USP7

USP7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NB8, 1NBF, 1YY6, 1YZE, 2F1W, 2F1X, 2F1Y, 2F1Z, 2FOJ, 2FOO, 2FOP, 2KVR, 2XXN, 2YLM, 3MQR, 3MQS, 4JJQ, 4KG9, 4M5W, 4M5X, 4PYZ, 4WPH, 4WPI, 4YOC, 5C56, 5C6D, 4YSI, 5FWI
Dynodwyr
Cyfenwau	USP7, HAUSP, TEF1, ubiquitin specific peptidase 7 (herpes virus-associated), ubiquitin specific peptidase 7, HAFOUS
Dynodwyr allanol	OMIM: 602519 HomoloGene: 2592 GeneCards: USP7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • p53 binding • transcription factor binding • GO:0070122 peptidase activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • thiol-dependent deubiquitinase • cysteine-type endopeptidase activity • hydrolase activity • ubiquitin protein ligase binding • GO:1904265 deubiquitinase activity • Lys48-specific deubiquitinase activity Cydrannau o'r gell • cytoplasm • PML body • nuclear body • nucleoplasm • cnewyllyn cell • cytosol • Cromosom • GO:0009327 protein-containing complex Prosesau biolegol • maintenance of DNA methylation • ubiquitin-dependent protein catabolic process • protein stabilization • proteolysis • cellular response to DNA damage stimulus • multicellular organism development • regulation of DNA-binding transcription factor activity • regulation of telomere capping • transcription-coupled nucleotide-excision repair • GO:0022415 viral process • negative regulation of NF-kappaB transcription factor activity • GO:0100026 DNA repair • protein ubiquitination • protein deubiquitination • monoubiquitinated protein deubiquitination • histone H2B conserved C-terminal lysine deubiquitination • regulation of protein stability • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • protein K48-linked deubiquitination • positive regulation of DNA demethylation • regulation of circadian rhythm • proses rythmig Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7874	n/a
Ensembl	ENSG00000187555	n/a
UniProt	Q93009	n/a
RefSeq (mRNA)	NM_003470 NM_001286457 NM_001286458 NM_001321858	n/a
RefSeq (protein)	NP_001273386 NP_001273387 NP_001308787 NP_003461	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn USP7 yw USP7 a elwir hefyd yn Ubiquitin carboxyl-terminal hydrolase 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn USP7.

• TEF1
• HAUSP

Llyfryddiaeth

• "USP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma. ". Tumour Biol. 2015. PMID 25519684.
• "USP7 controls Chk1 protein stability by direct deubiquitination. ". Cell Cycle. 2014. PMID 25483066.
• "Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role. ". J Struct Biol. 2016. PMID 27183903.
• "USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. ". Cell Rep. 2016. PMID 26971997.
• "Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells.". Biochem Biophys Res Commun. 2016. PMID 26768359.