_005052; NM_001316307
	n/a
	NP_001303236; NP_005043
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAC3 yw RAC3 a elwir hefyd yn Rac family small GTPase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q25.3.^[2]

Llyfryddiaeth

"Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines. ". BMC Cancer. 2013. PMID 23388133.
"Nuclear receptor coactivator RAC3 inhibits autophagy. ". Cancer Sci. 2012. PMID 22957814.
"Rac3 regulates cell proliferation through cell cycle pathway and predicts prognosis in lung adenocarcinoma. ". Tumour Biol. 2016. PMID 27402308.
"RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging. ". Cell Death Dis. 2015. PMID 26469953.
"Silencing of Rac3 inhibits proliferation and induces apoptosis of human lung cancer cells.". Asian Pac J Cancer Prev. 2015. PMID 25854406.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RAC3 - Cronfa NCBI

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[2]