TBX3

TBX3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1H6F
Dynodwyr
Cyfenwau	TBX3, TBX3-ISO, UMS, XHL, T-box 3, T-box transcription factor 3
Dynodwyr allanol	OMIM: 601621 HomoloGene: 4371 GeneCards: TBX3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • sequence-specific DNA binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001948, GO:0016582 protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cnewyllyn cell;
Prosesau biolegol	• forelimb morphogenesis; • cellular senescence; • branching involved in mammary gland duct morphogenesis; • positive regulation of stem cell proliferation; • atrioventricular bundle cell differentiation; • negative regulation of epithelial cell differentiation; • female genitalia development; • transcription, DNA-templated; • male genitalia development; • multicellular organism development; • anterior/posterior axis specification, embryo; • outflow tract morphogenesis; • skeletal system development; • ventricular septum morphogenesis; • embryonic forelimb morphogenesis; • cardiac muscle cell fate commitment; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • heart morphogenesis; • regulation of cell population proliferation; • heart looping; • negative regulation of myoblast differentiation; • specification of animal organ position; • stem cell population maintenance; • luteinizing hormone secretion; • follicle-stimulating hormone secretion; • blood vessel development; • positive regulation of cell population proliferation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • roof of mouth development; • mammary placode formation; • in utero embryonic development; • mesoderm morphogenesis; • GO:0009373 regulation of transcription, DNA-templated; • limb morphogenesis; • sinoatrial node cell development; • positive regulation of cell cycle; • cardiac muscle cell differentiation; • limbic system development; • embryonic hindlimb morphogenesis; • animal organ morphogenesis; • embryonic heart tube development; • embryonic digit morphogenesis; • mammary gland development; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologau
	6926
	n/a
	ENSG00000135111
	n/a
	O15119
	n/a
	NM_016569; NM_005996
	n/a
	NP_005987; NP_057653
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TBX3 yw TBX3 a elwir hefyd yn T-box 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q24.21.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TBX3.

UMS
XHL
TBX3-ISO

Llyfryddiaeth

"Genome-Wide Association Study of Absolute QRS Voltage Identifies Common Variants of TBX3 as Genetic Determinants of Left Ventricular Mass in a Healthy Japanese Population. ". PLoS One. 2016. PMID 27195777.
"Overexpression of Tbx3 predicts poor prognosis of patients with resectable pancreatic carcinoma. ". Asian Pac J Cancer Prev. 2015. PMID 25743805.
"Novel TBX3 mutation in a family of Cypriot ancestry with ulnar-mammary syndrome. ". Clin Dysmorphol. 2017. PMID 28145909.
"Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion. ". Virchows Arch. 2016. PMID 27553355.
"The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer.". BMC Cancer. 2016. PMID 27553211.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TBX3 - Cronfa NCBI

[1]

[2]