TSHR

TSHR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2XWT, 3G04
Dynodwyr
Cyfenwau	TSHR, CHNG1, LGR3, hTSHR-I, thyroid stimulating hormone receptor, Thyrotropin receptor, thyrotropin (TSH) receptor
Dynodwyr allanol	OMIM: 603372 HomoloGene: 315 GeneCards: TSHR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • G protein-coupled peptide receptor activity • GO:0001948, GO:0016582 protein binding • G protein-coupled receptor activity • protein-hormone receptor activity • signal transducer activity • thyroid-stimulating hormone receptor activity • GO:0032403 protein-containing complex binding • signaling receptor activity Cydrannau o'r gell • integral component of membrane • receptor complex • integral component of plasma membrane • bilen • cell surface • Cellbilen • basolateral plasma membrane • intracellular anatomical structure Prosesau biolegol • cell-cell signaling • G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cell population proliferation • activation of adenylate cyclase activity • hormone-mediated signaling pathway • GO:0072468 signal transduction • nervous system development • cell surface receptor signaling pathway • positive regulation of adenylate cyclase activity • cellular response to glycoprotein • cellular response to thyrotropin-releasing hormone • thyroid-stimulating hormone signaling pathway • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7253	n/a
Ensembl	ENSG00000165409	n/a
UniProt	P16473	n/a
RefSeq (mRNA)	NM_000369 NM_001018036 NM_001142626	n/a
RefSeq (protein)	NP_000360 NP_001018046 NP_001136098	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TSHR yw TSHR a elwir hefyd yn Thyroid stimulating hormone receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TSHR.

• LGR3
• CHNG1
• hTSHR-I

Llyfryddiaeth

• "Novel germline mutation (Leu512Met) in the thyrotropin receptor gene (TSHR) leading to sporadic non-autoimmune hyperthyroidism. ". J Pediatr Endocrinol Metab. 2017. PMID 28195550.
• "High-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies. ". Clin Exp Immunol. 2017. PMID 28099999.
• "Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?". Genet Mol Res. 2016. PMID 27525921.
• "Association of polymorphisms of rs179247 and rs12101255 in thyroid stimulating hormone receptor intron 1 with an increased risk of Graves' disease: A meta-analysis. ". J Huazhong Univ Sci Technolog Med Sci. 2016. PMID 27465319.
• "TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective.". Endocr Rev. 2016. PMID 27454362.