The 1962 United States Senate special election in Wyoming was held on November 6, 1962. Following the death of Senator-elect Keith Thomson after his election to the Senate in 1960, Democratic Governor John J. Hickey appointed himself to fill the vacancy. A special election was held to fill the remaining four years of the term in 1962, and Hickey faced a strong challenge from former Republican Governor Milward Simpson in a rematch of the 1958 gubernatorial election. Despite a political environment largely favorable to Democrats nationwide, Democratic candidates faced strong headwinds in Wyoming. Senator Hickey overwhelmingly lost re-election to Simpson as Democratic Governor Jack R. Gagelost re-election by a wide margin, as well. Hickey was the last Democratic Senator from Wyoming to serve after Gale McGee began his tenure, though McGee was the last remaining.